The influence of substituents on the properties of certain pyrazolines, with particular regard to fluorescence

The preparation of a series of thirty -five pyrazolines and two anomalous compounds (the latter obtained from cinnamylideneacetophenone and cinnamylidenepinacoline, respectively), twenty -five of which are believed to be new, is described.Most of these pyrazolines fluoresce in the solid state on exposure to ultraviolet rays. Many fluoresce in daylight when dissolved in organic solvents. Of those which exhibit no visible fluorescence in daylight, many fluoresce in ultraviolet rays; those which fluoresce in daylight do so with increased brilliance on ultraviolet irradiation.The behaviour of the members of the series in alcoholic, chloroform and benzene solution, on exposure to ultraviolet rays, has been investigated

Transionospheric signal modelling for epop and Superdarn

In 2011, the Canadian enhanced Polar Outflow Probe (ePOP) satellite will be launched. The ePOP satellite is equipped with several scientific Earth observation instruments, including a Radio Receiver Instrument (RRI) which will be used to detect High Frequency (HF) radio waves transmitted from a ground-based transmitter. The ground-based instrument will be one of the Super Dual Auroral Radar Network (SuperDARN) array of radars. A radio wave transmitted from the SuperDARN radar will propagate through the ionosphere and be detected by the RRI on ePOP. Analysis of the characteristics of the signal received by the RRI will provide information about the plasma density in the ionosphere between the transmitter and receiver. As the ePOP satellite is not yet operational, extensive ray path modelling has been performed to simulate the expected signal at the RRI for various ionospheric conditions. The other major objective of this research was to examine the effect of the variable refractive index in the ionosphere on SuperDARN drift velocity measurements. Past comparisons between velocities measured by SuperDARN and other instruments have found that velocities measured by SuperDARN typically were about 20-30% lower. This research has shown that underestimation of drift velocities by SuperDARN is a consequence of not including the refractive index when these velocities are calculated. As refractive index measurements are not readily available, this research has involved developing and implementing various methods to estimate the refractive index in the ionosphere. These methods have demonstrated that plasma density values within the SuperDARN scattering volume are appreciably higher than background plasma densities in the ionosphere. Application of these methods, which has resulted in a much better understanding of the physics of the coherent scattering process, has resulted in agreement between velocities measured by SuperDARN and other instruments

Modelling of transionospheric HF radio wave propagation for the ISIS II and ePOP satellites

The enhanced Polar Outflow Probe (ePOP) satellite is to be launched in 2007. One of the 8 instruments it will carry is a Radio Receiver Instrument (RRI) which is a passive radio receiver. The RRI will detect HF (High Frequency band 3 to 30 MHz) radio waves from ground transmitters, one of which is the Saskatoon SuperDARN radar. The modification of an HF radar wave as it propagates through the ionosphere to the satellite is the dominant scientific interest of this thesis. The modification of a radar wave as it propagates through the ionosphere can be used to characterize the ionosphere and reveal a better understanding of magnetoionic radar wave propagation. A ray tracing program has been written to determine characteristics of the wave, including the wave path and the full polarization state, at the satellite receiver. As a confirmation of the ray tracing program abilities, data from a similar transionospheric experiment in 1978, the ISIS II satellite mission, has been analyzed and compared with simulated results. The ISIS II transionospheric experiment received radar signals from a transmitter (9.303 MHz) located in Ottawa, Canada. These signals were analyzed and it was noted that the signal periodically faded in and out both due to differential Faraday rotation effects (due to propagation through an ionized medium and reception on a single dipole antenna) and due to satellite spin rotation at rates up to 13 Hz. Also observed was a splitting of the received signal into Ordinary (O-mode) and Extraordinary (X-mode) components causing a delay between the arrival of the modes at ISIS II of up to 0.8 ms. Simulations have been carried out to model the radar wave propagation from the ground transmitter through the ionized medium of the ionosphere to the spacecraft. The modelled signal shows very similar trends to the observed signal. A linear regression analysis comparing observed to simulated fade rates gave values of slope equal to 1.07 and regression coefficient equal to 0.934. The regression analysis of mode delay gave values of slope equal to 1.14 and regression coefficient equal to 0.930. Ray path modelling has also been simulated for the RRI experiment on ePOP. These simulations have been carried out for various ionospheric and satellite pass configurations. The expected fade rates, mode delays, and latitudinal range of received signal was determined from the simulated data in each case. The dependence of these characteristics on the various pass configurations are presented and discussed

