Prospectus, April 20, 2011

EARTH WEEK: ALTERNATIVE OPTIONS FOR TRANSPORTATION, Empty Bowls Fundraiser: Feeding Local Youth, Chuck Shepherd\u27s News of the Weird, Q & A With Eddie Argos from Art Brut, PCSEA Prepares, Excites Students for Education, Colleges Price Out Middle Class: Even Best and Brightest Can Afford It, How the \u27Wild West\u27 of the Seas was Won, Commencement Speakers Shouldn\u27t Cash In, Behind the Scenes (Part One): The Parkland Print Shop, Game Review: Fight Night Champion, Recent Turmoil Doesn\u27t Rattle the Snakeshttps://spark.parkland.edu/prospectus_2011/1003/thumbnail.jp

Prospectus, June 1, 2011

PARKLAND SERVES THOSE WHO SERVE, Tornadoes! Floods! Droughts! Scientists Say It\u27s Global Warming, Civil Union Licenses Now Available, An Education Will Get You More Than a Diploma, Parkland Commencement 2011, Quest for Educational Success: University Creates Gaming Platform for Students, Chuck Shepherd\u27s News of the Weird, College: To Be or Not To Be (Yourself), In the 2012 Campaign, Environmentalists Don\u27t Matter, Cellphones: Quieting the Public Nuisances, The Three R\u27s, Plus Coal: American Coal Foundation Works With Scholastic, Parkland Student to Perform at Taste of C-U, Behind the Scenes: Campus Technologies, 10 Facebook Settings to Check Right Now, Expiration Dates to be Observed as Guidelines, Web Winners: Retirement Planning for All Ages, Hard Work Pays Off! Parkland Athletes Ring in Numerous Awards on the Year, For Some Athletes, the Mental Game is the Toughest, Album Review: Company of Thieves Running From a Gamble, Students Learn by Producing Sitcom, Video-Game Review: \u27L.A. Noire\u27https://spark.parkland.edu/prospectus_2011/1006/thumbnail.jp

Prospectus, May 4, 2011

A COMPREHENSIVE GUIDE TO FINALS, Hospital, Volunteer Trip Inspires Many, Chuck Shepherd\u27s News of the Weird, Pygmalion Looking Bigger, Better Than Ever, Cram Time: Tips on How to Finish Out the Semester (the right way), Opposing Views: The Death of Osama Bin Laden, PlayStation Network: Compromised!, Green Roof Project Now Complete, Paving the Road to Nationals - Cobras Softball Gearing Up for the Big Eventhttps://spark.parkland.edu/prospectus_2011/1005/thumbnail.jp

Prospectus, April 27, 2011

YEAR-ROUND PELL GRANT ELIMINATED, Japanese Culture Club: Small Group, Big Heart, Parkland Students to Help Install LiveRoof System on Campus, Chuck Shepherd\u27s News of the Weird, News From the Studio: The Latest from 88.7 WPCD, With Parents in Korea, Sis Becomes Mom, Will We Ever Be Able to Fight for a Common Goal Again?, Attack the Law, Not the Lawyer, Is Everybody Happy?, A Look into the World of Focus Testing, Shoes That Can Be Recycled, Real Men Wear Pink! Cobras Host Invitational for Breast Cancer Research, Heartland Takes Bite Out of PC Softball, Stay Safehttps://spark.parkland.edu/prospectus_2011/1004/thumbnail.jp

Optical switching of radical pair conformation enhances magnetic sensitivity

The yield of chemical reactions involving intermediate radical pairs is influenced by magnetic fields well beyond the levels expected from energy considerations. This dependence can be traced back to the microscopic dynamics of electron spins and constitutes the basis of the chemical compass. Here we propose a new experimental approach based on molecular photoswitches to achieve additional control on the chemical reaction and to allow short-time resolution of the spin dynamics. Our proposal enables experiments to test some of the standard assumptions of the radical pair model and improves the sensitivity of chemical magnetometers by two orders of magnitude

