A MODIFIED LOCKSET APPROACH FOR ENHANCING ROUTING EFFECTIVENESS

Productivity Analysis,

COST REDUCTION CONSIDERATIONS FOR PEDDLE-RUN DISTRIBUTION SYSTEMS

Emphasizes the importance of the awareness of visit frequency savings potential.Agribusiness,

A POSITIVE ROLE FOR GRADUATE AGRIBUSINESS PROGRAMS IN AGRICULTURAL ECONOMICS

Agribusiness graduate students should do problem-solving and take business courses to understand the environment in which they will practice their theory. The longer we wait to teach them application, the greater are the chances of losing our critical mass in terms of relevancy and political support. We can, and should, cultivate a broader range of agribusiness problems and clientele groups. We can effect change immediately by doing more agribusiness research. We can assure our long-run existence through a stronger political support base by educating our graduate students in the ways of firm-level agribusiness application.Agribusiness, Teaching/Communication/Extension/Profession,

THE RELATIONSHIP BETWEEN MANAGERIAL HEURISTICS AND ECONOMICS IN PRICING RETAIL MEATS

This study develops a theoretical model of the multiproduct firm which allows for imperfect competition in the output market. Hypotheses are tested for retail meat prices concerning the degree and speed of price transmission, the effects of interfirm competition, and the interrelationship between prices within the store. Empirical results indicated that meat prices within a store were highly interrelated. Further, the firm was found to be very responsive to prices of competitors in the short run, but more responsive to wholesale price changes in the long run.Demand and Price Analysis,

time points study

"December 2013.""A Thesis presented to the Faculty of the Graduate School at the University of Missouri In Partial Fulfillment of the Requirements for the Degree Master of Science."Thesis supervisor: Dr. Christian L. Lorson.Spinal muscular atrophy (SMA) is caused by the loss of a single gene, survival motor neuron-1 (SMN1), which results in the rapid deterioration of motor neuron integrity and function, most often leading to infantile death. Administration of self complementary adeno-associated virus expressing full-length SMN cDNA (scAAV-SMN) has proven an effective means to rescue the SMA phenotype in SMA mice, either by intravenous (IV) or intracerebroventricular (ICV) administration at very early time points. We have recently shown that ICV delivery of scAAV9- SMN is more effective than a similar dose of vector administered via an IV injection, thereby providing an important mechanism to examine a timeline for ameliorating the disease and determining the optimal therapeutic window. SMN[delta]7 mice were injected with scAAV9-SMN vector via ICV injection on a single day, from P2 through P8. At each delivery point from P2 through P7, scAAV9-SMN decreased disease severity, ranging from a near complete rescue (P2) to a significant, albeit lesser degree (P7) in which animals lived ̃130% longer. Our study demonstrates that a maximal benefit is obtained when treatment is delivered during a specified therapeutic window of the pre-symptomatic stages of SMA in the SMN[delta]7 mouse model. Although disease severity can be significantly decreased when SMN levels are increased at later stages of the disease, there is a time (after postnatal day 8) at which therapy is no longer effective.Includes bibliographical references (pages 57-66)

THE EFFECTS OF FIRM EXIT IN A RETAIL GROCERY MARKET

Agribusiness,

Pharmacologic inhibition of RGD-binding integrins ameliorates fibrosis and improves function following kidney injury

Fibrosis is a final common pathway for many causes of progressive chronic kidney disease (CKD). Arginine-glycine-aspartic acid (RGD)-binding integrins are important mediators of the pro-fibrotic response by activating latent TGF-β at sites of injury and by providing myofibroblasts information about the composition and stiffness of the extracellular matrix. Therefore, blockade of RGD-binding integrins may have therapeutic potential for CKD. To test this idea, we used small-molecule peptidomimetics that potently inhibit a subset of RGD-binding integrins in a murine model of kidney fibrosis. Acute kidney injury leading to fibrosis was induced by administration of aristolochic acid. Continuous subcutaneous administration of CWHM-12, an RGD integrin antagonist, for 28 days improved kidney function as measured by serum creatinine. CWHM-12 significantly reduced Collagen 1 (Col1a1) mRNA expression and scar collagen deposition in the kidney. Protein and gene expression markers of activated myofibroblasts, a major source of extracellular matrix deposition in kidney fibrosis, were diminished by treatment. RNA sequencing revealed that inhibition of RGD integrins influenced multiple pathways that determine the outcome of the response to injury and of repair processes. A second RGD integrin antagonist, CWHM-680, administered once daily by oral gavage was also effective in ameliorating fibrosis. We conclude that targeting RGD integrins with such small-molecule antagonists is a promising therapeutic approach in fibrotic kidney disease

