A note on Dolby and Gull on radar time and the twin "paradox"

Recently a suggestion has been made that standard textbook representations of hypersurfaces of simultaneity for the travelling twin in the twin "paradox" are incorrect. This suggestion is false: the standard textbooks are in agreement with a proper understanding of the relativity of simultaneity.Comment: LaTeX, 3 pages, 2 figures. Update: added new section V and updated reference

Photometric Monitoring of the Gravitationally Lensed Ultraluminous BAL Quasar APM08279+5255

We report on one year of photometric monitoring of the ultraluminous BAL quasar APM 08279+5255. The temporal sampling reveals that this gravitationally lensed system has brightened by ~0.2 mag in 100 days. Two potential causes present themselves; either the variability is intrinsic to the quasar, or it is the result of microlensing by stars in a foreground system. The data is consistent with both hypotheses and further monitoring is required before either case can be conclusively confirmed. We demonstrate, however, that gravitational microlensing can not play a dominant role in explaining the phenomenal properties exhibited by APM 08279+5255. The identification of intrinsic variability, coupled with the simple gravitational lensing configuration, would suggest that APM 08279+5255 is a potential golden lens from which the cosmological parameters can be derived and is worthy of a monitoring program at high spatial resolution.Comment: 17 pages, with 2 figures. Accepted for publication in P.A.S.

Restrictive antibiotic stewardship associated with reduced hospital mortality in gram-negative infection

Introduction: Antimicrobial stewardship has an important role in the control of Clostridium difficile infection (CDI) and antibiotic resistance. An important component of UK stewardship interventions is the restriction of broad-spectrum beta-lactam antibiotics and promotion of agents associated with a lower risk of CDI such as gentamicin. Whilst the introduction of restrictive antibiotic guidance has been associated with improvements in CDI and antimicrobial resistance evidence of the effect on outcome following severe infection is lacking. Methods: In 2008, Glasgow hospitals introduced a restrictive antibiotic guideline. A retrospective before/after study assessed outcome following gram-negative bacteraemia in the 2-year period around implementation. Results: Introduction of restrictive antibiotic guidelines was associated with a reduction in utilisation of ceftriaxone and co-amoxiclav and an increase in amoxicillin and gentamicin. 1593 episodes of bacteraemia were included in the study. The mortality over 1 year following gram-negative bacteraemia was lower in the period following guideline implementation (RR 0.852, P = 0.045). There was no evidence of a difference in secondary outcomes including ITU admission, length of stay, readmission, recurrence of bacteraemia and need for renal replacement therapy. There was a fall in CDI (RR 0.571, P = 0.014) and a reduction in bacterial resistance to ceftriaxone and co-amoxiclav but no evidence of an increase in gentamicin resistance after guideline implementation. Conclusion: Restrictive antibiotic guidelines were associated with a reduction in CDI and bacterial resistance but no evidence of adverse outcomes following gram-negative bacteraemia. There was a small reduction in one year mortality

Optical pattern formation with a 2-level nonlinearity

We present an experimental and theoretical investigation of spontaneous pattern formation in the transverse section of a single retro-reflected laser beam passing through a cloud of cold Rubidium atoms. In contrast to previously investigated systems, the nonlinearity at work here is that of a 2-level atom, which realizes the paradigmatic situation considered in many theoretical studies of optical pattern formation. In particular, we are able to observe the disappearance of the patterns at high intensity due to the intrinsic saturable character of 2-level atomic transitions.Comment: 5 pages, 4 figure

Effects of Footstrike Pattern on Low Back Posture, Shock Attenuation, and Comfort During Running

Purpose: Barefoot running (BF) is popular in the running community. Biomechanical changes occur with BF, especially when initial contact changes from rearfoot strike (RFS) to forefoot strike (FFS). In addition, changes in lumbar spine range of motion (ROM), particularly involving lumbar lordosis, have been associated with increased low back pain (LBP). However it is not known how changing from RFS to FFS affects lumbar lordosis or LBP. Thus, the purpose of this study was to determine if a change from RFS to FFS would change lumbar lordosis, and/or decrease shock attenuation, and/or change comfort levels in healthy recreational/experienced runners. Methods: Forty-three subjects performed a warm up on the treadmill where a self-selected footstrike pattern was determined. Instructions on running RFS/FFS were taught and two conditions were examined. Each condition consisted of 90 s of BF with RFS or FFS; order randomly assigned. A comfort questionnaire was completed after both conditions. Fifteen consecutive strides from each condition were extracted for analyses. Results: Statistically significant differences between FFS and RFS shock attenuation (p Conclusion: Change in footstrike from RFS to FFS decreased overall ROM in the lumbar spine but did not make a difference in flexion or extension in which the lumbar spine is positioned. Shock attenuation was greater in RFS. RFS was perceived a more comfortable running pattern

Chaotic resonances of a Bose-Einstein condensate in a cavity pumped by a modulated optical field

