Universal Constraints on Low-Energy Flavour Models

It is pointed out that in a general class of flavour models one can identify certain universally present FCNC operators, induced by the exchange of heavy flavour messengers. Their coefficients depend on the rotation angles that connect flavour and fermion mass basis. The lower bounds on the messenger scale are derived using updated experimental constraints on the FCNC operators. The obtained bounds are different for different operators and in addition they depend on the chosen set of rotations. Given the sensitivity expected in the forthcoming experiments, the present analysis suggests interesting room for discovering new physics. As the highlights emerge the leptonic processes, $\mu\rightarrow e\gamma$, $\mu\rightarrow eee$ and $\mu\rightarrow e$ conversion in nuclei.Comment: 18 pages, 3 figures; v2 matches published versio

The anti-myeloma activity of a novel purine scaffold HSP90 inhibitor PU-H71 is via inhibition of both HSP90A and HSP90B1

<p>Abstract</p> <p>Background</p> <p>Heat shock protein 90 (HSP90) inhibitors have emerged as a promising class of anti-cancer drugs in both solid and hematologic malignancies. The HSP90 family includes the cytosolic HSP90 (HSP90AA1), the ER paralogue gp96 (HSP90B1) and the mitochondrial member TRAP1 (HSP90L). We evaluated the <it>in vitro </it>anti-tumor activity and mechanism of action of PU-H71, a novel purine scaffold HSP90 inhibitor in human multiple myeloma cell lines.</p> <p>Methods</p> <p>Multiple human myeloma cell lines including cells that are resistant to corticosteroids and bortezimab were treated with PU-H71, followed by analysis of cell viability, cell cycle progression and apoptosis, by flow cytometry and caspase 3 immunoblot. Induction of unfolded protein response was studied by XBP-1 s immunoblot. The role of gp96 was further assessed by small hairpin RNA knockdown of gp96 before treatment with PU-H71.</p> <p>Results</p> <p>PU-H71 has potent <it>in vitro </it>anti-myeloma activity in both drug-sensitive and drug-resistant cell lines. PU-H71 activates the unfolded protein response and induces caspase-dependent apoptosis. The stable gp96 knockdown human myeloma cell line was found to be more resistant to PU-H71 and other HSP90 inhibitors including 17-AAG and 17-DMAG, even though these cells are more sensitive to conventional anti-myeloma drugs.</p> <p>Conclusion</p> <p>We conclude that PU-H71 is a promising drug for the treatment of myeloma. Our finding further suggests that PU-H71 and the geldanamycin analogues work in part by inhibiting the endoplasmic reticulum gp96 along with the cytosolic HSP90.</p

FCNC Effects in a Minimal Theory of Fermion Masses

As a minimal theory of fermion masses we extend the SM by heavy vectorlike fermions, with flavor-anarchical Yukawa couplings, that mix with chiral fermions such that small SM Yukawa couplings arise from small mixing angles. This model can be regarded as an effective description of the fermionic sector of a large class of existing flavor models and thus might serve as a useful reference frame for a further understanding of flavor hierarchies in the SM. Already such a minimal framework gives rise to FCNC effects through exchange of massive SM bosons whose couplings to the light fermions get modified by the mixing. We derive general formulae for these corrections and discuss the bounds on the heavy fermion masses. Particularly stringent bounds, in a few TeV range, come from the corrections to the Z couplings.Comment: 19 pages, 1 figur

Low-cost, high-precision, single-frequency GPS–BDS RTK positioning

The integration of the Chinese BDS with other systems, such as the American GPS, makes precise RTK positioning possible with low-cost receivers. We investigate the performance of low-cost ublox receivers, which cost a few hundred USDs, while making use of L1 GPS + B1 BDS data in Dunedin, New Zealand. Comparisons will be made to L1 + L2 GPS and survey-grade receivers which cost several thousand USDs. The least-squares variance component estimation procedure is used to determine the code and phase variances and covariances of the receivers and thus formulate a realistic stochastic model. Otherwise, the ambiguity resolution and hence positioning performance would deteriorate. For the same reasons, the existence of receiver-induced time correlation is also investigated. The low-cost RTK performance is then evaluated by formal and empirical ambiguity success rates and positioning precisions. It will be shown that the code and phase precision of the low-cost receivers can be significantly improved by using survey-grade antennas, since they have better signal reception and multipath suppression abilities in comparison with low-cost patch antennas. It will also be demonstrated that the low-cost receivers can achieve competitive ambiguity resolution and positioning performance to survey-grade dual-frequency GPS receivers

An assessment of smartphone and low-cost multi-GNSS single-frequency RTK positioning for low, medium and high ionospheric disturbance periods

