7 research outputs found
Diplomado HSEQ 2018 El estudio de caso real para un sector productivo, basado en la norma ISO 14001:2015 Industrias Santo Domingo S.A.S.
- Publication venue
- Universidad Nacional Abierta y a Distancia UNAD
- Publication date
- 06/12/2018
- Field of study
Imágenes, tablasLas empresas ladrilleras colombianas en su gran mayoría son industrias artesanales, ya que muchas de ellas no cuentan con técnicas adecuadas para la fabricación de sus productos. Dentro de los procesos que se realizan en el contexto industrial, este proceso es uno de los que provoca altos niveles de contaminación ambiental, sin embargo, esta actividad económica dinamiza diversas zonas en los municipios provocando impactos negativos y positivos; afortunadamente algunas empresas encargadas de la fabricación de ladrillo implementan diferentes estrategias en pro de disminuir los daños ambientales que se genera por dicha actividad.
En muchas ocasiones esta actividad se realiza por sucesión de generación en generación, sin prever los posibles daños generados por su realización. La educación y promoción de estrategias organizacionales juegan un papel fundamental en la construcción de una cultura ambiental, que facilite la comprensión de los problemas y comprometa la acción ciudadana en el desarrollo de estrategias de mitigación y conservación del ambiente y los recursos naturales. Una educación que promueva un desarrollo en armonía con la naturaleza y una ética de la convivencia basada en los principios de la solidaridad, la equidad y la responsabilidad.
El presente trabajo tiene el objetivo de diagnosticar, identificar y evaluar de qué manera la Industria Santo Domingo SAS está cumpliendo con los requisitos normativos, su aproximación a lo estipulado en la norma ISO 14001:2015 y qué actividades se están ejecutando con el fin de mitigar, compensar o evitar los impactos ambientales negativos que se pueden generar por la fabricación de ladrillo.Colombian brick companies are mostly artisanal industries, since many of them do not have adequate techniques for the manufacture of their products. Within the processes that are carried out in the industrial context, this process is one of those that causes high levels of environmental contamination, however, this economic activity stimulates diverse zones in the municipalities causing negative and positive impacts; Fortunately, some companies responsible for brick manufacturing implement different strategies in order to reduce the environmental damage that is generated by this activity.
In many occasions this activity is carried out by succession from generation to generation, without foreseeing the possible damages generated by its realization. The education and promotion of organizational strategies play a fundamental role in the construction of an environmental culture, which facilitates the understanding of the problems and compromises the citizen action in the development of mitigation strategies and conservation of the environment and natural resources. An education that promotes development in harmony with nature and an ethic of coexistence based on the principles of solidarity, equity and responsibility.
The present work has the objective of diagnosing, identifying and evaluating how the Santo Domingo SAS Industry is complying with the regulatory requirements, its approximation to what is stipulated in ISO 14001: 2015 and what activities are being carried out in order to mitigate , compensate or avoid the negative environmental impacts that can be generated by the manufacture of brick
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Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial
- Author
- Abbasciano Isabella
- Abrantes Catarina
- Accarino Simone
- Adler Sharon
- Adoberg Annika
- Afsari Rouzbeh
- Ahmad Syeda
- Ahmed Jafar
- Ahn Wooin
- Ajayi Bamidele
- Aksamit Dariusz
- Al Chalabi Saif
- Alamartine Eric
- Alchi Bassam
- Ali Mohammad
- Aliotta Roberta
- Almaani Salem
- Almeida Catarina
- Almeida Edgar
- Alpers Charles E
- Alvarez Francisco de la Prada
- Alves Patricia
- Annese Francesca
- Appel Gerald
- Arduan Alberto Ortiz
- Arena Maria
- Arevalo Marta Calvo
- Arfaania Dariush
- Arias Carlos
- Aristoy Emma Calatayud
- Asakiene Egle
- Ashley Sarah
- Assefi Ali
- Atenza Alba
- Auerbach Asta
- Augustyniak-Bartosik Hanna
- Avella Monroy
- Ayling-Smith Jonathan
- Ayoub Isabelle
- Ayvazyan Christine
- Baccaro Rocco
- Bailey Asha
- Baker Bruce
- Balamuthusamy Saravanan
- Ballarin Jose
- Barata Rui
- Barbic Jerko
- Barisic Dunja
- Barratt Jonathan
- Barreto Jose Carlos de Jesus
- Barrios Clara
- Belingheri Mirco
- Benesova Anna
- Bernabeu Ana Avila
- Bernhardt Wanja
- Bhadra Shamik
- Biancone Luigi
- Bieler Stewart
- Blanchard Anne
- Boaglio Elena
- Bolignano Davide
- Bomback Andrew
- Bonilla Gustavo Andres Useche
- Bordoli Monica
- Bose Bhadran
- Boudville Neil
- Brandon Donald
- Brown Karen
- Broyet Christian
- Bucknall Thomas
- Buffet Alexandre
- Bumblyte' Inga Arune
- Burdese Manuel
- Burgos Natalia Allende
- Burguet Laure
- Burtey Stephane
- Busch Martin
- Cakiroglu Figen
- Campbell Victoria
- Canetta Pietro
- Capaccio Flavia
- Carbonell Juan
- Cardoso Filipa
- Carro Clara Garcia
- Carroll Robert
- Carron Pierre-Louis
- Carullo Nazareno
- Cassia Matthias
- Caster Dawn
- Castillo Belen Vizcaino
- Catucci Davide
- Cavalli Andrea
- Chae Dong-Wan
- Chakera Aron
- Chan Anthony Ting Pong
- Chan Doris
- Chan Gary Chi Wang
- Chan Lai Wan
- Chang Jae Hyun
- Chang Ming-Shan
- Chapman Fiona
- Charytan Chaim
- Chaudhry Asghar
- Cheetham Melissa
- Chen Cheng-Hsu
- Chen Chien-Liang
- Chen Hsin-Yu
- Chen Hung-Chun
- Chen Hung-Yuan
- Chenine Leila
- Cheung Chee Kay
- Cheung Siu Fai
- Chiche-Jourde Noemie
- Chiu Hsien-Fu
- Chiu Ian
- Chiu Yen-Ling
- Chiu Yi-Wen
- Choi Hoon Young
- Chou Kang-Ju
- Chowdhury Paramit
- Chowdhury Pradip
- Chrysochou Constantina
- Chukwu Chukwuma
- Chun Ka Yeong
- Chung Wookyung
- Cieniawski Dominik
- Claisse Guillaume
- Clayton Philip
- Cleary Catalina Martín
- Clement Nisha
- Coates Toby
- Cogno Chiara
- Colla Loredana
- Collins Michael
- Colucci Marco
- Combe Christian
- Comi Nicolino
- Comunale Roderick
- Contreras Gabriel
- Cooper Bruce
- Coppock Gaia
- Costa Ana Cortesão
- Costanzi Stefano
- Cozzolino Mario
- Crail Susan
- Cunha Liliana
- Curry Elizabeth
- Dai Tiane
- Daina Erica
- Daneshvari Sam
- Dasgupta Indranil
- DaSilva Louise
- Davidson Robert
- De Bhailis Aine Maire
- de Précigout Valérie
- Decupere Marc
- Delmas Yahsou
- Deodato Francesca
- Dhaun Neeraj
- Dhaygude Ajay
- Dhelaria Ranjit
- Di Maio Federica
- Diezhandino Maria Angeles Goicoechea
- Dika Zivka
- Dinic Miriana
- Dittmer Ian
- Diva Ulysses A
- Dobre Mirela
- Doctor Gabriel
- Donati Gabriele
- Doubel Peter
- Douthit Nicole
- Draganova Diliana
- Drexler Yelena
- Drinkovic Martin
- Drinovska Klara
- Dudreuilh Caroline
- Dumond Clement
- Durlen Ivan
- Dussol Bertrand
- Encarnacion Montserrat Diaz
- Endre Zoltan
- Enrique Jorge
- Eqbal Yusuf
- Erlich Jonathan
- Esposito Ciro
- Esposito Vittoria
- Fakih Faisal
- Fang Hua-Chang
- Farinha Ana
- Fearday Aaron
- Felgueiras Joana de Sousa Soares
- Felicjanczuk Elzbieta
- Fernandes Adriana
- Fernandes João Carlos
- Fernandes Sara
- Fernandez Jose Luño
- Fernandez Victor
- Fernando Mangalee
- Figueiredo Ana Carolina
- Firre Eric
- Floege Jürgen
- Flossmann Oliver
- Floyd Lauren
- Fonseca Jose Nuno de Almeida Agapito
- Fonseca Nuno
- Foote Celine
- Forbes Suzanne
- Forcen Angel
- Fornoni Alessia
- Fouassier David
- Fraser Ian
- Fung Ka Shun Samuel
- Furlano Monica
- Furtado Teresa
- Gadh Rajdeep
- Gaisset Roxane
- Gallagher Martin
- Gameiro Joana
- Gangadharan Muralikrishna
- Garcia Fabiola Alonso
- Garcia Olga Gracia
- Garg Gunjan
- Garrouste Cyril
- Gautam Archana
- Geara Abdallah
- Geddes Colin
- Gellineo Lana
- Germain Michael
- Gesualdo Loreto
- Ghalli Farid
- Giaroni Francesco
- Giles Harold
- Gillies Alastair
- Gimeno Ana Vilar
- Girardet Annette
- Glaze Jeffrey
- Goh Tze
- Gois Mario
- Goldsmith Christopher
- Goma Elena
- Gomes Ana Marta
- Goncalves Luis Pedro Falcao
- Goncalves Sara
- Gontarek-Kacprzak Julita
- Gonzalez Carlos
- Gopu Arun
- Gowda Nayan
- Gray Nicholas
- Greco Barbara
- Green Heather
- Greze Clarisse
- Griffin Sian
- Guldris Secundino Cigarran
- Guzman Ursula Verdalles
- Ha Jeffrey Tsun Kit
- Hall Amanda
- Hamilton Patrick
- Han Seung Hyeok
- Haws Robert
- Hayat Ashik
- Heath Lauren
- Heerspink Hiddo J L
- Heinrichs Sven
- Henderson Amy
- Henderson Andrew
- Hendren Elizabeth
- Heng Anne-Elisabeth
- Heres Salia Virxinia Pol
- Herfurth Johann Konstantin
- Herrero Evangelina Merida
- Ho Tzung-Yo
- Hogan Jonathan
- Hohenstein Bernd
- Hollett Peter
- Horvatic Ivica
- Hsu Bang-Gee
- Hsu Chia-Tien
- Hsu Chih-Yang
- Hsu Shih-Ping
- Huang Chien-Wei
- Hudson Amy
- Hung Chi-Chih
- Hwang Daw-Yang
- Hwang Shang-Jyh
- Hyun Young Youl
- Ilmoja Madis
- Inrig Jula K
- Irish Georgina
- Jacob Radu
- Jahan Sadia
- Jain Arunima
- Jamar Sofie
- Jander Anna
- Jang Hye Ryoun
- Janko Catherine
- Jardine Meg
- Jaskowski Piotr
- Jeantet Guillaume
- Jelakovic Bojan
- Jeon Junseok
- Jeong Jong Cheol
- Jesudason Shilpanjali
- Jittirat Arksarapuk
- Jo Sang-Kyung
- Jones Rachel
- Joo Narae
- Jorge Sofia
- Julian Bruce
- Jung JiYong
- Jyothinagaram Praveena
- Kadakia Jigar
- Kamal Fahameedah
- Kanigicherla Durga
- Karanovic Sandra
- Karras Alexandre
- Kasimatis Theodoros
- Kassem Mohamad
- Kattamanchi Siddhartha
- Keller Christopher
- Kentric Dubravka Trajbar
- Kettner Christiane
- Khalil Kassem
- Kim Aejin
- Kim Dana
- Kim Hyung Wook
- Kim Jwa-Kyung
- Kim Myung-Gyu
- Kim Se Joong
- Kim Sunggyun
- Kim Yeong Hoon
- Kim Yunmi
- Kimber Cassandra
- Klamm Kathryn
- Koch Annegret
- Koester Eric
- Kohan Donald E
- Kolvald Kulli
- Komers Radko
- Kon Sui
- Kooienga Laura Ann
- Kotwal Sradha
- Krajewska Magdalena
- Kratka Karolina
- Krishnan Anoushka
- Krishnasamy Rathika
- Krueger Thilo
- Kruljac Ivan
- Kulka Simone
- Kunzendorf Ulrich
- Kuo Hung-Tien
- Kuo Mei-Chuan
- Kuo Sheng
- Kwan Lorraine Pui Yuen
- Kwella Bogna
- Kwella Norbert
- Kyaw Kay
- Labat Aurore
- Lafayette Richard
- Lagatta Mark
- Lam Chi Kwan Darwin
- Lambie Mark
- Lanaret Camille
- Latif Farah
- Laute Margo
- Law Wai Ping
- Lawman Sarah
