On the Rates of Type Ia Supernovae in Dwarf and Giant Hosts with ROTSE-IIIb

We present a sample of 23 spectroscopically confirmed Type Ia supernovae that were discovered in the background of galaxy clusters targeted by ROTSE-IIIb and use up to 18 of these to determine the local (z = 0.05) volumetric rate. Since our survey is flux limited and thus biased against fainter objects, the pseudo-absolute magnitude distribution (pAMD) of SNeIa in a given volume is an important concern, especially the relative frequency of high to low-luminosity SNeIa. We find that the pAMD derived from the volume limited Lick Observatory Supernova Search (LOSS) sample is incompatible with the distribution of SNeIa in a volume limited (z<0.12) sub sample of the SDSS-II. The LOSS sample requires far more low-luminosity SNeIa than the SDSS-II can accommodate. Even though LOSS and SDSS-II have sampled different SNeIa populations, their volumetric rates are surprisingly similar. Using the same model pAMD adopted in the SDSS-II SNeIa rate calculation and excluding two high-luminosity SNeIa from our sample, we derive a rate that is marginally higher than previous low-redshift determinations. With our full sample and the LOSS pAMD our rate is more than double the canonical value. We also find that 5 of our 18 SNeIa are hosted by very low-luminosity (M_B > -16) galaxies, whereas only 1 out 79 nearby SDSS-II SNeIa have such faint hosts. It is possible that previous works have under-counted either low luminosity SNeIa, SNeIa in low luminosity hosts, or peculiar SNeIa (sometimes explicitly), and the total SNeIa rate may be higher than the canonical value.Comment: 18 pages; accepted for publication in The Astronomical Journa

Complete and safe resection of challenging retroperitoneal tumors: anticipation of multi-organ and major vascular resection and use of adjunct procedures.

BackgroundRetroperitoneal tumors are often massive and can involve adjacent organs and/or vital structures, making them difficult to resect. Completeness of resection is within the surgeon's control and critical for long-term survival, particularly for malignant disease. Few studies directly address strategies for complete and safe resection of challenging retroperitoneal tumors.MethodsFifty-six patients representing 63 cases of primary or recurrent retroperitoneal tumor resection between 2004-2009 were identified and a retrospective chart review was performed. Rates of complete resection, use of adjunct procedures, and perioperative complications were recorded.ResultsIn 95% of cases, complete resection was achieved. Fifty-eight percent of these cases required en bloc multi-organ resection, and 8% required major vascular resection. Complete resection rates were higher for primary versus recurrent disease. Adjunct procedures (ureteral stents, femoral nerve monitoring, posterior laminotomy, etc.) were used in 54% of cases. Major postoperative complications occurred in 16% of cases, and one patient died (2% mortality).ConclusionsComplete resection of challenging retroperitoneal tumors is feasible and can be done safely with important pre- and intraoperative considerations in mind

PET and P300 Relationships in Early Alzheimer\u27s Disease

The P300 (P3) wave of the auditory brain event-related potential was investigated in patients with probable Alzheimer\u27s disease to determine whether P300 latency discriminated these patients from controls and whether prolonged P300 latency correlated with rates of brain glucose metabolism as measured by Positron Emission Tomography. P300 latency was prolonged by more than 1.5 standard deviations from age expectancy in 14 of 18 patients, but none of 17 controls. In these subjects P300 latency was shown to be inversely correlated with relative metabolic rates of parietal and, to a lesser extent, temporal and frontal association areas, but not with subcortical areas

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles

Notch is a highly conserved transmembrane protein that is involved in cell fate decisions and is found in organisms ranging from Drosophila to humans. A human homologue of Notch, TAN1, was initially identified at the chromosomal breakpoint of a subset of T-cell lymphoblastic leukemias/lymphomas containing a t(7;9) chromosomal translocation; however, its role in oncogenesis has been unclear. Using a bone marrow reconstitution assay with cells containing retrovirally transduced TAN1 alleles, we analyzed the oncogenic potential of both nuclear and extranuclear forms of truncated TAN1 in hematopoietic cells. Although the Moloney leukemia virus long terminal repeat drives expression in most hematopoietic cell types, retroviruses encoding either form of the TAN1 protein induced clonal leukemias of exclusively immature T cell phenotypes in approximately 50% of transplanted animals. All tumors overexpressed truncated TAN1 of the size and subcellular localization predicted from the structure of the gene. These results show that TAN1 is an oncoprotein and suggest that truncation and overexpression are important determinants of transforming activity. Moreover, the murine tumors caused by TAN1 in the bone marrow transplant model are very similar to the TAN1-associated human tumors and suggest that TAN1 may be specifically oncotropic for T cells

Exploring Stakeholders’ Perceptions of Urban Growth Scenarios for Metropolitan Boston (USA): The Relationship Between Urban Trees and Perceived Density

