Financial and credit mechanism for attraction of real investments in a system of money flows regulation

Optimization of funding sources of real investments is a key stage in development and successful functioning of enterprises' investment activity. Currently big attention is drawn to questions of state and private partnership during development of investment projects, as well as to possible prospects of development of state and private interaction forms in investment sphere, and concessions particularly. Improvement of forms of interaction between state and corporate sector of economy in the sphere of real investments and as a part of development of specific priority investment programs requiring considerable investments has a strategic federal and regional value. Thus, it is important to understand role and benefit of each participant of the investment market, to define clear statutory, legislative and contractual base, and to swiftly analyze financial efficiency of real investments at all stages of realization. In modern conditions, stable development of economy of any country depends on condition of investment process. Need to integrate finance capital and to promote investment activity is obvious in new management conditions of market relations development. The main condition of successful investment activity at each stage is a choice of effective and correct finance and credit mechanism as a tool of real investments financing. Prior to suggest modern tools of such financing, it is necessary to analyze theoretically proved program and targeted method of real investments financing within the state and private partnership, in order to improve previously examined methodology. © 2015, Mediterranean Center of Social and Educational Research. All rights reserved

ОСОБЕННОСТИ РАКА ЯИЧНИКОВ У БОЛЬНЫХ С МУТАЦИЕЙ BRCA1 5382insC

Molecular genetic characteristics of the ovarian tumors can provide much quicker information about treatment effectiveness. The paper was aimed to study the frequency of BRCA1 5382insC mutation among ovarian cancer patients living in Siberia (the Tomsk region) and to detect the main clinical morphological and immunohistochemical characteristics of this disease. It was found that the frequency of BRCA1 5382insC mutation among ovarian cancer patients in the Tomsk region was 9.19 %. The partial response to platinum-based chemotherapy was observed in 75 % of ovarian cancer patients having BRCA1 5382insC mutation. Optimal cytoreduction is a significant predictor of the treatment effectiveness of hereditary ovarian cancer associated with BRCA1 5382insC mutation.Молекулярно-генетические особенности опухоли у больных раком яичников определяют особенности клинического течения и эффективность лечения. Цель работы – изучить частоту мутации BRCA1 5382insC у больных раком яичников в Сибирском регионе на примере Томской области и выявить основные клинико-морфологические и иммуногистохимические особенности заболевания. Показано, что частота выявления мутации BRCA1 5382insC среди больных РЯ Томской области не отличается от средних показа- телей по РФ и составляет 9,19 %. Ответ на платиносодержащие режимы химиотерапии в виде частичной регрессии отмечается у 75 % больных РЯ с мутацией BRCA1 5382insC. Оптимальность выполнения циторедукции является значимым фактором прогноза эффективности лечения наследственного РЯ, ассоциированного с мутацией BRCA1 5382insC

OVARIAN CANCER IN PATIENTS WITH BRCA1 5382insC MUTATION

Molecular genetic characteristics of the ovarian tumors can provide much quicker information about treatment effectiveness. The paper was aimed to study the frequency of BRCA1 5382insC mutation among ovarian cancer patients living in Siberia (the Tomsk region) and to detect the main clinical morphological and immunohistochemical characteristics of this disease. It was found that the frequency of BRCA1 5382insC mutation among ovarian cancer patients in the Tomsk region was 9.19 %. The partial response to platinum-based chemotherapy was observed in 75 % of ovarian cancer patients having BRCA1 5382insC mutation. Optimal cytoreduction is a significant predictor of the treatment effectiveness of hereditary ovarian cancer associated with BRCA1 5382insC mutation

CAUSE AND EFFECT RELATIONSHIPS WITHIN THE FRAMEWORK OF IMPROVING THE CREDIT PROCESS OF A COMMERCIAL BANK

Актуальность исследования обусловлена тем, что в настоящее время из-за сложной геополитической обстановки кредитная нагрузка на население окажется еще больше, чем во времена пандемии. Кредитный риск растет, доходы населения падают или находятся в стагнации, в условиях роста цен, при этом потребности остаются на прежнем уровне. Риск не имманентно присущее банку свойство, поэтому исследование рисков и их минимизация является основной деятельность банка, а в структуре различных банковских рисков наибольшее значение имеет кредитный риск.The relevance of the study is since at present, due to the difficult geopolitical situation, the credit burden on the population will be even greater than during the pandemic. Credit risk is growing, incomes of the population are falling or stagnating, in conditions of rising prices, while the needs remain at the same level. The risk is not an immanent property of the bank, therefore, the study of risks and their minimization is the main activity of the bank, and in the structure of various banking risks, credit risk is of the greatest importance