Interactions of host miRNAs in the flavivirus 3´UTR genome:From bioinformatics predictions to practical approaches

The genus Flavivirus of the Flaviviridae family includes important viruses, such as Dengue, Zika, West Nile, Japanese encephalitis, Murray Valley encephalitis, tick-borne encephalitis, Yellow fever, Saint Louis encephalitis, and Usutu viruses. They are transmitted by mosquitoes or ticks, and they can infect humans, causing fever, encephalitis, or haemorrhagic fever. The treatment resources for these diseases and the number of vaccines available are limited. It has been discovered that eukaryotic cells synthesize small RNA molecules that can bind specifically to sequences present in messenger RNAs to inhibit the translation process, thus regulating gene expression. These small RNAs have been named microRNAs, and they have an important impact on viral infections. In this review, we compiled the available information on miRNAs that can interact with the 3’ untranslated region (3’UTR) of the flavivirus genome, a conserved region that is important for viral replication and translation

Review: The Role Of Hyperleptinemia In Chronic Degenerative Diseases

Leptin is a protein that belongs to the family of cytokines, it’s mainly produced by adipose tissue and its main function is to inform the nervous system about the amount of such tissue present in the organism, it also participates in the regulation of the neuroendocrine function and in the control of food intake; however, this molecule can also act in other tissues because their receptors are present in them. It has been identified that abnormal values of this protein can lead to have or aggravate some pathologies, such as cardiovascular, inflammatory, cancer, etc; since leptin is considered as a hormone that has proliferative, mitogenic, antiapoptotic and proinflammatory activity. Hyperleptinemia is a condition presented when leptin levels are above the normal level in the bloodstream (1-15 ng/ml) usually caused by physiological disorders such as obesity. Hyperleptinemia has been associated with several chronic degenerative diseases, where it has a strong relationship with the molecular basis of these diseases, either by direct action on the tissue or by its chemotactic ability to attract other molecules involved in the development of the disease. Because of these, abnormal levels of leptin in the body can be considered as a marker of disease, as described in this review

Genes and proteins associated with chemotherapeutic resistance in breast cancer

Breast cancer is the main type of cancer that affects women in the world. Treatment with chemotherapeutic agents for this type of cancer depends to a large extent on the phenotypic characteristics that appear in the tumor, such as some receptors. The treatment of breast cancer is complex since not all patients respond adequately to it and this is partly due to mechanisms of resistance to treatment. The resistance either acquired or intrinsic to chemotherapeutics against breast cancer is related to multiple genes and proteins that are actively involved in the development of resistance mechanisms, which may be inhibiting the binding of the drug to the target receptor, inhibiting the gene expression of the receptors, activating signaling pathways, inducing the action of transporters that expel the drug from the cell, etc. As a result of this review, the mechanisms of chemotherapeutic resistance in breast cancer derived from genes and proteins related to say disease are described, including genes related to different types of breast cancer, as well as with different therapeutic strategies. These genes and their products of expression include a wide range of interactions and activations of signalling pathways that trigger a poor response to treatment, which translates into a worse prognosis, higher risk of prevalence and death, favouring breast cancer to be the main cause of cancer death in women. Objective: Conduct an updated review of genes and proteins, that have been associated with conferring resistance to the different chemotherapeutic agents used for the treatment of breast cancer, including the mechanism of resistance and the type of cancer in which it is generated. Method: The search for indexed articles in the PubMed (https://www.ncbi.nlm.nih.gov/pubmed/) and ScienceDirect (http://www.sciencedirect.com) databases was performed, using the words “Breast cancer resistance” as a search criterion, articles published in the period 2015-2017 were selected

English vocabulary learning through interactive reading using short stories in ninth graders

This research project is focused on the description and analysis of the processes of learning vocabulary with the implementation of interactive model of reading by using short stories with topics of interest to students of ninth grade in a private school in Bogota. Ten students participated in the project for more than six months. Among the main sources used to obtain data, field notes, and test artifacts Student`s generated during the process. Data analysis revealed that activities based on interactive reading model allowed the acquisition of new vocabulary to help students understand the stories and engage with the text, the author and the context in which the story was written

Estrategias de captación solar aplicados al diseño de un centro de investigación agrícola en Julcán, La Libertad