The Ursinus Weekly, May 6, 1963

Report submitted by 1963-64 Women\u27s Customs Committee • Proctors named for coming year • Fred Yocum and Dr. Zucker to represent UC in June Y conference • Debating Club to present mock College Bowl • Douglas Steere to speak in expanded Forum Wednesday • Sophs & new frosh receive required Summer reading • Spring Festival weekend May 10-11; The staring match begins activities • Dr. Wagner plied by students in 3rd Controversy • Bob Larzelere elected to head Men\u27s Customs next year • Tibetan lamas to visit Ursinus • Letters to the editor • It\u27s all over • Greek gleanings • Whistlestops final step in Spring rushing • Pre-med society hears Dr. Cochran • Mike Bernstein receives honors • Nominations made for class officers • UC Band concert scheduled May 11 • Pre-med elections this week • Cheerleaders name squad members • Meistersingers performance superb • WSGA meeting • Bears out-poll Diplomats 10-4; Deep-freeze, rain dissolve E-Town • Wilkes stuns UC\u27s chances 2-1 • UC downs WC in lacrosse, 10-4 • Netmen conquer Drexel and PMC • Favored Drexel smashed by UC golf club • Cindermen raise season record 6-1 • Haverford defeats UC golf teamhttps://digitalcommons.ursinus.edu/weekly/1295/thumbnail.jp

Content and Methods of Teaching Literacy: The Effect of One-on-One Tutoring in Preservice Clinical Education in Two Low-Performing, Diverse School Settings on the Effectiveness of Preservice Teachers’ Reading Instruction

This is a study of preservice teachers’ ability to teach reading to struggling, diverse students, after participating in a school-embedded course incorporating a one-on-one tutorial directly supervised by reading experts. Changes in reading performance as well as plans to analyze changes in the preservice teachers will be discussed

Mammals of Fort Leavenworth, Kansas: a 60-year followup to Brumwell (1951)

More than 60 years have elapsed since Brumwell\u27s (1951) comprehensive assessment during 193911940 of resident terrestrial vertebrates from Fort Leavenworth Military Rooervation in northeastern Kansas. Subsequent studies have been accomplished for the amphibians, reptiles, and birds. Our study is the first to assess intervening changes in the mammalian composition of this diverse local fauna. Notable observations include: the decline or extirpation of the black-tailed jackrabbit (Lepus californicus), Franklin\u27s ground squirrel (Spermophilus franklinii), muskrat (Ondatra zibethicus), long-tailed weasel (Mustela frenata) and eastern spotted skunk (Spilogale putorius); the return or recovery of locally extirpated gray fox (Urocyon cinereoargenteus), puma (Puma concolor), and white-tailed deer (Odocoileus virginianus), the increases of the once uncommon eastern chipmunk (Tamias striatus) and striped skunk (Mephitis mephitis), the invasion and establishment of the hispid cotton rat (Sigmodon hispidus), and the displacement of the eastern fox squirrel (Sciurus niger) by the eastern gray squirrel (S. carolinensis) as the most common squirrel. Documented species either not mentioned by Brumwell (1951) or listed by him as hypothetically occurring on the post, included northern myotis (Myotis septentrionalis), eastern pipistrelle (Pipistrellus subflavus), evening bat (Nycticeius humeralis), southern bog lemming (Synaptomys cooperi), and meadow jumping mouse (Zapus hudsonius)