Prospectus, June 29, 2011

PROGRESS BEING MADE FOR MASTER PLAN, New Courses, Programs to be Offered, Substance Abuse Recovery May Begin on Campus, How to Take Amazing Pictures of Fireworks, Whole Health Lecture Series: Alternative Health Care for Pets, Chuck Shepherd\u27s News of the Weird, Extreme Drinking Means Extreme Danger, War Has Been Waged on College Fraternities, Kindle vs. Books: The Dead Trees Society, The Risks Exist: What You Need to Know Before Getting Tattoos and Piercings, Pursuing Scholarships is Worth the College Savings, A Prospectus News Guide to Road Trips, The Road to Success: How to Find the Right College, A Community College That Hold Up to Its Name, Album Review: Bon Iver\u27s Bon Iver, Bon Iver, Video-game Review: The Legend of Zelda, I Could be Your Jack Dawson...https://spark.parkland.edu/prospectus_2011/1007/thumbnail.jp

Prospectus, April 13, 2011

STUDENT CREATES SIGNATURE IMAGE FOR BONEYARD ARTS FESTIVAL, No Space? No Problem! Gardening Tips for Students, Where Even Cell Phones Aren\u27t Safe, Chuck Shepherd\u27s News of the Weird, Record Store Day, Fungus Sweeps Across the Country, Killing Bats, Spammers Target Facebook, Teaching: A Very Noble Profession, Empower the FCC to Protect Internet Access, Taking a Shot at Providing a Libya-Endgame Strategy, A How-To Guide on Avoiding Scams and Fraud, Meeting Roger Wolfson of Bungie, Sprint to Take Lead in Mobile-Payment Technology, Parkland Women\u27s Basketball: Making a Habit of Success, Golf Team Wins M-WAC Title, Parkland Softball Sweeps Weekend Increases Winning Streak to 9,https://spark.parkland.edu/prospectus_2011/1002/thumbnail.jp

A phase I pharmacokinetic and pharmacodynamic study of the oral mitogen-activated protein kinase kinase (MEK) inhibitor, WX-554, in patients with advanced solid tumours

Purpose: We performed a multi-centre phase I study to assess the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of the orally available small molecule mitogen-activated protein kinase kinase (MEK) 1/2 inhibitor, WX-554, and to determine the optimal biological dose for subsequent trials. Experimental design: Patients with treatment-refractory, advanced solid tumours, with adequate performance status and organ function were recruited to a dose-escalation study in a standard 3 + 3 design. The starting dose was 25 mg orally once weekly with toxicity, PK and PD guided dose-escalation with potential to explore alternative schedules. Results: Forty-one patients with advanced solid tumours refractory to standard therapies and with adequate organ function were recruited in eight cohorts up to doses of 150 mg once weekly and 75 mg twice weekly. No dose-limiting toxicities were observed during the study, and a maximum tolerated dose (MTD) was not established. The highest dose cohorts demonstrated sustained inhibition of extracellular signal-regulated kinase (ERK) phosphorylation in peripheral blood mononuclear cells following ex-vivo phorbol 12-myristate 13-acetate stimulation. There was a decrease of 70 ± 26% in mean phosphorylated (p)ERK in C1 day 8 tumour biopsies when compared with pre-treatment tumour levels in the 75 mg twice a week cohort. Prolonged stable disease (>6 months) was seen in two patients, one with cervical cancer and one with ampullary carcinoma. Conclusions: WX-554 was well tolerated, and an optimal biological dose was established for further investigation in either a once or twice weekly regimens. The recommended phase 2 dose is 75 mg twice weekly

Integration of decision support systems to improve decision support performance

Decision support system (DSS) is a well-established research and development area. Traditional isolated, stand-alone DSS has been recently facing new challenges. In order to improve the performance of DSS to meet the challenges, research has been actively carried out to develop integrated decision support systems (IDSS). This paper reviews the current research efforts with regard to the development of IDSS. The focus of the paper is on the integration aspect for IDSS through multiple perspectives, and the technologies that support this integration. More than 100 papers and software systems are discussed. Current research efforts and the development status of IDSS are explained, compared and classified. In addition, future trends and challenges in integration are outlined. The paper concludes that by addressing integration, better support will be provided to decision makers, with the expectation of both better decisions and improved decision making processes