Dental extraction in patients rece iving dual antiplatelet therapy

Background: Dual antiplatelet therapy consists of administering antiplatelet (antiaggregant) drugs (clopidogrel and aspirin) to prevent thrombotic processes, as a preventative measure in patients with acute coronary disease, or in patients subjected to percutaneous coronary intervention. Objective: The purpose of this study was to evaluate the efficacy of a protocol for performing dental extraction in patients receiving dual antiplatelet therapy. Material and Methods: Thirty-two patients undergoing dental extractions were included in the study. The variables evaluated were: collagen-epinephrine fraction, collagen- adenosine diphosphate fraction, surgical surface, post-surgical measures, and adverse effects. Alveolar sutures and gauzes impregnated with an antifibrinolytic agent (tranexamic acid), which the patient pressed in place for 30 minutes, were applied to all patients as post- surgical measures. Descriptive statistics were calculated and analyzed with Student’s t-test to compare pairs of quantitative variables; simple regression analysis was performed using Pearson’s correlation coefficient. Statistical significance was set at p <0.05. Results: Collagen/epinephrine fraction was 264.53±55.624 seconds with a range of 135 to 300 seconds, and collagen/ADP fraction was 119.41±44.216 seconds, both values being higher than normal. As a result of the postsurgical measures taken, no patients presented post-operative bleeding, hematoma or infection. Conclusions: Dental extraction was safe for patients receiving dual anti-platelet therapy when using sutures and gauze impregnated with tranexamic acid, which the patient pressed in place for 30 minutes

The Bariloche Neutron Physics Group Current Activities

Our group has evolved around a small accelerator-based neutron source (ABNS), the 25 million electron Volt (MeV) linear electron accelerator at the Bariloche Atomic Centre. It is dedicated to applications of neutronic methods to tackle problems of basic sciences and to technological applications. Among these, the determination of total cross section of a material as a function of neutron energy by means of transmission experiments for thermal and sub-thermal neutrons is very sensitive to the geometric arrangement and movement of the atoms, over distances ranging from the 'first-neighbour scale' up to the microstructural level or 'grain scale'. This also allowed to test theoretical models of calculated cross sections and scattering kernels. Interest has moved from pulsed neutron diffraction towards deep inelastic neutron scattering (DINS), a powerful tool for the determination of atomic momentum distribution in condensed matter and for non-destructive mass spectroscopy. In recent years non-intrusive techniques aimed at the scanning of large cargo containers have started to be developed with this ABNS, testing the capacity and limitations to detect special nuclear material and dangerous substances in thick cargo arrangements. More recently, the use of the ever-present “bremsstrahlung” radiation has been recognized as a useful complement to instrumental neutron activation, as it permits to detect other nuclear species through high-energy photon activation. The facility is also used for graduate and undergraduate students experimental work within the frame of Instituto Balseiro Physics and Nuclear Engineering courses of study, and also MSc and PhD theses work.Fil: Mayer, Roberto Edmundo. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; ArgentinaFil: D'Amico, N. M. B.. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; ArgentinaFil: Granada, Jose Rolando. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Dawidowski, Javier. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Santisteban, Javier Roberto. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Blostein, Juan Jeronimo. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Tartaglione, Aureliano. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rodriguez Palomino, Luis Alberto. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Marquez Damian, Jose Ignacio. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sepúlveda Sosa, C.. Comision Chilena de Energia Nuclear; Chil

Sangrado uterino anormal en la postmenopausia: diagnóstico y manejo

Postmenopausal women in the presence of abnormal uterine bleeding spontaneously and unexpectedly requires rigorous evaluation to determine the source of the bleeding. The most common cause of postmenopausal bleeding is endometrial atrophy and endometrial polyp; however, must be ruled endometrial cancer is the cause in about 10 percent of patients. The gold standard for evaluating the endometrium is transvaginal ultrasonography and endometrial biopsy, which are two key components that help reach an accurate diagnosis.En la mujer postmenopáusica la presencia de sangrado uterino anormal en forma espontánea e inesperada requiere evaluación rigurosa para determinar el origen de dicho sangrado. La causa más común de sangrado postmenopáusico es la atrofia endometrial y pólipo endometrial; sin embargo, es necesario descartar cáncer endometrial que es la causa en aproximadamente el 10 por ciento de pacientes. El estándar de oro para evaluar el endometrio es la ultrasonografía transvaginal y la biopsia endometrial, que son dos componentes claves que ayudan a llegar a un diagnóstico certero

