No X-Rays or Radio from the Nearest Black Holes and Implications for Future Searches

Astrometry from the Gaia mission was recently used to discover the two nearest known stellar-mass black holes (BHs), Gaia BH1 and Gaia BH2. Both systems contain $\sim 1\,M_{\odot}$ stars in wide orbits ($a\approx$1.4 AU, 4.96 AU) around $\sim9\,M_{\odot}$ BHs. These objects are among the first stellar-mass BHs not discovered via X-rays or gravitational waves. The companion stars -- a solar-type main sequence star in Gaia BH1 and a low-luminosity red giant in Gaia BH2 -- are well within their Roche lobes. However, the BHs are still expected to accrete stellar winds, leading to potentially detectable X-ray or radio emission. Here, we report observations of both systems with the Chandra X-ray Observatory and radio observations with the Very Large Array (for Gaia BH1) and MeerKAT (for Gaia BH2). We did not detect either system, leading to X-ray upper limits of $L_X < 10^{29.4}$ and $L_X < 10^{30.1}\,\rm erg\,s^{-1}$ and radio upper limits of $L_r < 10^{25.2}$ and $L_r < 10^{25.9}\,\rm erg\,s^{-1}$. For Gaia BH2, the non-detection implies that the the accretion rate near the horizon is much lower than the Bondi rate, consistent with recent models for hot accretion flows. We discuss implications of these non-detections for broader BH searches, concluding that it is unlikely that isolated BHs will be detected via ISM accretion in the near future. We also calculate evolutionary models for the binaries' future evolution using Modules for Experiments in Stellar Astrophysics (MESA). We find that Gaia BH1 will be X-ray bright for 5--50 Myr when the star is a red giant, including 5 Myr of stable Roche lobe overflow. Since no symbiotic BH X-ray binaries are known, this implies either that fewer than $\sim 10^4$ Gaia BH1-like binaries exist in the Milky Way, or that they are common but have evaded detection, perhaps due to very long outburst recurrence timescales.Comment: Submitted to PAS

The 4G/5G PAI-1 polymorphism influences the endothelial response to IL-1 and the modulatory effect of pravastatin

BACKGROUND: Increased plasminogen activator inhibitor (PAI-1) levels lead to impaired fibrinolytic function associated with higher cardiovascular risk. PAI-1 expression may be regulated by different inflammatory cytokines such as interleukin-1alpha (IL-1). Several polymorphisms have been described in the PAI-1 gene. AIM: We examined the influence of the 4G/5G polymorphism in the promoter region on IL-1alpha-induced PAI-1 expression by human umbilical vein endothelial cells (HUVEC) in presence or absence of pravastatin. METHODS AND RESULTS: Genotyped HUVEC were incubated with IL-1alpha (500 U mL(-1)) in presence or absence of pravastatin (1-10 microm). PAI-1 expression was analyzed by real time polymerase chain reaction (PCR), and PAI-1 antigen measured in supernatants by ELISA. IL-1alpha increased PAI-1 secretion in a genotype-dependent manner, and higher values were observed for 4G/4G compared with both 4G/5G and 5G/5G cultures (P < 0.05). Preincubation of HUVEC with 10 microm pravastatin significantly reduced IL-1-induced PAI-1 expression in 4G/4G HUVEC compared with untreated cultures (177.5% +/- 24.5% vs. 257.9% +/- 39.0%, P < 0.05). Pravastatin also attenuated the amount of secreted PAI-1 by 4G/4G HUVEC after IL-1 stimulation (5020.6 +/- 165.7 ng mL(-1) vs. 4261.1 +/- 309.8 ng mL(-1), P < 0.05). This effect was prevented by coincubation with mevalonate, indicating a dependence on HMG-CoA reductase inhibition. CONCLUSIONS: The endothelial 4G/5G PAI-1 genotype influences the PAI-1 response to IL-1alpha and the modulatory effect of pravastatin. As increased PAI-1 levels have been linked to cardiovascular disease the observed endothelial modulation by pravastatin may have potential clinical implications

Matrix metalloproteinase-10 is upregulated by thrombin in endothelial cells and increased in patients with enhanced thrombin generation

OBJECTIVE: Thrombin is a multifunctional serine protease that promotes vascular proinflammatory responses whose effect on endothelial MMP-10 expression has not previously been evaluated. METHODS AND RESULTS: Thrombin induced endothelial MMP-10 mRNA and protein levels, through a protease-activated receptor-1 (PAR-1)-dependent mechanism, in a dose- and time-dependent manner. This effect was mimicked by a PAR-1 agonist peptide (TRAP-1) and antagonized by an anti-PAR-1 blocking antibody. MMP-10 induction was dependent on extracellular regulated kinase1/2 (ERK1/2) and c-jun N-terminal kinase (JNK) pathways. By serial deletion analysis, site-directed mutagenesis and electrophoretic mobility shift assay an AP-1 site in the proximal region of MMP-10 promoter was found to be critical for thrombin-induced MMP-10 transcriptional activity. Thrombin and TRAP-1 upregulated MMP-10 in murine endothelial cells in culture and in vivo in mouse aorta. This effect of thrombin was not observed in PAR-1-deficient mice. Interestingly, circulating MMP-10 levels (P<0.01) were augmented in patients with endothelial activation associated with high (disseminated intravascular coagulation) and moderate (previous acute myocardial infarction) systemic thrombin generation. CONCLUSIONS: Thrombin induces MMP-10 through a PAR-1-dependent mechanism mediated by ERK1/2, JNK, and AP-1 activation. Endothelial MMP-10 upregulation could be regarded as a new proinflammatory effect of thrombin whose pathological consequences in thrombin-related disorders and plaque stability deserve further investigation

