302 research outputs found

    Mission: Impossible, Mission: Accomplished or Mission: Underway? A Survey and Analysis of Current Trends in Professionalism Education in American Law Schools

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    This Article identifies common characteristics of effective professionalism instruction to provide guidance in how to design innovative professionalism instruction. After introducing the topic in Part I, Part II of this Article describes the origins and development of the professionalism education movement in American Law schools. Part III of this Article explains our methods for collecting information and identifies and summarizes the predominant trends, and provides examples of noteworthy programs or initiatives. Part IV concludes by describing our method for assessing successful programs and identifying the characteristics of effective professionalism instruction

    Mission: Impossible, Mission: Accomplished or Mission: Underway? A Survey and Analysis of Current Trends in Professionalism Education in American Law Schools

    Get PDF
    This Article identifies common characteristics of effective professionalism instruction to provide guidance in how to design innovative professionalism instruction. After introducing the topic in Part I, Part II of this Article describes the origins and development of the professionalism education movement in American Law schools. Part III of this Article explains our methods for collecting information and identifies and summarizes the predominant trends, and provides examples of noteworthy programs or initiatives. Part IV concludes by describing our method for assessing successful programs and identifying the characteristics of effective professionalism instruction

    Mission: Impossible, Mission: Accomplished or Mission: Underway? A Survey and Analysis of Current Trends in Professionalism Education in American Law Schools

    Get PDF
    This Article identifies common characteristics of effective professionalism instruction to provide guidance in how to design innovative professionalism instruction. After introducing the topic in Part I, Part II of this Article describes the origins and development of the professionalism education movement in American Law schools. Part III of this Article explains our methods for collecting information and identifies and summarizes the predominant trends, and provides examples of noteworthy programs or initiatives. Part IV concludes by describing our method for assessing successful programs and identifying the characteristics of effective professionalism instruction

    The Human T-Cell Leukemia Virus Type I (HTLV-I) X Region Encoded Protein p13II Interacts with Cellular Proteins

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    AbstractInteractions between the Human T-cell leukemia virus type I (HTLV-I) gene product p13II and cellular proteins were investigated using the yeast two-hybrid system. Variant forms of p13II were derived from two HTLV-I molecular clones, K30p and K34p, that differ in both virus production and in vivo and in vitro infectivity. Two nucleotide differences between the p13 from K30p (p13K30) and K34p (p13K34) result in a Trp-Arg substitution at amino acid 17 and the truncation of the 25 carboxyl-terminal residues of p13K34. A cDNA library from an HTLV-I-infected rabbit T-cell line was screened with p13K30 and p13K34 as bait. Products of two cDNA clones, C44 and C254, interacted with p13K34 but not with p13K30. Interactions were further confirmed using the GST-fusion protein coprecipitation assay. Sequence analysis of C44 and C254 cDNA clones revealed similarities to members of the nucleoside monophosphate kinase superfamily and actin-binding protein 280, respectively. Further analysis of the function of these two proteins and the consequence of their interaction with p13 may help elucidate a role for p13 in virus production, infectivity, or the pathogenesis of HTLV-I

    Community Leadership: Maximizing Returns- Investing in Nontraditional Leaders

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    This report is a part of Kids matter Here: An Analytic Review of the 10-year Good Neighborhoods Initiative. The Skillman Foundation's Good Neighborhoods Initiative was a $100-million commitment to six Detroit neighborhoods, spanning from 2006-2016. To best understand the outcomes of the long-term neighborhood-based work, the Foundation worked with a variety of evaluators, residetns, stakeholders, grant partners, staff, Trustees and community allies to form a series of analyses and dialogues.The goals of the Analytic Review are to synthesize what the decade of work has accomplished, inform decisions about the Foundation's work going forward, and build and share knowledge locally and nationally

    Identification of a Novel Staphylococcus aureus Two-Component Leukotoxin Using Cell Surface Proteomics

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    Staphylococcus aureus is a prominent human pathogen and leading cause of bacterial infection in hospitals and the community. Community-associated methicillin-resistant S. aureus (CA-MRSA) strains such as USA300 are highly virulent and, unlike hospital strains, often cause disease in otherwise healthy individuals. The enhanced virulence of CA-MRSA is based in part on increased ability to produce high levels of secreted molecules that facilitate evasion of the innate immune response. Although progress has been made, the factors that contribute to CA-MRSA virulence are incompletely defined. We analyzed the cell surface proteome (surfome) of USA300 strain LAC to better understand extracellular factors that contribute to the enhanced virulence phenotype. A total of 113 identified proteins were associated with the surface of USA300 during the late-exponential phase of growth in vitro. Protein A was the most abundant surface molecule of USA300, as indicated by combined Mascot score following analysis of peptides by tandem mass spectrometry. Unexpectedly, we identified a previously uncharacterized two-component leukotoxin–herein named LukS-H and LukF-G (LukGH)-as two of the most abundant surface-associated proteins of USA300. Rabbit antibody specific for LukG indicated it was also freely secreted by USA300 into culture media. We used wild-type and isogenic lukGH deletion strains of USA300 in combination with human PMN pore formation and lysis assays to identify this molecule as a leukotoxin. Moreover, LukGH synergized with PVL to enhance lysis of human PMNs in vitro, and contributed to lysis of PMNs after phagocytosis. We conclude LukGH is a novel two-component leukotoxin with cytolytic activity toward neutrophils, and thus potentially contributes to S. aureus virulence

    The Otterbein Miscellany - Spring 1991

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    https://digitalcommons.otterbein.edu/miscellany/1003/thumbnail.jp

    Psychosocial Adjustment During Pregnancy: The Experience of Mature Gravidas

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    To determine if gravidas ages 35 years and older have greater conflict in adapting to pregnancy than do younger gravidas. Design : Static group comparison. Setting : Prenatal care facilities and prenatal education classes. Participants : Sixty-four older gravidas (35 years and older) and 46 younger gravidas (32 years and younger) who were in their 3rd trimester of pregnancy. Main Outcome Measure : Lederman Prenatal Self-Evaluation Questionnaire II, which contains seven scales measuring conflict in psychosocial tasks during pregnancy. Results : Older gravidas had significantly less fear of helplessness and loss of control in labor than did younger gravidas. Age and education but not parity may account for this finding. Conclusions : Age and education may balance the additional concerns older gravidas may have about pregnancy and allow older gravidas to adjust to pregnancy as well as younger women do.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73870/1/j.1552-6909.1997.tb02134.x.pd
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