Mergers, Acquisitions, and Other Joint Arrangements

http://deepblue.lib.umich.edu/bitstream/2027.42/106654/1/MBA Renee-Robinson Noel-Tichey Spring 1998.PD

Motivating growth : a step-by-step plan to achieving higher returns on equity

http://deepblue.lib.umich.edu/bitstream/2027.42/96935/1/MBA_Robinson_1997Final.pd

Role of Outsourcing in Stress and Job Satisfaction of Information Technology Professionals

Information technology (IT) outsourcing poses a potential job loss threat to IT professionals, which can decrease job security, job satisfaction, and organizational commitment. The problem that this study addressed was the perceived role of IT outsourcing in the job stress, job dissatisfaction, and turnover intention of IT professionals. The purpose of this study was to explore how job-related stress, job dissatisfaction, and turnover intention within the IT profession are influenced by outsourcing as perceived by IT workers themselves. Phenomenology was the methodology used, and the person-environment fit theory formed the theoretical framework for this study. The research questions addressed outsourcing and its impact on IT employees, based on the perceptions of the participants. Data were collected from 20 IT professionals at 4 medium-sized firms within Central Florida using open-ended interview questions. Significant themes emerged as the interview data were analyzed and coded using words that best described the data. Synthesis of the data collected indicated that job stress and job dissatisfaction were continuing concerns among the participants, as indicated in current general literature. However, turnover intention had a less consequential impact on the IT workers\u27 reactions to the effects of outsourcing. Contrary to the expectation that IT outsourcing plays a negative role in the job satisfaction of the participants, the study results indicated that the majority of the participants were still satisfied in their positions following IT outsourcing activities. Managers could impact social change by understanding the levels of stress and job satisfaction IT professionals experience during outsourcing. Insights from this study may help improve employees\u27 productivity, commitment, and contributions to their local economies

Advancement of photodissociation mass spectrometry methods for the analysis of protein post-translational modifications

Post-translational modifications (PTMs) are important for regulating protein structure and function. Despite significant progress for PTM analysis using liquid chromatography tandem mass spectrometry (LC-MS/MS), opportunities for new method development remain. The research presented in this dissertation promotes 193 nm ultraviolet photodissociation (UVPD) as an alternative activation technique for PTM analysis with specific utility for phosphorylated and sulfated peptides. A novel de novo sequencing method with applications for unbiased PTM discovery was developed utilizing Lys-N proteolysis, N-terminal imidazolinylation, and UVPD to direct fragmentation for the formation of N-terminal ions. The N-terminal a, b, and c ions generated by UVPD were differentiated from one another by characteristic mass shifts. Sets of triplet peaks were used to distinguish N-terminal ions from confounding C-terminal ions and improve the accuracy of de novo sequencing. UVPD was evaluated for the analysis of phosphopeptide cations and anions. Negative mode analysis was advantageous for the detection of casein peptides in high phosphorylation states, while positive mode proved more robust for global phosphoproteomic analysis of HeLa and HCC70 cell lysates. Compared to collisional activation, the depth of coverage was lower using UVPD yet more extensive fragmentation and improved phosphate retention on products ions was achieved. Phosphorylation mapping by LC-UVPD-MS was carried out in the C-terminal domain (CTD) of RNA polymerase II as a function of kinase treatment, ERK2 or TFIIH, and organism, yeast or fruit fly. Single phosphorylations on Ser2 or Ser5 in the consensus heptad, YSPTSPS, were observed across all experimental conditions. Analysis of the non-consensus fruit fly CTD revealed the significance of Tyr1 and Pro residues in the +1 position relative to Ser for phosphorylation to occur. For sulfated peptides, negative mode UVPD yielded a and x ions that largely retained the labile sulfate modification, facilitating peptide sequencing and PTM localization. With appropriate MS/MS tools established, the next step towards global sulfoproteomics was the development of enrichment methods. Weak anion exchange (WAX) was applied for this purpose. Following carbamylation to neutralize primary amines which otherwise repel the anion exchanger; improved WAX retention was observed for sulfopeptides relative to a complex mixture of unmodified bovine serum albumin peptides.Chemistr

Compare Healthcare Utilization in the First Three Years of Life for Infants with Prenatal Opioid Exposure Based on Type of Neonatal Care Received

Purpose/Background: Infants with prenatal opioid and other drug exposure often experience withdrawal symptoms known as neonatal abstinence syndrome (NAS). Some hospitals have modified clinical environments to promote recovery (reduced stimulation, nursery-like rooms, permitting rooming-in). While existing research has demonstrated efficacy of lower-stimulation environment, there is no known research evaluating longer-term implications of clinical environment on infant health beyond immediate neonatal period in states disproportionately affected by the opioid epidemic with diverse urban-rural populations such as Alaska. Materials & Methods: The goal of this project is to determine whether supportive care decreases the likelihood of foster care placement from birth to age three by the type of neonatal care received using linked administrative health data from Alaska Medicaid and the Alaska Office· of Children\u27s Services (OCS) for infants born between 201O and 2017, in the State of Alaska. Data sourced from Alaska Department of Health and Social Services (DHSS) Medicaid database was linked with data from Vital Statistics (birth and death records), and OCS data. Demographic data (e.g., age of mother, urban and rural residence (based on census classification)) was extracted from Vital Statistics database. Reports of child maltreatment, duration of foster care placement, rates of adoption, and return to the biological family among infants placed in foster care based on NAS status and the type of neonatal care received sourced from OCS data. Regression was used to assess likelihood of infants removed to foster care at birth being returned to their mother by one year, Poisson or negative binomial regression to determine if there are significant differences foster care days and rates of adoption by infants with NAS based on receipt of neonatal supportive care. Results: Based on interim analysis, infants with NAS who have been treated in a supportive care setting (e.g. Alaska Regional NEST) that uses rooming-in and a family oriented approach will have fewer days in foster care. This may be due to increased education and support provided to mothers and infants in lower-stimulation environment. Discussion/Conclusion: Further study is necessary to understand the impact of supportive care interventions on the health outcomes of infants with NAS

