One Hundred Years Later: Stern-Gerlach Experiment and Dimension Witnesses

Inspired by the one-hundredth anniversary of the seminal works of Stern and Gerlach, our contribution is a proposal of how to use their famous experiment in a more contemporary perspective. Our main idea is to re-cast the experiment in the modern language of prepare-and-measure scenarios. By doing so, it is possible to connect geometric and algebraic aspects of the space of states with the physical space. We also discuss possible simulations of the SG experiment as well as some experimental properties of the experiment revealed at the statistical level. Merging a more modern perspective with a paradigmatic experiment, we hope this paper can serve as an entry door for quantum information theory and the foundations of quantum mechanics.Comment: 23 pages, 6 figures. Minor adjustments, according to referee suggestion

A Contribution on the Modelling of Wire Electrical Discharge Machining of a γ-TiAl Alloy

AbstractWire electrical discharge machining (WEDM) is a manufacturing process suitable for high-precision cutting of complex and irregular shapes through difficult-to-machine electrically conductive components. In recent years, wire EDM has become a key non-traditional machining process, widely used in the aerospace and automotive industry. Although this technology has been broadly investigated, literature is still limited on the use of wire EDM for intermetallic alloys, and the applications on gamma titanium aluminides are rather unexplored. Such materials are attracting considerable interest due to the outstanding combination of properties, and they have proved to be eligible for thermo-mechanically stressed parts of aeroengines. Nevertheless, the poor machinability of gamma titanium aluminides has been reported in conventional (i.e. turning, milling, and drilling) and non-conventional machining, such as ECM. Further, machinability results strictly depend on the chemical composition of the specific alloy. This paper investigates the interactions between common process parameters of WEDM and final quality of the generated surface, through analysis of variance (ANOVA) and regression models based on experimental results. In particular, the paper is focused on the effects of pulse on time, pulse off time, servo-reference voltage, and wire tension on the surface finish during the WEDM of a Ti-48Al-2Cr-2Nb (at. %) γ-TiAl alloy. Results are discussed and compared with reference to the models available in literature

. Microwave-assisted solvothermal controlled synthesis of Fe-Co

Syntheses of bimetallic cobalt-iron-based nanoparticles starting from Co(acac)2 and Fe(acac)3 (acac = acetylacetonate) were carried out by microwave-assisted solvothermal process, using ethylene glycol as the solvent and (polyvinylpyrrolidone) PVP, as the stabilizer. Indeed, the reaction mechanism in the presence of ethylene glycol is well understood [1] with the role of PVP being the inhibition of nanoparticles growth [2]. However, the control of the morphology of the synthetized nanoparticles is still a great challenge. Herein, we demonstrated that by adding amines to the reaction mixture, it is possible to control the morphology of the prepared bimetallic cobalt-iron materials. Thus, different Co-Fe micro-composites were synthetized by an innovative microwave assisted solvothermal synthesis, which allows to considerably reduce reaction time from 12 h to 15 min, with respect to classical thermal methods. The procedure was optimized by varying several parameters, such as: amount of PVP, in the presence or in the absence of amines, reaction temperature. The dark brown obtained powders were characterized by scanning electron microscopy, infrared spectroscopy and thermogravimetric analysis, confirming the beneficial effect of the presence of the amine in the morphology of the obtained composites. The obtained results open a new scenario for further studies on the possibility to control the morphology of bimetallic composite materials. [1] Fievet F, Lagier J P and Figlarz M Mater. Res. Soc. Bull. 24 (1989) 29–34 [2] Teranishi T, Kurita R and Miyake M J. Inorg. Organometall. Polym. 10 (2000) 145–5

New "Green" approaches to the synthesis of pyrazole derivatives.

A novel approach to the synthesis of pyrazole derivatives from tosylhydrazones of alpha,beta-unsaturated carbonyl compounds possessing a beta-hydrogen is proposed, exploiting microwave (MW) activation coupled with solvent free reaction conditions. The cycloaddition was studied on three ketones (trans-4-phenyl-3-buten-2-one, beta-ionone and trans-chalcone). The corresponding 3,5-disubstituted-1H-pyrazoles were obtained in high yields and after short reaction times. In order to simplify and point out the green chemistry features of the method, a further improvement was achieved under the same catalytic conditions with a "one pot" synthesis of these heterocyclic compounds, starting directly from their carbonyl precursors via tosylhydrazones generated in situ. For an exhaustive study, the dielectric properties of the solid reaction mixtures were also measured, in order to obtain input data for the numerical simulation of their heating behaviour in the single mode MW cavity which was used for experimental work. In order to supply a valid methodology and tool for measuring the environmental impact, a comparative study between the synthetic route proposed and the classical synthetic route has been carried out

Human enzyme PADI4 binds to the nuclear carrier Importin a3

PADI4 is a peptidyl-arginine deiminase (PADI) involved in the conversion of arginine to citrulline. PADI4 is present in macrophages, monocytes, granulocytes, and several cancer cells. It is the only PADI family member observed within both the nucleus and the cytoplasm. PADI4 has a predicted nuclear localization sequence (NLS) comprising residues Pro56 to Ser83, to allow for nuclear translocation. Recent predictors also suggest that the region Arg495 to Ile526 is a possible NLS. To understand how PADI4 is involved in cancer, we studied the ability of intact PADI4 to bind importin a3 (Impa3), a nuclear transport factor that plays tumor-promoting roles in several cancers, and its truncated species (¿Impa3) without the importin-binding domain (IBB), by using fluorescence, circular dichroism (CD), and isothermal titration calorimetry (ITC). Furthermore, the binding of two peptides, encompassing the first and the second NLS regions, was also studied using the same methods and molecular docking simulations. PADI4 interacted with both importin species, with affinity constants of ~1–5 µM. The isolated peptides also interacted with both importins. The molecular simulations predict that the anchoring of both peptides takes place in the major binding site of Impa3 for the NLS of cargo proteins. These findings suggest that both NLS regions were essentially responsible for the binding of PADI4 to the two importin species. Our data are discussed within the framework of a cell mechanism of nuclear transport that is crucial in cancer