- Lazo Mercedes Salgueira
- Lee Hajeong
- Lee Hyun Hee
- Lee Hyung-seok
- Lee JungEun
- Lee Kyu-Beck
- Lee Moon Hyoung
- Lee Po-Tsang
- Leis Liisi
- Lemahieu Wim
- Leung Janson
- Li Yan
- Lie Davina Ngoi Wah
- Lifland Howard
- Lilienthal Kadri
- Lim Wai
- Limardo Monica
- Livrozet Marine
- Longhi Selena
- Lopes Daniela
- Lopes Jose Antonio
- Lorde Nathan
- Luxton Grant
- Ma Mingyao
- Madhrira Machaiah
- Madonia Phillip
- Maes Bart
- Mahadevan Kumaradevan
- Mahdi Amar
- Mahdi Eamon
- Maillard Nicolas
- Maixnerova Dita
- Majstorovic Barac Karolina
- Malecki Robert
- Malfait Thomas
- Malvica Silvia
- Mandayam Sreedhar
- Manley Paul
- Mansfield Nick
- Marcantoni Carmelita
- Mariat Christophe
- Marin Lida Maria Rodas
- Marin Tamara Malek
- Mark Patrick
- Marques Joana
- Martinez Eduardo Gutierrez
- Martinez Stacy
- Masset Catherine
- Masson Ingrid
- Mather Amanda
- Maung Myint Thida Maung
- Mayet Valentin
- Małecki Robert
- McCafferty Kieran
- McCarthy Ellen
- McDonald Stephen
- McGreal Kerri
- McMahon Kellyn
- McNally Andrew
- McQuarrie Emily
- Medina Allyson
- Meeus Gert
- Mehta Kshama
- Mendoza Elder
- Menezes Maria
- Meng Jerry
- Mercer Alex
- Messa Piergiorgio
- Messias Ana
- Miarka Przemyslaw
- Miglinas Marius
- Mikacic Ivana
- Mikhail Ashraf
- Milicevic Martina
- Minasian Raffi
- Moeller Marcus
- Mohey Hesham
- Mojarrab Javad
- Mok Maggie Ming Yee
- Moncasi Eduardo Parra
- Moonen Martial
- Morales Wenceslao Adrian Aguilera
- Moreno Antolina
- Moreno Eduardo Verde
- Morris Adam
- Moutzouris Dimitrios
- Moya Mercedes Gonzalez
- Mucha Simon
- Musolino Michela
- Napodano Pietro
- Natario Ana
- Negrea Lavinia
- Nelson Bradley
- Neuen Brendon
- Newsome Britt
- Ng Kit Chung Jack
- Nguyen Thu
- Nguyen Viet
- Nicolo Clementine
- Nitschke Martin
- Noble Euan
- Nolasco Fernando
- Noronha Irene L
- O'Lone Emma
- O'Shaughnessy Michelle
- Ochoa Adriana Sierra
- Oh Kook-Hwan
- Oh Se Won
- Oh SeWon
- Okoh Pedro
- Ombelet Sara
- Ou Shih-Hsiang
- Packham David
- Padiyar Aparna
- Pai Mei-Fen
- Pamplona Irene Agraz
- Pan Szu-Yu
- Pandya Bhavna
- Papadia Federica
- Pardinhas Clara
- Parikh Nishita
- Parikh Samir
- Park Hyeong Cheon
- Park Jung Tak
- Parreira Lucia
- Passerini Patrizia
- Patak Ramachandra
- Patecki Margret
- Patel Suthar Meera
- Patel Jusmin
- Patel Rajan
- Patella Gemma
- Patrikyan Artashes
- Pavlovic Drasko
- Paxton William
- Peh Chen
- Peh Chen Au
- Peleg Yonatan
- Pelicano Josep Miquel Blasco
- Peng Yu-Sen
- Pereira de Vicente Manuel
- Perez de Jose Ana
- Perez Lluna Leticia
- Perez Erika
- Perez Jonay Pantoja
- Peri Usha
- Perico Norberto
- Perkovic Vlado
- Philipponnet Carole
- Phua Elaine
- Piel Julia
- Pillai Unnikrishnan
- Pilmore Helen
- Plavljanic Djuro
- Plaza Mercedes Velo
- Pollock Carol
- Ponnusamy Arvind
- Ponti Serena
- Powell Thomas
- Pradhan Nishigandha
- Prado Raul Fernandez
- Praga Manuel
- Preciado Priscila
- Prkacin Ingrid
- Pruthi Rishi
- Pugh Dan
- Pérez Gómez María Vanessa
- Quinn Sarah
- Quintana Luis F
- Raakesh Lathika
- Rabindranath Kannaiyan
- Radermacher Luc
- Radhakrishnan Jai
- Ragy Omar Sherin Ibrahim
- Raichoudhury Ritesh
- Raimundo Mario
- Randone Paolo
- Razavian Mona
- Reichel Helmut
- Reis Marina
- Remuzzi Giuseppe
- Reynolds Annie
- Rheault Michelle N
- Ricchiuto Anna
- Rico Ivon Maritza Bobadilla
- Rigothier Claire
- Ritchie Angus
- Rivero Maria Antonieta Azancot
- Rizk Dana
- Ro Han
- Rodriguez Garcia Eva
- Rodriguez Alfred
- Roger Simon
- Rony Mohammad
- Rosenberg Mai
- Rote William E
- Roueff Stephane
- Rovin Brad
- Rovin Brad H
- Roxburgh Sarah
- Ruiz Mario
- Rusinol Helena Marco
- Rychlik Ivan
- Salehi Tania
- Sanden Silja
- Santockiene Lina
- Santos Iara Da Silva
- Santos Patricia Valerio
- Sargsyan Mari
- Sarnow Franziska
- Sat Sebahat
- Satora Ewa
- Savuk Ana
- Sayer Matthew
- Schlieper Georg
- Schlosser Mandy
- Schmidt-Guertler Hans
- Schockaert Olivier
- Schulte Kevin
- Schulz Lisa
- Selvaskandan Haresh
- Semple David
- Sen Shaundeep
- Seppet Elviira
- Serrano Antonio Galan
- Serre Jean-Emmanuel
- Sevillano Angel
- Shah Sapna
- Shen Yvonne
- Sheridan Brittany
- Shu Kai-Hsiang
- Sightler Ford
- Silva Arnold
- Silva Sónia
- Sinha Smeeta
- Siriwardana Amanda
- Sitas Zvonimir
- Sivo Carmen
- Sizeland Peter
- Sly Cathylee
- Smith Priscilla
- Snow Brian
- Soares Elsa Sofia Quadrado
- Solazzo Andrea
- Solis Elena Gutierrez
- Solomon Laurence
- Song Young Rim
- Sousa Helena
- Spinowitz Bruce
- Stallworthy Elizabeth
- Stamellou Eleni
- Stanczyk Malgorzata
- Stangenberg Stefanie
- Stankovic Marija
- Stankuviene Asta
- Stea Emma Diletta
- Stompor Tomasz
- Storrar Joshua
- Sullivan James
- Sulowicz Wladyslaw
- Suyumova Irina
- Szeto Cheuk Chun
- Sá Helena
- Sánchez de la Nieta Maria Dolores
- Tamarit Esther
- Tan Eddie
- Tan May
- Tang Hon
- Tang Sydney C W
- Tang Sydney Chi Wai
- Teixeira Catarina
- Telling Kadri
- Terrades Natalia Ramos
- Tesar Vladimir
- Tez Didem
- Thervet Eric
- Thibaudin Damien
- Thomas Mark
- Thyagarajan Nikhil
- Tkaczyk Marcin
- Torreggiani Massimo
- Trachtman Howard
- Trillini Matias
- Trimarchi Hernán
- Tsai Jer-Chia
- Tsai Shang-Feng
- Tsai Wan-Chuan
- Tseng Po-Yu
- Tumlin James
- Tumlin James A
- Tung Kuei-Ting
- Turnbull Angus
- Udani Suneel
- Uhlinova Jana
- Unt Kristin
- Urciuolo Federica
- Vanacker An
- Vandewiele Bert
- Vaz Alvaro
- Veermae Kristi
- Viaene Liesbeth
- Vickiene Alvita
- Vigano Sara
- Vila Maria Antonia Munar
- Vilayur Eswari
- Villanueva Caridad Martinez
- Villarroya Cristina Medrano
- Villen Alejandro Soria
- Viramontes Veronica
- Vita Caterina
- Vujcic Dunja
- Wahba Mona
- Wan Susan
- Wang Chih-Hsien
- Warling Xavier
- Waters Gerald
- Waugh Jane
- Weiland Lea
- Weiner Stefan
- Weinreich Thomas
- Werth Stephan Christian
- Wickens Olivia
- Wijeratne Vidu
- Wilder Karen
- Willcocks Lisa
- Williams Allister
- Winiarska Agata
- Wirtz Nikolaus
- Wolf Gunter
- Wolf Lothar
- Wong Muh Geot
- Wong Sze Ho Sunny
- Wong Yick Hei
- Workeneh Biruh
- Wu Hon-Yen
- Wu Ming-Ju
- Wyndham Roger
- Yang Jihyun
- Yang Ju-Yeh
- Yeap Chii
- Yim Ka Fai
- Yong Kenneth
- Yoo Tae-Hyun
- Yoon Songuk
- Yu Tung-Min
- Yue Tak Tai Andrew
- Zakari Michel
- Zakauskiene Urte
- Zaoui Philippe
- Zbrzezniak Justyna
- Zielinska Dorota
- Zizzi Carlotta Federica
- Publication venue
- Publication date
- 01/11/2023
- Field of study
BackgroundSparsentan, a novel, non-immunosuppressive, single-molecule, dual endothelin angiotensin receptor antagonist, significantly reduced proteinuria versus irbesartan, an angiotensin II receptor blocker, at 36 weeks (primary endpoint) in patients with immunoglobulin A nephropathy in the phase 3 PROTECT trial's previously reported interim analysis. Here, we report kidney function and outcomes over 110 weeks from the double-blind final analysis.MethodsPROTECT, a double-blind, randomised, active-controlled, phase 3 study, was done across 134 clinical practice sites in 18 countries throughout the Americas, Asia, and Europe. Patients aged 18 years or older with biopsy-proven primary IgA nephropathy and proteinuria of at least 1·0 g per day despite maximised renin–angiotensin system inhibition for at least 12 weeks were randomly assigned (1:1) to receive sparsentan (target dose 400 mg oral sparsentan once daily) or irbesartan (target dose 300 mg oral irbesartan once daily) based on a permuted-block randomisation method. The primary endpoint was proteinuria change between treatment groups at 36 weeks. Secondary endpoints included rate of change (slope) of the estimated glomerular filtration rate (eGFR), changes in proteinuria, a composite of kidney failure (confirmed 40% eGFR reduction, end-stage kidney disease, or all-cause mortality), and safety and tolerability up to 110 weeks from randomisation. Secondary efficacy outcomes were assessed in the full analysis set and safety was assessed in the safety set, both of which were defined as all patients who were randomly assigned and received at least one dose of randomly assigned study drug. This trial is registered with ClinicalTrials.gov, NCT03762850.FindingsBetween Dec 20, 2018, and May 26, 2021, 203 patients were randomly assigned to the sparsentan group and 203 to the irbesartan group. One patient from each group did not receive the study drug and was excluded from the efficacy and safety analyses (282 [70%] of 404 included patients were male and 272 [67%] were White) . Patients in the sparsentan group had a slower rate of eGFR decline than those in the irbesartan group. eGFR chronic 2-year slope (weeks 6–110) was −2·7 mL/min per 1·73 m2 per year versus −3·8 mL/min per 1·73 m2 per year (difference 1·1 mL/min per 1·73 m2 per year, 95% CI 0·1 to 2·1; p=0·037); total 2-year slope (day 1–week 110) was −2·9 mL/min per 1·73 m2 per year versus −3·9 mL/min per 1·73 m2 per year (difference 1·0 mL/min per 1·73 m2 per year, 95% CI −0·03 to 1·94; p=0·058). The significant reduction in proteinuria at 36 weeks with sparsentan was maintained throughout the study period; at 110 weeks, proteinuria, as determined by the change from baseline in urine protein-to-creatinine ratio, was 40% lower in the sparsentan group than in the irbesartan group (−42·8%, 95% CI −49·8 to −35·0, with sparsentan versus −4·4%, −15·8 to 8·7, with irbesartan; geometric least-squares mean ratio 0·60, 95% CI 0·50 to 0·72). The composite kidney failure endpoint was reached by 18 (9%) of 202 patients in the sparsentan group versus 26 (13%) of 202 patients in the irbesartan group (relative risk 0·7, 95% CI 0·4 to 1·2). Treatment-emergent adverse events were well balanced between sparsentan and irbesartan, with no new safety signals.InterpretationOver 110 weeks, treatment with sparsentan versus maximally titrated irbesartan in patients with IgA nephropathy resulted in significant reductions in proteinuria and preservation of kidney function
Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial
- Author
- Aaron Fearday
- Abdallah Geara
- Adam Morris
- Adriana Fernandes
- Adriana Sierra Ochoa
- Aejin Kim
- Agata Winiarska
- Aine Maire De Bhailis
- Ajay Dhaygude
- Alastair Gillies
- Alba Atenza
- Alberto Ortiz Arduan
- Alejandro Soria Villen
- Alessia Fornoni
- Alex Mercer PhD g
- Alexandre Buffet
- Alexandre Karras
- Alfred Rodriguez
- Ali Assefi
- Allister Williams
- Allyson Medina
- Alvaro Vaz
