Mitigation of the effect of secondary salinization by micro soil conditioning

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Effect of Soil Conditioning on the Moisture Content and the Salt Profile of the Soil Under Irrigation with Saline Water

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Assessment of measured and estimated meteorological data in terms of sorghum production on the example of Hamelmalo, Eritrea

Eritrea is exposed to climate variability and extreme events like drought and precipitation variability. Hamelmalo, a sub region in Eritrea, suffers from all the problems brought by climate change, especially because local people mainly depend on rainfed agriculture. I it is difficult to conduct climate related research activities for the region due to the shortage of meteorological data. However, in 2015, a new, complete meteorological station was established providing the chance of the first observations for practical and scientific purposes. The main objective of this study was to evaluate some climatic parameters from crop productional point of view by comparing the observed values with ones calculated by the Local Climate Estimator (LCE) model. Chi-square test was used to statistically analyse the differences. Based on the results, all the studied climatic parameters, except for precipitation, were almost on a par, which means there were no statistically significant differences between the observed and the estimated values. It can be concluded that the most variable climatic parameter in Hamelmalo is precipitation and this also affects the climatic water balance hence the need for irrigation if higher yields are wanted to be achieved. Sufficient water is vital in the mid-season and the late developmental stage of sorghum. Therefore, sowing time is advised to be adjusted to early July to ensure the maximum vegetative growth and seed setting period to be reached at the end of August in order to take the advantage of the positive climatic water balance of these two months

Post-intervention Status in Patients With Refractory Myasthenia Gravis Treated With Eculizumab During REGAIN and Its Open-Label Extension

OBJECTIVE: To evaluate whether eculizumab helps patients with anti-acetylcholine receptor-positive (AChR+) refractory generalized myasthenia gravis (gMG) achieve the Myasthenia Gravis Foundation of America (MGFA) post-intervention status of minimal manifestations (MM), we assessed patients' status throughout REGAIN (Safety and Efficacy of Eculizumab in AChR+ Refractory Generalized Myasthenia Gravis) and its open-label extension. METHODS: Patients who completed the REGAIN randomized controlled trial and continued into the open-label extension were included in this tertiary endpoint analysis. Patients were assessed for the MGFA post-intervention status of improved, unchanged, worse, MM, and pharmacologic remission at defined time points during REGAIN and through week 130 of the open-label study. RESULTS: A total of 117 patients completed REGAIN and continued into the open-label study (eculizumab/eculizumab: 56; placebo/eculizumab: 61). At week 26 of REGAIN, more eculizumab-treated patients than placebo-treated patients achieved a status of improved (60.7% vs 41.7%) or MM (25.0% vs 13.3%; common OR: 2.3; 95% CI: 1.1-4.5). After 130 weeks of eculizumab treatment, 88.0% of patients achieved improved status and 57.3% of patients achieved MM status. The safety profile of eculizumab was consistent with its known profile and no new safety signals were detected. CONCLUSION: Eculizumab led to rapid and sustained achievement of MM in patients with AChR+ refractory gMG. These findings support the use of eculizumab in this previously difficult-to-treat patient population. CLINICALTRIALSGOV IDENTIFIER: REGAIN, NCT01997229; REGAIN open-label extension, NCT02301624. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that, after 26 weeks of eculizumab treatment, 25.0% of adults with AChR+ refractory gMG achieved MM, compared with 13.3% who received placebo

Minimal Symptom Expression' in Patients With Acetylcholine Receptor Antibody-Positive Refractory Generalized Myasthenia Gravis Treated With Eculizumab

The efficacy and tolerability of eculizumab were assessed in REGAIN, a 26-week, phase 3, randomized, double-blind, placebo-controlled study in anti-acetylcholine receptor antibody-positive (AChR+) refractory generalized myasthenia gravis (gMG), and its open-label extension

Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers

https://deepblue.lib.umich.edu/bitstream/2027.42/138963/1/12987_2017_Article_71.pd

Possibility of mitigation on the effect of secundary salinization by micro soil conditioning

In order to mitigate Soil salinization by secundary salinization, we introduce the method micro soil conditioning which is an analog of fertigation or drop irrigation. This technique were tested in Lysimeters and Capsicum annumm was the indicator crop. We found 4 reazons to support this technique. First this technique is an Input of organic material, also improve the soil properties in the root zone, the excess of salts were leached and increase the yiel. However this results are only for an agricultural season, so more studies are needed.MSc/MAEnvironmental Managemen

Mitigation of the effect of secondary salinization by micro soil conditioning

This research has the general goal to meet the customization of agriculture in small scale farming. We are developing a technique using micro doses of soil conditioners and organic material applied in the root zone of vegetable crops. We expected to change the physical and chemical properties of the affected soil, which has been irrigated with salty water. Two different soil conditioners were tested. A lysimeter experiment including 8 simple drainage lysimeters was set up in the Research Institute of Karcag IAREF University of Debrecen in 2017. The main goal was to study the effect of different soil conditioners on the soil endangered by secondary salinization induced by irrigation with saline water. In order to compare the difference between the treatments, we collected soil samples, water samples, and determined the yields. Chili pepper (Capsicum annuum) was used as an indicator crop during one specific agricultural season. The technique called micro soil conditioning is rational because several reasons. The roles of the technique are various, for example it can serve as a source of carbon or a container for soil amendments and can minimize evaporation. We found this technique not to interfere with the chemical reaction or the interaction with the plants. However, the micro doses of soil amendments had the role to minimize the risk of soil degradation and do not significantly influence soil respiration. In addition, by improving soil properties, soil conditioning increases the leaching of the excess of salts from the root zone. In fact, this technique can decrease the cost of the inputs and improves the production of vegetables, and at the same time mitigates the effect of secondary salinization