PAL: the percussive audio lexicon. An approach to describing the features of percussion instruments and the sounds they produce

In music, the diversity of percussion instruments and the sounds they make is immense. There are millions of recordings in sound libraries, cataloguing the sounds of thousands of different instruments. Finding ways to effectively describe and label all of them is challenging. The Percussive Audio Lexicon provides a comprehensive and uniform vocabulary of over 2500 words and phrases, which users and creators of sound libraries can use to label and catalogue percussive sounds and instruments. It can also function as a tool for teaching music students about percussion. It is the only system of its kind in the world

Normal levels of prepulse inhibition in the euthymic phase of bipolar disorder

Background: Deficits in prepulse inhibition (PPI) of the acoustic startle response have been suggested as a potentially useful endophenotype for schizophrenia spectrum disorders and may explain certain symptoms and cognitive deficits observed in the psychoses. PPI deficits have also been found in mania, but it remains to be confirmed whether this dysfunction is present in the euthymic phase of bipolar disorder. Methods: Twenty-three adult patients with DSM-IV bipolar disorder were compared to 20 controls on tests of acoustic startle reactivity and PPI of the startle response. Sociodemographic and treatment variables were recorded and symptom scores assessed using the Hamilton Depression Inventory and the Young Mania Rating Scale. Results: Overall, the patient and control groups demonstrated similar levels of startle reactivity and PPI, although there was a trend for the inter-stimulus interval to differentially affect levels of PPI in the two groups. Conclusions: In contrast to bipolar patients experiencing a manic episode, general levels of PPI were normal in this euthymic sample. Further studies are required to confirm this finding and to determine the mechanisms by which this potential disruption/normalization occurs. It is suggested that an examination of PPI in a high-risk group is required to fully discount dysfunctional PPI as a potentially useful endophenotype for bipolar disorder

Additional file 1: of Communication interventions to promote the public’s awareness of antibiotics: a systematic review

Appendices A-D. Appendix A delineates the individualized search strategies for PubMed, Google Scholar, Embase, CINAHL, and Scopus. Appendix B includes article localization and article study design. Appendix C lists the antibiotic educational interventions and their associated articles. Appendix D is a table of coded intervention characteristics. (DOCX 141 kb

Additional file 3: of Metagenomic and metatranscriptomic analysis of human prostate microbiota from patients with prostate cancer

Comparison of bacterial composition between metagenome and metatranscriptome. (A) Venn diagram of bacterial genera identified by metagenome, metatranscriptome and the study by Yow et al. [13]. (B) The NMDS plot shows that the metagenomic and metatranscriptomic data could be clearly separated in terms of bacterial composition. Each dot represented a specimen. (TIF 217 kb

Additional file 5: of Metagenomic and metatranscriptomic analysis of human prostate microbiota from patients with prostate cancer

Detailed annotation and nucleotide sequences of the 10 bacterial genes that have the correlated expression profile with the eight small RNA genes. (XLSX 25 kb

Additional file 1: of Metagenomic and metatranscriptomic analysis of human prostate microbiota from patients with prostate cancer

Clinical pathological information of study cohort. (XLSX 14 kb

Additional file 2: of Metagenomic and metatranscriptomic analysis of human prostate microbiota from patients with prostate cancer

The number of raw and normalized reads for each taxonomic unit for both metagenome and metatranscriptome. (XLSX 337 kb

Additional file 4: of Metagenomic and metatranscriptomic analysis of human prostate microbiota from patients with prostate cancer

Prostatic virome. The heatmap represents the normalized read counts for the identified viruses. (TIF 236 kb

Legislative Documents

Also, variously referred to as: House bills; House documents; House legislative documents; legislative documents; General Court documents

Additional file 3: of Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury

Figure S1. In vivo selectivity of CPD-4645. Levels of inhibition of MAGL, ABHD6, and FAAH in the brain after 10 mg/kg subcutaneous dose of CPD-4645 at given tie point as determined by activity-based protein profiling using the pan-serine hydrolase probe FP-rhodamine. Full MAGL inhibition was normalized by effect seen at 2 h post-subcutaneous administration of 16 mg/kg JZL-184. (TIFF 1521 kb