- Alvita Vickiene
- Amanda Hall
- Amanda Mather
- Amanda Siriwardana
- Amar Mahdi
- Amy Henderson
- Amy Hudson
- An Vanacker
- Ana Avila Bernabeu
- Ana Carolina Figueiredo
- Ana Cortesão Costa
- Ana Farinha
- Ana Marta Gomes
- Ana Messias
- Ana Natario
- Ana Perez de Jose
- Ana Savuk
- Ana Vilar Gimeno
- Andrea Cavalli
- Andrea Solazzo
- Andrew Bomback
- Andrew Henderson
- Andrew McNally
- Angel Forcen
- Angel Sevillano
- Angus Ritchie
- Angus Turnbull
- Anna Benesova
- Anna Jander
- Anna Ricchiuto
- Anne Blanchard
- Anne-Elisabeth Heng
- Annegret Koch
- Annette Girardet
- Annie Reynolds
- Annika Adoberg
- Anoushka Krishnan
- Anthony Ting Pong Chan
- Antolina Moreno
- Antonio Galan Serrano
- Aparna Padiyar
- Archana Gautam
- Arksarapuk Jittirat
- Arnold Silva
- Aron Chakera
- Artashes Patrikyan
- Arun Gopu
- Arunima Jain
- Arvind Ponnusamy
- Asghar Chaudhry
- Asha Bailey
- Ashik Hayat
- Ashraf Mikhail
- Asta Auerbach
- Asta Stankuviene
- Aurore Labat
- Bamidele Ajayi
- Bang-Gee Hsu
- Barbara Greco
- Bart Maes
- Bassam Alchi
- Belen Vizcaino Castillo
- Bernd Hohenstein
- Bert Vandewiele
- Bertrand Dussol
- Bhadran Bose
- Bhavna Pandya
- Biruh Workeneh
- Bogna Kwella
- Bojan Jelakovic
- Brad Rovin
- Bradley Nelson
- Brendon Neuen
- Brian Snow
- Britt Newsome
- Brittany Sheridan
- Bruce Baker
- Bruce Cooper
- Bruce Julian
- Bruce Spinowitz
- Camille Lanaret
- Caridad Martinez Villanueva
- Carlos Arias
- Carlos Gonzalez
- Carlotta Federica Zizzi
- Carmelita Marcantoni
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- Noemie Chiche-Jourde
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- Paolo Randone
- Paramit Chowdhury
- Patricia Alves
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- Patrick Hamilton
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- Patrizia Passerini
- Paul Manley
- Pedro Okoh
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- Peter Hollett
- Peter Sizeland
- Philip Clayton
- Philippe Zaoui
- Phillip Madonia
- Piergiorgio Messa
- Pierre-Louis Carron
- Pietro Canetta
- Pietro Napodano
- Piotr Jaskowski
- Po-Tsang Lee
- Po-Yu Tseng
- Pradip Chowdhury
- Praveena Jyothinagaram
- Priscilla Smith
- Prof Brad Rovin MD j
- Prof Charles E Alpers MD d
- Prof Hiddo J L Heerspink PhD a b
- Prof Howard Trachtman MD k
- Prof Irene L Noronha MD h
- Prof Jai Radhakrishnan MD c
- Prof Jonathan Barratt PhD e
- Prof Vlado Perkovic MD b ofor the PROTECT Investigators† Author links open overlay panelEric Alarmartine
- Przemyslaw Miarka
- Rachel Jones
- Radko Komers MD f
- Radu Jacob
- Raffi Minasian
- Rajan Patel
- Rajdeep Gadh
- Ramachandra Patak
- Ranjit Dhelaria
- Rathika Krishnasamy
- Rathika Krishnasamy
- Raul Fernandez Prado
- Richard Lafayette
- Rishi Pruthi
- Ritesh Raichoudhury
- Robert Carroll
- Robert Davidson
- Robert Haws
- Robert Malecki
- Roberta Aliotta
- Rocco Baccaro
- Roderick Comunale
- Roderick Comunale
- Roger Wyndham
- Rouzbeh Afsari
- Roxane Gaisset
- Rui Barata
- Sadia Jahan
- Saif Al Chalabi
- Salem Almaani
- Salia Virxinia Pol Heres
- Sam Daneshvari
- Samir Parikh
- Sandra Karanovic
- Sang-Kyung Jo
- Sapna Shah
- Sara Fernandes
- Sara Goncalves
- Sara Ombelet
- Sara Vigano
- Sarah Ashley Ford Sightler
- Sarah Lawman
- Sarah Quinn
- Sarah Roxburgh
- Saravanan Balamuthusamy
- Se Joong Kim
- Sebahat Sat
- Secundino Cigarran Guldris
- Selena Longhi
- Serena Ponti
- Seung Hyeok Han
- SeWon Oh
- Shamik Bhadra
- Shang-Feng Tsai
- Shang-Jyh Hwang
- Sharon Adler
- Shaundeep Sen
- Sheng Kuo
- Shih-Hsiang Ou
- Shih-Ping Hsu
- Shilpanjali Jesudason
- Sian Griffin
- Siddhartha Kattamanchi
- Silja Sanden
- Silvia Malvica
- Simon Mucha
- Simon Roger
- Simone Accarino
- Simone Kulka
- Siu Fai Cheung
- Smeeta Sinha
- Sofia Jorge
- Sofie Jamar
- Songuk Yoon
- Sradha Kotwal
- Sreedhar Mandayam
- Stacy Martinez
- Stefan Weiner
- Stefanie Stangenberg
- Stefano Costanzi
- Stephan Christian Werth
- Stephane Burtey
- Stephane Roueff
- Stephen McDonald
- Stewart Bieler BA a
- Sui Kon
- Suneel Udani
- Sunggyun Kim
- Susan Crail
- Susan Wan
- Suzanne Forbes
- Sven Heinrichs
- Sydney Chi Wai Tang
- Syeda Ahmad
- Sze Ho Sunny Wong
- Szu-Yu Pan
- Sónia Silva
- Tae-Hyun Yoo
- Tak Tai Andrew Yue
- Tamara Malek Marin
- Tania Salehi
- Teresa Furtado
- Theodoros Kasimatis
- Thida Maung Maung Myint
- Thilo Krueger
- Thomas Bucknall
- Thomas Malfait
- Thomas Powell
- Thomas Weinreich
- Thu Nguyen
- Tiane Dai
- Toby Coates
- Tomasz Stompor
- Tung-Min Yu
- Tze Goh
- Tzung-Yo Ho
- Ulrich Kunzendorf
- Ulysses Diva PhD f
- Unnikrishnan Pillai
- Unnikrishnan Pillai
- Ursula Verdalles Guzman
- Urte Zakauskiene
- Usha Peri
- Valentin Mayet
- Valérie de Précigout
- Veronica Viramontes
- Victor Fernandez
- Victoria Campbell
- Victoria Campbell
- Vidu Wijeratne
- Viet Nguyen
- Viet Nguyen
- Vittoria Esposito
- Vladmir Tesar
- Wai Lim
- Wai Ping Law
- Wan-Chuan Tsai
- Wanja Bernhardt
- Wenceslao Adrian Aguilera Morales
- William Paxton
- William Rote PhD f
- Wim Lemahieu
- Wladyslaw Sulowicz
- Wooin Ahn
- Wookyung Chung
- Xavier Warling
- Yahsou Delmas
- Yan Li
- Yelena Drexler
- Yen-Ling Chiu
- Yeong Hoon Kim
- Yi-Wen Chiu
- Yick Hei Wong
- Yonatan Peleg
- Young Rim Song
- YoungYoul Hyun
- Yu-Sen Peng
- Yunmi Kim
- Yusuf Eqbal
- Yusuf Eqbal
- Yvonne Shen
- Zivka Dika
- Zoltan Endre
- Zvonimir Sitas
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background: Sparsentan is a novel, non-immunosuppressive, single-molecule, dual endothelin and angiotensin receptor antagonist being examined in an ongoing phase 3 trial in adults with IgA nephropathy. We report the prespecified interim analysis of the primary proteinuria efficacy endpoint, and safety. Methods: PROTECT is an international, randomised, double-blind, active-controlled study, being conducted in 134 clinical practice sites in 18 countries. The study examines sparsentan versus irbesartan in adults (aged ≥18 years) with biopsy-proven IgA nephropathy and proteinuria of 1·0 g/day or higher despite maximised renin-angiotensin system inhibitor treatment for at least 12 weeks. Participants were randomly assigned in a 1:1 ratio to receive sparsentan 400 mg once daily or irbesartan 300 mg once daily, stratified by estimated glomerular filtration rate at screening (30 to 1·75 g/day). The primary efficacy endpoint was change from baseline to week 36 in urine protein-creatinine ratio based on a 24-h urine sample, assessed using mixed model repeated measures. Treatment-emergent adverse events (TEAEs) were safety endpoints. All endpoints were examined in all participants who received at least one dose of randomised treatment. The study is ongoing and is registered with ClinicalTrials.gov, NCT03762850. Findings: Between Dec 20, 2018, and May 26, 2021, 404 participants were randomly assigned to sparsentan (n=202) or irbesartan (n=202) and received treatment. At week 36, the geometric least squares mean percent change from baseline in urine protein-creatinine ratio was statistically significantly greater in the sparsentan group (-49·8%) than the irbesartan group (-15·1%), resulting in a between-group relative reduction of 41% (least squares mean ratio=0·59; 95% CI 0·51-0·69; p<0·0001). TEAEs with sparsentan were similar to irbesartan. There were no cases of severe oedema, heart failure, hepatotoxicity, or oedema-related discontinuations. Bodyweight changes from baseline were not different between the sparsentan and irbesartan groups. Interpretation: Once-daily treatment with sparsentan produced meaningful reduction in proteinuria compared with irbesartan in adults with IgA nephropathy. Safety of sparsentan was similar to irbesartan. Future analyses after completion of the 2-year double-blind period will show whether these beneficial effects translate into a long-term nephroprotective potential of sparsentan. Funding: Travere Therapeutics
NEOTROPICAL CARNIVORES: a data set on carnivore distribution in the Neotropics
- Author
- Abra Fernanda Delborgo
- Abreu Ribeiro Edvandro
- Age Stefani Gabrieli
- Aguiar Erick Francisco
- Aguiar Gabriel Lima
- Aguiar Leonardo Dos Santos
- Akkawi Paula
- Albanesi Sebastian
- Alberici Vinicius
- Alencar Raony de Macêdo
- Alexandrino Eduardo Roberto
- Almeida Meyline Oliveira
- Althoff Sérgio Luiz
- Alvarez Martín R
- Alves Prado Helena
- Alves Giselle Bastos
- Alves Rafael Souza Cruz
- Alves Romulo Romeu Nobrega
- Alves-Eigenheer Milene
- Anaguano-Yancha Fernando
- Andrade da Silva Maria Augusta
- Andrade Bruna da Silva
- Andrade Rúbia Santana
- Antas Paulo de Tarso Zuquim
- Antunes Andre Pinassi
- Aquino Ana Carla Medeiros Morato
- Araujo Raylenne da Silva
- Araújo Luciana
- Araújo Rodrigo Paulo da Cunha
- Araújo Valquíria Cabral
- Arimoro Omolabake Alhambra
- Arrabal Juan Pablo
- Arroyo-Gerala Paulina
- Assis Jasmine Resende
- Assis Julia Camara
- Astete Samuel
- Astúa Diego
- Auricchio Paulo
- Ayala Crespo Guido Marcos
- Bacellar Ana Elisa de Faria
- Bager Alex
- Bailey Larissa L
- Banhos Aureo
- Barbier Eder
- Barbosa Larissa de Nazaré Barros
- Barreto Larissa Nascimento
- Barros Maria Claudene
- Barros Marília A S
- Barros-Battesti Darci Moraes
- Bassini-Silva Ricardo
- Bastazini Vinicius A G
- Batista Graziele Oliveira
- Bazilio Sergio
- Beca Gabrielle
- Beduschi Julia
- Behling Greici Maia
- Beisiegel Beatriz de Mello
- Beltrão Mayara Guimarães
- Beltrão-Mendes Raone
- Benavalli Letícia
- Benchimol Maíra
- Bercê William
- Bergallo Helena de Godoy
- Bergel Mariano Maudet
- Bernardi Itiberê
- Bernardo Christine Steiner S
- Bernardo Rodrigo
- Bertagni de Camargo Bruna
- Bertassoni Alessandra
- Bertoldi Ariane Teixeira
- Bessa Rafael
- Bezerra Alexandra Maria Ramos
- Bianchi Rita de Cassia
- Bocchiglieri Adriana
- Bogoni Juliano André
- Bonanomi Juliana
- Bonfim Fernando César Gonçalves
- Bonjorne Lilian
- Bordallo Samanta Uchôa
- Borges Luiz Henrique Medeiros
- Bovo Alex Augusto Abreu
- Bowler Mark
- Braga Caryne
- Brandão Vecchi Maurício
- Bravata de la Cruz Yaribeth
- Braz Vivian da Silva
- Brennand Pamella
- Bubadué Jamile
- Buitenwerf Robert
- Burs Kathrin
- Buscariol Daiane
- Buschiazzo Martin
- Cabral Hugo
- Calaça Analice Maria
- Calouro Armando Muniz
- Camara Edeltrudes Maria Valadares Calaça
- Camargo Paulo H S A
- Campelo Ana Kellen Nogueira
- Campos Krauer Juan Manuel
