892 research outputs found

    The Small Farmer-Tuskegee University-Walmart Project: Observations of the Steps within Commercial Supply

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    Abstract Observations of the various efforts necessary in an initiative, the Small Farmer-Tuskegee University-Walmart Project, to assist small farmers to comply with produce industry standards and supply produce to a major retailer over a six-year period were documented through an illustrative case study. The observations were taken from meetings with commercial buyers and farmers, site visits to processing centers and corporate farms, conference calls, and, mainly, from the authors’ “hands-on” participation with the functioning and preservation of this initiative. Consequently, these observations were organized into a framework of criteria that must be successively satisfied to be able to supply produce commercially. These criteria were capacity, capability, quality, food safety, consistency, sustainability, and marketability. A key finding was that for small farmers to meet these criteria, they required organization and support. It was concluded that although the effort was successful, the information gained through the effort was perhaps more valuable. Keywords: Small Farmers, Produce Markets, Commercial Supply, Capacit

    The Challenges of Developing a Successful Cooperative through an Integrated Resource Approach: Small Farmer-Tuskegee University-Walmart Project

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    Abstract This paper shares the challenges that small, socially disadvantaged Alabama vegetable and fruit producers in Alabama faced and overcame to secure their USDA Produce Good Agricultural Practices (GAPs) food safety certification. The commercial buyers, collaborating with the Small Farmers Agricultural Cooperative (SFAC) producers, required the producers to be certified. This certification was based on the regulated security standards for food safety, the Harmonized Food Safety Standards with the Global Addendum (Global Markets Primary Production Assessments). This venture entailed the integrated resource approach, which comprised experts from Tuskegee University (Extension and Research staff) working closely with SFAC producers. Additional support and experiential guidance was provided by other collaborating partners: Walmart, Lipman Produce, WP Rawls, Pura Vida, C.H. Robinson, Federal and State Auditors, and the USDA (Strike Force Initiative). The collaborative efforts led to the producers successfully obtaining their GAP certification and fulfilling their contractual agreement obligations, despite the unexpected challenges. Keywords: Socially Disadvantaged Farmers, GAP Certification, Integrated Resource Approac

    Case Study of a Food Safety/Good Agricultural Practices (GAPs) Educational Program for Small and Limited Resource Produce Farmers

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    This case study examined methods used in a food safety/Good Agricultural Practices (GAPs) educational program with small and limited resource produce farmers in Alabama to assist them with obtaining certification. Two methods were used, namely, the identification of challenges to food safety certification and development of strategies to address the challenges, and the enlistment of educational methods to facilitate food safety certification. As a result, there were four challenges to food safety certification identified; needs for motivation, information, clarification, and resources. In addition, the educational methods enlisted included group meetings, instructional material distribution, individual farm instruction, and expert instruction. The program was found to be limitedly successful, producing ten GAPs certified operations; further evaluation of the methods is needed. Key Words: Food Safety, Certification, Good Agricultural Practices, Produc

    Significantly different clinical phenotypes associated with mutations in synthesis and transamidase+remodeling glycosylphosphatidylinositol (GPI)-anchor biosynthesis genes.

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    BACKGROUND: Defects in the glycosylphosphatidylinositol (GPI) biosynthesis pathway can result in a group of congenital disorders of glycosylation known as the inherited GPI deficiencies (IGDs). To date, defects in 22 of the 29 genes in the GPI biosynthesis pathway have been identified in IGDs. The early phase of the biosynthetic pathway assembles the GPI anchor (Synthesis stage) and the late phase transfers the GPI anchor to a nascent peptide in the endoplasmic reticulum (ER) (Transamidase stage), stabilizes the anchor in the ER membrane using fatty acid remodeling and then traffics the GPI-anchored protein to the cell surface (Remodeling stage). RESULTS: We addressed the hypothesis that disease-associated variants in either the Synthesis stage or Transamidase+Remodeling-stage GPI pathway genes have distinct phenotypic spectra. We reviewed clinical data from 58 publications describing 152 individual patients and encoded the phenotypic information using the Human Phenotype Ontology (HPO). We showed statistically significant differences between the Synthesis and Transamidase+Remodeling Groups in the frequencies of phenotypes in the musculoskeletal system, cleft palate, nose phenotypes, and cognitive disability. Finally, we hypothesized that phenotypic defects in the IGDs are likely to be at least partially related to defective GPI anchoring of their target proteins. Twenty-two of one hundred forty-two proteins that receive a GPI anchor are associated with one or more Mendelian diseases and 12 show some phenotypic overlap with the IGDs, represented by 34 HPO terms. Interestingly, GPC3 and GPC6, members of the glypican family of heparan sulfate proteoglycans bound to the plasma membrane through a covalent GPI linkage, are associated with 25 of these phenotypic abnormalities. CONCLUSIONS: IGDs associated with Synthesis and Transamidase+Remodeling stages of the GPI biosynthesis pathway have significantly different phenotypic spectra. GPC2 and GPC6 genes may represent a GPI target of general disruption to the GPI biosynthesis pathway that contributes to the phenotypes of some IGDs
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