Tensor meson exchange at low energies

We complete the analysis of meson resonance contributions to chiral low-energy constants of O(p^4) by including all quark-antiquark bound states with orbital angular momentum less or equal to one. Different tensor meson Lagrangians used in previous work are shown to produce the same final results for the low-energy constants once QCD short-distance constraints are properly implemented. We also discuss the possible relevance of axial-vector mesons with odd C-parity.Comment: 20 pages, comparison with previous work updated, typos removed, results unchanged, version to appear in EPJ

Stochastic Production Of Kink-Antikink Pairs In The Presence Of An Oscillating Background

We numerically investigate the production of kink-antikink pairs in a $(1+1)$ dimensional $\phi^4$ field theory subject to white noise and periodic driving. The twin effects of noise and periodic driving acting in conjunction lead to considerable enhancement in the kink density compared to the thermal equilibrium value, for low dissipation coefficients and for a specific range of frequencies of the oscillating background. The dependence of the kink-density on the temperature of the heat bath, the amplitude of the oscillating background and value of the dissipation coefficient is also investigated. An interesting feature of our result is that kink-antikink production occurs even though the system always remains in the broken symmetry phase.Comment: Revtex, 21 pages including 7 figures; more references adde

Recurrent dynamical symmetry breaking and restoration by Wilson lines at finite densities on a torus

In this paper we derive the general expression of a one-loop effective potential of the nonintegrable phases of Wilson lines for an SU(N) gauge theory with a massless adjoint fermion defined on the spactime manifold $R^{1,d-3}\times T^2$ at finite temperature and fermion density. The Phase structure of the vacuum is presented for the case with $d=4$ and N=2 at zero temperature. It is found that gauge symmetry is broken and restored alternately as the fermion density increases, a feature not found in the Higgs mechanism. It is the manifestation of the quantum effects of the nonintegrable phases.Comment: 17 pages, 2 figure

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Understanding sediment bypassing processes through analysis of high-frequency observations of Ameland Inlet, the Netherlands

Ameland inlet is centrally located in the chain of West Frisian Islands (the Netherlands). A globally unique dataset of detailed bathymetric charts starting in the early 19th century, and high-resolution digital data since 1986 allows for detailed investigations of the ebb-tidal delta morphodynamics and sediment bypassing over a wide range of scales. The ebb-tidal delta exerts a large influence on the updrift and downdrift shorelines, leading to periodic growth and decay (net erosion) of the updrift (Terschelling) island tip, while sequences of sediment bypassing result in shoal attachment to the downdrift coastline of Ameland. Distinct differences in location, shape and volume of the attachment shoals result from differences in sediment bypassing, which can be driven by morphodynamic interactions at the large scale of the inlet system (O(10 km)), and through interactions that originate at the smallest scale of individual shoal instabilities (O(0.1 km)). Such shoal instabilities would not be considered to affect the ebb-tidal delta and inlet dynamics as a whole, but as we have shown in this paper, they can trigger a new sediment bypassing cycle and result in complete relocation of channels and shoals. These subtle dynamics are difficult, if not impossible, to capture in existing general conceptual models and empirical relationships. These differences are, however, essential for understanding tidal inlet and channel morphodynamics and hence coastal management.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Coastal Engineerin

Large-Scale Scour in Response to Tidal Dominance in Estuaries

Channel beds in estuaries and deltas often exhibit a local depth maximum close to the river mouth. There are two known mechanisms of large-scale (i.e., >10 river widths along-channel) channel bed scours: width constriction and draw-down during river discharge extremes, both creating flow acceleration. Here, we study a potential third mechanism: tidal scour. We use a 1D-morphodynamic model to reproduce tidal dynamics and scours in estuaries that are in morphologic equilibrium. A morphologic equilibrium is reached when the net (seaward) sediment transport matches the upstream supply along the entire reach. The residual (river) current and river-tide interactions create seaward transport. Herein, river-tide interactions represent the seaward advection of tide-induced suspended sediment by the river flow. Tidal asymmetry typically creates landward transport. Scours form when tidal flow is amplified through funneling of tidal energy. Scours simultaneously reduce the residual (river) current and the river-tide interaction contribution to sediment transport, thereby maintaining morphologic equilibrium. When tidal influence is relatively large, and when channel convergence is strong, an equilibrium is only obtained with a scouring profile. We propose a predictor dependent on the width convergence, quantified as SB, and on the ratio between the specific peak tidal discharge at the mouth and the specific river discharge at the landward boundary (qtide/qriver). Scours develop if (qtide/qriver)/SB exceeds 0.3. Scour conditions were found to occur globally across a range of scales, which allows its prediction in estuaries under future changes