Autonomous Underwater Vehicles as Tools for Deep-Submergence Archaeology

Marine archaeology beyond the capabilities of scuba divers is a technologically enabled field. The tool suite includes ship-based systems such as towed side-scan sonars and remotely operated vehicles, and more recently free-swimming autonomous underwater vehicles (AUVs). Each of these platforms has various imaging and mapping capabilities appropriate for specific scales and tasks. Broadly speaking, AUVs are becoming effective tools for locating, identifying, and surveying archaeological sites. This paper discusses the role of AUVs in this suite of tools, outlines some specific design criteria necessary to maximize their utility in the field, and presents directions for future developments. Results are presented for a recent joint AUV–towed system survey and a demonstration of current mine-hunting technologies applied to archaeology

Fish species associated with shipwreck and natural hard-bottom habitats from the middle to outer continental shelf of the Middle Atlantic Bight near Norfolk Canyon

Fish species of the Middle Atlantic Bight (MAB) continental shelf are well known; however, species occupying hard-bottom habitats, particularly on the outer shelf, are poorly documented. Reef-like habitats are relatively uncommon on the MAB shelf; therefore, shipwrecks may represent a significant habitat resource. During fall 2012 and spring 2013, 9 sites (depths: 42–126 m) near Norfolk Canyon were surveyed by using remotely operated vehicles. One site consisted of sand bottom, one consisted of predominantly natural hard bottom, and 7 sites included 8 large shipwrecks. Of 38 fish taxa identified, 33 occurred on hard bottom and 25 occurred on soft substrata. Fourteen fish taxa occurred almost exclusively on hard bottom, and 6 species were observed only on soft bottom. The most abundant taxa, especially on reef habitat, were the chain dogfish (Scyliorhinus retifer), a scorpionfish (Scorpaena sp.), the yellowfin bass (Anthias nicholsi), the red barbier (Baldwinella vivanus), the black sea bass (Centropristis striata), unidentified anthiine serranids, and the deepbody boarfish (Antigonia capros). Depth, location, and season did not significantly influence fish assemblages. Fish assemblages on natural and artificial hard-bottom habitat were similar but significantly different from soft-bottom assemblages. Deep-reef fishes of the southern MAB may be constrained by zoogeography, depth, and inadequate habitat— limitations that could increase their vulnerability

Attitudes and beliefs regarding organ donation among South Asian people in the UK

There is an acute shortage of organ donors in the UK, specifically among South Asian communities. This article reports the findings from the largest ever study undertaken among South Asian people in the UK that seeks to explore attitudes and beliefs towards organ donation. This article highlights that seemingly intractable factors, such as religion and culture, are often tied to more complex issues, such as distrust in the medical system and lack of awareness, that contribute to the shortage of organ donors among South Asian communities in the U

Mouse Chromosome 11

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46996/1/335_2004_Article_BF00648429.pd

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

The Royal Navy Advice Boat Swift and the Potential of Unrated Warships

M.A