- Canassa Nathália Fernandes
- Cantagallo Devids Camila
- Canteri Adriano
- Caribé Grando Raquel L S C
- Carrano Eduardo
- Carreira Daiane Cristina
- Carrillo-Percastegui Samia E
- Carrizo María Celina
- Cartes Jose Luis
- Carvalho Jr, Elildo Alves Ribeiro
- Carvalho Andrea Siqueira
- Carvalho-Leite Ludimila Juliele
- Castro Érika Paula
- Catenacci Lilian
- Cavalcante Thiago
- Cavarzere Vagner
- Cervini Marcelo
- Cezila Beatriz Azevedo
- Chacón Pacheco Julio Javier
- Chagas Renata
- Charre-Medellin Juan Felipe
- Chaves Dos Santos José Carlos
- Chaves Flávia Guimarães
- Cheida Carolina Carvalho
- Chein Alonso André
- Cherem Jorge José
- Chiarello Adriano Garcia
- Chávez Cuauhtémoc
- Chávez-Congrains Karla
- Chávez-González Edgar
- Cinta Claudia Cristina
- Ciocheti Giordano
- Cobra Priscilla De Paula Andrade
- Coelho Igor Pfeifer
- Concone Henrique Villas Boas
- Contreras Palma Kamila Marianne
- Contreras-Moreno Fernando M
- Cordeiro José
- Cordeiro-Estrela Pedro
- Corrêa Matheus Rocha Jorge
- Costa Braga David
- Costa Lopes Alexandre Martins
- Costa Alan Nilo
- Costa Claudia Guimaraes
- Costa Francys Emanuelle
- Costa Jociel Ferreira
- Costa Rômulo
- Costa Sebastián Andrés
- Coutinho Raphaella
- Cravino Mol Alexandra
- Cronemberger Cecilia
- Cruz Paula
- Cueva Loachamín Rubén Darío
- Cullen Jr, Laury
- Cunha Costa Ana Raissa
- Cáceres Nilton C
- D'Bastiani Elvira
- da Cunha Cristina Jaques
- da Cunha Rogério Grassetto Teixeira
- da Rosa Clarissa Alves
- da Silva André Luiz Ferreira
- da Silva Leonardo Henrique
- da Silva Marcelo
- da Silva Murillo Prado
- da Silva Rafaela Aparecida
- da Silva Raquel Costa
- Dahmer Lais Camila
- Dantas José Oliveira
- de Albuquerque Anna Carolina Figueiredo
- de Albuquerque Natasha Moraes
- de Almeida Curi Nelson Henrique
- de Almeida Lana Resende
- de Almeida-Rocha Juliana Monteiro
- De Angelo Carlos
- de Azevedo Fernanda Cavalcanti
- de Barros Barban Ananda
- de Barros Fernanda Cristina
- de Camargo E Timo Thiago Philipe
- de Castilho Pedro Volkmer
- de Freitas Evellyn Borges
- De la Maza Javier
- de la Peña-Cuéllar Erika
- de la Sancha Noé U
- de la Torre J Antonio
- de Lima Camilla Angélica
- de Lima Camilo Ribeiro
- De Lima Natani Da Silva
- de Matos Jose Roberto
- de Melo Fabiano Rodrigues
- de Oliveira Ramonna
- de Paula Almir
- de Paula Lívia Maria
- de Paula Milton
- de Paula Rogério Cunha
- de Sousa E Silva Júnior José
- de Souza Agnis Cristiane
- de Souza Rafael Cerqueira Castro
- de Thoisy Benoit
- De-Carvalho Crizanto Brito
- Dechner Andrea
- Deffaci Ângela Camila
- Del Castillo Hugo Fernando
- Del Vechio Christine
- Denkiewicz Natalia Mariana
- Devlin Allison L
- Di Bitetti Mario S
- Dias Douglas de Matos
- Dias Leticia Coutinho Sangy
- Diaz-Santos Fabricio
- Didier Karl
- do Nascimento Fabio Oliveira
- do Rosário Maria Cristina Ferreira
- Dos Reis Júnior José Clemensou
- Dos Santos Junior Marcelo Augusto
- Duarte Gabriela Teixeira
- Duarte Herbert
- Duarte José Maurício Barbanti
- Durigan Carlos Cesar
- Durães Rayssa Mainette Nantes
- Dáttilo Wesley
- Díaz-Santos Fabio Gabriel
- Eaton Donald P
- Eizirik Eduardo
- Endo Whaldener
- Eriksson Alan
- Ermenegildo Hiago
- Espinosa Caroline da Costa
- Espinosa Santiago
- Espíndola Hack Robson Odeli
- Falconi Nereyda
- Faria Peres Pedro Henrique
- Faria Michel Barros
- Faria Rhayssa Terra
- Farias Danilo Augusto
- Feijó Anderson
- Fernandes Arthur
- Fernandes Maria Emília Avelar
- Fernandes-Ferreira Hugo
- Fernández Ramirez Sixto
- Ferraz Daniel da Silva
- Ferraz Katia M P M B
- Ferreguetti Atilla Colombo
- Ferreira Paulino Neto Hipólito
- Ferreira Arystene Nicodemo
- Ferreira Paula Modenesi
- Fieker Carolline Zatta
- Figueiredo Marcos de Souza Lima
- Figuerêdo Duarte Moraes Marcela
- Fischer Erich
- Flesher Kevin
- Fleytas Jover Maria Del Carmen
- Fonseca Carlos
- Forero-Medina German
- Fornitano Larissa
- Fraga Elmary da Costa
- Fragoso Carlos Eduardo
- Franceschi Ingridi Camboim
- Francisco Beatriz da Silva de Souza
- França Bruno Rodrigo de Albuquerque
- França Frederico G R
- Freitas-Junior Mozart Caetano
- Friedeberg Diana
- Fróes Rodrigo Medina
- Fusco-Costa Roberto
- Gaboardi Viviane Telles Rodrigues
- Galetti Jr, Pedro Manoel
- Galetti Mauro
- Galiano Daniel
- Galliez Maron
- Garcia-Anleu Rony
- García-Olaechea Alvaro
- Gaspar Denise Alemar
- Gaspar Lucas Pacciullio
- Gatica Ailin
- Gatti Andressa
- Gestich Carla Cristina
- Gilmore Michael P
- Giné Gastón Andrés Fernandez
- Giovanelli João Gabriel Ribeiro
- Girardi Fabiane
- Godoi Mauricio Neves
- Gomes Ana Paula Nascimento
- Gomes Felipe Bittioli R
- Gomes Leonardo de Paula
- Gomez Vinassa Maria Laura
- Gompper Matthew E
- Gondim Tayana Mendonça da Silva
- González Enrique
- González-Gallina Alberto
- Gonçalves da Silva Lucas
- Gonçalves Fernando
- Gonçalves Pablo Rodrigues
- Gouvea Jéssica Abonizio
- Graipel Maurício Eduardo
- Grossel Laís Aline
- Grotta-Neto Francisco
- Gräbin Diogo Maia
- Guaragni Samara Arsego
- Guedes da Silva Fernanda
- Guedes Layme Viviane Maria
- Guenther Mariana
- Guijosa-Guadarrama Emiliano
- Guimarães Luiza Neves
- Gurgel-Filho Newton Mota
- Haberfeld Mario
- Hannibal Wellington
- Hartmann Marilia Teresinha
- Hartmann Paulo Afonso
- Hartz Sandra Maria
- Hass Adriani
- Hass Carlos
- Hasui Érica
- Hatakeyama Richard
- Hatano Fernanda Martins
- Hawes Joseph E
- Heliodoro Gabriela
- Hermann Andiara Paula
- Herrera Victoria Ana María
- Herrera Heitor Miraglia
- Hidalgo-Mihart Mircea G
- Hilário Renato Richard
- Hinojosa Javier
- Hofmann Gabriel Selbach
- Hoogesteijn Rafael Jan
- Huerta Maria Emilia
- Hufnagel Ludmila
- Hurtado Cindy Meliza
- Iezzi María Eugenia
- Ilha Júlia
- Ingberman Bianca
- Isasi-Catalá Emiliana
- Islas Camila Alvez
- Iwakami Victor
- Jacinavicius Fernando de Castro
- Jardim Marcia Maria de Assis
- Jenkins Clinton N
- Jesus de la Cruz Alejandro
- Jesus Anamélia Souza
- Jordao Juliana
- Jorge Maria Luisa S P
- Jorge Rodrigo Silva Pinto
- Juarez Keila Macfadem
- Just João Paulo Gava
- Juárez Rugieri
- Jácomo Anah Tereza de Almeida
- Kaizer Mariane
- Kanaan Vanessa Tavares
- Kanda Claudia Zukeran
- Karlovic Thamíris Christina
- Kasper Carlos Benhur
- Keesen Ferreira Fabíola
- Keuroghlian Alexine
- Keuroghlian-Eaton Sean
- Konzen Maurício Quoos
- Kubiak Bruno Busnello
- Lacerda Ana Cristyna Reis
- Lamattina Daniela
- Landis Mariana Bueno
- Lanna Andre Monnerat
- Lautenschlager Laís
- Leite de Oliveira Márcio
- Leles Bruno
- Lemos Frederico Gemesio
- Lemos Hudson Macedo
- Leuchtenberger Caroline
- León Pérez Rodrigo Raúl
- Lima da Silva Marina
- Lima Edson de Souza
- Lima Marcela Guimarães Moreira
- Lizcano Diego J
- Lombardi Pryscilla Moura
- Longo Jose Milton
- Lopes Cíntia M
- Loretto Diogo
- Lorini Maria Lucia
- Luiz Micheli Ribeiro
- Luna Cecília Licarião
- Luna Pedro
- Luza André Luís
- Lyra Luiz Henrique
- López-Fuerte Cristina Fabiola
- Maccarini Thiago
- Machado da Silva Douglas
- Machado Cauanne Iglesias Campos
- Machado Sávio Augusto de Souza
- Magalhães Laura Martins
- Magalhães Rodolfo Assis
- Magioli Marcelo
- Mangione Antonio Marcelo
- Mantovani Jose Eduardo
- Marinho Jorge Reppold
- Marinho Paulo Henrique
- Marinho-Filho Jader
- Marques Costa Leonardo
- Marques Leandro
- Marques Marinêz Isaac
- Martello Felipe
- Martin Cristiane
- Martin Paula Sanches
- Martinez Jaime
- Martins Maísa Ziviani Alves
- Martins Paulo Wesley
- Martins Rogério
- Martins Waldney Pereira
- Martínez Lanfranco Juan Andrés
- Martínez Nambo Erik Daniel
- Martínez Retta Lucía
- Massara Rodrigo Lima
- Mata Julia Carolina
- Matos Rayanne Gama
- Medeiro Akyllam Zoppi
- Melo Geruza L
- Melo Isabel
- Melo Vanessa Lazaro
- Melo-Dias Mateus
- Mendes Pontes Antonio Rossano
- Mendes Sergio Lucena
- Mendonça André Faria
- Mendonça Eloisa Neves
- Mendonça Leonardo Siqueira
- Metzger Jean Paul
- Michalski Fernanda
- Miotto Renata
- Miranda João
- Mongelli Melissa
- Monroy-Vilchis Octavio
- Montanarin Anelise
- Monteiro André
- Monterrubio Tiberio Cesar
- Montes Martin Alejandro
- Morais Kimberly Danielle Rodrigues
- Morandi Maria Elisa de Freitas
- Morato Ronaldo Gonçalves
- Moreira Ramírez José Fernando
- Moreira Danielle Oliveira
- Moreira Leandro Santana
- Moreira Tainah Cruz
- Moreli Fantacini Felipe
- Moreno Daniele Janina
- Morini Maria Santina
- Moura André Luis Botelho
- Moura Mauricio O
- Mourthe Italo
- Mourão Guilherme de Miranda
- Munhoes Leticia Prado
- Muylaert Renata Lara
- Nagy-Reis Mariana
- Nakano-Oliveira Eduardo
- Napiwoski Silvio Junior
- Nascimento Lorena Anne
- Neves Bianca Dos Santos
- Nobre Andrezza Bellotto
- Nobre Rodrigo de Almeida
- Nobrega Rodrigo Affonso de Albuquerque
- Nodari Joana Zorzal
- Novaes Claudio Leite
- Novaro Andres Jose
- Nunes André Valle
- Nunez-Regueiro Mauricio
- Nuñez María Beatriz
- Ochoa Ana Cecilia
- Olifiers Natalie
- Oliveira Santos Luiz Gustavo Rodrigues
- Oliveira Jasmim Felipe
- Oliveira Leonardo de Carvalho
- Oliveira Luiz Flamarion
- Oliveira Marcela Alvares
- Oliveira Valeska Buchemi
- Oliveira-Bevan Isabella
- Olímpio Ana Priscila Medeiros
- Onofrio Valeria Castilho
- Orsini Vinícius Santana
- Ortiz-Moreno Martha Lucia
- Oshima Júlia Emi de Faria
- Paglia Adriano Pereira
- Pagoto Anderson
- Pagotto Renata Valls
- Palacios Perez Jaime Xavier
- Palmeira Francesca Belem Lopes
- Palomares Francisco
- Pandini Favoretti João Paulo
- Paolino Roberta Montanheiro
- Pardo Maximiliano Víctor
- Paschoal Ana Maria de Oliveira
- Pasqualotto Nielson
- Passamani Marcelo
- Passos Fernando C
- Patiu Fabio Mello
- Pays Olivier
- Pedroni Fernando
- Pedrosa Felipe
- Pedroso Rayssa Faria
- Pedó Ezequiel
- Penteado Marcel José Franco
- Percequillo Alexandre
- Pereira Mendes Calebe
- Pereira Adriele Aparecida
- Pereira Fabiane de Aguiar
- Pereira Taiguã Corrêa
- Pereira-Ribeiro Juliane
- Pereira-Silva Brenda
- Perera-Romero Lucy E
- Peres Carlos A
- Perilli Miriam Lucia Lages
- Perillo Lucas Neves
- Peroni Nivaldo
- Pessoa da Silva Felipe
- Peña-Mondragón Juan L
- Peñuela Mora María Cristina
- Pianca Camila
- Picinatto Filho Vilmar
- Pincheira-Ulbrich Jimmy
- Pinheiro Shery Duque
- Pinto Antonio Millas Silva
- Piovezan Ubiratan
- Pires José Salatiel Rodrigues
- Pires Ricardo Araújo
- Polisar John
- Polli Daiana Jeronimo
- Porfirio Grasiela Edith de Oliveira
- Potrich Ana Paula
