Get Your Shirts At Moody’s! Samuel Nadin Moody: Advertising Genius in New Orleans, 1848 to 1874

Mid-nineteenth century immigrant to New Orleans and businessman, Samuel Nadin Moody, leveraged the tools of the market revolution to pioneer advertisement with innovation and flamboyance to sell men’s clothing, specifically men’s shirts of his own manufacture. Through over saturation of billboards, a massive, sustained, and creative newspaper advertising campaign, and the invention—and careful curation of—a personal brand, Moody thrived in the era’s volatile marketplace. This micro-history peers into this impressive success story enjoyed by a singular individual

Get Your Shirts At Moody’s! Samuel Nadin Moody: Advertising Genius in New Orleans, 1848 to 1874

Mid-nineteenth century immigrant to New Orleans and businessman, Samuel Nadin Moody, leveraged the tools of the market revolution to pioneer advertisement with innovation and flamboyance to sell men’s clothing, specifically men’s shirts of his own manufacture. Through over saturation of billboards, a massive, sustained, and creative newspaper advertising campaign, and the invention—and careful curation of—a personal brand, Moody thrived in the era’s volatile marketplace. This micro-history peers into this impressive success story enjoyed by a singular individual

Moulting phenology of the harbour seal in south-west Ireland

Studies on the phenology of harbour seal moult have been carried out in the Atlantic and Pacific, however there has been no research into this process in the Republic of Ireland, at the southern edge of the species range in the north-east Atlantic. Population estimates of harbour seals are derived by counts primarily during the moulting seasons. In the absence of information on the moult phenology planning the optimal timing of such surveys is impossible. Furthermore, changes in moult phenology may reflect changes in resource availability or competition, or demographic changes. The phenology of the harbour seal moult was investigated in south-west Ireland in this study. Timing of the moult differed among all cohorts, yearlings began moulting first followed by adult females and finally adult males. The number of seals hauled out was generally positively related to the proportion of seals in active moult. The timing of the moult period was different to other parts of the species' range and should be considered in determining optimal timing of future surveys for assessing populations abundance and trends in Ireland

The Potential Clinical and Economic Value of Primary Tumour Identification in Metastatic Cancer of Unknown Primary Tumour: A Population-Based Retrospective Matched Cohort Study.

PurposeSeveral genomic tests have recently been developed to identify the primary tumour in cancer of unknown primary tumour (CUP). However, the value of identifying the primary tumour in clinical practice for CUP patients remains questionable and difficult to prove in randomized trials.ObjectiveWe aimed to assess the clinical and economic value of primary tumour identification in CUP using a retrospective matched cohort study.MethodsWe used the Manitoba Cancer Registry to identify all patients initially diagnosed with metastatic cancer between 2002 and 2011. We defined patients as having CUP if their primary tumour was found 6 months or more after initial diagnosis or never found during the course of disease. Otherwise, we considered patients to have metastatic cancer from a known primary tumour (CKP). We linked all patients with Manitoba Health databases to estimate their direct healthcare costs using a phase-of-care approach. We used the propensity score matching technique to match each CUP patient with a CKP patient on clinicopathologic characteristics. We compared treatment patterns, overall survival (OS) and phase-specific healthcare costs between the two patient groups and assessed association with OS using Cox regression adjustment.ResultsOf 5839 patients diagnosed with metastatic cancer, 395 had CUP (6.8%); 1:1 matching created a matched group of 395 CKP patients. CUP patients were less likely to receive surgery, radiation, hormonal and targeted therapy and more likely to receive cytotoxic empiric chemotherapeutic agents. Having CUP was associated with reduced OS (hazard ratio [HR] 1.31; 95% confidence interval 1.1-1.58), but this lost statistical significance with adjustment for treatment differences. CUP patients had a significant increase in the mean net cost of initial diagnostic workup before diagnosis and a significant reduction in the mean net cost of continuing cancer care.ConclusionIdentifying the primary tumour in CUP patients might enable the use of more effective therapies, improve OS and allow more efficient allocation of healthcare resources

Chlamydia trachomatis infection and the risk of perinatal mortality in Hungary

Introduction: Chlamydial infections of the genital tract are thought to often lead to preterm birth, which is the most important perinatal problem in Hungary. Aim of study: A multicenter study was carried out to determine the prevalence of Chlamydia trachomatis infection, risk factors for the infection and to relate the infection to perinatal mortality, accounting for potential confounding effects. Methods: The nucleic acid hybridization method (PACE2 Gen-Probe) was applied for the examination of Chlamydia trachomatis. Logistic regression analysis was used to assess risk. Results: A total of 6156 pregnant women were examined for the occurrence of Chlamydia trachomatis. The observed overall rate of chlamydial infection was 5.9%. Young age (less than 24 years old) (OR and 95% CI:1.6 (1.3-2.0)), unmarried status (1.5 (1.2-1.9)) and the high unemployment rate (2.1 (1.6-2.7)) were statistically significant predictors of the infection. In logistic regression analysis, chlamydial infection (1.9 (1.1-3.3)). high unemployment rate (1.5 (1.2-2.2)) and low birth weight (1.7 (1.1-2.7) were significant predictors of perinatal mortality. Conclusions: Testing pregnant women for diseases that can be transmitted perinatally is an important part of obstetric cart. Screening for C. trachomatis of unmarried women under 24 years of age is suggested and need increased observation during labor

Cost-effectiveness of using a gene expression profiling test to aid in identifying the primary tumour in patients with cancer of unknown primary.

We aimed to investigate the cost-effectiveness of a 2000-gene-expression profiling (GEP) test to help identify the primary tumor site when clinicopathological diagnostic evaluation was inconclusive in patients with cancer of unknown primary (CUP). We built a decision-analytic-model to project the lifetime clinical and economic consequences of different clinical management strategies for CUP. The model was parameterized using follow-up data from the Manitoba Cancer Registry, cost data from Manitoba Health administrative databases and secondary sources. The 2000-GEP-based strategy compared to current clinical practice resulted in an incremental cost-effectiveness ratio (ICER) of $44,151 per quality-adjusted life years (QALY) gained. The total annual-budget impact was$36.2 million per year. A value-of-information analysis revealed that the expected value of perfect information about the test\u27s clinical impact was $4.2 million per year. The 2000-GEP test should be considered for adoption in CUP. Field evaluations of the test are associated with a large societal benefit.The Pharmacogenomics Journal advance online publication, 29 March 2016; doi:10.1038/tpj.2015.94

Pulse Dryer Technology for Developing Nations Its Application to Sludge

This paper describes a simple but efficient process for converting sludge and other miscellaneous liquid/solid mixtures into a very dry powder form. Its simplicity lends itself to ease of use, mobility and cost effectiveness. The operation of this process does not present any unreviewed or new environmental issues and accommodates Best Available Treatment requirements. The process provides an opportunity for the treatment of small or large quantities of sludge and other existing hazardous wastes to create a dry product that is more easily handled, disposed of or otherwise dispositioned