We present a theoretical analysis of a Bose-Einstein condensate (BEC) enclosed in an optical cavity driven by a modulated external laser beam where the cavity-field variable is adiabatically eliminated. The modulation of the amplitude of the pump laser induces nonlinear resonances and the widespread presence of chaotic oscillations even when repulsive atom-atom interactions are negligible. Close to resonance, varying the modulation amplitude by just a few percent causes abrupt and erratic changes to the output laser intensity with peak power increasing by almost an order of magnitude. We also use a simplified model of the BEC-cavity system that considers only a small number of spatial modes of the BEC to show that, despite the disruptive presence of a modulation in the pump beam, the system can still be considered to be low-dimensional

Investigating magnetic activity in very stable stellar magnetic fields: long-term photometric and spectroscopic study of the fully convective M4 dwarf V374 Peg

The ultrafast-rotating ($P_\mathrm{rot}\approx0.44 d$) fully convective single M4 dwarf V374 Peg is a well-known laboratory for studying intense stellar activity in a stable magnetic topology. As an observable proxy for the stellar magnetic field, we study the stability of the light curve, and thus the spot configuration. We also measure the occurrence rate of flares and coronal mass ejections (CMEs). We analyse spectroscopic observations, $BV(RI)_C$ photometry covering 5 years, and additional $R_C$ photometry that expands the temporal base over 16 years. The light curve suggests an almost rigid-body rotation, and a spot configuration that is stable over about 16 years, confirming the previous indications of a very stable magnetic field. We observed small changes on a nightly timescale, and frequent flaring, including a possible sympathetic flare. The strongest flares seem to be more concentrated around the phase where the light curve indicates a smaller active region. Spectral data suggest a complex CME with falling-back and re-ejected material, with a maximal projected velocity of $\approx$675km/s. We observed a CME rate much lower than expected from extrapolations of the solar flare-CME relation to active stars.Comment: 15 figures, 4 tables, accepted for publication in A&

Measurement and feedback for cooling heavy levitated particles in low-frequency traps

We consider a possible route to ground-state cooling of a levitated nanoparticle, magnetically trapped by a strong permanent magnet, using a combination of measurement and feedback. The trap frequency of this system is much lower than those involving trapped ions or nanomechanical resonators. Minimization of environmental heating is therefore challenging as it requires control of the system on a timescale comparable to the inverse of the trap frequency. We show that these traps are an excellent platform for performing optimal feedback control via real-time state estimation, for the preparation of motional states with measurable quantum properties

Defining epitope coverage requirements for T cell-based HIV vaccines: Theoretical considerations and practical applications

<p>Abstract</p> <p>Background</p> <p>HIV vaccine development must address the genetic diversity and plasticity of the virus that permits the presentation of diverse genetic forms to the immune system and subsequent escape from immune pressure. Assessment of potential HIV strain coverage by candidate T cell-based vaccines (whether natural sequence or computationally optimized products) is now a critical component in interpreting candidate vaccine suitability.</p> <p>Methods</p> <p>We have utilized an N-mer identity algorithm to represent T cell epitopes and explore potential coverage of the global HIV pandemic using natural sequences derived from candidate HIV vaccines. Breadth (the number of T cell epitopes generated) and depth (the variant coverage within a T cell epitope) analyses have been incorporated into the model to explore vaccine coverage requirements in terms of the number of discrete T cell epitopes generated.</p> <p>Results</p> <p>We show that when multiple epitope generation by a vaccine product is considered a far more nuanced appraisal of the potential HIV strain coverage of the vaccine product emerges. By considering epitope breadth and depth several important observations were made: (1) epitope breadth requirements to reach particular levels of vaccine coverage, even for natural sequence-based vaccine products is not necessarily an intractable problem for the immune system; (2) increasing the valency (number of T cell epitope variants present) of vaccine products dramatically decreases the epitope requirements to reach particular coverage levels for any epidemic; (3) considering multiple-hit models (more than one exact epitope match with an incoming HIV strain) places a significantly higher requirement upon epitope breadth in order to reach a given level of coverage, to the point where low valency natural sequence based products would not practically be able to generate sufficient epitopes.</p> <p>Conclusions</p> <p>When HIV vaccine sequences are compared against datasets of potential incoming viruses important metrics such as the minimum epitope count required to reach a desired level of coverage can be easily calculated. We propose that such analyses can be applied early in the planning stages and during the execution phase of a vaccine trial to explore theoretical and empirical suitability of a vaccine product to a particular epidemic setting.</p

Quantum SASE FEL with a laser wiggler

Quantum effects in high-gain FELs are ruled by the quantum FEL parameter, \u3c1 = pmcy/hkr, which is the ratio between the momentum spread at saturation and the one photon momentum recoil. It has been shown that when 3c\u3c1 64 1 the spectrum of the emitted radiation changes from the broad continuous and chaotic spectrum of the classical regime to a series of discrete and equally spaced very narrow lines, due to transitions between discrete momentum states. In this paper we show that the quantum regime can be achieved using Kilometers long magnetic wigglers or a laser wiggler. In this paper we state the scaling laws necessary to operate a Quantum SASE FEL in the Angstrom region with a laser wiggler. Specific example is given having in mind a high power Ti: Sa laser wiggler at \u3bb= 0.8 \u3bcm, in construction at LNF-INFN Laboratories, for the SPARC/PLASMON-X project