- Powell George V N
- Prado Paulo Inácio
- Prestes Nêmora Pauletti
- Priante Camila Fátima
- Prist Paula Ribeiro
- Puertas Fernando Henrique
- Pérez-Torres Jairo
- Pônzio Marcella do Carmo
- Quatrocchi Maira Giuliana
- Querido Luciano Carramaschi de Alagão
- Quigley Howard
- Quintilham Lucas
- Rajão Henrique
- Ramalho Emiliano Esterci
- Ramalho Fernanda do Passo
- Ramis Segura Lucas
- Ramos Lima Saulo
- Ramos Pereira Maria João
- Rampim Lilian Elaine
- Ramírez Pinto Fredy
- Rechenberg Elisabete
- Reis Matheus Gonçalves
- Renaud Pierre-Cyril
- Reyna-Hurtado Rafael
- Rezende Bernardo Luis Renato
- Rezende Guilherme Zamarian
- Rezende Lucas Rodrigo
- Ribeiro de Andrade Gabrielle
- Ribeiro Adauto de Souza
- Ribeiro Igor Kintopp
- Ribeiro Milton C
- Ribeiro Otávio Santi
- Ribeiro Renan Lieto Alves
- Ribeiro Yuri Geraldo Gomes
- Rigacci Eduardo Delgado
- Rivero Marina
- Rocha Carlos Frederico Duarte
- Rocha Ednaldo Cândido
- Rocha Eliana César Laranjeira Duarte
- Rocha Erick Sekiama
- Rocha Fabiana Lopes
- Rocha Joedison
- Rocha Patrício
- Rocha Vlamir José
- Rodrigues Camila
- Rodrigues Flavio Henrique Guimarães
- Rodrigues Manoel
- Rodrigues Thiago Ferreira
- Rodriguez Castro Karen Giselle
- Rodriguez-Pulido Jose Ariel
- Rogeri Patricia
- Rohe Fabio
- Roig Henrique Llacer
- Rojas Bonzi Viviana B
- Rojas Lucia Nathaly Stefany
- Rolim Anderson Claudino
- Romagna Rafael Spilere
- Roque Fabio de Oliveira
- Rosa Augusto Lisboa Martins
- Rossi Junior João Luiz
- Rudolf Juan Carlos
- Ruffino Paulo Henrique Peira
- Ruiz Carmen Elena Barragán
- Ruiz-Esparza Juan
- Saito Erica Naomi
- Salles Munerato Marina
- Salvador Carlos Henrique
- Sampaio Ricardo
- Santana Gindomar Gomes
- Santos Almeida Rony Peterson
- Santos Bruna Silva
- Santos Cyntia Cavalcante
- Santos Eduardo Marques
- Santos Fernanda da Silva
- Santos Filipe Martins
- Santos Joyce Gonçalves
- Santos Paloma Marques
- Saranholi Bruno Henrique
- Sarasola José Hernán
- Sarmento Pedro
- Sartor Caroline Charão
- Sartorello Leonardo
- Sartorello Ricardo
- Scabin Andressa Barbara
- Scarascia Pietro Oliveira
- Schuchmann Karl L
- Schutte Michel
- Seber Samile
- Secco Helio
- Seibert Jardel Brandão
- Seixas Cristiana Simão
- Sekiama Margareth L
- Setz Eleonore
- Severo Magnus Machado
- Silva Diego Afonso
- Silva Ramon Lima
- Silva Wesley R
- Silveira Dos Santos Juliana
- Silveira Jana Rangel
- Silveira Leandro
- Silveira Marcos
- Silvestre Saulo Meneses
- Siviero Maria Brunini
- Soares Fábio Angelo Melo
- Souto Glauber Henrique Borges de Oliveira
- Souza Andiara Silos Moraes de Castro E
- Souza Franco Leandro
- Souza Jesus Rodrigues Domingos
- Souza-Alves João Pedro
- Sponchiado Jonas
- Srbek-Araujo Ana Carolina
- Strier Karen B
- Svenning Jens-Christian
- Sánchez Amadeo
- Sánchez-Lalinde Catalina
- Talamoni Sonia Aparecida
- Tavares Davi Castro
- Tavares Mariana Silva
- Tedesco Carla Denise
- Thompson Jeffrey James
- Thornton Daniel
- Tirelli Flavia Pereira
- Tobler Mathias W
- Toledo Gustavo Alves da Costa
- Tomas Walfrido Moraes
- Tomasi Roberto Junior
- Tomazzoni Ana Cristina
- Tonetti Vinicius Rodrigues
- Torres Parahyba Campos Bruno Augusto
- Torres Natalia Mundim
- Tortato Fernando Rodrigo
- Tortato Marcos Adriano
- Towns Valeria
- Trigo Tatiane Campos
- Trinca Cristiano Trapé
- Trovati Roberto Guilherme
- Twardowsky Ramalho Bonikowski Renata
- Ubaid Flávio Kulaif
- Vale Mariana M
- Vale Victor
- Valenzuela Leonor Adriana
- Varela Diego M
- Velez-Garcia Felipe
- Velilla Marianela
- Venancio José Otávio
- Venticinque Eduardo Martins
- Verdade Luciano Martins
- Verona Carlos Eduardo
- Viana Diego Carvalho
- Vieira Carlos Leonardo
- Vieira Marcus Vinícius
- Vilas Boas Flávio Eduardo
- Villalba Laura Magnolia
- Villalva Pablo
- Villani João Paulo
- Villarroel Glenda Jéssica
- Villegas Marcelo Alejandro
- Viscarra Siñani Maria Estela
- Vogliotti Alexandre
- Wallace Robert
- Wilson Fernandes Geraldo
- Xavier da Silva Marina
- Xavier Mariana Sampaio
- Yamane Marcelo Hideki
- Yanosky Alberto A
- Zago da Silva Luciana
- Zanella Noeli
- Zanin Marina
- Zaniratto Cristiane Patrícia
- Zanoni Juliani Bruna
- Zanón-Martínez Juan Ignacio
- Zapata-Ríos Galo
- Zecchini Gebin João Carlos
- Ziegler Jörn
- Zárate-Castañeda Claudia Paola
- Zúñiga Hartley Alfonso Christopher
- Álvarez Solas Sara
- Publication venue
- 'Wiley'
- Publication date
- 01/11/2020
- Field of study
Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae. Herein, we include published and unpublished data on native terrestrial Neotropical carnivores (Canidae; Felidae; Mephitidae; Mustelidae; Procyonidae; and Ursidae). NEOTROPICAL CARNIVORES is a publicly available data set that includes 99,605 data entries from 35,511 unique georeferenced coordinates. Detection/non-detection and quantitative data were obtained from 1818 to 2018 by researchers, governmental agencies, non-governmental organizations, and private consultants. Data were collected using several methods including camera trapping, museum collections, roadkill, line transect, and opportunistic records. Literature (peer-reviewed and grey literature) from Portuguese, Spanish and English were incorporated in this compilation. Most of the data set consists of detection data entries (n = 79,343; 79.7%) but also includes non-detection data (n = 20,262; 20.3%). Of those, 43.3% also include count data (n = 43,151). The information available in NEOTROPICAL CARNIVORES will contribute to macroecological, ecological, and conservation questions in multiple spatio-temporal perspectives. As carnivores play key roles in trophic interactions, a better understanding of their distribution and habitat requirements are essential to establish conservation management plans and safeguard the future ecological health of Neotropical ecosystems. Our data paper, combined with other large-scale data sets, has great potential to clarify species distribution and related ecological processes within the Neotropics. There are no copyright restrictions and no restriction for using data from this data paper, as long as the data paper is cited as the source of the information used. We also request that users inform us of how they intend to use the data
Efficacy and safety of sparsentan versus irbesartan in patients with IgA nephropathy (PROTECT): 2-year results from a randomised, active-controlled, phase 3 trial
- Author
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- Hanna Augustyniak-Bartosik (17385997)
- Hans Schmidt-Guertler (17386900)
- Haresh Selvaskandan (7669754)
- Harold Giles (17386306)
- Heather Green (17386348)
- Helen Pilmore (17386786)
- Helena Marco Rusinol (17386855)
- Helena Sousa (10092899)
- Helena Sá (17386858)
- Helmut Reichel (15917925)
- Hernán Trimarchi (7803695)
- Hesham Mohey (17386636)
- Hiddo JL Heerspink (8335752)
- Hon Tang (17386981)
- Hon-Yen Wu (286645)
- Hoon Young Choi (9194354)
- Howard Lifland (17386537)
- Howard Trachtman (792031)
- Hsien-Fu Chiu (4753323)
- Hsin-Yu Chen (2165956)
- Hua-Chang Fang (803678)
- Hung-Chun Chen (106543)
- Hung-Tien Kuo (106539)
- Hung-Yuan Chen (315717)
- Hye Ryoun Jang (8845448)
- Hyeong Cheon Park (13776409)
- Hyun Hee Lee (9009827)
- Hyung Wook Kim (10035228)
- Hyung-seok Lee (17386522)
- Ian Chiu (17386120)
- Ian Dittmer (13410392)
- Ian Fraser (4708297)
- Iara Da Silva Santos (17386876)
- Indranil Dasgupta (3343091)
- Inga Arune Bumblyte' (17386063)
- Ingrid Masson (6501308)
- Ingrid Prkacin (17386804)
- Irene Agraz Pamplona (17386717)
- Irene L Noronha (15277288)
- Irina Suyumova (17386972)
- Isabella Abbasciano (9524821)
- Isabelle Ayoub (800894)
- Ivan Durlen (17386213)
- Ivan Kruljac (17386486)
- Ivan Rychlik (126460)
- Ivana Mikacic (17386627)
- Ivica Horvatic (17386390)
- Ivon Maritza Bobadilla Rico (17386834)
- Jae Hyun Chang (9009821)
- Jafar Ahmed (17385940)
- Jai Radhakrishnan (2827253)
- James A Tumlin (17385925)
- James Sullivan (2883074)
- James Tumlin (6427517)
- Jana Uhlinova (17387008)
- Jane Waugh (17387062)
- Janson Leung (17386531)
- Javad Mojarrab (17386639)
- Jean-Emmanuel Serre (6437384)
- Jeffrey Glaze (17386318)
- Jeffrey Tsun Kit Ha (17386360)
- Jer-Chia Tsai (106527)
- Jerko Barbic (17386021)
- Jerry Meng (2200843)
- Jigar Kadakia (17386435)
- Jihyun Yang (6943178)
- JiYong Jung (17386429)
- Joana de Sousa Soares Felgueiras (17386234)
- Joana Gameiro (6302495)
- Joana Marques (2368660)
- Johann Konstantin Herfurth (17386378)
- Jonathan Ayling-Smith (17386003)
- Jonathan Barratt (3387179)
- Jonathan Erlich (8878460)
- Jonathan Hogan (17386384)
- Jonay Pantoja Perez (17386762)
- Jong Cheol Jeong (1372383)
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- Jose Carlos de Jesus Barreto (17386027)
- Jose Luño Fernandez (17386240)
- Jose Nuno de Almeida Agapito Fonseca (17386258)
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- Liliana Cunha (8077970)
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- Loreto Gesualdo (156871)
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- Louise DaSilva (17386165)
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- Luis F Quintana (17386810)
- Luis Pedro Falcao Goncalves (17386333)
- Machaiah Madhrira (17386555)
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- Maggie Ming Yee Mok (17386642)
- Mai Rosenberg (45877)
- Malgorzata Stanczyk (17386960)
- Mandy Schlosser (17386897)
- Mangalee Fernando (576315)
- Manuel Burdese (11721855)
- Manuel Pereira de Vicente (17386759)
- Manuel Praga (746076)
- Marc Decupere (17386174)
- Marcin Tkaczyk (17386996)
- Marco Colucci (8214813)
- Marcus Moeller (5331401)
- Margo Laute (17386513)
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- Maria Angeles Goicoechea Diezhandino (17386186)
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- Marija Stankovic (17386963)
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- Marine Livrozet (601975)
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- Melissa Cheetham (17386111)
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- Michael Collins (1905367)
- Michael Germain (6863543)
- Michel Zakari (17387119)
- Michela Musolino (17386666)
- Michelle N Rheault (15277291)
- Michelle O'Shaughnessy (17386711)
- Ming-Ju Wu (454092)
- Ming-Shan Chang (17386105)
- Mingyao Ma (7206872)
- Mirco Belingheri (17386030)
