109 research outputs found
In Whose Backyard?: Concern About Sitting a Nuclear Waste Facility
Proponents of hazardous and nuclear waste depositories label opponents to local siting of such facilities NIMBYs (Not In My Backyard). This study assesses the extent to which the NIMBY label and the strategies of industry proponents to reduce opposition function on a reasonable set of assumptions. Using survey data and multiple regression techniques, the levels of concern of residents living in the county selected as the site of a low level radioactive wane disposal facility (imminent threat condition) are compared with a statewide sample (hypothetical threat condition). Consistent with proponents\u27 theoretical assumptions, the levels of concern are greater for respondents under conditions of imminent threat than of hypothetical threat. However, within the host county, levels of concern are lowest, albeit most polarized, in the community closest to the proposed site. A conflict theory approach enhances an understanding of these findings by suggesting that within the most proximate community levels of concern are lowest for citizens who stand to gain the most economic benefits from the facility but highest for those citizens who are least likely to derive tangible gains
In Whose Backyard?: Concern About Sitting a Nuclear Waste Facility
Proponents of hazardous and nuclear waste depositories label opponents to local siting of such facilities NIMBYs (Not In My Backyard). This study assesses the extent to which the NIMBY label and the strategies of industry proponents to reduce opposition function on a reasonable set of assumptions. Using survey data and multiple regression techniques, the levels of concern of residents living in the county selected as the site of a low level radioactive wane disposal facility (imminent threat condition) are compared with a statewide sample (hypothetical threat condition). Consistent with proponents\u27 theoretical assumptions, the levels of concern are greater for respondents under conditions of imminent threat than of hypothetical threat. However, within the host county, levels of concern are lowest, albeit most polarized, in the community closest to the proposed site. A conflict theory approach enhances an understanding of these findings by suggesting that within the most proximate community levels of concern are lowest for citizens who stand to gain the most economic benefits from the facility but highest for those citizens who are least likely to derive tangible gains
Quark Masses: An Environmental Impact Statement
We investigate worlds that lie on a slice through the parameter space of the
Standard Model over which quark masses vary. We allow as many as three quarks
to participate in nuclei, while fixing the mass of the electron and the average
mass of the lightest baryon flavor multiplet. We classify as "congenial" worlds
that satisfy the environmental constraint that the quark masses allow for
stable nuclei with charges one, six, and eight, making organic chemistry
possible. Whether a congenial world actually produces observers depends on a
multitude of historical contingencies, beginning with primordial
nucleosynthesis, which we do not explore. Such constraints may be independently
superimposed on our results. Environmental constraints such as the ones we
study may be combined with information about the a priori distribution of quark
masses over the landscape of possible universes to determine whether the
measured values of the quark masses are determined environmentally, but our
analysis is independent of such an anthropic approach.
We estimate baryon masses as functions of quark masses and nuclear masses as
functions of baryon masses. We check for the stability of nuclei against
fission, strong particle emission, and weak nucleon emission. For two light
quarks with charges 2/3 and -1/3, we find a band of congeniality roughly 29 MeV
wide in their mass difference. We also find another, less robust region of
congeniality with one light, charge -1/3 quark, and two heavier, approximately
degenerate charge -1/3 and 2/3 quarks. No other assignment of light quark
charges yields congenial worlds with two baryons participating in nuclei. We
identify and discuss the region in quark-mass space where nuclei would be made
from three or more baryon species.Comment: 40 pages, 16 figures (in color), 4 tables. See paper for a more
detailed abstract. v4: Cleaning up minor typo
Lions and tigers and bears, oh my! Three barriers to progress in computer-aided molecular design
Anti-tumour activity of bisphosphonates in preclinical models of breast cancer
There is increasing evidence of anti-tumour effects of bisphosphonates from pre-clinical studies, supporting a role for these drugs beyond their traditional use in treatment of cancer-induced bone disease. A range of model systems have been used to investigate the effects of different bisphosphonates on tumour growth, both in bone and at peripheral sites. Most of these studies conclude that bisphosphonates cause a reduction in tumour burden, but that early intervention and the use of high and/or repeated dosing is required. Successful eradication of cancer may only be achievable by targeting the tumour cells directly whilst also modifying the tumour microenvironment. In line with this, bisphosphonates are demonstrated to be particularly effective at reducing breast tumour growth when used in combination with agents that directly target cancer cells. Recent studies have shown that the effects of bisphosphonates on breast tumours are not limited to bone, and that prolonged anti-tumour effects may be achieved following their inclusion in combination therapy. This has opened the field to a new strand of bisphosphonate research, focussed on elucidating their effects on cells and components of the local, regional and distal tumour microenvironment. This review highlights the recent developments in relation to proposed anti-tumour effects of bisphosphonates reported from in vitro and in vivo models, and summarises the data from key breast cancer studies. Evidence for effects on different processes and cell types involved in cancer development and progression is discussed, and the main outstanding issues identified
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