Edad materna avanzada y morbilidad obstétrica

Objective: To evaluate the obstetric outcome of pregnant women with advanced maternal age (EMA) treated at the NationalMaternal Perinatal Institute. Materials and methods: Observational, descriptive and retrospective study of 321 maternaloutgoings occurred during the period from January 1 to June 30, 2016.Objetivo: Evaluar el resultado obstétrico de gestantes con edad materna avanzada (EMA) atendidas en el Instituto NacionalMaterno Perinatal. Materiales y métodos: Estudio observacional, descriptivo y retrospectivo de 321 egresos maternos ocurridasdurante el periodo de 1 de enero al 30 de junio 2016

Instrumentos utilizados para la medición de la calidad de vida relacionada con la salud durante el climaterio

The evaluation of quality of life should focus mainly on the patient’s perception of her state of health, being an activeparticipant in this process. Instruments for measuring health-related quality of life (HRQL) can be classified into genericinstruments that measure multiple areas or domains and that are applicable to all individuals, regardless of the pathologythat affects them; And specific instruments, which are those that measure the functioning of the patient in one or severalareas and are characterized by paying particular attention to those symptoms or problems specific to a particular diseaseand those areas considered to be most affected, being only applicable to patients Specific. In daily clinical practice it is usefulto evaluate: improvement of clinical diagnosis, individualization and prioritization of treatments, improving the doctor-patientrelationship, and monitoring compliance with therapies that contribute to the improvement of the female quality of life.La evaluación de la calidad de vida se debe centrar, principalmente, en la percepción de la paciente sobre su estado desalud, siendo ella partícipe activa en este proceso. Los instrumentos para medir la calidad de vida relacionada con la salud(CVRS) se pueden clasificar en instrumentos genéricos, que miden múltiples áreas o dominios y que son aplicables a todoslos individuos, independientemente de la patología que les afecte; y en instrumentos específicos, que son los que midenel funcionamiento del paciente en una o varias áreas y se caracterizan por prestar especial atención a aquellos síntomas oproblemas propios de una enfermedad concreta y a aquellas áreas que se consideran más afectadas, siendo sólo aplicablesa pacientes específicas. En la práctica clínica diaria es útil para evaluar: mejoría del diagnóstico clínico, individualizacióny priorización de los tratamientos, mejorar la relación médico-paciente, y monitorizar el cumplimiento de las terapias quecontribuyan en la mejora de la calidad de vida femenina

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase&nbsp;1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation&nbsp;disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age&nbsp; 6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score&nbsp; 652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc&nbsp;= 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N&nbsp;= 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in&nbsp;Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in&nbsp;Asia&nbsp;and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Performance of the second Deep Inelastic Neutron Scattering spectrometer at the Bariloche electron LINAC

We report on the new Deep Inelastic Neutron Scattering detector bank recently implemented at the Bariloche electron LINAC. We show the characterization and calibration process carried out, which comprises the determinarion of the detector bank efficiency, and the evaluation of the performance of the filter difference technique. As part of the benchmarking process, polyethylene spectra were measured and analyzed, and the scattering cross sections for carbon and hydrogen were determined in the process. With the addition of this new detector bank to the existing one, we evaluate the combined capacity of the two banks.Fil: Rodriguez Palomino, Luis Alberto. Comision Nacional de Energia Atomica. Centro Atomico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Area de Energía Nuclear. Instituto Balseiro; ArgentinaFil: Blostein, Juan Jeronimo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comision Nacional de Energia Atomica. Centro Atomico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Area de Energía Nuclear. Instituto Balseiro; ArgentinaFil: Dawidowski, Javier. Comision Nacional de Energia Atomica. Centro Atomico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Area de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Measurements of the neutron cross sections of hydrogen and deuterium in H2O-D2O mixtures using the deep inelastic neutron-scattering technique

