Observation of magnetocoriolis waves in a liquid metal Taylor-Couette experiment

The first observation of fast and slow magnetocoriolis (MC) waves in a laboratory experiment is reported. Rotating nonaxisymmetric modes arising from a magnetized turbulent Taylor-Couette flow of liquid metal are identified as the fast and slow MC waves by the dependence of the rotation frequency on the applied field strength. The observed slow MC wave is damped but the observation provides a means for predicting the onset of the Magnetorotational Instability

Phase I study of dose escalation to dominant intraprostatic lesions using high-dose-rate brachytherapy.

PurposeRadiation dose escalation for prostate cancer improves biochemical control but is limited by toxicity. Magnetic resonance spectroscopic imaging (MRSI) can define dominant intraprostatic lesions (DIL). This phase I study evaluated dose escalation to MRSI-defined DIL using high-dose-rate (HDR) brachytherapy.Material and methodsEnrollment was closed early due to low accrual. Ten patients with prostate cancer (T2a-3b, Gleason 6-9, PSA < 20) underwent pre-treatment MRSI, and eight patients had one to three DIL identified. The eight enrolled patients received external beam radiation therapy to 45 Gy and HDR brachytherapy boost to the prostate of 19 Gy in 2 fractions. MRSI images were registered to planning CT images and DIL dose-escalated up to 150% of prescription dose while maintaining normal tissue constraints. The primary endpoint was genitourinary (GU) toxicity.ResultsThe median total DIL volume was 1.31 ml (range, 0.67-6.33 ml). Median DIL boost was 130% of prescription dose (range, 110-150%). Median urethra V120 was 0.15 ml (range, 0-0.4 ml) and median rectum V75 was 0.74 ml (range, 0.1-1.0 ml). Three patients had acute grade 2 GU toxicity, and two patients had late grade 2 GU toxicity. No patients had grade 2 or higher gastrointestinal toxicity, and no grade 3 or higher toxicities were noted. There were no biochemical failures with median follow-up of 4.9 years (range, 2-8.5 years).ConclusionsDose escalation to MRSI-defined DIL is feasible. Toxicity was low but incompletely assessed due to limited patients' enrollment

Integral Equations for Heat Kernel in Compound Media

By making use of the potentials of the heat conduction equation the integral equations are derived which determine the heat kernel for the Laplace operator $-a^2\Delta$ in the case of compound media. In each of the media the parameter $a^2$ acquires a certain constant value. At the interface of the media the conditions are imposed which demand the continuity of the `temperature' and the `heat flows'. The integration in the equations is spread out only over the interface of the media. As a result the dimension of the initial problem is reduced by 1. The perturbation series for the integral equations derived are nothing else as the multiple scattering expansions for the relevant heat kernels. Thus a rigorous derivation of these expansions is given. In the one dimensional case the integral equations at hand are solved explicitly (Abel equations) and the exact expressions for the regarding heat kernels are obtained for diverse matching conditions. Derivation of the asymptotic expansion of the integrated heat kernel for a compound media is considered by making use of the perturbation series for the integral equations obtained. The method proposed is also applicable to the configurations when the same medium is divided, by a smooth compact surface, into internal and external regions, or when only the region inside (or outside) this surface is considered with appropriate boundary conditions.Comment: 26 pages, no figures, no tables, REVTeX4; two items are added into the Reference List; a new section is added, a version that will be published in J. Math. Phy

A quantum mechanical description of the experiment on the observation of gravitationally bound states

Quantum states in the Earth's gravitational field were observed, when ultra-cold neutrons fall under gravity. The experimental results can be described by the quantum mechanical scattering model as it is presented here. We also discuss other geometries of the experimental setup which correspond to the absence or the reversion of gravity. Since our quantum mechanical model describes, particularly, the experimentally realized situation of reversed gravity quantitatively, we can practically rule out alternative explanations of the quantum states in terms of pure confinement effects.Comment: LaTeX, 10 pages, 4 figures, v2: references adde

Understanding the effect of sheared flow on microinstabilities

The competition between the drive and stabilization of plasma microinstabilities by sheared flow is investigated, focusing on the ion temperature gradient mode. Using a twisting mode representation in sheared slab geometry, the characteristic equations have been formulated for a dissipative fluid model, developed rigorously from the gyrokinetic equation. They clearly show that perpendicular flow shear convects perturbations along the field at a speed we denote by $Mc_s$ (where $c_s$ is the sound speed), whilst parallel flow shear enters as an instability driving term analogous to the usual temperature and density gradient effects. For sufficiently strong perpendicular flow shear, $M >1$, the propagation of the system characteristics is unidirectional and no unstable eigenmodes may form. Perturbations are swept along the field, to be ultimately dissipated as they are sheared ever more strongly. Numerical studies of the equations also reveal the existence of stable regions when $M < 1$, where the driving terms conflict. However, in both cases transitory perturbations exist, which could attain substantial amplitudes before decaying. Indeed, for $M \gg 1$, they are shown to exponentiate $\sqrt{M}$ times. This may provide a subcritical route to turbulence in tokamaks.Comment: minor revisions; accepted to PPC

