Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes.

This review focuses on the role of the Cytochrome p450 subfamily 26 (CYP26) retinoic acid (RA) degrading enzymes during development and regeneration. Cyp26 enzymes, along with retinoic acid synthesising enzymes, are absolutely required for RA homeostasis in these processes by regulating availability of RA for receptor binding and signalling. Cyp26 enzymes are necessary to generate RA gradients and to protect specific tissues from RA signalling. Disruption of RA homeostasis leads to a wide variety of embryonic defects affecting many tissues. Here, the function of CYP26 enzymes is discussed in the context of the RA signalling pathway, enzymatic structure and biochemistry, human genetic disease, and function in development and regeneration as elucidated from animal model studies

An Overview of Rendering from Volume Data --- including Surface and Volume Rendering

Volume rendering is a title often ambiguously used in science. One meaning often quoted is: `to render any three volume dimensional data set'; however, within this categorisation `surface rendering'' is contained. Surface rendering is a technique for visualising a geometric representation of a surface from a three dimensional volume data set. A more correct definition of Volume Rendering would only incorporate the direct visualisation of volumes, without the use of intermediate surface geometry representations. Hence we state: `Volume Rendering is the Direct Visualisation of any three dimensional Volume data set; without the use of an intermediate geometric representation for isosurfaces'; `Surface Rendering is the Visualisation of a surface, from a geometric approximation of an isosurface, within a Volume data set'; where an isosurface is a surface formed from a cross connection of data points, within a volume, of equal value or density. This paper is an overview of both Surface Rendering and Volume Rendering techniques. Surface Rendering mainly consists of contouring lines over data points and triangulations between contours. Volume rendering methods consist of ray casting techniques that allow the ray to be cast from the viewing plane into the object and the transparency, opacity and colour calculated for each cell; the rays are often cast until an opaque object is `hit' or the ray exits the volume

Sticky Pixels: Evolutionary Growth by Random Drop Ballistic Aggregation

Over the years many techniques have been developed for simulating and modelling trees, ferns, crystals and natural structures. Indeed, many complex and realistic images have been formed. Often, these rely on rule based systems to create the structure, they start with a simple form and progressively refine it into a more complex form by applying rules. We use the notion of Sticky Pixels to form textures. The pixels (or objects) move around the space, when they touch another object they stick together to form a larger cluster. The objects aggregate and stop at the place and position where they first touched. Such an aggregation generates neighbourhoods of pixels that form natural looking shapes. The pixels may randomly walk around (such as using Brownian motion), or be guided along pre-defined routes (often described as ballistic), to obtain different structures. We use a ballistic aggregation technique, where the particles are randomly dropped onto a canvas, migrate and stick onto the closest position of the nearest cluster. We present Sticky Pixels, explain different parameters and describe our algorithm

Aspects of Dynamical Chiral Symmetry Breaking

Dynamical chiral symmetry breaking is a nonperturbative phenomenon that may be studied using QCD's gap equation. Model-independent results can be obtained with a nonperturbative and symmetry preserving truncation. The gap equation yields the massive dressed-quark propagator, which has a spectral representation when considered as a function of the current-quark mass. This enables an explication of the connection between the infrared limit of the QCD Dirac operator's spectrum and the quark condensate appearing in the operator product expansion.Comment: 11, LaTeX2e, ws-procs9x6; contribution to proceedings of the "5th International Conference on Quark Confinement and the Hadron Spectrum," Gargnano, Italy, 10-14/Sept./0

Probing States in the Mott Insulator Regime

We propose a method to probe states in the Mott insulator regime produced from a condensate in an optical lattice. We consider a system in which we create time-dependent number fluctuations in a given site by turning off the atomic interactions and lowering the potential barriers on a nearly pure Mott state to allow the atoms to tunnel between sites. We calculate the expected interference pattern and number fluctuations from such a system and show that one can potentially observe a deviation from a pure Mott state. We also discuss a method in which to detect these number fluctuations using time-of-flight imaging.Comment: 4 pages, 3 figures. Send correspondence to [email protected]

Exposing the dressed quark's mass

This snapshot of recent progress in hadron physics made in connection with QCD's Dyson-Schwinger equations includes: a perspective on confinement and dynamical chiral symmetry breaking (DCSB); a pre'cis on the physics of in-hadron condensates; results on the hadron spectrum, including dressed-quark-core masses for the nucleon and Delta, their first radial excitations, and the parity-partners of these states; an illustration of the impact of DCSB on the electromagnetic pion form factor, thereby exemplifying how data can be used to chart the momentum-dependence of the dressed-quark mass function; and a prediction that F_1^{p,d}/F_1^{p,u} passes through zero at Q^2\approx 5m_N^2 owing to the presence of nonpointlike scalar and axial-vector diquark correlations in the nucleon.Comment: 10 pages, 4 figures, 2 tables. Contribution to the Proceedings of the 4th Workshop on Exclusive Reactions at High Momentum Transfer, Thomas Jefferson National Accelerator Facility Newport News, Virginia, 18-21 May 201