8 research outputs found
Epigenetic Activation of a Subset of mRNAs by eIF4E Explains Its Effects on Cell Proliferation
- Author
- A De Benedetti
- A De Benedetti
- A Gradi
- A Grolleau
- A Lazaris-Karatzas
- A Lazaris-Karatzas
- AC Gingras
- AC Gingras
- AC Gingras
- AE Koromilas
- AR Tee
- B Thompson
- BM Engels
- BP Lewis
- CF Bassoe
- CG Proud
- CW Rinker-Schaeffer
- D Karan
- D Nadano
- D Ruggero
- D Ruggero
- DC Altieri
- DC Fingar
- DJ Santa Cruz
- E Berezikov
- E Petroulakis
- EC Holland
- EF Morand
- EI Boyle
- Emmanuel Petroulakis
- F Mignone
- HG Wendel
- HJ Chae
- HW Hwang
- I Bentwich
- I Ruvinsky
- IB Rosenwald
- J Dostie
- J Pelletier
- JM Wettenhall
- JR Graff
- JR Graff
- K Dua
- K Khaleghpour
- LM Shantz
- LM Shantz
- LS Hiremath
- M Ashburner
- M Grzmil
- M Holcik
- M Mathews
- MA Ferraiuolo
- MA Valencia-Sanchez
- ML Hammond
- N Hay
- N Oridate
- NA Hong
- Nahum Sonenberg
- O Larsson
- O Larsson
- O Larsson
- Ola Larsson
- P Jorgensen
- P Jorgensen
- P Trempat
- R Duncan
- R Schneider
- RA Irizarry
- RC Gentleman
- RL Kaspar
- S Avdulov
- S Ferrari
- S Li
- T Decker
- T Preiss
- T Shimizu
- T Stromberg
- T Tomonaga
- T Uechi
- Taka-Aki Sato
- TG Kinzy
- Thomas Preiss
- TL Hamilton
- VG Tusher
- Vinagolu K. Rajasekhar
- VK Rajasekhar
- WT Loging
- X Mao
- Y Mamane
- Y Shi
- Yaël Mamane
- YH Yang
- Yvan Martineau
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2007
- Field of study
BACKGROUND: Translation deregulation is an important mechanism that causes aberrant cell growth, proliferation and survival. eIF4E, the mRNA 5′ cap-binding protein, plays a major role in translational control. To understand how eIF4E affects cell proliferation and survival, we studied mRNA targets that are translationally responsive to eIF4E. METHODOLOGY/PRINCIPAL FINDINGS: Microarray analysis of polysomal mRNA from an eIF4E-inducible NIH 3T3 cell line was performed. Inducible expression of eIF4E resulted in increased translation of defined sets of mRNAs. Many of the mRNAs are novel targets, including those that encode large- and small-subunit ribosomal proteins and cell growth-related factors. In addition, there was augmented translation of mRNAs encoding anti-apoptotic proteins, which conferred resistance to endoplasmic reticulum-mediated apoptosis. CONCLUSIONS/SIGNIFICANCE: Our results shed new light on the mechanisms by which eIF4E prevents apoptosis and transforms cells. Downregulation of eIF4E and its downstream targets is a potential therapeutic option for the development of novel anti-cancer drugs
RURAL NEUROTRAUMA IN AUSTRALIA: IMPLICATIONS FOR SURGICAL TRAINING
- Author
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Phenology and Remote Sensing
- Author
- A Vinogradova
- AB Park
- AL Sorem
- CD Sapp
- CE Olson Jr
- CE Olson Jr
- CF Cooper
- D Steiner
- DC Parker
- DD Egbert
- DH Brunnschweiler
- DJ Mary
- DM Gates
- EB Knipling
- EM Zaitzeff
- FP Weber
- GP Motovilov
- H Boesch
- JD Lent
- JN Rinker
- JT Smith
- KG Northrup
- KJ Stein
- KY Kondrat
- MR Holter
- NASA Goddard Space Flight Center.
