Investigating the structure of the autism-spectrum quotient using Mokken scaling

Traits similar to those shown in autism spectrum condition (ASC) are apparent in relatives of individuals with ASC, and in the general population without necessarily meeting diagnostic criteria for an ASC. We assess whether the Autism-Spectrum Quotient (AQ), a self-report measure, has hierarchical properties using Mokken scaling. Hierarchical scales allow the presence of a latent trait to be identified by discovering whether and how many specific items form an ordered array along it. Data were collected from 2 groups: (1) people with ASC (n = 449: 240 males, 209 females, M age 35.4 years, SD = 12.8) and (2) university students (n = 943: 465 males, 475 females, M age = 23.0 years, SD = 8.4). A single Mokken scale was obtained in the data from university students and 3 scales were obtained in the data from people with ASC. The scales all showed moderate Mokken scaling properties with the single scale obtained from university students showing weak invariant item ordering and 2 of the scales from people with ASC showing weak invariant item ordering. The AQ formed reliable Mokken scales. There was a large overlap between the scale from the university student sample and the sample with ASC, with the first scale, relating to social interaction, being almost identical. The present study confirms the utility of the AQ as a single instrument that can dimensionalize autistic traits in both university student and clinical samples of ASC, and confirms that items of the AQ are consistently ordered relative to one another

The Extremely Red Objects Found Thus Far in the Caltech Faint Galaxy Redshift Survey

We discuss the very red objects found in the first field of the Caltech Faint Galaxy Redshift Survey, for which the observations and analysis are now complete. In this field, which is 15 arcmin$^2$ and at J005325+1234 there are 195 objects with $K_s < 20$ mag, of which 84% have redshifts. The sample includes 24 spectroscopically confirmed Galactic stars, 136 galaxies, three AGNs, and 32 objects without redshifts. About 10% of the sample has $(R-K) \ge 5$ mag. Four of these objects have redshifts, with $0.78 \le z \le 1.23$. Three of these are based on absorption features in the mid-UV, while the lowest redshift object shows the standard features near 4000\AA. Many of the objects still without redshifts have been observed spectroscopically, and no emission lines were seen in their spectra. We believe they are galaxies with $z \sim 1 - 1.5$ that are red due to their age and stellar content and not to some large amount of internal reddening from dust. Among the many other results from this survey of interest here is a determination of the median extinction in the mid-UV for objects with strong emission line spectra at $z \sim 1 - 1.3$. The result is extinction by a factor of $\sim$2 at 2400\AA.Comment: 6 pages, Latex, with 2 figures. To be published in the proceedings of the conference "Infrared Surveys: A Prelude to SIRTF

The oxygen-II luminosity density of the Universe

Equivalent widths of [OII] 3727 A lines are measured in 375 faint galaxy spectra taken as part of the Caltech Faint Galaxy Redshift Survey centered on the Hubble Deep Field. The sensitivity of the survey spectra to the [OII] line is computed as a function of magnitude, color and redshift. The luminosity function of galaxies in the [OII] line and the integrated luminosity density of the Universe in the [OII] line are computed as a function of redshift. It is found that the luminosity density in the [OII] line was a factor of ~10 higher at redshifts z~1 than it is at the present day. The simplest interpretation is that the star formation rate density of the Universe has declined dramatically since z~1.Comment: accepted for publication in Ap

Drosophila Cdi4 is a p21/p27/p57-like cyclin-dependent kinase inhibitor with specificity for cyclin E complexes.

The eukaryotic cell cycle is controlled by a network of interacting regulatory proteins. We used an interaction mating two-hybrid assay to identify connections within the cell cycle regulatory network in Drosophila. We tested interactions between Drosophila cyclins and a panel of hundreds of previously identified proteins. One of the connections we identified was the interaction between cyclin E and a novel Drosophila protein, Cdi4. Because Cdi4 was originally identified by its ability to interact with a Drosophila cyclin-dependent kinase, the finding that it interacts with cyclin E strengthened the notion that it functions in cell cycle regulation. We show that Cdi4 can inhibit cyclin E function both in a yeast assay and in vitro. In light of these results, our sequence analysis revealed that Cdi4 is a unique member of the p21/p27/p57 family of Cdk inhibitors. Our results demonstrate that interaction mating assays using large informative panels of proteins can aid the analysis of regulatory networks by generating and constraining hypotheses that guide further work

Counts and Colors of Faint Galaxies in the U and R Bands

Ground-based counts and colors of faint galaxies in the U and R bands in one field at high Galactic latitude are presented. Integrated over flux, a total of 1.2x10^5 sources per square degree are found to U=25.5 mag and 6.3x10^5 sources per square degree to R=27 mag, with d log N/dm ~ 0.5 in the U band and d log N/dm ~ 0.3 in the R band. Consistent with these number-magnitude curves, sources become bluer with increasing magnitude to median U-R=0.6 mag at 24<U<25 mag and U-R=1.2 mag at 25 < R < 26 mag. Because the Lyman break redshifts into the U band at z~3, at least 1.2x10^5 sources per square degree must be at redshifts z<3. Measurable U-band fluxes of 73 percent of the 6.3x10^5 sources per square degree suggest that the majority of these also lie at z < 3. These results require an enormous space density of objects in any cosmological model.Comment: 17 pages, MNRAS in pres