Achieving multiple goals rather than trading one goal off for another is the essence of sustainability. Visualizing alternative futures in a participatory planning process helps disentangle complex planning issues particularly when stakeholders may perceive key goals as imposing potential tradeoffs, such as increased housing for a growing population and availability of green space. This study explored the effects of using visualization and scenarios as planning tools in a workshop with stakeholders in the Boston Metro Area, Massachusetts (USA), in achieving multiple benefits of sustainable future growth of the region. We applied mixed methods sequential explanatory design and a survey instrument with a landscape preference survey designed to garner stakeholders\u27 preference and acceptability of perceived urban density versus urban greening in four future growth scenarios reflecting multiple goals in sustainability. The results of the landscape preference survey demonstrated that increasing tree canopy appears to ameliorate the low ratings of high-rise buildings for the region\u27s urban development. In addition, the scenario planning process, especially the use of small group discussions, represented an effective tool in facilitating stakeholders\u27 discussion about achieving the multiple benefits of the three goals of sustainability: Environment, Economy, Equity. This study provided theoretical and applied insights for planners in the use of visualization and scenario planning methodologies to engage stakeholders in the participatory planning process. It revealed the potential for a policy decision shift among stakeholders in the Boston region, namely that higher density urban development would likely be more acceptable to them when combined with a simultaneous increase in tree canopy cover. Through practices like these, stakeholders are more likely to consider policies and designs that embrace a variety of goals for their community’s future instead of simplistically placing one goal in opposition to another or trading them off against each other

Targeted Assembly of Short Sequence Reads

As next-generation sequence (NGS) production continues to increase, analysis is becoming a significant bottleneck. However, in situations where information is required only for specific sequence variants, it is not necessary to assemble or align whole genome data sets in their entirety. Rather, NGS data sets can be mined for the presence of sequence variants of interest by localized assembly, which is a faster, easier, and more accurate approach. We present TASR, a streamlined assembler that interrogates very large NGS data sets for the presence of specific variants, by only considering reads within the sequence space of input target sequences provided by the user. The NGS data set is searched for reads with an exact match to all possible short words within the target sequence, and these reads are then assembled strin-gently to generate a consensus of the target and flanking sequence. Typically, variants of a particular locus are provided as different target sequences, and the presence of the variant in the data set being interrogated is revealed by a successful assembly outcome. However, TASR can also be used to find unknown sequences that flank a given target. We demonstrate that TASR has utility in finding or confirming ge-nomic mutations, polymorphism, fusion and integration events. Targeted assembly is a powerful method for interrogating large data sets for the presence of sequence variants of interest. TASR is a fast, flexible and easy to use tool for targeted assembly

Perovskite CsPbBr3 Solar Cells With Novel Hole-Transporting Layer of Metal Complexes

For the first time, the novel application of Schiff-base copper complexes in all-inorganic perovskite CsBrBr3 solar cells has been explored and turns out they could be utilized as effective hole-transporting materials. Schiff-base copper complexes with halogen ligands (R=Cl and Br) are synthesized with an ease approach at a low cost, both of which exhibit decent power conversion efficiency of 4.55% and 5.71%, respectively, when being constructed into solar devices as hole transport layers. Thanks to high thermal/chemical stability of those Schiff-base metal complexes, the strengthened stability was achieved which is comparable to that of carbon-based CsBrBr3 solar cells. Although the power conversion efficiency is not as competitive as expected, the great potential exists for further optimizing the functionality of perovskite solar devices by finely tuning the photovoltaic properties of those Schiff-base metal complexes through coordinating ligands or replacing with other transition metals

Observations and simulations of recurrent novae: U Sco and V394 CrA

Observations and analysis of the Aug. 1987 outburst of the recurrent nova V394 CrA are presented. This nova is extremely fast and its outburst characteristics closely resemble those of the recurrent nova U Sco. Hydrodynamic simulations of the outbursts of recurrent novae were performed. Results as applied to the outbursts of V394 CrA and U Sco are summarized

A Study of Thymidylate Synthase Expression as a Biomarker for Resectable Colon Cancer: Alliance (Cancer and Leukemia Group B) 9581 and 89803.

PurposeTumor levels of thymidylate synthase (TS), a target of 5-fluorouracil (5-FU)-based chemotherapy for colorectal cancer, have been studied as a predictive or prognostic biomarker with mixed results.Patients and methodsTumor TS levels were prospectively evaluated in two adjuvant therapy trials for patients with resected stage II or III colon cancer. TS expression was determined by standard immunohistochemistry and by automated quantitative analysis. Tumor mismatch repair deficiency (MMR-D) and BRAF c.1799T &gt; A (p.V600E) mutation status were also examined. Relationships between tumor TS, MMR-D, and BRAF mutation status, overall survival (OS), and disease-free survival (DFS) were investigated in the subset of stage III patients.ResultsPatients whose tumors demonstrated high TS expression experienced better treatment outcomes, with DFS hazard ratio (HR) = 0.67, 95% confidence interval (CI) = 0.53, 0.84; and OS HR = 0.68, 95% CI = 0.53, 0.88, for high versus low TS expression, respectively. No significant interaction between TS expression and stage was observed (DFS: interaction HR = 0.94; OS: interaction HR = 0.94). Tumors with high TS expression were more likely to demonstrate MMR-D (22.2% vs. 12.8%; p =  .0003). Patients whose tumors demonstrated both high TS and MMR-D had a 7-year DFS of 77%, compared with 58% for those whose tumors had low TS and were non-MMR-D (log-rank p =  .0006). Tumor TS expression did not predict benefit of a particular therapeutic regimen.ConclusionThis large prospective analysis showed that high tumor TS levels were associated with improved DFS and OS following adjuvant therapy for colon cancer, although tumor TS expression did not predict benefit of 5-FU-based chemotherapy. The Oncologist 2017;22:107-114Implications for Practice: This study finds that measurement of tumor levels of thymidylate synthase is not helpful in assigning specific adjuvant treatment for colorectal cancer. It also highlights the importance of using prospective analyses within treatment clinical trials as the optimal method of determining biomarker utility