404 research outputs found
Manipulation and assembly of nanowires with holographic optical traps
We demonstrate that semiconductor nanowires measuring just a few nanometers
in diameter can be translated, rotated, cut, fused and organized into
nontrivial structures using holographic optical traps. The holographic approach
to nano-assembly allows for simultaneous independent manipulation of multiple
nanowires, including relative translation and relative rotation.Comment: 5 pages, 5 figure
Probing CP-violating Higgs contributions in gamma-gamma -> f anti-f through fermion polarization
We discuss the use of fermion polarization for studying neutral Higgs bosons
at a photon collider. To this aim we construct polarization asymmetries which
can isolate the contribution of a Higgs boson in , , from that of the QED continuum. This can help in getting
information on the coupling in case is a CP
eigenstate. We also construct CP-violating asymmetries which can probe CP
mixing in case has indeterminate CP. Furthermore, we take the MSSM with
CP violation as an example to demonstrate the potential of these asymmetries in
a numerical analysis. We find that these asymmetries are sensitive to the
presence of a Higgs boson as well as its CP properties over a wide range of
MSSM parameters. In particular, the method suggested can cover the region where
a light Higgs boson may have been missed by LEP due to CP violation in the
Higgs sector, and may be missed as well at the LHC.Comment: 14 pages, 14 figures, typeset in revtex4. Version which has appeared
in Physical Review D; typos in two references correcte
A clinical study to assess the patterns of muco-cutaneous changes in newborns during the first five days after birth
Background: Skin is the largest organ in the human body accounting for approximately 13% of the neonatal body weight as compared to 3% of the adult weight. It is the most visible and easily accessible organ of the body. Objective: To study the patterns of muco-cutaneous changes in newborns during the first 5 days after birth. Materials and Methods: This prospective study was conducted in postnatal wards of department of Obstetrics and gynaecology and neonatal unit of department of Paediatrics of a tertiary care teaching hospital. All the newborns within first 5 days after birth, irrespective of gender, underlying disease and general condition of the baby were included in the study. All the newborns were examined within 24 h of birth and followed up till 4 days after birth and the findings were noted in the preformed case-study proforma. Results: The present study was conducted on 200 newborns with cutaneous lesions. The muco-cutaneous diseases were divided into physiological, transient and pathological diseases. Among these newborns 114 (57%) were males, and 86 (43%) were females. The most common manifestations observed were Mongolian spots 156 (78%), sebaceous gland hyperplasia 81 (40.5%), Epstein pearls 79 (39.5%), milia 43 (21.5%), physiological jaundice 16 (8%), vernix caseosa 14 (7%), erythema toxicum 13(6.5%), salmon patch 5 (2.5%), hypertrichosis/lanugo 2 (1%), sucking blisters 1 (0.5%) and bacterial infection of Staphylococcal scalded skin syndrome 1 (0.5%). Conclusion: Muco-cutaneous manifestations are very common in neonates but as these are the transient conditions, so no intervention is required. Early recognition of these lesions is important to distinguish them from more serious skin disorders
Estudios efectivos de potencial para algunas nuevas moléculas híbridas para su actividad contra el cáncer de próstata
Objective: The present work aimed at developing novel hybrid molecules for targeting the prostate cancer. It is observed that two human shock proteins Hsp70 and Hsp90 are over-expressed in prostate cancer making them one of the important drug targets. We have designed and developed twelve new hybrid molecules 6a-j for targeting these proteins. Methods: The designed molecules were prepared following a four step reaction protocol and characterized on the basis of proton NMR and Mass spectrometry. These were subjected to in vitro studies by means of Oncotest and CCK-8 assays with two cell lines DU145 and 22Rv1. The selected molecules 6b and 6i were subjected to molecular docking and then for SPR based affinity assay. Results: Compounds 6b and 6i were found to be highly active anticancer compounds comparable to standard drug enzalutamide. They have significant IC50 and high dock score for the Hsp70 and Hsp90. These compounds are selective and have good binding affinity for the Hsp70 due to high Kd. Conclusion: Compound 6b and 6i can serve as lead molecules for the development of antiprostate cancer drugs with Hsp70 as target.Objetivo: El presente trabajo tuvo como objetivo desarrollar nuevas moléculas híbridas para atacar el cáncer de próstata. Se observa que dos proteínas de choque humano, Hsp70 y Hsp90, se sobreexpresan en el cáncer de próstata, lo que las convierte en uno de los objetivos farmacológicos