Amelogenesis imperfecta- nyere forskning. En litteraturstudie fra perioden 2001-2011

Tanndannelsen er under sterk genetisk kontroll. Spesialiserte celler utvikles hos fosteret og ameloblastene som produserer emalje uttrykker gener som koder for ulike emaljeproteiner. Disse proteinene er viktig for normal tannutvikling. Innsikt i normal tannutvikling er en forutsetning for å forstå hva som skjer når tannutviklingsdefekter oppstår. Oppgaven har som hensikt å gi en oppdatert oversikt over den dentale utviklingsforstyrrelsen amelogenesis imperfecta (AI) med vekt på kliniske funn, klassifikasjon og molekylærbiologiske aspekter knyttet til sykdommens etiologi. Den første delen er en litteraturoversikt med hovedvekt på å beskrive dagens kunnskap om tannutvikling og genetisk kontroll samt å beskrive definisjoner, forekomst og kliniske karakteristika ved AI. I den andre delen, tar jeg sikte på å gjennomgå nyere forskning om AI, spesielt når det gjelder assosiasjon mellom AI og andre syndromer

Five-minute Apgar score ≤ 5 and molar incisor hypomineralisation (MIH) - a case control study

Background: The aetiology of molar incisor hypomineralisation (MIH) is unclear. The asymmetric distribution of MIH in the dentition may indicate that an insult of short duration that affects ameloblasts at a vulnerable stage could be a causative factor. Apgar ≤ 5 at 5 min may indicate asphyxia (hypoxic-ischemic insult) during birth. It was hypnotised that low Apgar score during birth may cause MIH. The present study aimed to examine a possible association between Apgar ≤ 5 at 5 min and the occurrence of MIH. Method: Two study groups were selected for examination. The cases comprised 67 children aged 8–10 years born with Apgar score equal to or below 5 after 5 min. The control group comprised 157 age-matched healthy children. First permanent molars, second primary molars and all permanent incisors were examined in all children. Clinical examination was undertaken by two calibrated examiners and intraoral close-up photographs of the teeth were later evaluated by three calibrated and blinded clinicians. Demarcated opacities, post-eruptive breakdown, atypical restorations and extractions due to MIH, according to the criteria of the European Association of Paediatric Dentistry, were assessed. Results: The prevalence of MIH did not differ between the two groups. A chi-square test failed to confirm any statistically significant relationship between 5-min Apgar scores and MIH occurrence. In addition, there was no statistically significant relationship between the number of affected first permanent molars in cases and controls. Conclusion: There was no association between Apgar ≤ 5 at 5 min and the occurrence of MIH