Correction of static pressure on a research aircraft in accelerated flight using differential pressure measurements

A method is described that estimates the error in the static pressure measurement on an aircraft from differential pressure measurements on the hemispherical surface of a Rosemount model 858AJ air velocity probe mounted on a boom ahead of the aircraft. The theoretical predictions for how the pressure should vary over the surface of the hemisphere, involving an unknown sensitivity parameter, leads to a set of equations that can be solved for the unknowns – angle of attack, angle of sideslip, dynamic pressure and the error in static pressure – if the sensitivity factor can be determined. The sensitivity factor was determined on the University of Wyoming King Air research aircraft by comparisons with the error measured with a carefully designed sonde towed on connecting tubing behind the aircraft – a trailing cone – and the result was shown to have a precision of about ±10 Pa over a wide range of conditions, including various altitudes, power settings, and gear and flap extensions. Under accelerated flight conditions, geometric altitude data from a combined Global Navigation Satellite System (GNSS) and inertial measurement unit (IMU) system are used to estimate acceleration effects on the error, and the algorithm is shown to predict corrections to a precision of better than ±20 Pa under those conditions. Some limiting factors affecting the precision of static pressure measurement on a research aircraft are discussed

Location Of Microearthquakes Induced By Hydraulic Fracturing

This paper examines the problem of locating microearthquakes induced by hydraulic fracturing using seismic arrival time data. In addition to the use of absolute arrival times measured for individual events, we consider the use of differential arrival times amongst a set of two or more seismic events as a means of constraining their locations relative to one another. Differential arrival times can be measured very accurately using cross-correlation techniques and are less sensitive than absolute arrival times to subsurface velocity structure. We have developed an algorithm which combines relative event location techniques with conventional absolute location techniques and applied it to a set of 19 microearthquakes recorded during a hydraulic fracturing experiment conducted as part of the Los Alamos Hot Dry Rock project. We find that the events, except for a few outliers, delineate a planar zone 30 meters in dimension, presumably a fracture plane. This example shows that the use of differential arrival times improves the accuracy of locating microearthquake clusters and that the relative locations of events within the cluster are better determined than their absolute locations. The results also suggest the need for directional data from three-component stations or better station geometry to further improve location accuracy

Earth Occultation Imaging of the Low Energy Gamma-Ray Sky with GBM

The Earth Occultation Technique (EOT) has been applied to Fermi's Gamma-ray Burst Monitor (GBM) to perform all-sky monitoring for a predetermined catalog of hard X-ray/soft gamma-ray sources. In order to search for sources not in the catalog, thus completing the catalog and reducing a source of systematic error in EOT, an imaging method has been developed -- Imaging with a Differential filter using the Earth Occultation Method (IDEOM). IDEOM is a tomographic imaging method that takes advantage of the orbital precession of the Fermi satellite. Using IDEOM, all-sky reconstructions have been generated for ~sim 4 years of GBM data in the 12-50 keV, 50-100 keV and 100-300 keV energy bands in search of sources otherwise unmodeled by the GBM occultation analysis. IDEOM analysis resulted in the detection of 57 sources in the 12-50 keV energy band, 23 sources in the 50-100 keV energy band, and 7 sources in the 100-300 keV energy band. Seventeen sources were not present in the original GBM-EOT catalog and have now been added. We also present the first joined averaged spectra for four persistent sources detected by GBM using EOT and by the Large Area Telescope (LAT) on Fermi: NGC 1275, 3C 273, Cen A, and the Crab

Grain‐energy release governs mobility of debris flow due to solid–liquid mass release

Debris flows often exhibit high mobility, leading to extensive hazards far from their sources. Although it is known that debris flow mobility increases with initial volume, the underlying mechanism remains uncertain. Here, we reconstruct the mobility–volume relation for debris flows using a recent depth‐averaged two‐phase flow model without evoking a reduced friction coefficient, challenging currently prevailing friction‐reduction hypotheses. Physical experimental debris flows driven by solid–liquid mass release and extended numerical cases at both laboratory and field scales are resolved by the model. For the first time, we probe into the energetics of the debris flows and find that, whilst the energy balance holds and fine and coarse grains play distinct roles in debris flow energetics, the grains as a whole release energy to the liquid due to inter‐phase and inter‐grain size interactions, and this grain‐energy release correlates closely with mobility. Despite uncertainty arising from the model closures, our results provide insight into the fundamental mechanisms operating in debris flows. We propose that debris flow mobility is governed by grain‐energy release, thereby facilitating a bridge between mobility and internal energy transfer. The initial volume of debris flow is inadequate for characterizing debris flow mobility, and a friction‐reduction mechanism is not a prerequisite for the high mobility of debris flows. By contrast, inter‐phase and inter‐grain size interactions play primary roles and should be incorporated explicitly in debris flow models. Our findings are qualitatively encouraging and physically meaningful, providing implications not only for assessing future debris flow hazards and informing mitigation and adaptation strategies, but also for unravelling a spectrum of earth surface processes including heavily sediment‐laden floods, subaqueous debris flows and turbidity currents in rivers, reservoirs, estuaries, and ocean

