Learning from medical data streams: an introduction

Clinical practice and research are facing a new challenge created by the rapid growth of health information science and technology, and the complexity and volume of biomedical data. Machine learning from medical data streams is a recent area of research that aims to provide better knowledge extraction and evidence-based clinical decision support in scenarios where data are produced as a continuous flow. This year's edition of AIME, the Conference on Artificial Intelligence in Medicine, enabled the sound discussion of this area of research, mainly by the inclusion of a dedicated workshop. This paper is an introduction to LEMEDS, the Learning from Medical Data Streams workshop, which highlights the contributed papers, the invited talk and expert panel discussion, as well as related papers accepted to the main conference

A study of topologies and protocols for fiber optic local area network

The emergence of new applications requiring high data traffic necessitates the development of high speed local area networks. Optical fiber is selected as the transmission medium due to its inherent advantages over other possible media and the dual optical bus architecture is shown to be the most suitable topology. Asynchronous access protocols, including token, random, hybrid random/token, and virtual token schemes, are developed and analyzed. Exact expressions for insertion delay and utilization at light and heavy load are derived, and intermediate load behavior is investigated by simulation. A new tokenless adaptive scheme whose control depends only on the detection of activity on the channel is shown to outperform round-robin schemes under uneven loads and multipacket traffic and to perform optimally at light load. An approximate solution to the queueing delay for an oscillating polling scheme under chaining is obtained and results are compared with simulation. Solutions to the problem of building systems with a large number of stations are presented, including maximization of the number of optical couplers, and the use of passive star/bus topologies, bridges and gateways

A Direct Multigrid Poisson Solver for Oct-Tree Adaptive Meshes

We describe a finite-volume method for solving the Poisson equation on oct-tree adaptive meshes using direct solvers for individual mesh blocks. The method is a modified version of the method presented by Huang and Greengard (2000), which works with finite-difference meshes and does not allow for shared boundaries between refined patches. Our algorithm is implemented within the FLASH code framework and makes use of the PARAMESH library, permitting efficient use of parallel computers. We describe the algorithm and present test results that demonstrate its accuracy.Comment: 10 pages, 6 figures, accepted by the Astrophysical Journal; minor revisions in response to referee's comments; added char

Liquid mixtures involving fluorinated alcohols: The equation of state (p, r, T, x) of (Ethanol + Trifluoroethanol) Experimental and Simulation

Liquid mixtures involving fluorinated alcohols: The equation of state (p, r, T, x) of (Ethanol + Trifluoroethanol) Experimental and Simulation Pedro Duartea, Djêide Rodriguesa, Marcelo Silvaa, Pedro Morgadoa, Luís Martinsa,b and Eduardo J. M. Filipea* aCentro de Química Estrutural, Instituto Superior Técnico, 1049-001 Lisboa, Portugal bCentro de Química de Évora, Universidade de Évora, 7000-671 Évora, Portugal Fluorinated alcohols are substances with unique properties and high technological value in the pharmaceutical and chemical industries. Trifluoroethanol (TFE), in particular, displays a number of unusual properties as a solvent. For example, it dissolves nylon at room temperature and is effectively used as solvent in bioengineering. The presence of the three fluorines atoms gives the alcohol a high ionization constant, strong hydrogen bonding capability and stability at high temperatures. In the pharmaceutical industry, TFE finds use as the major raw material for the production of inhalation anesthetics. Mixtures of TFE and water (known as Fluorinols®) are used as working fluids for Rankine cycle heat engines for terrestrial and space applications, as a result of a unique combination of physical and thermodynamic properties such as high thermal efficiency and excellent turbine expansion characteristics. Environmentally, TFE is a CFC substitute with an acceptable short lifetime and with small ozone depletion potential. Additionally, TFE is known to induce conformational changes in proteins and it is used as a co-solvent to analyze structural features of partially folded states. The (ethanol + TFE) system displays an interesting and peculiar behaviour, combining a negative azeotrope with high positive excess volumes. In this work, liquid mixtures of (ethanol + TFE) were investigated. The densities of the mixtures were measured as a function of composition between 278K and 338K and at pressures up to 700 bar. The corresponding excess volumes as a function of temperature and pressure, the isothermal compressibilities and thermal expansivities were calculated from the experimental results. The mixtures are highly non-ideal with excess volumes ranging from 0.8 - 1.0 cm3mol-1. Finally, molecular dynamic simulations were performed to model and interpret the experimental results. The Trappe force field was used to simulate the (TFE + ethanol) mixtures and calculate the corresponding excess volumes. The simulation results are able to reproduce the correct sign and order of magnitude of the experimental VE without fitting to the experimental data. Furthermore, the simulations suggest the presence of a particular type of hydrogen bridge between ethanol and TFE, that can help to rationalize the experimental results

Generalization of Dirac Non-Linear Electrodynamics, and Spinning Charged Particles

In this note we generalized the Dirac non-linear electrodynamics, by introducing two potentials (namely, the vector potential A and the pseudo-vector potential gamma^5 B of the electromagnetic theory with charges and magnetic monopoles) and by imposing the pseudoscalar part of the product omega.omega* to be zero, with omega = A + gamma^5 B. We show that the field equations of such a theory possess a soliton-like solution which can represent a priori a "charged particle", since it is endowed with a Coulomb field plus the field of a magnetic dipole. The rest energy of the soliton is finite, and the angular momentum stored in its electromagnetic field can be identified --for suitable choices of the parameters-- with the spin of the charged particle. Thus this approach seems to yield a classical model for the charged (spinning) particle, which does not meet the problems met by earlier attempts in the same direction.Comment: standard LaTeX file; 16 pages; it is a corrected version of a paper appeared in Found. Phys. (issue in honour of A.O.Barut) 23 (1993) 46