- Mirela Dobre (17386192)
- Miriana Dinic (17386189)
- Mohamad Kassem (7183745)
- Mohammad Ali (73095)
- Mohammad Rony (17386846)
- Mona Razavian (17386828)
- Mona Wahba (17387053)
- Monica Bordoli (17386048)
- Monica Furlano (17386273)
- Monica Limardo (17386543)
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- Patrizia Passerini (5042324)
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- Philippe Zaoui (6427586)
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- Piergiorgio Messa (180742)
- Pierre-Louis Carron (17386084)
- Pietro Canetta (4037123)
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- Piotr Jaskowski (17386411)
- Po-Tsang Lee (803674)
- Po-Yu Tseng (9194370)
- Pradip Chowdhury (2379133)
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- Sapna Shah (579169)
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- Sara Goncalves (17386336)
- Sara Ombelet (17386708)
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- Sarah Ashley (14954712)
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- Secundino Cigarran Guldris (17386354)
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- Seung Hyeok Han (8976257)
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- Shang-Feng Tsai (8251905)
- Shang-Jyh Hwang (5312)
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- Shaundeep Sen (121125)
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- Shih-Ping Hsu (315722)
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- Susan Crail (6164591)
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- Sven Heinrichs (17386366)
- Sydney Chi Wai Tang (9082208)
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- Thilo Krueger (309537)
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- Thomas Powell (297146)
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- Thu Nguyen (2179258)
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- Tomasz Stompor (3433691)
- Tung-Min Yu (546163)
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- Tzung-Yo Ho (7337477)
- Ulrich Kunzendorf (5780207)
- Ulysses A Diva (17385901)
- Unnikrishnan Pillai (17386783)
- Ursula Verdalles Guzman (17386357)
- Urte Zakauskiene (17387122)
- Usha Peri (17386777)
- Valentin Mayet (17386597)
- Valérie de Précigout (17386171)
- Veronica Viramontes (17387044)
- Victor Fernandez (17386243)
- Victoria Campbell (239881)
- Vidu Wijeratne (17387077)
- Viet Nguyen (79713)
- Vittoria Esposito (5787344)
- Vladimir Tesar (156920)
- Vlado Perkovic (141532)
- Wai Lim (3583598)
- Wai Ping Law (12288571)
- Wan-Chuan Tsai (5476856)
- Wanja Bernhardt (245782)
- Wenceslao Adrian Aguilera Morales (17386651)
- William E Rote (17385919)
- William Paxton (17386750)
- Wim Lemahieu (3547811)
- Wladyslaw Sulowicz (17386969)
- Wooin Ahn (17385943)
- Wookyung Chung (610342)
- Xavier Warling (17387056)
- Yahsou Delmas (4034183)
- Yan Li (23143)
- Yelena Drexler (12365018)
- Yen-Ling Chiu (442530)
- Yeong Hoon Kim (8962688)
- Yi-Wen Chiu (106535)
- Yick Hei Wong (12288568)
- Yonatan Peleg (9922071)
- Young Rim Song (13242926)
- Young Youl Hyun (13016397)
- Yu-Sen Peng (315725)
- Yunmi Kim (3040866)
- Yusuf Eqbal (17386222)
- Yvonne Shen (17386921)
- Zivka Dika (10281479)
- Zoltan Endre (714028)
- Zvonimir Sitas (17386936)
- Publication venue
- Publication date
- 01/12/2023
- Field of study
Background
Sparsentan, a novel, non-immunosuppressive, single-molecule, dual endothelin angiotensin receptor antagonist, significantly reduced proteinuria versus irbesartan, an angiotensin II receptor blocker, at 36 weeks (primary endpoint) in patients with immunoglobulin A nephropathy in the phase 3 PROTECT trial's previously reported interim analysis. Here, we report kidney function and outcomes over 110 weeks from the double-blind final analysis.
Methods
PROTECT, a double-blind, randomised, active-controlled, phase 3 study, was done across 134 clinical practice sites in 18 countries throughout the Americas, Asia, and Europe. Patients aged 18 years or older with biopsy-proven primary IgA nephropathy and proteinuria of at least 1·0 g per day despite maximised renin–angiotensin system inhibition for at least 12 weeks were randomly assigned (1:1) to receive sparsentan (target dose 400 mg oral sparsentan once daily) or irbesartan (target dose 300 mg oral irbesartan once daily) based on a permuted-block randomisation method. The primary endpoint was proteinuria change between treatment groups at 36 weeks. Secondary endpoints included rate of change (slope) of the estimated glomerular filtration rate (eGFR), changes in proteinuria, a composite of kidney failure (confirmed 40% eGFR reduction, end-stage kidney disease, or all-cause mortality), and safety and tolerability up to 110 weeks from randomisation. Secondary efficacy outcomes were assessed in the full analysis set and safety was assessed in the safety set, both of which were defined as all patients who were randomly assigned and received at least one dose of randomly assigned study drug. This trial is registered with ClinicalTrials.gov, NCT03762850.
Findings
Between Dec 20, 2018, and May 26, 2021, 203 patients were randomly assigned to the sparsentan group and 203 to the irbesartan group. One patient from each group did not receive the study drug and was excluded from the efficacy and safety analyses (282 [70%] of 404 included patients were male and 272 [67%] were White) . Patients in the sparsentan group had a slower rate of eGFR decline than those in the irbesartan group. eGFR chronic 2-year slope (weeks 6–110) was −2·7 mL/min per 1·73 m2 per year versus −3·8 mL/min per 1·73 m2 per year (difference 1·1 mL/min per 1·73 m2 per year, 95% CI 0·1 to 2·1; p=0·037); total 2-year slope (day 1–week 110) was −2·9 mL/min per 1·73 m2 per year versus −3·9 mL/min per 1·73 m2 per year (difference 1·0 mL/min per 1·73 m2 per year, 95% CI −0·03 to 1·94; p=0·058). The significant reduction in proteinuria at 36 weeks with sparsentan was maintained throughout the study period; at 110 weeks, proteinuria, as determined by the change from baseline in urine protein-to-creatinine ratio, was 40% lower in the sparsentan group than in the irbesartan group (−42·8%, 95% CI −49·8 to −35·0, with sparsentan versus −4·4%, −15·8 to 8·7, with irbesartan; geometric least-squares mean ratio 0·60, 95% CI 0·50 to 0·72). The composite kidney failure endpoint was reached by 18 (9%) of 202 patients in the sparsentan group versus 26 (13%) of 202 patients in the irbesartan group (relative risk 0·7, 95% CI 0·4 to 1·2). Treatment-emergent adverse events were well balanced between sparsentan and irbesartan, with no new safety signals.
Interpretation
Over 110 weeks, treatment with sparsentan versus maximally titrated irbesartan in patients with IgA nephropathy resulted in significant reductions in proteinuria and preservation of kidney function.</p
Description and performance of track and primary-vertex reconstruction with the CMS tracker
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdelalim Ahmed Ali
- Abdullin Salavat
- Abdulsalam Abdulla
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmed Imtiaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albert Eric
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Alexander James
- Aliev Takhmasib
- Alimena Juliette
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Ian
- Anderson Jacob
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Androsov Konstantin
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arezzini Silvia
- Arfaei Hessamaddin
- Argiro Stefano
- Arndt Kirk
- Arneodo Michele
- Arora Sanjay
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asghar Muhammad Irfan
- Asin Ivan
- Askew Andrew
- Aslanoglou Xenofon
- Assran Yasser
- Ata Metin
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian Tobias
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M.
- Babb John
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bahtiyar Hüseyin
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Ball Austin
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Monika
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbieri Richard
- Barbone Lucia
- Barfuss Anne-Fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barlas Esra
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Bartalini Paolo
- Barth Christian
- Bartosik Nazar
- Bartz Ed
- Barvich Tobias
- Basegmez Suzan
- Basti Andrea
- Battilana Carlo
- Bauer Gerry
- Bauerdick Lothar A. T.
- Baulieu Guillaume
- Baumgartel Darin
- Baus Colin
- Bayshev Igor
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaumont Willem
- Beaupere Nicolas
- Becker Robert
- Beernaert Kelly
- Behnamian Hadi
- Behr Joerg
- Behrenhoff Wolf
- Behrens Ulf
- Beirão Da Cruz E Silva Cristóvão
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Alan James
- Bell Ken W.
- Bellan Riccardo
- Bellato Marco
- Beluffi Camille
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Bencze Gyorgy
- Bendavid Joshua
- Benedetti Daniele
- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benitez Jose F.
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- Vilela Pereira Antonio
- Villasenor-Cendejas Luis Manuel
- Villella Ilaria
- Vinogradov Alexey
- Virdee Tejinder
- Viret Sébastien
- Vischia Pietro
- Vishnevskiy Dmitry
- Vitulo Paolo
- Vizan Garcia Jesus Manuel
- Vlasov Evgueni
- Vlimant Jean-Roch
- Vogel Helmut
- Voirin Erik
- Volkov Alexey
- Volobouev Igor
- Volpe Roberta
- von Gunten Hans Peter
- Vorobiev Igor
- Vorobyev Alexey
- Vorobyev Andrey
- Voutilainen Mikko
- Vuosalo Carl
- Vutova Mariana
- Wagner Stephen Robert
- Wagner-Kuhr Jeannine
- Wakefield Stuart
- Walker Matthew
- Wallny Rainer
- Walsh Roberval
- Walsh Sinead
- Waltenberger Wolfgang
- Wang Dayong
- Wang Fuqiang
- Wang Jian
- Wang Minzu
- Wang Quan
- Wang Xianyou
- Wang Zheng
- Wardle Nicholas
- Wasserbaech Steven
- Wayand Stefan
- Wayne Mitchell
- Weber Hannsjoerg Artur
- Weber Hendrik
- Weber Martin
- Weber Matthias
- Weiler Thomas
- Weinberg Marc
- Wendland Lauri
- Weng Yao
- Werner Jeremy Scott
- West Christopher
- Wetzel James
- Whitbeck Andrew
- White Dean
- Whitmore Juliana
- Wickramage Nadeesha
- Wilbur Scott
- Wilken Rachel
- Wilkinson Richard
- Williams Thomas
- Willmott Carlos
- Wimpenny Stephen
- Winer Brian L.