Modern Climatology - Full Text

Climatology, the study of climate, is no longer regarded as a single discipline that treats climate as something that fluctuates only within the unchanging boundaries described by historical statistics. The field has recognized that climate is something that changes continually under the influence of physical and biological forces and so, cannot be understood in isolation but rather, is one that includes diverse scientific disciplines that play their role in understanding a highly complex coupled “whole system” that is the Earth’s climate. The modern era of climatology is echoed in this book. On the one hand it offers a broad synoptic perspective but also considers the regional standpoint as it is this that affects what people need from climatology, albeit water resource managers or engineers etc. Aspects on the topic of climate change – what is often considered a contradiction in terms – is also addressed. It is all too evident these days that what recent work in climatology has revealed carries profound implications for economic and social policy; it is with these in mind that the final chapters consider acumens as to the application of what has been learned to date. This book is divided into four sections that cover sub-disciplines in climatology. The first section contains four chapters that pertain to synoptic climatology, i.e., the study of weather disturbances including hurricanes, monsoon depressions, synoptic waves, and severe thunderstorms; these weather systems directly impact humanity. The second section on regional climatology has four chapters that describe the climate features within physiographically defined areas. The third section is on climate change which involves both past (paleoclimate) and future climate: The first two chapters cover certain facets of paleoclimate while the third is centered towards the signals (observed or otherwise) of climate change. The fourth and final section broaches the sub-discipline that is often referred to as applied climatology; this represents the important goal of all studies in climatology–one that affects modes of living. Here, three chapters are devoted towards the application of climatological research that might have useful application for operational purposes in industrial, manufacturing, agricultural, technological and environmental affairs. Please click here to explore the components of this work.https://digitalcommons.usu.edu/modern_climatology/1014/thumbnail.jp

Observed change in Sahel rainfall, circulations, African easterly waves, and Atlantic hurricanes since 1979

Here, we examine the dynamic properties associated with the recent increase in the Sahel rainfall using an ensemble of five global reanalysis datasets (1979–2010). The rainfall that has been observed to be increasing over the Sahel is accounted for by enhancements in both the tropical easterly jet and the African easterly jet, both of which are known to induce wet anomalies. Moreover, positional shifts in the African easterly jet and African easterly waves (AEWs) accompanied the northward migration of the Sahel rainband. Change in the African easterly jet and AEWs are coupled to a northward shift and amplification of convective activity; this signals an increased potential for the occurrence of flash floods along the northern Sahel. In addition, the result from a wave tracking analysis suggests that the change in AEWs is closely linked to increased activity of intense hurricanes in the North Atlantic. The synoptic concurrence of AEWs in driving the dynamics of the Sahel greening and the increase in tropical cyclogeneses over the North Atlantic is an important aspect in the evaluation of climate model projections

Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane

BACKGROUND: Cancer cells, and a variety of normal cells, exhibit aerobic glycolysis, high rates of glucose fermentation in the presence of normal oxygen concentrations, also known as the Warburg effect. This metabolism is considered abnormal because it violates the standard model of cellular energy production that assumes glucose metabolism is predominantly governed by oxygen concentrations and, therefore, fermentative glycolysis is an emergency back-up for periods of hypoxia. Though several hypotheses have been proposed for the origin of aerobic glycolysis, its biological basis in cancer and normal cells is still not well understood. RESULTS: We examined changes in glucose metabolism following perturbations in membrane activity in different normal and tumor cell lines and found that inhibition or activation of pumps on the cell membrane led to reduction or increase in glycolysis, respectively, while oxidative phosphorylation remained unchanged. Computational simulations demonstrated that these findings are consistent with a new model of normal physiological cellular metabolism in which efficient mitochondrial oxidative phosphorylation supplies chronic energy demand primarily for macromolecule synthesis and glycolysis is necessary to supply rapid energy demands primarily to support membrane pumps. A specific model prediction was that the spatial distribution of ATP-producing enzymes in the glycolytic pathway must be primarily localized adjacent to the cell membrane, while mitochondria should be predominantly peri-nuclear. The predictions were confirmed experimentally. CONCLUSIONS: Our results show that glycolytic metabolism serves a critical physiological function under normoxic conditions by responding to rapid energetic demand, mainly from membrane transport activities, even in the presence of oxygen. This supports a new model for glucose metabolism in which glycolysis and oxidative phosphorylation supply different types of energy demand. Cells use efficient but slow-responding aerobic metabolism to meet baseline, steady energy demand and glycolytic metabolism, which is inefficient but can rapidly increase adenosine triphosphate (ATP) production, to meet short-timescale energy demands, mainly from membrane transport activities. In this model, the origin of the Warburg effect in cancer cells and aerobic glycolysis in general represents a normal physiological function due to enhanced energy demand for membrane transporters activity required for cell division, growth, and migration