Anomaly in the stability limit of liquid helium 3

We propose that the liquid-gas spinodal line of helium 3 reaches a minimum at 0.4 K. This feature is supported by our cavitation measurements. We also show that it is consistent with extrapolations of sound velocity measurements. Speedy [J. Phys. Chem. 86, 3002 (1982)] previously proposed this peculiar behavior for the spinodal of water and related it to a change in sign of the expansion coefficient alpha, i. e. a line of density maxima. Helium 3 exhibits such a line at positive pressure. We consider its extrapolation to negative pressure. Our discussion raises fundamental questions about the sign of alpha in a Fermi liquid along its spinodal.Comment: 5 pages, 3 figure

Quantum statistics of atoms in microstructures

This paper proposes groove-like potential structures for the observation of quantum information processing by trapped particles. As an illustration the effect of quantum statistics at a 50-50 beam splitter is investigated. For non-interacting particles we regain the results known from photon experiments, but we have found that particle interactions destroy the perfect bosonic correlations. Fermions avoid each other due to the exclusion principle and hence they are far less sensitive to particle interactions. For bosons, the behavior can be explained with simple analytic considerations which predict a certain amount of universality. This is verified by detailed numerical calculations.Comment: 18 pages incl. 13 figure

Measurement and physical interpretation of the mean motion of turbulent density patterns detected by the BES system on MAST

The mean motion of turbulent patterns detected by a two-dimensional (2D) beam emission spectroscopy (BES) diagnostic on the Mega Amp Spherical Tokamak (MAST) is determined using a cross-correlation time delay (CCTD) method. Statistical reliability of the method is studied by means of synthetic data analysis. The experimental measurements on MAST indicate that the apparent mean poloidal motion of the turbulent density patterns in the lab frame arises because the longest correlation direction of the patterns (parallel to the local background magnetic fields) is not parallel to the direction of the fastest mean plasma flows (usually toroidal when strong neutral beam injection is present). The experimental measurements are consistent with the mean motion of plasma being toroidal. The sum of all other contributions (mean poloidal plasma flow, phase velocity of the density patterns in the plasma frame, non-linear effects, etc.) to the apparent mean poloidal velocity of the density patterns is found to be negligible. These results hold in all investigated L-mode, H-mode and internal transport barrier (ITB) discharges. The one exception is a high-poloidal-beta (the ratio of the plasma pressure to the poloidal magnetic field energy density) discharge, where a large magnetic island exists. In this case BES detects very little motion. This effect is currently theoretically unexplained.Comment: 28 pages, 15 figures, submitted to PPC

Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites

The role of DNA methylation in the regulation of catabolic genes such as MMP13 and IL1B, which have sparse CpG islands, is poorly understood in the context of musculoskeletal diseases. We report that demethylation of specific CpG sites at -110 bp and -299 bp of the proximal MMP13 and IL1B promoters, respectively, detected by in situ methylation analysis of chondrocytes obtained directly from human cartilage, strongly correlated with higher levels of gene expression. The methylation status of these sites had a significant impact on promoter activities in chondrocytes, as revealed in transfection experiments with site-directed CpG mutants in a CpG-free luciferase reporter. Methylation of the -110 and -299 CpG sites, which reside within a hypoxia-inducible factor (HIF) consensus motif in the respective MMP13 and IL1B promoters, produced the most marked suppression of their transcriptional activities. Methylation of the -110 bp CpG site in the MMP13 promoter inhibited its HIF-2alpha-driven transactivation and decreased HIF-2alpha binding to the MMP13 proximal promoter in chromatin immunoprecipitation assays. In contrast to HIF-2alpha, MMP13 transcriptional regulation by other positive (RUNX2, AP-1, ELF3) and negative (Sp1, GATA1, and USF1) factors was not affected by methylation status. However, unlike the MMP13 promoter, IL1B was not susceptible to HIF-2alpha transactivation, indicating that the -299 CpG site in the IL1B promoter must interact with other transcription factors to modulate IL1B transcriptional activity. Taken together, our data reveal that the methylation of different CpG sites in the proximal promoters of the human MMP13 and IL1B genes modulates their transcription by distinct mechanisms

Mortality on Mount Everest, 1921-2006: descriptive study

Objective To examine patterns of mortality among climbers on Mount Everest over an 86 year period