We investigated the neutron cross sections of hydrogen and deuterium by means of the deep inelastic neutron-scattering technique in H2O-D2O mixtures. The interest in this work was to examine the anomalous behavior in the hydrogen neutron cross section reported in the past in similar experiments that raised a yet unsettled controversy. The measurements were made at the Bariloche pulsed neutron source (Argentina) in pure H2O and D2O, with mixtures of molar concentrations of deuterium of xD=0.3 and 0.4, at room temperature, under the same experimental conditions as the former experiments. The results are in good agreement with the standard cross sections and are incompatible with the anomalies pointed out. © 2009 The American Physical Society.Fil: Blostein, Juan Jeronimo. Comisión Nacional de Energía Atómica. Gerencia del Área de Investigaciones y Aplicaciones no Nucleares. Gerencia de Física (CAB); ArgentinaFil: Rodriguez Palomino, Luis Alberto. Comisión Nacional de Energía Atómica. Gerencia del Área de Investigaciones y Aplicaciones no Nucleares. Gerencia de Física (CAB); ArgentinaFil: Dawidowski, Javier. Comisión Nacional de Energía Atómica. Gerencia del Área de Investigaciones y Aplicaciones no Nucleares. Gerencia de Física (CAB); Argentin

Structure factor determination of deuterated 1- and 2-propanol using diffraction experiments with polarization analysis

We present the experimental structure factors of deuterated 1- and 2-propanol as determined at the Spin Polarized Hot Neutron Beam Facility (D3) of the Institut Laue Langevin. Polarized neutron scattering with polarization analysis has the advantage of experimentally separating the coherent and incoherent scattering intensities. Using a linear combination of non-spin-flip and spin-flip diffractograms, one can determine the coherent intensity, related to the structure factor. The corrections of experimental data for multiple scattering, attenuation and inelasticity are carried out using a Monte Carlo (MC) simulation code developed for this kind of experiments. This (hybrid) MC method is based on the combination of a modelled energy exchange and the experimental angular distribution. The good agreement observed between our simulations and the experimental results, confirms the goodness of this model. We also compare our results with experimental data from other authors and we stress the need of more experimental data in the low- region.Fil: Rodriguez Palomino, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Institut Laue Langevin; Francia. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Cuello, Gabriel Julio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Institut Laue Langevin; FranciaFil: Stunault, A.. Institut Laue Langevin; FranciaFil: Dawidowski, Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentin

Experimental corrections in neutron scattering experiments: A modern theoretical and computational approach

Experimental corrections in neutron scattering are a longstanding issue tha t has been addressed in different ways acc ording to the resources available in each age. Sin ce computational resources are not a constraint at present, the early approaches based on theoretical approximations have led to today’s computational methods based on numerical simulations. At the base of all the corrections, we must fi nd a numerical method and a suitable model of the neutron interaction with the system. Wit h regard to simulations, the demands posed by different experimental techniques, should lead to the design of specifi c solutions for each particular case, while models describing the interaction should include a wide variety of systems. In the Neutron Physics Department at Bariloche Atomic Center (Argentina), both issues were addressed for more than two decades. On the one hand, the development of models describing the interaction of neutrons with molecular and solid systems, has helped to strengthen the methods of analysis of various neutron techniques, and has fed nuclear data libraries of extensive employment in the area of Nuclear Engineering. On the other hand, the numerical simulation methods developed were applied in the analysis of very diverse experiments such as diffraction, inelastic neutron scattering, spectroscopy and electron-volt spectroscopy, and were successfully applied in experiments performed at Bariloche, as well as at ILL and ISIS. Moreover, we have validated the role of the technique of neutron transmission (to obtain the total cross section), as a reference tool in the process of absolute normalization of the experimental data, a rarely stated goal in the context of modern neutron scattering techniques.Fil: Dawidowski, Javier. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Rodriguez Palomino, Luis Alberto. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Blostein, Juan Jeronimo. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cuello, Gabriel Julio. Institut Laue Langevin; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin