A Genome Wide Association Scan of Bovine Tuberculosis Susceptibility in Holstein-Friesian Dairy Cattle

peer-reviewedBackground: Bovine tuberculosis is a significant veterinary and financial problem in many parts of the world. Although many factors influence infection and progression of the disease, there is a host genetic component and dissection of this may enlighten on the wider biology of host response to tuberculosis. However, a binary phenotype of presence/absence of infection presents a noisy signal for genomewide association study. Methodology/Principal Findings: We calculated a composite phenotype of genetic merit for TB susceptibility based on disease incidence in daughters of elite sires used for artificial insemination in the Irish dairy herd. This robust measure was compared with 44,426 SNP genotypes in the most informative 307 subjects in a genome wide association analysis. Three SNPs in a 65 kb genomic region on BTA 22 were associated (i.e. p,1025, peaking at position 59588069, p = 4.0261026) with tuberculosis susceptibility. Conclusions/Significance: A genomic region on BTA 22 was suggestively associated with tuberculosis susceptibility; it contains the taurine transporter gene SLC6A6, or TauT, which is known to function in the immune system but has not previously been investigated for its role in tuberculosis infection

Salt Marsh Accretion and Storm Tide Variation: an Example from a Barrier Island in the North Sea

We reconstruct past accretion rates of a salt marsh on the island of Sylt, Germany, using measurements of the radioisotopes 210Pb and 137Cs, as well as historical aerial photographs. Results from three cores indicate accretion rates varying between 1 and 16 mm year−1. Comparisons with tide gauge data show that high accretion rates during the 1980s and 1990s coincide with periods of increased storm activity. We identify a critical inundation height of 18 cm below which the strength of a storm seems to positively influence salt marsh accretion rates and above which the frequency of storms becomes the major factor. In addition to sea level rise, we conclude that in low marsh zones subject to higher inundation levels, mean storm strength is the major factor affecting marsh accretion, whereas in high marsh zones with lower inundation levels, it is storm frequency that impacts marsh accretion

Climate change risks for severe storms in developing countries in the context of poverty and inequality in Cambodia

Least developed countries are generally regarded as particularly sensitive to climate change due to among other vulnerable locations and low adaptation capabilities. In the present study, we address climate change hazards in least developed countries by presenting a methodological framework, which is suitable for the estimation damage costs as a function of risk aversion, equality, income distribution and climate scenario using state-of-the-art climate model projections. As a case study, the methodology is applied to study severe storms in Cambodia based on two future climate scenarios and data on historical damages from storm events, which are used as a proxy in performing a sensitivity analysis on all input parameters. For the assumptions and parameter ranges used here, the study shows a high sensitivity to the income distribution (reflected by discount rates) and risk aversion and smaller effects from equality measures and extreme wind climate scenario. We emphasize that the assumptions on risk aversion reflecting consumption smoothing possibilities of low-income households clearly depicts that climate risks can be particularly high as a consequence of poverty and therefore recommend that context-specific vulnerabilities and equity concerns in climate risk studies should be included when making assessments for least developed countries.</p

Towards the production of salt-tolerant crops

Crop production is affected by numerous environmental factors, with soil salinity and drought having the most detrimental effects. Attempts to improve yield under stress conditions by plant breeding have been unsuccessful, primarily due to the multigenic origin of the adaptive responses. The transfer of genes through genetic engineering of crop plants appears more feasible. Important adaptive mechanisms targeted for potential gene transfer would be the tonoplast Na+/H+ antiport, compatible solute synthesis and, regulation of water channel activity and expression, mechanisms involved in cellular osmoregulation. In this review we discuss recent advances in our understanding of these adaptive mechanism