Climatology of the U.S. Inter-Mountain West

The Inter-Mountain West (IMW) of North America is a region that lies between the Rocky Mountains to the east and the Cascades and Sierra Nevada to the west (Fig. 1). The climate of the IMW is generally semi-arid but this varies by location and elevation. An estimated 50- 80% of the IMW’s streams and rivers are fed by mountain snowpack (Marks and Winstral 2001), while the majority of the streams and rivers flow into desert sinks or closed-basin lakes such as the Great Salt Lake (Fig. 1). These streams and rivers create some agriculturally productive areas in the otherwise dry basins and mountain valleys. In particular, the Colorado River supplies water to the population-booming southwestern states and cities. Climate in the Colorado River Basin has been a subject of intense research due to its projected drying trend (Barnett and Pierce 2008). Change in winter precipitation regime (i.e. ratio between rainfall and snowfall) is also a subject of interest not only because its role in water resource but also its impact on recreational (ski) industry in the IMW.https://digitalcommons.usu.edu/modern_climatology/1005/thumbnail.jp

A remotely sensed index of deforestation/urbanization for use in climate models

The object of this research is to use indirect measurements, notably thermal infrared, to describe urbanization and deforestation with parameters that can be used to assess, as well as predict, the effects of land use changes on local microclimate. More specifically, we use a new approach for the treatment of remotely sensed data; this is referred to as the 'triangle' method. The name triangle is given because the envelope of data points, when plotted as a function of surface radiant temperature versus vegetation index or fractional vegetation cover, exhibits the shape of a triangle. From the information contained on these 'scatter plots', land use changes can be related to two intrinsic surface variables, the surface moisture availability (M(sub 0))(sup 1) and fractional vegetation cover. Recent work by Carlson et al. indicate that the triangle shape on the scatter plots may be scale similar, suggesting that these two parameters are subject to the same interpretation on differing scales. A second objective in this research is to determine if historical data for Advanced Very High Resolution Radiometer (AVHRR) (NOAA satellite; 1.1 km resolution at nadir) can be used to assess changes in regional land use over time. To this end, two target areas were chosen for the investigation of urbanization and two for deforestation. The former comprise tow areas in Pennsylvania, one a small but rapidly growing population center (State College) and the other a medium-sized urban area which continues to undergo development (Chester County). The two deforestation sites consist of rain forest areas in western and central Costa Rica and a region in the Brazilian Amazon

Pakistan’s two-stage monsoon and links with the recent climate change

Meteorological conditions related to the Pakistan floods of 2010 were examined in the context of monsoon dynamics and large‐scale circulations. Case and climatological analyses suggest that summer precipitation in northern Pakistan comprises two distinct phases: (1) a premonsoon trough phase (July) whose rainfall is more episodic and intense, occurring prior to arrival of the monsoon trough, and (2) a monsoon trough phase (August) whose rainfall is persistent, yet less episodic, driven by northward migration of the monsoon trough. Analyses of conditional instability, moisture flux, and circulation features support a persistent increase in conditional instability during the July premonsoon trough phase, accompanied by increased frequency of heavy rainfall events. Conversely, evidence does not support intensification of the August monsoon trough phase. The increased convective activity during the premonsoon trough phase agrees with the projected increase in the intensity of heavy rainfall events over northern Pakistan. Largescale circulation analysis reveals an upper‐level cyclonic anomaly over and to the west of Pakistan–a feature empirically associated with weak monsoon. The analysis also suggests that the anomalous circulation in 2010 is not sporadic but rather is part of a long‐term trend that defies the typical linkage of strong monsoons with an anomalous anticyclone in the upper troposphere