- PF Krumpe
- PF Krumpe
- PL Johnson
- RC Heller
- RK Moore
- RM Haralick
- RS Driscoll
- SA Aldrich
- WG Rohde
- WG Rohde
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1974
- Field of study
Burr-Hole Craniostomy for Chronic Subdural Hematomas by General Surgeons in Rural Kenya
- Author
- A Fuller
- A Ishibashi
- A Khamlichi El
- AG Kolias
- AL Albright
- BE Park
- BE Park
- C Parlato
- CF Rinker
- CN Mock
- CV Bishop
- DA Wilson
- DB Ellegala
- DB Ellegala
- DM Neils
- EL Margetts
- EM Horn
- G Ethem
- G Tumusiime
- GM Ibrahim
- I Phang
- IG Panourias
- J Coburger
- JD Pollock
- John K. Kanyi
- K Mori
- K Nayil
- K Wester
- KE Liang
- LB Miranda
- M El-Fiki
- M Gökmen
- M Sambasivan
- Mark J. Oloo
- ML Cheatham
- MM Qureshi
- PJ Treacy
- R Ologunde
- R Weigel
- RE White
- Robert K. Parker
- T Luck
- T Otieno
- T Santarius
- Timothy V. Ogada
- W Liu
- WM Kaptigau
- WP Schecter
- Y Mondorf
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Supplementation in mushroom crops and its impact on yield and quality
- Author
- A Pardo-Giménez
- A Pardo-Giménez
- A Pardo-Giménez
- A Pardo-Giménez
- A Pardo-Giménez
- A Pardo-Giménez
- A Pardo-Giménez
- A Payapanon
- A Rubini
- AD Carrol Jr
- AER Estrada
- AM Vos
- AR Werner
- B Desrumaux
- C Sánchez
- C Sánchez
- C Xie
- CF McGee
- CF McGee
- CH Liang
- D Goswami
- DC Zied
- DC Zied
- DJ Royse
- DJ Royse
- DJ Royse
- DK Bhattacharjya
- DL Rinker
- DO Natvig
- F Atila
- F Zarenejad
- FR Vieira
- G Koutrotsios
- G Lemke
- Georgios I. Zervakis
- GI Zervakis
- HT Hoa
- J Carrasco
- J Kopytowski Filho
- JE Pardo
- JE Sánchez
- JK Bird
- JW Sinden
- JW Taylor
- K Pratiksha
- K Yamanaka
- L Jeyanthi Rebecca
- LC Schisler
- M Jafarpour
- M Moonmoon
- M Rugolo
- MA Kabel
- MA Kertesz
- MM Coello-Castillo
- MR Picornell-BuendÃa
- MR Picornell-BuendÃa
- MR Picornell-BuendÃa
- P Rzymski
- PE Randle
- Q Liu
- Q Wang
- Q Zhou
- R Gaitán-Hernández
- R Naraian
- S Chang
- S Colmenares-Cruz
- S He
- V Kleofas
- Y Ma
- Y Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Clear Cell Tumors of the Head and Neck: An Overview
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- Bascones J Llanes F.
- Benton DC Eisenberg E.
- Cakarer S Selvi F, Isler SC, Soluk M.
- Damm DD White DK, Lyu PE, Puno P.
- de Aguiar CF Gomez RS, Silva EC, de Aradjo VC.
- de Oliverira MG Chaves ACM.
- Dubin MR Chang EW.
- Ellis GL.
- Eversole LR.
- Fletcher DM.
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- Krawczyk E Suprynowicz FA, Liu X, Dai Y, Hartmann DP, Hanover J, et al.
- Lee SD Ahn GH, Chi JG, Ham EK.
- Magrol CM Crowson AN, Mihm MC.
- Maiorano E Altini M, Favia G.
- Mills SE.
- Mokhtari S Mirafsharieh A.
- Ng KH Siar CH.
- Nichols C Geist RY, Kara M.
- Povysil C Matejovsky Z, Zidkova H.
- Rajendran R
- Rangel ALCA da Silva AA, Ito FA, Lopes MA, de Almeida, OP Vargas PA.
- Reichart PA Phillipsen HP.
- Rinker MH Fenske NA, Scalf LA, Glass LF.
- Rodriguez OM Garcia RG, Arias JM, Garcia CM, Serrano-Gil H, Alcojolet LV, et al.
- Ross MH Reith EJ, Romrell LJ.
- Said-Al-Naief Nasser Klein MJ.
- Sarma DP Olson D, Olivella J, Harbert T, Wang, Bo Ortman S.
- Seijas BP Franco FL, Sastre RM, Garcia AA, Luis Jose Lopez-Cedrun Cembranos.
- Shear M Speight PM.
- Tencate AN.
- Wenk PA.
- Yoon JH Ahn SG, Kim SG, Kim J.