Design and synthesis of non-peptide mimetics mapping the immunodominant myelin basic protein (MBP83–96) Epitope to function as T-cell receptor antagonists

Encephalitogenic T cells are heavily implicated in the pathogenesis of multiple sclerosis (MS), an autoimmune demyelinating disease of the central nervous system. Their stimulation is triggered by the formation of a trimolecular complex between the human leukocyte antigen (HLA), an immunodominant myelin basic protein (MBP) epitope, and the T cell receptor (TCR). We detail herein our studies directed towards the rational design and synthesis of non-peptide mimetic molecules, based on the immunodominant MBP83–96 epitope that is recognized by the TCR in complex with HLA. We focused our attention on the inhibition of the trimolecular complex formation and consequently the inhibition of proliferation of activated T cells. A structure-based pharmacophore model was generated, in view of the interactions between the TCR and the HLA-MBP83–96 complex. As a result, new candidate molecules were designed based on lead compounds obtained through the ZINC database. Moreover, semi-empirical and density functional theory methods were applied for the prediction of the binding energy between the proposed non-peptide mimetics and the TCR. We synthesized six molecules that were further evaluated in vitro as TCR antagonists. Analogues 15 and 16 were able to inhibit to some extent the stimulation of T cells by the immunodominant MBP83–99 peptide from immunized mice. Inhibition was followed to a lesser degree by analogues 17 and 18 and then by analogue 19. These studies show that lead compounds 15 and 16 may be used for immunotherapy against MS

Natural course of Myoclonus-Dystonia in adulthood: stable motor signs but increased psychiatry

Myoclonus‐dystonia (M‐D) is a rare hyperkinetic movement disorder characterized by upper body–predominant myoclonus and dystonia.1 A large proportion of cases are caused by autosomal‐dominant inherited mutations in the SGCE gene. In addition to the motor manifestations, psychiatric disorders are frequently reported.2 Several studies have suggested that they may form a primary component of the M‐D phenotype.3, 4 This study represents the first long‐term follow‐up study of both motor and psychiatric symptomatology in adults with M‐D (SGCE mutation), providing further insights into the natural history of M‐D and enabling more prognostic information

The Effect of wake Turbulence Intensity on Transition in a Compressor Cascade

Direct numerical simulations of separating flow along a section at midspan of a low-pressure V103 compressor cascade with periodically incoming wakes were performed. By varying the strength of the wake, its influence on both boundary layer separation and bypass transition were examined. Due to the presence of small-scale three-dimensional fluctuations in the wakes, the flow along the pressure surface undergoes bypass transition. Only in the weak-wake case, the boundary layer reaches a nearly-separated state between impinging wakes. In all simulations, the flow along the suction surface was found to separate. In the simulation with the strong wakes, separation is intermittently suppressed as the periodically passing wakes managed to trigger turbulent spots upstream of the location of separation. As these turbulent spots convect downstream, they locally suppress separation. © 2014 Springer Science+Business Media Dordrecht

Electrophysiologic testing aids diagnosis and subtyping of myoclonus

OBJECTIVE: To determine the contribution of electrophysiologic testing in the diagnosis and anatomical classification of myoclonus. METHODS: Participants with a clinical diagnosis of myoclonus were prospectively recruited, each undergoing a videotaped clinical examination and battery of electrophysiologic tests. The diagnosis of myoclonus and its subtype was reviewed after 6 months in the context of the electrophysiologic findings and specialist review of the videotaped clinical examination. RESULTS: Seventy-two patients with myoclonus were recruited. Initial clinical anatomical classification included 25 patients with cortical myoclonus, 7 with subcortical myoclonus, 2 with spinal myoclonus, and 15 with functional myoclonic jerks. In 23 cases, clinical anatomical classification was not possible because of the complexity of the movement disorder. Electrophysiologic testing was completed in 66, with agreement of myoclonus in 60 (91%) and its subtype in 28 (47%) cases. Subsequent clinical review by a movement disorder specialist agreed with the electrophysiologic findings in 52 of 60; in the remaining 8, electrophysiologic testing was inconclusive. CONCLUSIONS: Electrophysiologic testing is an important additional tool in the diagnosis and anatomical classification of myoclonus, also aiding in decision-making regarding therapeutic management. Further development of testing criteria is necessary to optimize its use in clinical practice