Embracing and Rejecting Student Agency: Documenting Critical Reflection Practices in the Basic Communication Course Classroom

This interpretive study explored classroom power through the implementation of critical reflection exercises aimed at promoting student agency and learning in the basic course classroom. Data included over 400 critical reflection responses from 81 undergraduate students from four different basic course sections. Three emergent patterns revealed students’ positive re-action to the critical reflection process, how students both embrace and reject power in the classroom, and connections between the critical reflection process and student learning. The findings offer teachers support for implementing critical reflection practices in the communication classroom

Changes in Gender Representation in Pharmacy Research Literature

Purpose/Background: Many health disciplines, such as pharmacy, have been historically male dominated. However, female gender representation continues to increase in health care and especially in pharmacy with women representing 57.5% of pharmacists in 2017. Shifts in workforce gender representation have not always translated to research and publication. Limited data exist regarding women’s authorship in pharmacy research literature. The purpose of our analysis was to determine whether the percentage of women as first authors of research articles in the pharmacy literature has increased over the past decade. Materials & Methods: We conducted a retrospective bibliometric analysis. Citations from key pharmacy practice journals from 2007 through 2017 were exported using Web of Science (WoS). We considered citations to be research if they were designated by WoS as “articles,” which is defined as reports of research on original works. Our outcome of interest was the proportion of research articles having feminine names as first authors. The U.S. Social Security Administration and genderize.io were used to determine femininity of names. Citations were excluded from analysis if gender could not be determined. The Cochrane-Armitage trend test was used to determine differences in proportions of women as first authors over time with a p-value \u3c0.05 considered statistically significant. We analyzed citations from journals individually and combined. Results: Our analysis included 9,354 citations from eight pharmacy practice journals. All journals evaluated, except Annals of Pharmacotherapy and Drugs, showed a significant increase in women as first authors from 2007 through 2017 (Table). The greatest change in the proportion of women as first authors was seen in the Journal of the American Pharmacist Association (+20.5%). In our combined analysis of all journals, the proportion of women as first authors significantly increased from 45.1% in 2007 to 55.4% in 2017 (Figure). Across the entire time period of interest, women were first author in slightly more than half (51.5%) of all citations Discussion/Conclusion: Women as first authors of research articles in pharmacy literature has significantly increased over the past decade. While our findings appear to show gender alignment between first authorship in pharmacy research literature and workforce representation, disparities in gender and other characteristics must be continually examined so that inequalities an be identified and addressed

NASA's Space Launch System: Unprecedented Payload Capabilities

As part of a renewed focus on deep space exploration, NASA and its private sector and international partners are building a new super heavy-lift launch vehicle, the Space Launch System (SLS), as well as the new Orion crew vehicle, and upgrading launch facilities at Kennedy Space Center. Progress made on the Block 1 vehicle, as well as its expected performance metrics and fiscal support from the U.S. administration and Congress, have opened up additional manifest possibilities that the Agency continues to evaluate. Offering a combination of power, payload capacity and departure energy unmatched in contemporary boosters, the SLS family of launch vehicles features the world's most-proven propulsion system: solid rocket boosters and RS-25 main engines with a modified existing cryogenic in-space stage. The initial SLS configuration, Block 1, will deliver at least 26 metric tons (t) of payload to trans-lunar injection (TLI). The vehicle's flexible architecture will enable the rocket to evolve over the next decade to meet the most demanding deep space mission requirements. The second configuration, Block 1B, will deliver at least 34 to 40 t to TLI, depending on whether the crewed or cargo variant is selected. Although designed to facilitate human exploration of deep space, the vehicle also provides game-changing benefits for large science payloads and even harnesses excess capacity to provide small satellites with affordable access to deep space. For the first integrated mission of SLS and Orion, launching from Kennedy Space Center in fiscal year 2020, SLS Block 1 will send Orion on a 25.5-day mission to a distant retrograde lunar orbit with the primary objective to test and validate new systems and procedures. That first mission, called Exploration Mission-1 (EM-1), also has 13 6U-class CubeSat payloads manifested. Those payloads, which will carry out a variety of scientific experiments and technology demonstrations, will deploy in several locations along the trajectory after Orion has separated from SLS. Contractors and suppliers have made significant progress since last year manufacturing the Block 1 vehicle for EM-1. The upper stage and adapters are complete as are the four RS-25 engines. All other major components are constructed and being outfitted for flight. In fact, hardware for the second flight is currently being manufactured at locations across the United States. This paper will outline hardware, avionics and testing progress toward the first and second flights of SLS. Manifest opportunities for primary, co-manifested and secondary payloads will be discussed. An in-depth look at payload utilization and integration will be provided, as well as lessons learned from installing a secondary payload deployment system for EM-1