- Winn Dave
- Winstrom Lucas
- Wissing Christoph
- Wittich Peter
- Wittmer Bruno
- Wlochal Michael
- Wolf Matthias
- Wolf Roger
- Wolfe Homer
- Wolszczak Weronika
- Womersley William John
- Won Steven
- Wood Darien
- Wood Jeffrey Scott
- Wood John
- Woodard Anna
- Woods Nathaniel
- Worm Steven
- Wright Douglas
- Wrochna Grzegorz
- Wu Weimin
- Wulsin Howard Wells
- Wulz Claudia-Elisabeth
- Wyslouch Bolek
- Wöhri Hermine Katharina
- Würthwein Frank
- Xiao Hong
- Xiao Meng
- Xie Si
- Xie Wei
- Xu Lingshan
- Yagil Avraham
- Yalvac Metin
- Yang Fan
- Yang Mingming
- Yang Yong
- Yang Zong-Chang
- Yazgan Efe
- Yelton John
- Yetkin Taylan
- Yi Kai
- Yilmaz Yetkin
- Yohay Rachel
- Yoo Hwi Dong
- Yoo Jaehyeok
- Yoon Sungho
- York Andrew
- Yu Intae
- Yu Shin-Shan
- Yumiceva Francisco
- Yun Jae Chul
- Yücel Mete
- Zabel James
- Zabi Alexandre
- Zablocki Jakub
- Zaganidis Nicolas
- Zakaria Mohammed
- Zalewski Piotr
- Zanetti Anna
- Zanetti Marco
- Zarubin Anatoli
- Zeinali Maryam
- Zeise Manuel
- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Linlin
- Zheng Yu
- Zhokin Alexander
- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zielinski Marek
- Zito Giuseppe
- Zoccarato Yannick
- Zotto Pierluigi
- Zou Wei
- Zsigmond Anna Julia
- Zuber Adam
- Zucca Stefano
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Zwalinski Lukasz
- Publication venue
- Publication date
- 01/01/2014
- Field of study
Description and performance of track and primary-vertex reconstruction with the CMS tracker
- Author
- Abbaneo Duccio
- Abbiendi Giovanni
- Abbrescia Marcello
- Abdelalim Ahmed Ali
- Abdullin Salavat
- Abdulsalam Abdulla
- Acosta Darin
- Acosta John Gabriel
- Adair Antony
- Adam Wolfgang
- Adams Mark Raymond
- Adams Todd
- Adiguzel Aytul
- Adler Volker
- Adzic Petar
- Agram Jean-Laurent
- Aguilar-Benitez Manuel
- Ahmad Ashfaq
- Ahmad Muhammad
- Ahmed Imtiaz
- Ahuja Sudha
- Akchurin Nural
- Akgun Bora
- Akgun Ugur
- Akin Ilina Vasileva
- Alagoz Enver
- Albajar Carmen
- Albayrak Elif Asli
- Albergo Sebastiano
- Albert Eric
- Albrow Michael
- Alcaraz Maestre Juan
- Aldaya Martin Maria
- Alderweireldt Sara
- Aldá Júnior Walter Luiz
- Alexander James
- Aliev Takhmasib
- Alimena Juliette
- Alverson George
- Alves Gilvan
- Amapane Nicola
- Amsler Claude
- Anagnostou Georgios
- Anastassov Anton
- Anderson Ian
- Anderson Jacob
- Andrea Jeremy
- Andreev Valeri
- Andreev Vladimir
- Andreev Yuri
- Andrews Warren
- Androsov Konstantin
- Antonelli Louis
- Antunovic Zeljko
- Apanasevich Leonard
- Apollinari Giorgio
- Appelt Eric
- Apresyan Artur
- Apyan Aram
- Arcidiacono Roberta
- Arenton Michael Wayne
- Arezzini Silvia
- Arfaei Hessamaddin
- Argiro Stefano
- Arndt Kirk
- Arneodo Michele
- Arora Sanjay
- Asavapibhop Burin
- Asawatangtrakuldee Chayanit
- Asghar Muhammad Irfan
- Asin Ivan
- Askew Andrew
- Aslanoglou Xenofon
- Assran Yasser
- Ata Metin
- Attikis Alexandros
- Auffray Etiennette
- Autermann Christian
- Auzinger Georg
- Avdeeva Ekaterina
- Avery Paul
- Avetisyan Aram
- Avila Carlos
- Azarkin Maksim
- Azhgirey Igor
- Aziz Tariq
- Azzi Patrizia
- Azzolini Virginia
- Azzurri Paolo
- Baarmand Marc M
- Babb John
- Baber Mark
- Bacchetta Nicola
- Bachmair Felix
- Bachtis Michail
- Baden Drew
- Baffioni Stephanie
- Bagliesi Giuseppe
- Bahtiyar Hüseyin
- Baillon Paul
- Bainbridge Robert
- Bakhshiansohi Hamed
- Bakirci Mustafa Numan
- Ball Austin
- Ban Yong
- Banerjee Sudeshna
- Banerjee Sunanda
- Bansal Monika
- Bansal Sunil
- Barbagli Giuseppe
- Barberis Emanuela
- Barbieri Richard
- Barbone Lucia
- Barfuss Anne-Fleur
- Bargassa Pedrame
- Barge Derek
- Baringer Philip
- Barker Anthony
- Barlas Esra
- Barnett Bruce Arnold
- Barney David
- Barone Luciano
- Bartalini Paolo
- Barth Christian
- Bartosik Nazar
- Bartz Ed
- Barvich Tobias
- Basegmez Suzan
- Basti Andrea
- Battilana Carlo
- Bauer Gerry
- Bauerdick Lothar AT
- Baulieu Guillaume
- Baumgartel Darin
- Baus Colin
- Bayshev Igor
- Bazterra Victor Eduardo
- Bean Alice
- Beauceron Stephanie
- Beaudette Florian
- Beaumont Willem
- Beaupere Nicolas
- Becker Robert
- Beernaert Kelly
- Behnamian Hadi
- Behr Joerg
- Behrenhoff Wolf
- Behrens Ulf
- Beirão Da Cruz E Silva Cristóvão
- Belforte Stefano
- Beliy Nikita
- Belknap Donald
- Bell Alan James
- Bell Ken W
- Bellan Riccardo
- Bellato Marco
- Beluffi Camille
- Belyaev Alexander
- Belyaev Andrey
- Benaglia Andrea
- Bencze Gyorgy
- Bendavid Joshua
- Benedetti Daniele
- Benelli Gabriele
- Benhabib Lamia
- Beni Noemi
- Benitez Jose F
- Benucci Leonardo
- Benussi Luigi
- Benvenuti Alberto
- Beranek Sarah
- Beretvas Andrew
- Bergauer Thomas
- Berger Joram
- Berger Lutz Olaf
- Bergholz Matthias
- Beri Suman Bala
- Bernardes Cesar Augusto
- Bernardini Jacopo
- Bernet Colin
- Berruti Gaia Maria
- Berry Douglas
- Berry Edmund
- Berryhill Jeffrey
- Bertl Willi
- Besancon Marc
- Betchart Burton
- Bethani Agni
- Betts Russell Richard
- Bhardwaj Ashutosh
- Bhat Pushpalatha C
- Bhatnagar Vipin
- Bhattacharya Saptaparna
- Bhattacharya Satyaki
- Bhatti Anwar
- Bialkowska Helena
- Bian Jian-Guo
- Bianchi Giovanni
- Bianchini Lorenzo
- Bianco Stefano
- Biasini Maurizio
- Biino Cristina
- Bilei Gian Mario
- Bilin Bugra
- Bilki Burak
- Bilmis Selcuk
- Bisello Dario
- Biskop Heike
- Bissi Lucia
- Bitioukov Sergei
- Blanchot Georges
- Blekman Freya
- Blobel Volker
- Bloch Daniel
- Bloch Philippe
- Bloom Kenneth
- Bluj Michal
- Blumenfeld Barry
- Blyweert Stijn
- Boccali Tommaso
- Bocci Andrea
- Bochenek Joseph
- Bodek Arie
- Boegelspacher Felix
- Boimska Bożena
- Bolla Gino
- Bolognesi Sara
- Bonacorsi Daniele
- Bonato Alessio
- Bondu Olivier
- Bonnin Christian
- Bontenackels Michael
- Boos Edouard
- Bornheim Adolf
- Borras Kerstin
- Borrello Laura
- Bortignon Pierluigi
- Bortoletto Daniela
- Bose Suvadeep
- Bose Tulika
- Bosi Filippo
- Botta Cristina
- Boudoul Gaelle
- Bouhali Othmane
- Bourilkov Dimitri
- Boutle Sarah
- Bradmiller-Feld John
- Braibant-Giacomelli Sylvie
- Branca Antonio
- Branson James G
- Breedon Richard
- Breto Guillermo
- Breuker Horst
- Brew Christopher
- Brianzi Mirko
- Brigliadori Luca
- Brigljevic Vuko
- Brinkerhoff Andrew
- Broccolo Giuseppe
- Brochero Cifuentes Javier Andres
- Brochet Sébastien
- Brom Jean-Marie
- Brona Grzegorz
- Brooke James John
- Brown Robert M
- Brownson Eric
- Brun Hugues
- Bruno Giacomo
- Bubna Mayur
- Buchmann Marco-Andrea
- Buchmuller Oliver
- Bucinskaite Inga
- Buhmann Peter
- Bunin Pavel
- Bunkowski Karol
- Bunn Julian
- Buontempo Salvatore
- Burgmeier Armin
- Burkett Kevin
- Burt Kira
- Burton Darren
- Busson Philippe
- Busza Wit
- Butler Joel Nathan
- Butler Philip H
- Butt Jamila
- Butz Erik
- Bylsma Ben
- Bäni Lukas
- Böser Christian
- Bösiger Kurt
- Cabrillo Iban Jose
- Caebergs Thierry
- Caillol Cécile
- Cakir Altan
- Calabria Cesare
- Calamba Aristotle
- Calderon De La Barca Sanchez Manuel
- Calderon Alicia
- Cali Ivan Amos
- Calligaris Luigi
- Calpas Betty
- Calvert Brian
- Calvo Enrique
- Calzolari Federico
- Campagnari Claudio
- Campanini Renato
- Campbell Alan
- Camporesi Tiziano
- Candelise Vieri
- Canelli Maria Florencia
- Cankocak Kerem
- Capiluppi Paolo
- Cappello Gigi
- Cardaci Marco
- Cariola Pasquale
- Carlin Roberto
- Carlsmith Duncan
- Carrillo Montoya Camilo Andres
- Carrillo Moreno Salvador
- Carroll Ryan
- Cartiglia Nicolo
- Carvalho Wagner
- Casal Bruno
- Casarsa Massimo
- Casasso Stefano
- Casimiro Linares Edgar
- Castaldi Rino
- Castello Roberto
- Castilla-Valdez Heriberto
- Castro Andrea
- Caudron Adrien
- Caudron Julien
- Cavallari Francesca
- Cavallo Francesca Romana
- Cavallo Nicola
- Cavanaugh Richard
- Ceard Ludivine
- Centis Vignali Matteo
- Cepeda Maria
- Cerati Giuseppe Benedetto
- Cerci Salim
- Ceresa Davide
- Cerminara Gianluca
- Cerrada Marcos
- Cervantes Mayra
- Chabert Eric Christian
- Chakaberia Irakli
- Chamizo Llatas Maria
- Chan Kwok Ming
- Chan Matthew
- Chang Paoti
- Chang Sunghyun
- Chang You-Hao
- Chang Yu-Wei
- Chanon Nicolas
- Chao Yuan
- Chaparro Sierra Luisa Fernanda
- Charaf Otman
- Charles Laurent
- Charlot Claude
- Chasco Matthew
- Chasserat Julien
- Chatrchyan Serguei
- Chatterjee Avishek
- Chatterjee Kalyanmoy
- Chatterjee Rajdeep Mohan
- Chauhan Sushil
- Checchia Paolo
- Checcucci Bruno
- Chen Guo-Ming
- Chen He-Sheng
- Chen Jie
- Chen Kai-Feng
- Chen Kuan-Hsin
- Chen Mingshui
- Chen Po-Hsun
- Chen Yi
- Cheng Tongguang
- Cherepanov Vladimir
- Chertok Maxwell
- Chetluru Vasundhara
- Cheung Harry
- Chhibra Simranjit Singh
- Chierici Roberto
- Chinellato Jose
- Chiochia Vincenzo
- Chiorboli Massimiliano
- Chlebana Frank
- Choi Minkyoo
- Choi Suyong
- Choi Young Kyu
- Choi Young-Il
- Chou John Paul
- Choudhary Brajesh C
- Choudhury Somnath
- Chramowicz John
- Christiansen Jorgen
- Christiansen Tim
- Christopher Grant
- Chwalek Thorsten
- Chávez Niemelä Aleksis Osku
- Ciampa Alberto
- Ciangottini Diego
- Ciaranfi Roberto
- Ciesielski Robert
- Cihangir Selcuk
- Cimmino Anna
- Ciocci Maria Agnese
- Cittolin Sergio
- Ciulli Vitaliano
- Civinini Carlo
- Claes Daniel R
- Clare Robert
- Clarida Warren
- Clement Emyr
- Clerbaux Barbara
- Cline David
- CMS Collaboration
- Coarasa Perez Jose Antonio
- Cockerill David JA
- Codispoti Giuseppe
- Colafranceschi Stefano
- Colaleo Anna
- Cole Joanne
- Colino Nicanor
- Collard Caroline
- Colling David
- Colombo Fabio
- Contardo Didier
- Conte Eric
- Conti Elia
- Contreras-Campana Christian
- Contreras-Campana Emmanuel
- Conway John
- Conway Rylan
- Cooper Seth
- Cooper William
- Cornelis Tom
- Correa Martins Junior Marcos
- Cossutti Fabio
- Costa Marco
- Costa Salvatore
- Costantini Silvia
- Costanza Francesco
- Couderc Fabrice
- Coughlan John A
- Cousins Robert
- Covarelli Roberto
- Cowden Christopher
- Cox Bradley
- Cox Peter Timothy
- Creanza Donato
- Cremaldi Lucien Marcus
- Cripps Nicholas
- Crucy Shannon
- Cuevas Javier
- Cuffiani Marco
- Cumalat John Perry
- Cussans David
- Custódio Analu
- Cutajar Michael
- Cutts David
- Cwiok Mikolaj
- Czellar Sandor
- D'Agnolo Raffaele Tito
- D'Alessandro Raffaello
- D'Alfonso Mariarosaria
- D'Angelo Pasqualino
- D'Auria Andrea
- D'Enterria David
- D'Hondt Jorgen
- Da Costa Eliza Melo
- Da Silva Di Calafiori Diogo Raphael
- Da Silveira Gustavo Gil
- Dabrowski Anne
- Daci Nadir
- Daguin Jerome
- Dahmes Bryan
- Dahms Torsten
- Dalchenko Mykhailo