3D simulations of a neon burning convective shell in a massive star

© 2024 The Author(s). Published by Oxford University Press on behalf of Royal Astronomical Society. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/The treatment of convection remains a major weakness in the modelling of stellar evolution with one-dimensional (1D) codes. The ever-increasing computing power makes now possible to simulate in three-dimensional (3D) part of a star for a fraction of its life, allowing us to study the full complexity of convective zones with hydrodynamics codes. Here, we performed state-of-the-art hydrodynamics simulations of turbulence in a neon-burning convective zone, during the late stage of the life of a massive star. We produced a set of simulations varying the resolution of the computing domain (from 1283 to 10243 cells) and the efficiency of the nuclear reactions (by boosting the energy generation rate from nominal to a factor of 1000). We analysed our results by the mean of Fourier transform of the velocity field, and mean-field decomposition of the various transport equations. Our results are in line with previous studies, showing that the behaviour of the bulk of the convective zone is already well captured at a relatively low resolution (2563), while the details of the convective boundaries require higher resolutions. The different boosting factors used show how various quantities (velocity, buoyancy, abundances, and abundance variances) depend on the energy generation rate. We found that for low boosting factors, convective zones are well mixed, validating the approach usually used in 1D stellar evolution codes. However, when nuclear burning and turbulent transport occur on the same time-scale, a more sophisticated treatment would be needed. This is typically the case when shell mergers occur.Peer reviewe

Shell mergers in the late stages of massive star evolution: new insight from 3D hydrodynamic simulations

© 2024 The Author(s). Published by Oxford University Press on behalf of Royal Astronomical Society. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/One-dimensional (1D) stellar evolution models are widely used across various astrophysical fields, however they are still dominated by important uncertainties that deeply affect their predictive power. Among those, the merging of independent convective regions is a poorly understood phenomenon predicted by some 1D models but whose occurrence and impact in real stars remain very uncertain. Being an intrinsically multi-D phenomenon, it is challenging to predict the exact behaviour of shell mergers with 1D models. In this work, we conduct a detailed investigation of a multiple shell merging event in a 20 M☉ star using 3D hydrodynamic simulations. Making use of the active tracers for composition and the nuclear network included in the 3D model, we study the merging not only from a dynamical standpoint but also considering its nucleosynthesis and energy generation. Our simulations confirm the occurrence of the merging also in 3D, but reveal significant differences from the 1D case. Specifically, we identify entrainment and the erosion of stable regions as the main mechanisms that drive the merging, we predict much faster convective velocities compared to the mixing-length theory velocities, and observe multiple burning phases within the same merged shell, with important effects for the chemical composition of the star, which presents a strongly asymmetric (dipolar) distribution. We expect that these differences will have important effects on the final structure of massive stars and thus their final collapse dynamics and possible supernova explosion, subsequently affecting the resulting nucleosynthesis and remnant.Peer reviewe

Polyacetylenes Bearing Chiral-Substituted Fluorene and Terfluorene Pendant Groups: Synthesis and Properties

The synthesis of the first polyacetylenes bearing chiral fluorene-based pendant groups is described. Poly{9,9-bis[(S)-3,7-dimethyloctyl]fluoren-2-ylacetylene} (PFA1), poly{9,9-bis[(S)-2-methylbutyl]- fluoren-2-ylacetylene} (PFA2), and poly{9,9,9′,9′,9′′,9′′-hexakis[(S)-2-methylbutyl]-7,2′;7′,2′′-terfluoren- 2-ylacetylene} (PFA3) have been obtained by Rh(I)-catalyzed polymerization of the corresponding terminal acetylene monomers 2-ethynyl-9,9-bis[(S)-3,7-dimethyloctyl]fluorene (2a), 2-ethynyl-9,9-bis[(S)-2-methylbutyl]fluorene (2b), and 2-ethynyl-9,9,9′,9′,9′′,9′′-hexakis[(S)-2-methylbutyl]-7,2′;7′,2′′-terfluorene (10). The effect of the alkyl chain length at the C-9 position of fluorene on the structural and conformational aspects of the polymers PFA1 and PFA2 as well as on their chiroptical properties was studied by XRD, DSC, TGA, GPC, UV-vis, and CD. A more planar conformation of the polyenic backbone of PFA1 with respect to PFA2 can be inferred by a red shift of the ð-ð* transition in the UV-vis spectra. Their photoluminescence properties are those typical of fluorene systems. CD measurements evidenced Cotton effects of opposite signs in correspondence of the backbone absorption region, ascribable to an excess of a screw sense of the helical conformations assumed by the two polymers. PFA3 revealed an amorphous structure and exhibited peculiar thermal stability features (as indicated by TGA and DSC). Its emission spectra interest the violet-blue region and do not show any substantial red shift passing from solution to solid state, thus pointing out an aggregation prevention of terfluorene groups by means of the polyacetylene backbone