La finalidad de esta investigación es definir y proponer un Centro de Investigación Agrícola, aplicando lineamientos de diseño arquitectónico, los cuales se basan en estrategias y técnicas de captación solar, y así poder mitigar las bajas temperaturas que se presentan en el lugar a intervenir. El proyecto planteado pretende solucionar y generar un aporte educativo y científico a diversas falencias presentadas en Julcán, así mismo integrar a las diferentes comunidades campesinas y a promover la formalización de productores agrícolas, reconociendo su labor y las diferentes adversidades que presentan. A través de referentes teóricos, hemos podido definir que existen 3 tipos de estrategias de capación solar: directa, indirecta y aislada; las cuales pueden aplicarse conjuntamente y adecuarse para control de temperatura, en caso haya sobrecalentamiento. Así mismo, gracias al análisis de casos arquitectónicos se ha establecido los lineamientos de diseño para el proyecto, garantizando el diseño de espacios funcionales y acogedoras, asegurando una temperatura interior confortable, la cual puede ser regulada según las diferentes actividades y zonas establecidas. Y hay que resaltar que existe una relación entre las estrategias de captación solar y los materiales utilizados en la envolvente de la edificación, lo cual nos permite optimizar resultados en cuanto se refiere a ganancias térmicas obtenidas y a la conservación de calor al interior de la edificación

Efecto de la varianza genética aditiva generacional sobre las componentes de la respuesta a la selección en una población con generaciones superpuestas

p.221-230El objetivo de esta investigación fue comparar la respuesta a la selección usando el Modelo Animal-BLUP con grupos genéticos, utilizando la variancia genética aditiva de cada generación (s²A(C), con aquel que utiliza la variancia aditiva en la población base (s²a), mediante simulación estocastica de una población animal con generaciones superpuestas. A diferencia de otros estudios, el modelo de generación de datos incluyó efectos fijos como el sexo (variable clasificatoria) y la edad del animal a la medición del carácter (covariable), con el objeto de asemejarse a los modelos de evaluación en poblaciones reales. Los resultados corresponden a 20 años de selección, tomando el promedio de 100 réplicas. La h² original en la población fue 0,4. La pérdida de información consistió en omitir al azar relaciones de parentesco, afín de incorporar los grupos al modelo de evaluación animal. El 25 por ciento de los animales poseían ambos padres desconocidos, 25 por ciento poseían la madre desconocida, 25 por ciento el padre y el 25 por ciento restante poseían ambos padres conocidos. En las condiciones simuladas no se observaron diferencias significativas (pmayor a 0,05), en las variables estudiadas: respuesta a la selección, variancia aditiva, exactitud, intensidad de selección, consanguinidad e intervalo generacional, para los casos de información completa e incompleta con la inclusión de grupos, según se consideró las s²a ó la s²a(g

Glosario de histopatología : tumores epiteliales de las glándulas salivales

Las neoplasias de glándulas salivales mayores y menores humanas constituyen un desafío para clínicos e histopatólogos. Son entidades nosológicas poco frecuentes y sus características histológicas, clínicas, epidemiológicas y evolutivas son muy complejas y variadas. En la literatura especializada se menciona que en las glándulas salivales se originan no menos de 30 tipos histológicos diferentes de tumores, con sus variedades y subtipos. Representan menos del 2% de todas las neoplasias humanas y alrededor del 3% de los tumores de cabeza y cuello. Dentro de los tumores benignos el más común es el adenoma pleomórfico, en tanto que el carcinoma mucoepidermoide es el tumor maligno más frecuente. Entre el 70 y 80% de las neoplasias asienta en parótida, siendo el paladar el sitio más común para glándulas salivales menores, reportándose en algunas investigaciones variaciones geográficas.Fil: Samar, María Elena. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Histología y Embriología A; ArgentinaFil: Avila, Rodolfo Esteban. Universidad Nacional de Córdoba. Facultad de Ciencias Médicas. Cátedra de Biología Celular, Histología y Embriología; ArgentinaOtras Medicina Básic

Meningitis tuberculosa en el niño: Tratamiento asociado con Hain y Estreptomicina en 84 casos

International audienceSoc. 10 mai 2007, pourvoi n° 05-44.313, publié au Bulleti

English vocabulary learning through interactive reading using short stories in ninth graders

This research project is focused on the description and analysis of the processes of learning vocabulary with the implementation of interactive model of reading by using short stories with topics of interest to students of ninth grade in a private school in Bogota. Ten students participated in the project for more than six months. Among the main sources used to obtain data, field notes, and test artifacts Student`s generated during the process. Data analysis revealed that activities based on interactive reading model allowed the acquisition of new vocabulary to help students understand the stories and engage with the text, the author and the context in which the story was written