TEXTBOOK OF FAMILY MEDICINE

1519 hlm. ; 22 x 28 c

Textbook of family medicine, 9th ed./ Rakel

xv, 1200 p.: ill, tab.; 28 cm

Textbook of family medicine, 9th ed./ Rakel

xv, 1200 p.: ill, tab.; 28 cm

Current Therapy

xxxvii;ill.;1192hal.;26c

Conn's: Current Thrapy 2005, 56\ub0 Edizione

Covering more than 300 clinically relevant topics, Conn's Current Therapy offers an in-depth, personal approach to treatment from international experts, ideally suited for today's busy medical practitioners

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the International Space Station; his twin served as a genetically matched ground control. Longitudinal assessments identified spaceflight-specific changes, including decreased body mass, telomere elongation, genome instability, carotid artery distension and increased intima-media thickness, altered ocular structure, transcriptional and metabolic changes, DNA methylation changes in immune and oxidative stress-related pathways, gastrointestinal microbiota alterations, and some cognitive decline postflight. Although average telomere length, global gene expression, and microbiome changes returned to near preflight levels within 6 months after return to Earth, increased numbers of short telomeres were observed and expression of some genes was still disrupted. These multiomic, molecular, physiological, and behavioral datasets provide a valuable roadmap of the putative health risks for future human spaceflight