Downsizing the Navy: Privatization of the Naval Air Warfare Center Aircraft Division, Indianapolis--A Case Study

Proceedings Paper (for Acquisition Research Program)Abstract: Case Objectives - Strategic: When faced with a BRAC decision (1) identify and analyze the stakeholders; (2) develop top level guidance with an overarching process framework; and, (3) develop and evaluate alternative courses of action, completing ''customer satisfaction,'' business case, and risk analyses. Tactical: Once an alternative is selected, develop a detailed implementation plan to address (1) transition issues; (2) economic development and agreement terms and conditions from City and business perspectives; and, (3) contract terms and conditions from the business and Navy perspectives. Lesson Learned/Reflections: Identify potential risks and mitigations, barriers to implementation, success factors, and best practices; and make recommendations for future privatizations.Naval Postgraduate School Acquisition Research ProgramApproved for public release; distribution is unlimited

Regulation of vascular endothelial growth factor bioactivity in patients with acute lung injury

Background: Reduced bioactive vascular endothelial growth factor (VEGF) has been demonstrated in several inflammatory lung conditions including the acute respiratory distress syndrome (ARDS). sVEGFR-1, a soluble form of VEGF-1 receptor, is a potent natural inhibitor of VEGF. We hypothesised that sVEGFR-1 plays an important role in the regulation of the bioactivity of VEGF within the lung in patients with ARDS. Methods: Forty one patients with ARDS, 12 at risk of developing ARDS, and 16 normal controls were studied. Bioactive VEGF, total VEGF, and sVEGFR-1 were measured by ELISA in plasma and bronchoalveolar lavage (BAL) fluid. Reverse transcriptase polymerase chain reaction for sVEGFR-1 was performed on BAL cells. Results: sVEGFR-1 was detectable in the BAL fluid of 48% (20/41) of patients with early ARDS (1.4– 54.8 ng/ml epithelial lining fluid (ELF)) compared with 8% (1/12) at risk patients (p = 0.017) and none of the normal controls (p = 0.002). By day 4 sVEGFR-1 was detectable in only 2/18 ARDS patients (p = 0.008). Patients with detectable sVEGFR-1 had lower ELF median (IQR) levels of bioactive VEGF than those without detectable sVEGFR-1 (1415.2 (474.9–3192) pg/ml v 4761 (1349–7596.6) pg/ml, median difference 3346 pg/ml (95% CI 305.1 to 14711.9), p = 0.016), but there was no difference in total VEGF levels. BAL cells expressed mRNA for sVEGFR-1 and produced sVEGFR-1 protein which increased following incubation with tumour necrosis factor a. Conclusion: This study shows for the first time the presence of sVEGFR-1 in the BAL fluid of patients with ARDS. This may explain the presence of reduced bioactive VEGF in patients early in the course of ARDS

Measurement and analysis of grip force during a golf shot

In this study, grip force was measured during a standard golf tee shot using two different measurement techniques. The first utilized a matrix-type thin-film sensor applied to a golf grip, from which total grip force could be readily determined. The second method involved 31 individual thin-film force sensors strategically placed on two golf gloves, allowing the force output of specific regions of the hands to be measured. Twenty golfers of varying ability participated in each test. The discovery of a unique grip force ‘signature’ for each golfer emerged from these data. That is, each golfer had a very repeatable total grip force trace, but these traces varied considerably between golfers. High-speed video was also recorded for many of the golfers tested so that key phases in the swing could be identified on the force traces

Evaluation of thin, flexible sensors for time-resolved grip force measurement

Three types of thin, flexible force sensor were studied under a variety of loading conditions to determine their suitability for measuring grip force. Static accuracy, hysteresis, repeatability, and drift errors were established, the effects of shear force and surface curvature were considered, and dynamic accuracy and drift were measured. Novel tests were developed to consider dynamic accuracy and sensitivity to shear loadings. Additionally, three sensors were evaluated in a real-life gripping scenario, measuring grip force during a golf shot. Comments are made on sensor performance, ease of use, and durability

Creating explanatory visualizations of algorithms for active learning

Visualizations have been used to explain algorithms to learners, in order to help them understand complex processes. These ‘explanatory visualizations’ can help learners understand computer algorithms and data-structures. But most are created by an educator and merely watched by the learner. In this paper, we explain how we get learners to plan and develop their own explanatory visualizations of algorithms. By actively developing their own visualizations learners gain a deeper insight of the algorithms that they are explaining. These depictions can also help other learners understand the algorithm

The Explanatory Visualization Framework: an active learning framework for teaching creative computing using explanatory visualizations

