O compositor em espaço cénico: estudo de alguns processos correlacionais

A presente dissertação surge no contexto da criação artística musical e pretende abranger um campo de possibilidades na exploração das relações entre os processos de composição musical e a experiência artística conduzida a partir da criação musical para as outras artes, recorrendo para tal à produção de conhecimento de significativa importância para mim no processo de coesão e competência artísticas. No contexto de processos relacionais múltiplos, é pretendido questionar dentro da criação musical, o limiar da ação ao nível do espaço, do movimento e do visual, em interligação com, entre outros, o instrumentista, o ator e o autor. Coloca-se assim em perspetiva o binómio da realidade espacial e do mundo visual, duas componentes em correlação musical. Numa atitude expansível de conhecimento e que em nada deveria ser fragmentária, como compositor, ao encontro dos meus interesses sobre a performance artística, é imperativo perceber a minha prática que coloca todas estas condicionantes em discussão, à emergência de um caminho confrontado com outros anteriormente percorridos.This thesis emerges in the context of musical and artistic creation with the intent to cover a field of possibilities for the exploration of the relationships between the processes of musical composition and artistic experience, driven from the musical creation to the other arts, producing knowledge of significant importance to me in the process of cohesion and artistic competence. In the context of multiple relational processes is intended to question the music creation, the threshold of the action in some levels like space, movement and visual, while related to, among others, the instrumentalist, the actor and author. This raises the binomial prospective of the reality space and the visual world, two components in musical correlation. With an attitude of expandable knowledge, where nothing should be fragmentary, as a composer, on the encounter to meet my interests on the artistic performance, it is imperative to understand my practice that put all these conditions under discussion

Anti-TNF Exposure during Pregnancy in Crohn’s Disease Patients

Inflammatory bowel disease (IBD) affects young people of reproductive age. Therefore, a broad discussion is needed about the possible disease effects in pregnancy, as well as the risks of fetal exposure to the medications used, especially biological therapy. This study aimed to describe the management of 4 Crohn’s disease patients who received anti-TNF therapy during pregnancy and present a literature review. We reported 4 cases composed of young women who became pregnant while receiving anti-TNF agents. The patients presented a satisfactory response to the clinical treatment and the pregnancies progressed without complications. We did not observe maternal or embryonic toxicity, or unfavorable outcomes. The available data point to inflammatory activity as the main risk factor for unfavorable gestational evolution to date, and showed anti-TNF therapy to be safe during pregnancy and breastfeeding. However, the benefits and risks must be discussed with the patient and management decisions should be taken on an individual basis

Conventional Versus Biological Therapy for Prevention of Postoperative Endoscopic Recurrence in Patients With Crohn's Disease: an International, Multicenter, and Observational Study

Background/AimsPostoperative endoscopic recurrence (PER) occurs in nearly 80% of patients 1 year after ileocecal resection in patients with Crohn's disease (CD). Biological agents were more effective in reducing the rates of PER in comparison with conventional therapy, in prospective trials. The aim of this study was to compare the PER rates of biological versus conventional therapy after ileocecal resections in patients with CD in real-world practice.MethodsThe MULTIPER (Multicenter International Postoperative Endoscopic Recurrence) database is a retrospective analysis of PER rates in CD patients after ileocecal resection, from 7 referral centers in 3 different countries. All consecutive patients who underwent ileocecal resections between 2008 and 2012 and in whom colonoscopies had been performed up to 12 months after surgery, were included. Recurrence was defined as Rutgeerts' score ≥i2. The patients were allocated to either biological or conventional therapy after surgery, and PER rates were compared between the groups.ResultsInitially, 231 patients were evaluated, and 63 were excluded. Of the 168 patients in the database, 96 received anti-tumor necrosis factor agents and 72 were treated with conventional therapy after resection. The groups were comparable regarding age, gender, and perianal disease. There was longer disease duration, more previous resections, and more open surgical procedures in patients on biologicals postoperatively. PER was identified in 25/96 (26%) patients on biological therapy and in 24/72 (33.3%) patients on conventional therapy (P=0.310).ConclusionsIn this retrospective observational analysis from an international database, no difference was observed between biological and conventional therapy in preventing PER after ileocecal resections in CD patients