An Analysis of and Conductor\u27s Guide to Eleanor Daley\u27s Requiem

This study provides a thorough analysis of and conductor\u27s guide to Eleanor Daley\u27s Requiem. It includes a theoretical analysis, a textual analysis, an analysis of performance and conducting considerations, a list of compositions by the composer, and a discography. Additionally, it includes score corrections, the composer\u27s biography, a brief history of the Requiem Mass and Christian funeral music, and historical connections to other Requiems, including a chapter dedicated to the Requiem of Herbert Howells. The study was informed by numerous correspondences and multiple interviews with the composer, as well as singing under her direction. It is the author\u27s hope that this study will encourage and equip future conductors to program this exceptional composition, and encourage greater exploration of other accessible modern works

Memoirs of Ruth Hooper

This edition was created from the manuscript of the Memoirs of Ruth Hooper, as well as images from the accompanying materials contained on Western Carolina University’s Digital Collections website. As a whole manuscript, Ruth Hooper’s memoirs detail events related to her life, as well as her marriage to W. Carr Hooper. The manuscript begins by telling details of her life with W. Carr Hooper in the Philippines of the 1930s. The document also covers events related to the beginning of World War II, the couple’s time spent as prisoners in the Japanese-run Santo Tomas Internment Camp, and of the camp’s liberation in 1945 by the United States military. A vast majority of Ruth Hooper’s memoirs (including the entirety of my assigned section) relates to the details surrounding the Santo Tomas camp: through both depictions of daily life and general goings-on in the camp. Hooper’s manuscript has a unique tone of voice, which says many things about the experiences of Santo Tomas internees. Living there under Japanese control was not easy, and the amount of malnutrition in the camp was exceedingly tragic. Yet despite all of this, the Hoopers (as well as many others in the camp) were determined to make it through until their liberation day

Being user-oriented: convergences, divergences, and the potentials for systematic dialogue between disciplines and between researchers, designers, and providers

The challenge this panel addresses is drawn from intersecting literature reviews and critical commentaries focusing on: 1) user studies in multiple fields; and 2) the difficulties of bringing different disciplines and perspectives to bear on user‐oriented research, design, and practice. 1 The challenge is that while we have made some progress in collaborative work, we have some distance to go to become user‐oriented in inter‐disciplinary and inter‐perspective ways. The varieties of our approaches and solutions are, as some observers suggest, an increasing cacophony. One major difficulty is that most discussions are solution‐oriented, offering arguments of this sort ‐‐ if only we addressed users in this way… Each solution becomes yet another addition to the cacophony. This panel implements a central approach documented for its utility by communication researchers and long used by communication mediators and negotiators ‐‐ that of focusing not on communication but rather on meta‐communication: communicating about communication. The intent in the context of this panel is to help us refocus attention from too frequent polarizations between alternative solutions to the possibility of coming to understand what is behind the alternatives and where they point to experientially‐based convergences and divergences, both of which might potentially contribute to synergies. The background project for this panel comes from a series of in‐depth interviews with expert researchers, designers, and providers in three field groupings ‐‐ library and information science; human computer interaction/information technology; and communication and media studies. One set of interviews involved 5‐hour focus groups with directors of academic and public libraries serving 44 colleges and universities in central Ohio; the second involved one‐on‐one interviews averaging 50 minutes with 81 nationally‐internationally known experts in the 3 fields, 25‐27 interviews per field. Using Dervin\u27s Sense‐Making Methodological approach to interviewing, the expert interviews of both kinds asked each interviewee: what he/she considered to be the big unanswered questions about users and what explained why the questions have not been answered; and, what he/she saw as hindering versus helping in attempts to communicate about users across disciplinary and perspective gaps. 2 The panel consists of six teams, two from each field. Prior to the panel presentation at ASIST, each team will have read the set of interviews and completed impressionistic essays of what patterns and themes they saw as emerging. At this stage, team members will purposively not homogenize their differences and most will write solo‐authored essays that will be placed on a web‐site accessible to ASIST members prior to the November meeting. In addition, at least one systematic analysis will be completed and available online. 3 At the ASIST panel, each team\u27s leader will present a brief and intentionally provocative impressionist account of what his/her team came to understand about our struggles communicating across fields and perspectives about users. Again, each team will purposively not homogenize its own differences in viewpoints, but rather highlight them as fodder for discussion. A major purpose will be to invite audience members to join the panel in discussion. At least 20 minutes will be left open for this purpose

Emma Robinette Senior Flute Recital

https://dc.ewu.edu/music_performances/1711/thumbnail.jp

Music Convocation

https://dc.ewu.edu/music_performances/1715/thumbnail.jp

Efficient generation of patient-matched malignant and normal primary cell cultures from clear cell renal cell carcinoma patients: clinically relevant models for research and personalized medicine

Abstract Background Patients with clear cell renal cell carcinoma (ccRCC) have few therapeutic options, as ccRCC is unresponsive to chemotherapy and is highly resistant to radiation. Recently targeted therapies have extended progression-free survival, but responses are variable and no significant overall survival benefit has been achieved. Commercial ccRCC cell lines are often used as model systems to develop novel therapeutic approaches, but these do not accurately recapitulate primary ccRCC tumors at the genomic and transcriptional levels. Furthermore, ccRCC exhibits significant intertumor genetic heterogeneity, and the limited cell lines available fail to represent this aspect of ccRCC. Our objective was to generate accurate preclinical in vitro models of ccRCC using tumor tissues from ccRCC patients. Methods ccRCC primary single cell suspensions were cultured in fetal bovine serum (FBS)-containing media or defined serum-free media. Established cultures were characterized by genomic verification of mutations present in the primary tumors, expression of renal epithelial markers, and transcriptional profiling. Results The apparent efficiency of primary cell culture establishment was high in both culture conditions, but genotyping revealed that the majority of cultures contained normal, not cancer cells. ccRCC characteristically shows biallelic loss of the von Hippel Lindau (VHL) gene, leading to accumulation of hypoxia-inducible factor (HIF) and expression of HIF target genes. Purification of cells based on expression of carbonic anhydrase IX (CA9), a cell surface HIF target, followed by culture in FBS enabled establishment of ccRCC cell cultures with an efficiency of >80 %. Culture in serum-free conditions selected for growth of normal renal proximal tubule epithelial cells. Transcriptional profiling of ccRCC and matched normal cell cultures identified up- and down-regulated networks in ccRCC and comparison to The Cancer Genome Atlas confirmed the clinical validity of our cell cultures. Conclusions The ability to establish primary cultures of ccRCC cells and matched normal kidney epithelial cells from almost every patient provides a resource for future development of novel therapies and personalized medicine for ccRCC patients