data on white matter lesions in bipolar disorder

The data sheet contains all volumetric and demographic variables and that were used for statistical analysis in our study. Data are either continuous or binary. A comprehensive description of variables is given in the file

Demographic data.

<p>Note: Results from <i>t</i>-tests (<i>t</i>), Chi square tests (<i>χ2</i>), Mann-Whitney-U-tests (<i>U</i>) and ANCOVA (<i>F</i>)</p><p>(1) For ANCOVA, WML volumes were normalized by individual total intracranial volume and controlled for age, diabetes, smoking and BMI.</p><p>Statistically significant effects are marked bold.</p><p>Demographic data.</p

Representative FLAIR slice of one patient.

<p>The left image shows an example of lesion areas, outlined semiautomatically by the instructed rater using a custom written IDL program (Exelis Visual Information Solutions, USA). The right image shows the native FLAIR scan.</p

Ratios of TRYCAT metabolism.

<p>Results from MANCOVA controlled for age, sex, body mass index, presence of a cardiovascular disease and smoking; *p<0.05, **p<0.01; KYN = kynurenine, KYNA = kynurenic acid, 3-HK = 3-hydroxykynurenine, AA = anthranilic acid.</p

Serum levels of TRYCATs in ng/mL.

<p>Results from MANCOVA controlled for age, sex, body mass index, presence of a cardiovascular disease and smoking; *p<0.05; KYN = kynurenine, KYNA = kynurenic acid, 3-HK = 3-hydroxykynurenine, AA = anthranilic acid.</p

Scatter graphs showing the distributions of the TRYCAT metabolism ratios.

<p>Scatter graphs showing the distributions of the TRYCAT metabolism ratios.</p

Demographic and clinical parameters.

<p>Demographic and clinical parameters.</p

Scatter graphs showing the distribution of the serum levels of the measured TRYCATs in ng/mL.

<p>Scatter graphs showing the distribution of the serum levels of the measured TRYCATs in ng/mL.</p