Spectroscopic follow-up of black hole and neutron star candidates in ellipsoidal variables from Gaia DR3

We present multi-epoch spectroscopic follow-up of a sample of ellipsoidal variables selected from Gaia DR3 as candidates for hosting quiescent black holes (BHs) and neutron stars (NSs). Our targets were identified as BH/NS candidates because their optical light curves -- when interpreted with models that attribute variability to tidal distortion of a star by a companion that contributes negligible light -- suggest that the companions are compact objects. From the likely BH/NS candidates identified in recent work accompanying Gaia DR3, we select 14 of the most promising targets for follow-up. We obtained spectra for each object at 2-10 epochs, strategically observing near conjunction to best-constrain the radial velocity semi-amplitude. From the measured semi-amplitudes of the radial velocity curves, we derive minimum companion masses of $M_{2,\min} \leq 0.5 ~ M_{\odot}$ in all cases. Assuming random inclinations, the typical inferred companion mass is $M_2 \sim 0.15 ~ M_{\odot}$. This makes it unlikely that any of these systems contain a BH or NS, and we consider alternative explanations for the observed variability. We can best reproduce the observed light curves and radial velocities with models for unequal-mass contact binaries with starspots. Some of the objects in our sample may also be detached main-sequence binaries, or even single stars with pulsations or starspot variability masquerading as ellipsoidal variation. We provide recommendations for future spectroscopic efforts to further characterize this sample and more generally to search for compact object companions in close binaries.Comment: 18 pages, 12 figures, Accepted to MNRA

LkHαα 225 (V1318 Cyg) South in Outburst

© 2022 The Author(s). Published by the American Astronomical Society. This is an open access article distributed under the Creative Commons Attribution License, to view a copy of the license, see: https://creativecommons.org/licenses/by/4.0/Magakian et al. called attention to the current bright state of LkHα 225 South, a well-known highly embedded,intermediate-mass young stellar object that over the past two decades has brightened visually from >20m to <13m.We present recent optical photometric monitoring showing colorless, nonsinusoidal, periodic brightnessoscillations occurring every 43 days with amplitude ∼0.7 mag. We also present new flux-calibrated optical andnear-infrared spectroscopy, which we model in terms of a Keplerian accretion disk, and high-dispersion spectrathat demonstrate similarity to some categories of “mixed-temperature” accretion-outburst objects. At bluewavelengths, LkHα 225 South has a pure absorption spectrum and is a good spectral match to the FU Ori starsV1515 Cyg and V1057 Cyg. At red optical and infrared wavelengths, however, the spectrum is more similar toGaia 19ajj, showing emission in TiO, CO, and metals. Sr II absorption indicates a low-surface-gravity atmosphere.There are also signatures of a strong wind/outflow. LkHα 225 South was moderately bright in the early 1950s aswell as in the late 1980s, with evidence for deep fades during intervening epochs. The body of evidence suggeststhat LkHα 225 South is another case of a source with episodically enhanced accretion that causes brightening byorders of magnitude, and development of a hot absorption spectrum and warm wind. It is similar to Gaia 19ajj, butalso reminiscent in its long brightening time and brightness oscillation near peak to the embedded sources L1634IRS7 and ESO Ha 99.Peer reviewe

Protective effect of the G-765C COX-2 polymorphism on subclinical atherosclerosis and inflammatory markers in asymptomatic subjects with cardiovascular risk factors

BACKGROUND: Cyclooxygenase (COX)-2, a key regulatory enzyme in prostanoid synthesis, plays an important role in inflammatory processes. The -765G>C COX-2 polymorphism has been associated with lower promoter activity in vitro and reduced levels of C-reactive protein (CRP) in atherosclerotic carriers of the C allele. However, its pathophysiological relevance in vivo has not been fully elucidated. METHODS AND RESULTS: We assessed the -765G>C polymorphism and COX-2 expression in 220 asymptomatic subjects free of cardiovascular disease, in relation to global vascular risk, carotid intima-media thickness (IMT), and inflammatory markers (fibrinogen, C-reactive protein [CRP], von Willebrand factor [vWF] and interleukin-6 [IL-6]). Genotype frequencies were: CC (7.7%), CG (34.5%), GG (57.7%). Among hypercholesterolemic subjects (n=140), C allele carriers had lower COX-2 expression (p<0.05), reduced carotid IMT (p<0.01) and diminished levels of inflammatory markers CRP, vWF and IL-6 (p<0.05), as compared to GG homozygous subjects. The association between carotid IMT and COX-2 polymorphism remained significant after adjusting for cardiovascular risk factors and inflammatory markers (p=0.008). CONCLUSIONS: In asymptomatic hypercholesterolemic subjects the C allele of -765G>C COX-2 polymorphism was associated with lower COX-2 expression, and reduced subclinical atherosclerosis and systemic inflammation compared with GG homozygous, thus conferring atherosclerosis protection in this cardiovascular risk population

Combinando Linked Data con servicios geoespaciales

La Web de Linked Data supone un nuevo paradigma que pretende explotar la Web como un espacio global de información. La aplicación de los principios de esta nueva Web a la información geoespacial superará la integración de información tradicional, logrando una articulación semántica de los datos que haga desaparecer los silos de datos presentes en las actuales Infraestructuras de Datos Espaciales. Ante esta propuesta, en este artículo se describe el trabajo desarrollado en el marco de un caso de uso utilizando una parte de los datos del SIGNA. En este caso de uso se ha llevado a cabo un proceso de generación y publicación de los mencionados datos conforme a los principios de Linked Data y estos se combinan con diversos servicios de la IDEE y CartoCiudad para explotar el componente geoespacial