importantes. Hemos diseñado y desarrollado doce nuevas moléculas híbridas 6a-j para dirigir estas proteínas. Métodos: Las moléculas diseñadas se prepararon siguiendo un protocolo de reacción de cuatro etapas y se caracterizaron sobre la base de RMN de protón y espectrometría de masas. Estos se sometieron a estudios in vitro por medio de ensayos Oncotest y CCK-8 con dos líneas celulares DU145 y 22Rv1. Las moléculas seleccionadas 6b y 6i se sometieron a acoplamiento molecular y luego a ensayo de afinidad basado en SPR. Resultados: Se descubrió que los Compuestos 6b y 6i son compuestos anticancerígenos muy activos comparables al fármaco estándar enzalutamida. Tienen un IC50 significativo y una puntuación alta para el muelle de Hsp70 y Hsp90. Estos compuestos son selectivos y tienen una buena afinidad de unión por la Hsp70 debido a la alta Kd. Conclusión: Los compuestos 6b y 6i pueden servir como moléculas principales para el desarrollo de fármacos antiprostáticos contra el cáncer con Hsp70 como objetivo
Context Mining with Machine Learning Approach: Understanding, Sensing, Categorizing, and Analyzing Context Parameters
Context is a vital concept in various fields, such as linguistics, psychology, and computer science. It refers to the background, environment, or situation in which an event, action, or idea occurs or exists. Categorization of context involves grouping contexts into different types or classes based on shared characteristics. Physical context, social context, cultural context, temporal context, and cognitive context are a few categories under which context can be divided. Each type of context plays a significant role in shaping our understanding and interpretation of events or actions. Understanding and categorizing context is essential for many applications, such as natural language processing, human-computer interaction, and communication studies, as it provides valuable information for interpretation, prediction, and decision-making.
In this paper, we will provide an overview of the concept of context and its categorization, highlighting the importance of context in various fields and applications. We will discuss each type of context and provide examples of how they are used in different fields. Finally, we will conclude by emphasizing the significance of understanding and categorizing context for interpretation, prediction, and decision-making
Estudios efectivos de potencial para algunas nuevas moléculas híbridas para su actividad contra el cáncer de próstata
Objective: The present work aimed at developing novel hybrid molecules for targeting the prostate
cancer. It is observed that two human shock proteins Hsp70 and Hsp90 are over-expressed in prostate
cancer making them one of the important drug targets. We have designed and developed twelve new
hybrid molecules 6a-j for targeting these proteins.
Methods: The designed molecules were prepared following a four step reaction protocol and characterized
on the basis of proton NMR and Mass spectrometry. These were subjected to in vitro studies by
means of Oncotest and CCK-8 assays with two cell lines DU145 and 22Rv1. The selected molecules 6b
and 6i were subjected to molecular docking and then for SPR based affinity assay.
Results: Compounds 6b and 6i were found to be highly active anticancer compounds comparable to
standard drug enzalutamide. They have significant IC50 and high dock score for the Hsp70 and Hsp90.
These compounds are selective and have good binding affinity for the Hsp70 due to high Kd.
Conclusion: Compound 6b and 6i can serve as lead molecules for the development of antiprostate cancer
drugs with Hsp70 as target.Objetivo: El presente trabajo tuvo como objetivo desarrollar nuevas moléculas híbridas para atacar el
cáncer de próstata. Se observa que dos proteínas de choque humano, Hsp70 y Hsp90, se sobreexpresan
en el cáncer de próstata, lo que las convierte en uno de los objetivos farmacológicos importantes. Hemos
diseñado y desarrollado doce nuevas moléculas híbridas 6a-j para dirigir estas proteínas.
Métodos: Las moléculas diseñadas se prepararon siguiendo un protocolo de reacción de cuatro etapas
y se caracterizaron sobre la base de RMN de protón y espectrometría de masas. Estos se sometieron a
estudios in vitro por medio de ensayos Oncotest y CCK-8 con dos líneas celulares DU145 y 22Rv1. Las
moléculas seleccionadas 6b y 6i se sometieron a acoplamiento molecular y luego a ensayo de afinidad
basado en SPR.
Resultados: Se descubrió que los Compuestos 6b y 6i son compuestos anticancerígenos muy activos
comparables al fármaco estándar enzalutamida. Tienen un IC50 significativo y una puntuación alta para
el muelle de Hsp70 y Hsp90. Estos compuestos son selectivos y tienen una buena afinidad de unión por
la Hsp70 debido a la alta Kd.
Conclusión: Los compuestos 6b y 6i pueden servir como moléculas principales para el desarrollo de
fármacos antiprostáticos contra el cáncer con Hsp70 como objetivo
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