Visualizations are nowadays appearing in popular media and are used everyday in the workplace. This democratisation of visualization challenges educators to develop effective learning strategies, in order to train the next generation of creative visualization specialists. There is high demand for skilled individuals who can analyse a problem, consider alternative designs, develop new visualizations, and be creative and innovative. Our three-stage framework, leads the learner through a series of tasks, each designed to develop different skills necessary for coming up with creative, innovative, effective, and purposeful visualizations. For that, we get the learners to create an explanatory visualization of an algorithm of their choice. By making an algorithm choice, and by following an active-learning and project-based strategy, the learners take ownership of a particular visualization challenge. They become enthusiastic to develop good results and learn different creative skills on their learning journey

Molecular containers in complex chemical systems.

Over the last decade molecular containers have been increasingly studied within the context of complex chemical systems. Herein we discuss selected examples from the literature concerning three aspects of this field: complex host-guest behaviour, adaptive transformations of molecular containers and reactivity modulation within them.The UK Engineering and Physical Sciences Research Council (SZ, JRN), The European Research Council (DMW) and the Gates Cambridge Trust (DAR) are acknowledged for financial support.This is the accepted manuscript. The final version is available from RSC at http://pubs.rsc.org/en/Content/ArticleLanding/2015/CS/c4cs00165f#!divAbstract

Post-assembly Modification of Tetrazine-Edged Fe(II)4L6 Tetrahedra.

Post-assembly modification (PAM) is a powerful tool for the modular functionalization of self-assembled structures. We report a new family of tetrazine-edged Fe(II)4L6 tetrahedral cages, prepared using different aniline subcomponents, which undergo rapid and efficient PAM by inverse electron-demand Diels-Alder (IEDDA) reactions. Remarkably, the electron-donating or -withdrawing ability of the para-substituent on the aniline moiety influences the IEDDA reactivity of the tetrazine ring 11 bonds away. This effect manifests as a linear free energy relationship, quantified using the Hammett equation, between σ(para) and the rate of the IEDDA reaction. The rate of PAM can thus be adjusted by varying the aniline subcomponent.This work was supported by the UK Engineering and Physical Sciences Research Council (EPSRC). The au-thors thank Diamond Light Source (UK) for synchro-tron beamtime on I19 (MT8464), the Department of Chemistry NMR facility, University of Cambridge, and the EPSRC UK National Mass Spectrometry Facility at Swansea University. D.A.R. acknowledges the Gates Cambridge Trust for Ph.D. funding. B.S.P. acknowledges the Herchel Smith Research Fellowship from the University of Cambridge and the Fellowship from Corpus Christi College, Cambridge.This is the final version of the article. It first appeared from the American Chemical Society via http://dx.doi.org/10.1021/jacs.5b0508

Stacking Interactions Drive Selective Self-Assembly and Self-Sorting of Pyrene-Based M(II)4L6 Architectures.

Subcomponent self-assembly of two isomeric bis(3-aminophenyl)pyrenes, 2-formylpyridine and the metal ions Fe(II), Co(II), and Zn(II) led to the formation of two previously unidentified structure types: a C2-symmetric M(II)4L6 assembly with meridionally coordinated metal centers, and a C3-symmetric self-included M(II)4L6 assembly with facially coordinated metal centers. In both structures the meta linkages within the ligands facilitate π-stacking between the pyrene panels of the ligands. A C2h-symmetric M(II)2L2 box was also obtained, which was observed to selectively bind electron-deficient aromatic guests between two parallel pyrene subunits. Similar donor-acceptor interactions drove the selective self-assembly of a singular M(II)4L4L'2 architecture incorporating both a pyrene-containing diamine and an electron-deficient NDI-based diamine. This heteroleptic architecture was shown to be thermodynamically favored over the corresponding homoleptic M(II)4L6 and M(II)4L'6 complexes, which were nonetheless stable in each others' absence. By contrast, an isomeric pyrene-based diamine was observed to undergo narcissistic self-sorting in the presence of the NDI-based diamine.This work was supported by the UK Engineering and Physical Sciences Research Council (EPSRC). D.A.R. acknowledges the Gates Cambridge Trust for Ph.D. funding (Gates Cambridge Scholarship). We thank the EPSRC Mass Spectrometry Service at Swansea for carrying out the high resolution mass spectrometry and Diamond Light Source (UK) for synchrotron beamtime on I19 (MT8464). We also thank the NMR service team at the Department of Chemistry, University of Cambridge for performing some NMR experiments.This is the final version of the article. It first appeared from the American Chemical Society via http://dx.doi.org/10.1021/jacs.5b0992