Crystal and Molecular Structure of the Cyclodimeric Propylene-1,3-phenylenediacetate and of Its Di-n-butyltin Dichloride Complex

As part of a systematic Study on the synthesis and binding properties of a series of cyclophane ester hosts, the crystal structures of the cyclodimeric propylene-1,3-phenylenediacetate (C26H28O8) and of its di-n-butyltin dichloride complex {(C26H26O8) [SnCl2(C4H9)2]2} have been determined by X-ray analyses. The crystals of the free macrocycle are triclinic, space group P1̅, with a = 5.071(6), b = 8.108(3), c = 14.640(4) Å, α = 76.46(3), β = 85.35(8), γ= 86.04(7)°, Z = 1. Similarly, the crystals of the complex belong to the P1̅ space group of the triclinic system and have the following cell parameters: a = 8.378(4), b = 11.524(3), c = 14.009(4) Å, α = 109.16(2), β = 92.64(2), γ= 100.93(3)°, Z= 1. The most important feature of the complex structure is represented by the unambiguous interaction between two cyclophane ester carbonyls and two molecules of Bu2SnCl2, the distance being 2.865(4) Å. The usual tetrahedral geometry of the organotin(IV) center is significantly influenced by the interaction, changing into a distorted trigonal bipyramid, with a longer apical distance, typical of the five-coordinate stannate complexes. Conformations of the cyclophane in the two structures have been analyzed in some detail

Phosphate binding by a novel Zn(II) complex featuring a trans-1,2-diaminocyclohexane ligand. Effective anion recognition in water

Excellent affinities and selectivities toward triphosphates are achieved through an adaptive ditopic receptor featuring a metal ion and a macrocyclic polyammonium cation binding sites, concertedly bridging phosphate anions

Biomimetic Tweezers for N-Glycans: Selective Recognition of the Core GlcNAc(2) Disaccharide of the Sialylglycopeptide SGP

In recent years, glycomics have shown how pervasive the role of carbohydrates in biological systems is and how chemical tools are essential to investigate glycan function and modulate carbohydrate-mediated processes. Biomimetic receptors for carbohydrates can carry out this task but, although significant affinities and selectivities toward simple saccharides have been achieved, targeting complex glycoconjugates remains a goal yet unattained. In this work we report the unprecedented recognition of a complex biantennary sialylglycopeptide (SGP) by a tweezers-shaped biomimetic receptor, which selectively binds to the core GlcNAc2 disaccharide of the N-glycan with an affinity of 170 μM. Because of the simple structure and the remarkable binding ability, this biomimetic receptor can represent a versatile tool for glycoscience, opening the way to useful applications.We thank MIUR-Italy “Progetto Dipartimenti di Eccellenza 2018–2022” allocated to Department of Chemistry Ugo Schiff, COST Action (CA18132), MIUR-Italy PRIN2017 (2017XZ2ZBK) for granting a fellowship to F.M. and Ente Cassa di Risparmio di Firenze (Italy) is acknowledged for granting an ITC nanocalorimeter and a high-field NMR spectrometer. Open Access funding provided by Università degli Studi di Firenze within the CRUI-CARE Agreement

Chloride anion transporters inhibit growth of methicillin-resistant: Staphylococcus aureus (MRSA) in vitro

A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many were found to be effective Cl(−) transporters and to inhibit clinical strains of Staphylococcus aureus growth in vitro. The best transporters proved effective against the methicillin-resistant Staphylococcus aureus (MRSA) strains, Mu50 and HP1173. Tris-thiourea tren-based chloride transporters were also shown to inhibit the growth of S. aureus. in vitro

Chloride anion transporters inhibit growth of methicillin-resistant Staphylococcus aureus (MRSA) in vitro

A series of aminopyrrolic receptors were tested as anion transporters using POPC liposome model membranes. Many were found to be effective Cl– transporters and to inhibit clinical strains of Staphylococcus aureus growth in vitro. The best transporters proved effective against the methicillin-resistant Staphylococcus aureus (MRSA) strains, Mu50 and HP1173. Tris-thiourea tren-based chloride transporters were also shown to inhibit the growth of S. aureus. in vitro.<br/