Challenges of modern capitalism

The future of the U.S. market economy may well be determined by how we resolve three dilemmas: rising income inequality; improving our business culture; and providing important public services.Capitalism

Targeting urban revitalization

A movement to focus public improvement efforts on neighborhoods with the greatest potential to spread the benefits is gaining adherents. Former Federal Reserve Board vice chairman Alice Rivlin discusses her recent research into targeting.Community development

Systematic Analysis of Defense Issues: The Role of the Congress

In a representative democracy, national security decisions are necessarily political. The subject of this paper is the role of systematic analysis in raising the level of that political debate, especially in the Congress

Annotating Synapses in Large EM Datasets

Reconstructing neuronal circuits at the level of synapses is a central problem in neuroscience and becoming a focus of the emerging field of connectomics. To date, electron microscopy (EM) is the most proven technique for identifying and quantifying synaptic connections. As advances in EM make acquiring larger datasets possible, subsequent manual synapse identification ({\em i.e.}, proofreading) for deciphering a connectome becomes a major time bottleneck. Here we introduce a large-scale, high-throughput, and semi-automated methodology to efficiently identify synapses. We successfully applied our methodology to the Drosophila medulla optic lobe, annotating many more synapses than previous connectome efforts. Our approaches are extensible and will make the often complicated process of synapse identification accessible to a wider-community of potential proofreaders

Prevention of suicidal behaviour in prisons: an overview of initiatives based on a systematic review of research on near-lethal suicide attempts

Background: Worldwide, prisoners are at high risk of suicide. Research on near-lethal suicide attempts can provide important insights into risk and protective factors, and inform suicide prevention initiatives in prison. Aims: To synthesize findings of research on near-lethal attempts in prisons, and consider their implications for suicide prevention policies and practice, in the context of other research in custody and other settings. Method: We searched two bibliographic indexes for studies in any language on near-lethal and severe self-harm in prisoners, supplemented by targeted searches over the period 2000–2014. We extracted information on risk factors descriptively. Data were not meta-analyzed owing to heterogeneity of samples and methods. Results: We identified eight studies reporting associations between prisoner near-lethal attempts and specific factors. The latter included historical, prison-related, and clinical factors, including psychiatric morbidity and comorbidity, trauma, social isolation, and bullying. These factors were also identified as important in prisoners' own accounts of what may have contributed to their attempts (presented in four studies). Conclusion: Factors associated with prisoners' severe suicide attempts include a range of potentially modifiable clinical, psychosocial, and environmental factors. We make recommendations to address these factors in order to improve detection, management, and prevention of suicide risk in prisoners

Colonoscopy Coverage Revisited: Identifying Scanning Gaps in Real-Time

Colonoscopy is the most widely used medical technique for preventing Colorectal Cancer, by detecting and removing polyps before they become malignant. Recent studies show that around one quarter of the existing polyps are routinely missed. While some of these do appear in the endoscopist's field of view, others are missed due to a partial coverage of the colon. The task of detecting and marking unseen regions of the colon has been addressed in recent work, where the common approach is based on dense 3D reconstruction, which proves to be challenging due to lack of 3D ground truth and periods with poor visual content. In this paper we propose a novel and complementary method to detect deficient local coverage in real-time for video segments where a reliable 3D reconstruction is impossible. Our method aims to identify skips along the colon caused by a drifted position of the endoscope during poor visibility time intervals. The proposed solution consists of two phases. During the first, time segments with good visibility of the colon and gaps between them are identified. During the second phase, a trained model operates on each gap, answering the question: Do you observe the same scene before and after the gap? If the answer is negative, the endoscopist is alerted and can be directed to the appropriate area in real-time. The second phase model is trained using a contrastive loss based on auto-generated examples. Our method evaluation on a dataset of 250 procedures annotated by trained physicians provides sensitivity of 0.75 with specificity of 0.9.Comment: 10 pages, 5 figure