The emerging GNSSs make single-frequency (SF) RTK positioning possible. In this contribution two different types of low-cost (few hundred USDs) RTK receivers are analyzed, which can track L1 GPS, B1 BDS, E1 Galileo and L1 QZSS, or any combinations thereof, for a location in Dunedin, New Zealand. These SF RTK receivers can potentially give competitive ambiguity resolution and positioning performance to that of more expensive (thousands USDs) dual-frequency (DF) GPS receivers. A smartphone implementation of one of these SF receiver types is also evaluated. The least-squares variance component estimation (LS-VCE) procedure is first used to formulate a realistic stochastic model, which assures that our receivers at hand can achieve the best possible ambiguity resolution and RTK positioning performance. The best performing low-cost SF RTK receiver types are then assessed against DF GPS receivers and survey-grade antennas. Real data with ionospheric disturbances at low, medium and high levels are analyzed, while making use of the ionosphere-weighted model. It will be demonstrated that when the presence of the residual ionospheric delays increases, instantaneous RTK positioning is not possible for any of the receivers, and a multi-epoch model is necessary to use. It is finally shown that the low-cost SF RTK performance can remain competitive to that of more expensive DF GPS receivers even when the ionospheric disturbance level reaches a Kp-index of 7-, i.e. for a strong geomagnetic storm, for the baseline at hand

Asymptotic stability of solitary waves

We show that the family of solitary waves (1-solitons) of the Korteweg-de Vries equation is asymptotically stable. Our methods also apply for the solitary waves of a class of generalized Korteweg-de Vries equations, In particular, we study the case where f(u)=u p+1 / (p+1) , p =1, 2, 3 (and 30, with f ∈ C 4 ). The same asymptotic stability result for KdV is also proved for the case p =2 (the modified Korteweg-de Vries equation). We also prove asymptotic stability for the family of solitary waves for all but a finite number of values of p between 3 and 4. (The solitary waves are known to undergo a transition from stability to instability as the parameter p increases beyond the critical value p =4.) The solution is decomposed into a modulating solitary wave, with time-varying speed c(t) and phase γ( t ) ( bound state part ), and an infinite dimensional perturbation ( radiating part ). The perturbation is shown to decay exponentially in time, in a local sense relative to a frame moving with the solitary wave. As p →4 − , the local decay or radiation rate decreases due to the presence of a resonance pole associated with the linearized evolution equation for solitary wave perturbations.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46489/1/220_2005_Article_BF02101705.pd

Measurement of Branching Fractions of B0 Decays to K1(1270)+ pi- and K1(1400)+ pi-

We present a measurement of the branching fraction of neutral B meson decaying to final states containing a K1 meson, i.e. K{sub 1}(1270) and K{sub 1}(1400), and a charged pion. The data, collected with the BABAR detector at the Stanford Linear Accelerator Center, represent 454 million B{bar B} pairs produced in e{sup +}e{sup -} annihilation. We measure the branching fraction {Beta}(B{sup 0} {yields} K{sub 1}{sup +}{pi}{sup -}) = (31.0 {+-} 2.7 {+-} 6.9) x 10{sup -6}, where the first error quoted is statistical and the second is systematic. In the framework of the K-matrix formalism used to describe these decays, we also set limits on the ratio of the production constants for the K{sub 1}(1270){sup +} and K{sub 1}(1400){sup +} mesons in B{sup 0} decays

Improved Measurement of CP Observables in B- to D0_CP K- Decays

We present a study of the decay B{sup -} {yields} D{sub (CP)}{sup 0}K{sup -} and its charge conjugate, where D{sub (CP)}{sup 0} is reconstructed in both a non-CP flavor eigenstate and in CP (CP-even and CP-odd) eigenstates, based on a sample of 382 million {Upsilon}(4S) {yields} B{bar B} decays collected with the BABAR detector at the PEP-II e{sup +}e{sup -} storage ring. We measure the direct CP asymmetries A{sub CP{+-}} and the ratios of the branching fractions R{sub CP{+-}}: A{sub CP+} = 0.27 {+-} 0.09(stat) {+-} 0.04(syst), A{sub CP-} = -0.09 {+-} 0.09(stat) {+-} 0.02(syst), R{sub CP+} = 1.06 {+-} 0.10(stat) {+-} 0.05(syst), R{sub CP-} = 1.03 {+-} 0.10(stat) {+-} 0.05(syst). These results will help to better constrain the gamma phase parameter of the Cabibbo-Kobayashi-Maskawa quark mixing matrix

Amplitude Analysis of the Decay B0->K+pi-pi0

We report an updated amplitude analysis of the charmless hadronic decays of neutral B mesons to K{sup +} {pi}{sup -}{pi}{sup 0}. With a sample of 454 million {Upsilon}(4S) {yields} B{bar B} decays collected by the BABAR detector at the PEP-II asymmetric-energy B Factory at SLAC, we measure the magnitudes and phases of the intermediate resonant and nonresonant amplitudes for B{sup 0} and B{sup 0} decays and determine the corresponding CP-averaged fit fractions and charge asymmetries