Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is a deficit in DC numbers and IFN-α production, which has been associated with disease severity. In this work, we described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers. Remarkably, previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients, while no restoration of integrin β7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed. These findings contribute to a better understanding of the immunological sequelae of COVID-19

Prolonged emersion of Solea senegalensis, Kaup 1858, for its application in transport

This study aimed to determine the maximum time of emersion of Senegalese sole (Solea senegalensis) specimens to form the basis for a dry sole transport procedure. For this purpose, 56 specimens (922.33 29.52 g body weight) were individually placed in polystyrene boxes on a wet cloth, maintaining constant temperature (15°C) during emersion trial. Specimens (n = 7 per group) were sampled for plasma, and mortality was monitored at different points (0, 2, 6, 12, 20, 28, 36 and 44 h of emersion), and several tress (cortisol, glucose and lactate) and metabolic (triglycerides, proteins and amino acids) parameters were assessed. After sampling, each experimental group was placed in recovery tanks for the assessment of delayed mortality and feeding performance after emersion trial. Transport periods longer than 28 h produced high stress level indicated by (i) significant increase in circulating cortisol and lactate and (ii) glucose reserves mobilization. These alterations originated physiological problems during the emersion trial that induced mortality as well as problems for recovering correct feeding performance of specimens. These results suggested that at 15°C for S. senegalensis specimens (around 900 g body weight), a waterless transport is posible without direct or delayed mortality up toThis study aimed to determine the máximum time of emersión of to 28 h.S

IS IT POSSIBLE TO TRANSPORT SOLEA SENEGALENSIS SPECIMENS WITHOUT WATER?

This study aimed to determine the maximum emersion time of Solea senegalensis specimens, as well as stress level caused by this procedure. Results will be useful for its application in transport. For this purpose, 56 Senegalese soles of 922.33 ± 29.52 g were individually placed in polystyrene boxes on a wet cloth, maintaining constant temperature during emersion (15 °C). Specimens (n = 7) were sampled for plasma at different points (0, 2, 6, 12, 20, 28, 36, and 44 hours of emersion), and several stress and metabolic parameters were assessed. After that, each experimental group was placed in recovery tanks for assessing delayed mortality after emersion trial. The results showed that a waterless transport is possible without direct or delayed mortality up to 28 hours. From this moment, high stress level indicated by i) significantly cortisol and lactate enhancement, as well as ii) glucose reserves mobilization originated physiological problems during emersion that induced mortality of specimens

La esclavitud en el siglo XXI. Solidaridad y voluntariado

Convocatoria Proyectos de innovación de Extremadura 2018/2019Se describe un proyecto llevado a cabo en el IES Zurbarán (Badajoz) en el que se reflexiona sobre las distintas formas de explotación que se dan en la sociedad actual y la respuesta que puede dar la solidaridad y el voluntariado a estas situaciones. El tema se aborda desde distintas áreas convirtiéndolo en un proyecto transversal. Los objetivos principales del proyecto fueron: conocer la realidad para crear una ciudadanía consciente, crítica y comprometida; fomentar la participación para crear iniciativas de cambio y alternativas para un mundo más justo e igualitario; desarrollar la empatía; favorecer el pensamiento crítico; mejorar la inteligencia emocional y social; fomentar el respeto a los demás valorando la identidad propia y posibilitar la transformación personalExtremaduraES

Revolution: Museo de las estrellas un paseo por la fama : Hollywood

Convocatoria proyectos de innovación de Extremadura 2020/2021Se describe un proyecto llevado a cabo entre 13 centros educativos extremeños que consistió en desarrollar cinco unidades de trabajo gamificadas, cinco historias detectivescas con misterios por resolver, donde se ponían a prueba las habilidades de lógica, la capacidad de observación, de concentración y de atención de los alumnos. Los objetivos principales de la propuesta fueron: promover la puesta en práctica de proyectos intercentros; impulsar pedagogías activas; desarrollar la competencia digital a través del uso de las pedagogías emergentes lo que ha permitido llevar a cabo una enseñanza presencial, híbrida y virtual y atender a la diversidadExtremaduraES