Preliminary Results of Porosity and Permeability of Cores From Doe Wells in the Palo Duro Basin, Texas Panhandle

Information on permeability and porosity of the Deep-Basin Brine Aquifer is important for describing flow pattern and flow velocity of deep-basinal fluids. Permeabilities were estimated from drill-stem tests, pumping tests, and published values of equivalent geologic materials. In addition, permeabilities and porosities of different lithologies were determined from laboratory tests of cores. The objectives of core analysis are: 1. Determine porosities and permeabilities of the different geologic lithofacies. 2. Relate porosities to petrographic description of pore types and lithology. 3. Obtain vertical and horizontal distribution of porosity and permeability from the analyzed core intervals. 4. Compare core permeabilities to drill-stem test and pumping test analyses. 5. Compare core-derived porosity values with porosities from neutron-density cross plots.Bureau of Economic Geolog

On the boundaries of highly connected, almost closed manifolds

Building on work of Stolz, we prove for integers $0 \le d \le 3$ and $k>232$ that the boundaries of $(k-1)$-connected, almost closed $(2k+d)$-manifolds also bound parallelizable manifolds. Away from finitely many dimensions, this settles longstanding questions of C.T.C. Wall, determines all Stein fillable homotopy spheres, and proves a conjecture of Galatius and Randal-Williams. Implications are drawn for both the classification of highly connected manifolds and, via work of Kreck and Krannich, the calculation of their mapping class groups. Our technique is to recast the Galatius and Randal-Williams conjecture in terms of the vanishing of a certain Toda bracket, and then to analyze this Toda bracket by bounding its $\mathrm{H}\mathbb{F}_p$-Adams filtrations for all primes $p$. We additionally prove new vanishing lines in the $\mathrm{H}\mathbb{F}_p$-Adams spectral sequences of spheres and Moore spectra, which are likely to be of independent interest. Several of these vanishing lines rely on an Appendix by Robert Burklund, which answers a question of Mathew about vanishing curves in $\mathrm{BP} \langle n \rangle$-based Adams spectral sequences.Comment: Typos corrected and exposition improved. Comments welcome

Implementation of PhotoZ under Astro-WISE - A photometric redshift code for large datasets

We describe the implementation of the PhotoZ code in the framework of the Astro-WISE package and as part of the Photometric Classification Server of the PanSTARRS pipeline. Both systems allow the automatic measurement of photometric redshifts for the millions of objects being observed in the PanSTARRS project or expected to be observed by future surveys like KIDS, DES or EUCLID.Comment: Accepted for publication in topical issue of Experimental Astronomy on Astro-WISE information system, references update

Systolic blood pressure reduction during the first 24 h in acute heart failure admission: friend or foe?

Aims: Changes in systolic blood pressure (SBP) during an admission for acute heart failure (AHF), especially those leading to hypotension, have been suggested to increase the risk for adverse outcomes. Methods and results: We analysed associations of SBP decrease during the first 24 h from randomization with serum creatinine changes at the last time-point available (72 h), using linear regression, and with 30- and 180-day outcomes, using Cox regression, in 1257 patients in the VERITAS study. After multivariable adjustment for baseline SBP, greater SBP decrease at 24 h from randomization was associated with greater creatinine increase at 72 h and greater risk for 30-day all-cause death, worsening heart failure (HF) or HF readmission. The hazard ratio (HR) for each 1 mmHg decrease in SBP at 24 h for 30-day death, worsening HF or HF rehospitalization was 1.01 [95% confidence interval (CI) 1.00–1.02; P = 0.021]. Similarly, the HR for each 1 mmHg decrease in SBP at 24 h for 180-day all-cause mortality was 1.01 (95% CI 1.00–1.03; P = 0.038). The associations between SBP decrease and outcomes did not differ by tezosentan treatment group, although tezosentan treatment was associated with a greater SBP decrease at 24 h. Conclusions: In the current post hoc analysis, SBP decrease during the first 24 h was associated with increased renal impairment and adverse outcomes at 30 and 180 days. Caution, with special attention to blood pressure monitoring, should be exercised when vasodilating agents are given to AHF patients

Predictors and associations with outcomes of length of hospital stay in patients with acute heart failure: results from VERITAS

Background: The length of hospital stay (LOS) is important in patients admitted for acute heart failure (AHF) because it prolongs an unpleasant experience for the patients and adds substantially to health care costs. Methods and Results: We examined the association between LOS and baseline characteristics, 10-day post-discharge HF readmission, and 90-day post-discharge mortality in 1347 patients with AHF enrolled in the VERITAS program. Longer LOS was associated with greater HF severity and disease burden at baseline; however, most of the variability of LOS could not be explained by these factors. LOS was associated with a higher HF risk of both HF readmission (odds ratio for 1-day increase: 1.08; 95% confidence interval [CI] 1.01–1.16; P = .019) and 90-day mortality (hazard ratio for 1-day increase: 1.05; 95% CI 1.02–1.07; P < .001), although these associations are partially explained by concurrent end-organ damage and worsening heart failure during the first days of admission. Conclusions: In patients who have been admitted for AHF, longer length of hospital stay is associated with a higher rate of short-term mortality. Clinical Trial Registration: VERITAS-1 and -2: Clinicaltrials.gov identifiers NCT00525707 and NCT00524433

SuperTarget and Matador: resources for exploring drug-target relationships

The molecular basis of drug action is often not well understood. This is partly because the very abundant and diverse information generated in the past decades on drugs is hidden in millions of medical articles or textbooks. Therefore, we developed a one-stop data warehouse, SuperTarget that integrates drug-related information about medical indication areas, adverse drug effects, drug metabolization, pathways and Gene Ontology terms of the target proteins. An easy-to-use query interface enables the user to pose complex queries, for example to find drugs that target a certain pathway, interacting drugs that are metabolized by the same cytochrome P450 or drugs that target the same protein but are metabolized by different enzymes. Furthermore, we provide tools for 2D drug screening and sequence comparison of the targets. The database contains more than 2500 target proteins, which are annotated with about 7300 relations to 1500 drugs; the vast majority of entries have pointers to the respective literature source. A subset of these drugs has been annotated with additional binding information and indirect interactions and is available as a separate resource called Matador. SuperTarget and Matador are available at http://insilico.charite.de/supertarget and http://matador.embl.d