Radioactive Iodine Administration Is Associated with Persistent Related Symptoms in Patients with Differentiated Thyroid Cancer

Context. Radioiodine (RAI) administration has adverse effects in patients treated for thyroid cancer (DTC), but there is scarce information regarding their intensity and duration. Objective. To evaluate frequency and intensity of early and late RAI-related symptoms in patients with DTC. Design. Observational prospective study. Patients. DTC patients who underwent thyroidectomy, with or without RAI. Measurements. Patients answered 2 surveys: (1) from 0 to 6 months and (2) between 6 and 18 months after initial treatment. Results. 110 patients answered the first survey and 61 both. Nearly 80 percent received RAI. Among early symptoms, periorbital edema, excessive tearing, salivary gland disturbances, dry mouth, taste disorders, and nausea were more frequent and intense among RAI patients. Regarding late symptoms, periorbital edema, salivary gland pain and swelling, and dry mouth were more frequent and intense in RAI patients. Frequency and intensity of adverse effects were not different between low and high RAI doses (50 versus ≥100 mCi). Conclusion. RAI-related symptoms are frequent and usually persist after 6 months of administration, even when low doses are given. This finding must be considered when deciding RAI administration, especially in low risk patients, among whom RAI benefit is controversial

CARDIOLOGÍA NUCLEAR: NUEVOS DESARROLLOS Y PERSPECTIVAS FUTURAS

La cardiología nuclear ha sido tradicionalmente una herramienta de apoyo, principalmente en la evaluación de la cardiopatía coronaria. Los avances computacionales y desarrollo de nuevas técnicas han permitido mejorar la calidad de los estudios de cardiología nuclear, mejorando la exactitud diagnóstica. En este trabajo se revisarán los avances de los distintos equipamientos para obtención de imágenes con énfasis en la tecnología híbrida SPECT/CT y PET/CT, así como el desarrollo de nuevos trazadores y fármacos utilizados en la obtención de estas imágenes. Además, se revisan los protocolos actuales y los cambios que se debieran ver en el futuro cercano para adaptarse a los nuevos equipos y fármacos disponibles

Exercise sensitizes skeletal muscle to extracellular ATP for IL-6 expression in mice

Active skeletal muscle synthesizes and releases interleukin-6 (IL-6), which plays important roles in the organism's adaptation to exercise. Autocrine/paracrine ATP signaling has been shown to modulate IL-6 expression. The aim of this study was to determine whether a period of physical activity modifies the ATP-induced IL-6 expression. BalbC mice were either subject to 5 weeks voluntary wheel running (VA) or kept sedentary (SED). Flexor digitorum brevis muscles were dissected, stimulated with different ATP concentrations (0-100 μM) and IL-6 mRNA levels were measured using qPCR. ATP evoked a concentration-dependent rise in IL-6 mRNA in both SED and VA mice. VA mice however, had significantly higher ATP sensitivity (pD2 pharmacological values: VA=5.58±0.02 vs. SED=4.95±0.04, p<0.05). Interestingly, in VA mice we observed a positive correlation between the level of physical activity and the IL-6 mRNA increase following fiber stimulation with 10μM ATP. In addition, there were lower P2Y2- a

New insights into IGF-1 signaling in the heart

Artículo de publicación ISIInsulin-like growth factor 1 (IGF-1) signaling regulates contractility, metabolism, hypertrophy, autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an increased risk of cardiovascular disease, whereas cardiac activation of IGF-1 receptor (IGF-1R) protects from the detrimental effects of a high-fat diet and myocardial infarction. IGF-1R activates multiple pathways through its intrinsic tyrosine kinase activity and through coupling to heterotrimeric G protein. These pathways involve classic second messengers, phosphorylation cascades, lipid signaling, Ca2+ transients, and gene expression. In addition, IGF-1R triggers signaling in different subcellular locations including the plasma membrane, perinuclear T tubules, and also in internalized vesicles. In this review, we provide a fresh and updated view of the complex IGF- 1 scenario in the heart, including a critical focus on therapeutic strategies.This work was supported by FONDECYT (grant 1120212 to S.L. and grant 11130285 to R.T.) and CONICYT (grant Anillo ACT 1111 to E.J. and S.L.; FONDAP 15130011 to S.L. and R.T.; Red 120003 to S.L.

Comparison of radionuclide ventriculography using SPECT and planar techniques in different cardiac conditions

Purpose: Accurate assessment of ventricular function is required to optimize therapeutic management of cardiac diseases. The aim of this study was to correlate planar equilibrium multigated acquisition (MUGA) with tomographic ventriculography (SPECT) in patients with diverse volumes and wall motion abnormalities. Methods: Eighty-three studies in 80 patients (56±14 years; 56% women) were classified according to ventricular dilation, wall motion abnormalities and systolic dysfunction. Left and right ventricular ejection fraction (LVEF and RVEF) and end-diastolic and end-systolic left ventricular volumes (EDV and ESV) were obtained using a commercial QBS program for SPECT. On planar acquisition, LVEF and RVEF were obtained using standard techniques and volumes were determined using the count-based method, without blood sampling. Results: A. Total group: With the planar method, LVEF was 44±17%, RVEF 42±13%, left EDV 147±97 ml (range 31-487 ml) and left ESV 93±85 ml (range 15-423 ml); wit

NEUROIMÁGENES EN DEMENCIAS

Las demencias constituyen un problema severo de salud a nivel mundial, y describen una gran cantidad de síntomas. Se caracterizan por un deterioro cognitivo adquirido irreversible que afecta principalmente, pero no exclusivamente, la memoria. Además, afecta especialmente a las personas mayores, pero no constituye una consecuencia normal del envejecimiento. Existen múltiples técnicas imagenológicas que apoyan el diagnóstico, que están en etapa de investigación o que se utilizan actualmente en el aspecto clínico. Protocolos estándar de imágenes de resonancia magnética, escalas de evaluación visual de la atrofia, técnicas de volumetría cerebral, paradigmas de resonancia magnética funcional, técnicas de conectividad funcional de reposo, SPECT y PET son las técnicas que se comentarán en este artículo