- Dall'Osso Martino
- Dallavalle Gaetano-Marco
- Damgov Jordan
- Danielson Thomas
- Das Souvik
- Daskalakis Georgios
- Dasu Sridhara
- Daubie Evelyne
- Dauncey Paul
- David Tinoco Mendes Andre
- Davies Gavin
- De Almeida Dias Flavia
- de Barbaro Pawel
- De Benedetti Abraham
- De Boer Wim
- De Callatay Bernard
- De Cosa Annapaola
- De Filippis Nicola
- De Gruttola Michele
- De Guio Federico
- De Jesus Damiao Dilson
- De La Cruz Begona
- De La Cruz-Burelo Eduard
- De Lentdecker Gilles
- De Mattia Marco
- De Moraes Gregores Eduardo
- De Oliveira Martins Carley
- De Palma Mauro
- De Robertis Giuseppe
- De Roeck Albert
- de Trocóniz Jorge F
- De Visscher Simon
- De Wolf Eddi A
- Degano Alessandro
- Deisher Amanda
- Deiters Konrad
- Dejardin Marc
- Del Re Daniele
- Delaere Christophe
- Delannoy Andrés G
- Delgado Peris Antonio
- Dell'Orso Roberto
- Della Negra Michel
- Della Ricca Giuseppe
- Demaria Natale
- Demina Regina
- Demiragli Zeynep
- Demortier Luc
- Denegri Daniel
- Deniz Muhammed
- Depasse Pierre
- Deptuch Grzegorz
- Dermenev Alexander
- Derylo Greg
- Descroix Alexis
- Detraz Stephane
- Devroede Olivier
- Deyrail Dominique
- Dhingra Nitish
- Di Giovanni Gian Piero
- Di Guida Salvatore
- Di Marco Emanuele
- Di Matteo Leonardo
- Diamond Brendan
- Diemoz Marcella
- Dierlamm Alexander
- Dietz Charles
- Dietz-Laursonn Erik
- Diez Pardos Carmen
- Dildick Sven
- Dilsiz Kamuran
- Dimitrov Anton
- Dinardo Mauro Emanuele
- Dishaw Adam
- Dissertori Günther
- Dittmann Jay
- Dittmar Michael
- Djambazov Lubomir
- Dobrzynski Ludwik
- Dobson Marc
- Dobur Didar
- Doesburg Robert
- Dolen James
- Dolinska Ganna
- Dominguez Aaron
- Dominik Wojciech
- Domínguez Vázquez Daniel
- Donato Silvio
- Donegà Mauro
- Dooling Samantha
- Dordevic Milos
- Dorigo Tommaso
- Dorland Tyler
- Dorney Brian
- Doroba Krzysztof
- Dos Reis Martins Thiago
- Dozen Candan
- Dragicevic Marko
- Dragoiu Cosmin
- Drell Brian Robert
- Dremin Igor
- Drouhin Frédéric
- Drozdetskiy Alexey
- Du Pree Tristan
- Du Ran
- Duarte Campderros Jordi
- Duarte Javier
- Dubinin Mikhail
- Duchardt Deborah
- Dudero Phillip Russell
- Dudko Lev
- Dugad Shashikant
- Duggan Daniel
- Dumanoglu Isa
- Dupont-Sagorin Niels
- Duric Senka
- Durkin Lloyd Stanley
- Duru Firdevs
- Dutta Dipanwita
- Dutta Suchandra
- Dutta Valentina
- Dünser Marc
- Eber Robert
- Eckerlin Guenter
- Ecklund Karl Matthew
- Eckstein Doris
- Edelhoff Matthias
- Eerola Paula
- Eggert Nicholas
- Eichhorn Thomas
- Ekmedzic Marko
- El Mamouni Houmani
- Elgammal Sherif
- Eller Philipp
- Elliott-Peisert Anna
- Ellison John Anthony
- Ellithi Kamel Ali
- Elmer Peter
- Elvira Victor Daniel
- Enderle Holger
- Eno Sarah Catherine
- Epshteyn Vladimir
- Erbacher Robin
- Erdmann Martin
- Erdmann Wolfram
- Erdogan Yusuf
- Erfle Joachim
- Erhan Samim
- Ershov Alexander
- Erö Janos
- Eshaq Yossof
- Eskut Eda
- Esser Hans
- Etesami Seyed Mohsen
- Eugster Jürg
- Eusebi Ricardo
- Evangelou Ioannis
- Evans David
- Evdokimov Olga
- Everaerts Pieter
- Everett Adam
- Fabbri Fabrizio
- Fabbri Franco
- Fabbricatore Pasquale
- Fabbro Bernard
- Fabjan Christian
- Fabozzi Francesco
- Faccio Federico
- Faccioli Pietro
- Fahim Ali
- Fan Jiawei
- Fanfani Alessandra
- Fangmeier Caleb
- Fantasia Cory
- Fanò Livio
- Farrell Chris
- Fasanella Daniele
- Faulkner James
- Faure Jean-Louis
- Favaro Carlotta
- Favart Denis
- Favart Laurent
- Fay Jean
- Fedi Giacomo
- Fehling David
- Feindt Michael
- Felcini Marta
- Feld Lutz
- Felici Daniele
- Ferapontov Alexey
- Ferbel Thomas
- Ferencek Dinko
- Ferguson Thomas
- Ferguson William
- Fernandez Bedoya Cristina
- Fernandez Menendez Javier
- Fernandez Marcos
- Fernández Ramos Juan Pablo
- Ferrando Antonio
- Ferreira Parracho Pedro Guilherme
- Ferretti Roberta
- Ferri Federico
- Ferro Cristina
- Ferro Fabrizio
- Field Richard D
- Finger Jr Michael
- Finger Miroslav
- Fiore Luigi
- Fiorendi Sara
- Fiori Francesco
- Fischer Robert
- Fisher Matthew
- Fisk Ian
- Flacher Henning
- Flanagan Will
- Flix Jose
- Florent Alice
- Flores Chad
- Florez Carlos
- Flouris Giannis
- Flowers Kristen
- Flowers Sean
- Flucke Gero
- Flügge Günter
- Focardi Ettore
- Folgueras Santiago
- Fonseca De Souza Sandro
- Fontaine Jean-Charles
- Ford William T
- Forthomme Laurent
- Foudas Costas
- Fouz Maria Cruz
- Foà Lorenzo
- Francis Brian
- Franco Sevilla Manuel
- Franco Michele
- Frank Norbert
- Franzoni Giovanni
- Frazier Robert
- Freeman Jim
- Frensche Benno
- Friedl Markus
- Friis Evan
- Frueboes Tomasz
- Fruehwirth Rudolf
- Fu Yu
- Fulcher Jonathan
- Funk Wolfgang
- Furic Ivan-Kresimir
- Futyan David
- Gabusi Michele
- Gadrat Sébastien
- Gaioni Luigi
- Galanti Mario
- Gallinaro Michele
- Gallo Elisabetta
- Gamsizkan Halil
- Ganguly Sanmay
- Ganjour Serguei
- Gao Yanyan
- Garabedian Alex
- Garcia Guillaume
- Garcia-Abia Pablo
- Garcia-Bellido Aran
- Gardner Michael
- Garutti Erika
- Gary J William
- Gascon Susan
- Gasparini Fabrizio
- Gasparini Ugo
- Gaultney Vanessa
- Gauthier Lucie
- Gavrilenko Mikhail
- Gavrilov Vladimir
- Gay Arnaud
- Gaz Alessandro
- Geenen Heiko
- Geffert Paul
- Geiser Achim
- Geisler Matthias
- Gelé Denis
- Genchev Vladimir
- Gennai Simone
- George Christopher
- George Jimin
- Geralis Theodoros
- Gerber Cecilia Elena
- Gerosa Raffaele
- Gershtein Yuri
- Geurts Frank JM
- Ghete Vasile Mihai
- Ghezzi Alessio
- Ghosh Saranya
- Giacomelli Paolo
- Giammanco Andrea
- Giassi Alessandro
- Gibbons Lawrence Kent
- Giffels Manuel
- Gigi Dominique
- Gilbert Andrew
- Gill Karl
- Gilmore Jason
- Gingu V Cristinel
- Giordano Domenico
- Giordano Ferdinando
- Girgis Semiray
- Girone Maria
- Giubilato Piero
- Giunta Marina
- Givernaud Alain
- Glege Frank
- Glushkov Ivan
- Gninenko Sergei
- Gobbo Benigno
- Godinovic Nikola
- Godshalk Andrew
- Goebel Kristin
- Goerlach Ulrich
- Goetzmann Christophe
- Goh Junghwan
- Gokbulut Gul
- Goldenzweig Pablo
- Goldstein Joel
- Golf Frank
- Gollapinni Sowjanya
- Golovtsov Victor
- Golubev Nikolai
- Golutvin Igor
- Gomber Bhawna
- Gomez Ceballos Guillelmo
- Gomez Moreno Bernardo
- Gomez Gervasio
- Gomez Jaime
- Gomez Juan Pablo
- Gomez-Reino Garrido Robert
- Goncharov Maxim
- Gonzalez Caballero Isidro
- Gonzalez Lopez Oscar
- Gonzalez Sanchez Javier
- Gonzalez Suarez Rebeca
- Gonzi Sandro
- Goodell Joseph
- Gorbunov Ilya
- Gori Valentina
- Gosselink Martijn
- Gottschalk Erik
- Goulianos Konstantin
- Gouskos Loukas
- Gouzevitch Maxime
- Govoni Pietro
- Gowdy Stephen
- Goy Lopez Silvia
- Gozzelino Andrea
- Grab Christoph
- Grandi Claudio
- Granier de Cassagnac Raphael
- Gras Philippe
- Grassi Marco
- Gray Julia
- Gray Lindsey
- Gray Richard
- Graziano Alberto
- Grebenyuk Anastasia
- Green Dan
- Greene Senta
- Gribushin Andrey
- Grimes Mark
- Grippo Maria Teresa
- Gritsan Andrei
- Gronberg Jeffrey
- Gross Laurent
- Grothe Monika
- Grundler Ulysses
- Grunewald Martin
- Grünendahl Stefan
- Guchait Monoranjan
- Gude Alexander
- Guida Roberto
- Guiducci Luigi
- Guler Ali Murat
- Gulhan Doga
- Guneratne Bryer Arlo
- Gunnellini Paolo
- Guo Yifei
- Gupta Ruchi
- Gurpinar Emine
- Gurrola Alfredo
- Gurtu Atul
- Guthoff Moritz
- Gutsche Oliver
- Gyun Dooyeon
- Górski Maciej
- Görner Martin
- Gülmez Erhan
- Günaydin Yusuf Oguzhan
- Güth Andreas
- Haas Jeff
- Habib Shiraz
- Hadjiiska Roumyana
- Hadley Nicholas John
- Hagopian Sharon
- Hagopian Vasken
- Hahn Kristan Allan
- Haj Ahmad Wael
- Hajdu Csaba
- Haley Joseph
- Halkiadakis Eva
- Hall Geoffrey
- Hall-Wilton Richard
- Haller Johannes
- Halyo Valerie
- Hamel de Monchenault Gautier
- Hammad Gregory Habib
- Hammer Josef
- Hampe Jan
- Han Jiyeon
- Hansen Karsten
- Hansen Magnus
- Hanson Gail
- Harder Kristian
- Hare Daryl
- Harel Amnon
- Harper Sam
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- Harris Robert M
- Hartl Christian
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- Hatakeyama Kenichi
- Hatherell Zoe
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- Hirosky Robert
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- Hits Dmitry
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- Hoehle Felix
- Hoepfner Kerstin
- Hoff Jim R
- Hoffmann Karl-Heinz
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- Hohlmann Marcus
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- Honma Alan
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- Zeinali Maryam
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- Zenz Seth Conrad
- Zeuner Wolfram Dietrich
- Zeyrek Mehmet
- Zhang Jinzhong
- Zhang Linlin
- Zheng Yu
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- Zhu Ren-Yuan
- Zhukov Valery
- Zhukova Victoria
- Zielinski Marek
- Zito Giuseppe
- Zoccarato Yannick
- Zotto Pierluigi
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- Zuber Adam
- Zucca Stefano
- Zucchetta Alberto
- Zumerle Gianni
- Zuranski Andrzej
- Zwalinski Lukasz
- Publication venue
- Publication date
- 01/01/2014
- Field of study
A description is provided of the software algorithms developed for the CMS tracker both for reconstructing charged-particle trajectories in proton-proton interactions and for using the resulting tracks to estimate the positions of the LHC luminous region and individual primary-interaction vertices. Despite the very hostile environment at the LHC, the performance obtained with these algorithms is found to be excellent. For tbar t events under typical 2011 pileup conditions, the average track-reconstruction efficiency for promptly-produced charged particles with transverse momenta of p(T) > 0.9GeV is 94% for pseudorapidities of |η| < 0.9 and 85% for 0.9 < |η| < 2.5. The inefficiency is caused mainly by hadrons that undergo nuclear interactions in the tracker material. For isolated muons, the corresponding efficiencies are essentially 100%. For isolated muons of p(T) = 100GeV emitted at |η| < 1.4, the resolutions are approximately 2.8% in p(T), and respectively, 10μm and 30μm in the transverse and longitudinal impact parameters. The position resolution achieved for reconstructed primary vertices that correspond to interesting pp collisions is 10–12μm in each of the three spatial dimensions. The tracking and vertexing software is fast and flexible, and easily adaptable to other functions, such as fast tracking for the trigger, or dedicated tracking for electrons that takes into account bremsstrahlung