The kinetics and efficacy of activated protein C-eluting coronary stents - preventing thrombosis in percutaneous coronary intervention

Abstract not available

Circles in the heart and cardiovascular system.

10.1093/cvr/cvz227Cardiovasc Re

The Role of Epigenetics in Congenital Heart Disease

10.3390/genes12030390GENES12

Following hearts, one cell at a time: recent applications of single-cell RNA sequencing to the understanding of heart disease

Abstract The mammalian heart contains heterogeneous cell types contributing to pathological changes in cardiac disease. In this Comment, we explore how single-cell transcriptomic approaches are unveiling intricate cellular mechanisms and gene co-expression networks that regulate the workings, and failings, of the heart

Effects of extended pharmacological disruption of zebrafish embryonic heart biomechanical environment on cardiac function, morphology, and gene expression

10.1002/dvdy.378Developmental Dynamics250121759-177

Germline genome modification through novel political, ethical, and social lenses

10.1371/journal.pgen.1009741PLoS Genetics179e1009741

Time-restricted feeding modulates the DNA methylation landscape, attenuates hallmark neuropathology and cognitive impairment in a mouse model of vascular dementia

10.7150/thno.71815THERANOSTICS1273007-302

Targeting the highly abundant circular RNA circSlc8a1 in cardiomyocytes attenuates pressure overload induced hypertrophy.

10.1093/cvr/cvz130Cardiovasc Re

Cohort profile : the diet and healthy aging (DaHA) study in Singapore

How diet is related with cognition and health has not been systematically examined in Asians whose eating habits are very different from their counterparts in the West and the biological mechanisms underlying such links are not well known yet. The diet and healthy aging (DaHA) study is a community-based longitudinal study conducted to examine the role of diet and nutrition in promoting cognitive, emotional, and physical health among community-living elderly Singaporeans. The first wave of DaHA, conducted from 2011 to 2017, provided detailed information on diet and baseline cognitive function and health from 1010 community-living elderly in Singapore. Biomarkers of oxidative stress, systemic inflammation, and genetic information were collected. The ongoing second wave of DaHA is conducted from 2017 to 2020, which provides follow- up assessments using established cognitive tests and clinical tools. This well-characterized cohort, with its archived biological samples and high-quality data on diet and lifestyle factors will allow researchers to explore the relationships among diet, nutrition, genes, cognition, mental and physical health in an extremely cost-effective manner. Translations of the research findings into clinical and public health practices will potentially help to promote cognitive health at the population level and reduce healthcare costs related to cognitive impairment.National Medical Research Council (NMRC)Published versionThis work is supported by the following grants awarded to Dr Lei Feng: the National University of Singapore Virtual Institute for the Study of Ageing [grant number VG-8]; the Alice Lim Memorial Fund, Singapore [grant number ALMFA/2010]; the National Medical Research Council of Singapore [grant number NMRC/TA/ 0053/2016]

Cohort profile: the Diet and Healthy Aging (DaHA) study in Singapore

10.18632/aging.104051AGING-US122323889-2389