- Publication venue
- 'Jaypee Brothers Medical Publishing'
- Publication date
- Field of study
Urogenital tuberculosis
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- A Cuenot
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- W Szybalski
- WA Moonen
- WA Murray
- WB Tucker
- WB Tucker
- WB Tucker
- WE Dye
- WE Kittredge
- WE Lower
- Wegelin
- WF Braasch
- WF Braasch
- WF Braasch
- WF Braasch
- WF Russell Jr
- WG Townsend
- WH Feldman
- WH Feldman
- WH Feldman
- WH Feldman
- WL Howard
- WM Borthwick
- WM Borthwick
- WM Borthwick
- WM Borthwick
- WM Borthwick
- WM Borthwick
- WP Herbst
- WR Barclay
- WT Munro
- WW Scott
- Y Yaoita
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1959
- Field of study
Traumatic Brain Injury
- Author
- A Chieregato
- A Engberg
- A Fabbri
- A Fabbri
- A Fukamachi
- A Jamjoom
- A Marmarou
- A Marmarou
- A Marmarou
- A Marmarou
- A Matsuno
- A McKinney
- A Menkü
- A Vik
- AB Jamjoom
- AC Lee
- AH Marshall
- AH Ropper
- AI Maas
- AI Maas
- AI Maas
- AI Maas
- AK Malohtra
- AK Ommaya
- AM Korinek
- American college of Surgeons Committee on Trauma
- AP Bricolo
- AR Joffe
- B Aarabi
- B Bouillon
- B Eyes
- B Holmes
- B Jennett
- B Jennett
- B Jennett
- B Jennett
- B Ludwig
- B Ratilal
- B Selhorst
- B Simon
- B Turnage
- BD Swinson
- BP Foreman
- BR O‘Neill
- BS Harhangi
- BT Andrews
- BT Andrews
- BT Andrews
- BT Foundation
- C Atzema
- C Licata
- C Lietard
- C Rivano
- C Steigerwald
- CA Hawley
- CE Goettler
- CF Miller
- CF Rinker
- CM Fisher
- CM Heever van den
- CM Muth
- CN Gallagher
- CS Robertson
- CS Specht
- CV Brown
- CW Chen
- CW Hukkelhoven
- D D‘Avella
- D D’Avella
- D Gentleman
- D Siccardi
- D Soloniuk
- DA Bruce
- DE Sakas
- DG Caldicott
- DG Hughes
- DG Vollmer
- DH Livingston
- DH Livingston
- DI Graham
- DJ Donovan
- DJ Gower
- E Alexander
- E Bor-Seng-Shu
- E Kunze
- E Lee
- E Muench
- ED George
- ED George
- EF Aldrich
- EF Chang
- EJ Herrera
- EL Wylen
- ER Cardoso
- ER Smith
- EW Lang
- F Massaro
- F Servadei
- F Servadei
- F Servadei
- F Servadei
- F Servadei
- F Servadei
- F Servadei
- F Tagliaferri
- FS Haddad
- FY Tsai
- G Akopian
- G Besson
- G Rubin
- G Schierhout
- G Scotti
- G Stranjalis
- G Talamonti
- G Teasdale
- G Teasdale
- G Wilms
- G York
- GD Murray
- GD Olden van
- GH Schneider
- GL Clifton
- GL Rockswold
- GM Paci
- GM Teasdale
- GS McHugh
- H Baechli
- H Chim
- H Fodstad
- H Goodman
- H Jonas
- H Nakaguchi
- H Wang
- H Yamakawa
- H Yokota
- HC Patel
- HH Jend
- HH Kaufman
- HJ Steiger
- HK Smith
- HS Levin
- HS Levin
- HS Levin
- I Arrese
- I Butcher
- I Feiz-Erfan
- IG Stiell
- J Acosta
- J Englander
- J Gonzalez Tortosa
- J Jagger
- J Meixensberger
- J Nortje
- J Osterwalder
- J Piek
- J Provenzale
- J Rankin
- J Ransohoff
- J Raveh
- J Schiffer
- J Schüttler
- J Seelig
- JB Ghajar
- JD Berne
- JD Miller
- JD Miller
- JD Miller
- JD Miller
- JD Miller
- JD Pickard
- JE Cohen
- JE Leedy
- JE Wilberger
- JE Wilberger Jr
- JF Annegers
- JF Annegers
- JF Kraus
- JG Beek Van
- JH Adams
- JH Adams
- JH McElhaney
- JH Piatt Jr
- JH Siegel
- JJ Plessis du
- JJ Rivas
- JJ Wilberger
- JL af Geijerstam
- JL af Geijerstam
- JL af Geijerstam
- JL Flibotte
- JL Sperry
- JL Stone
- JL Stone
- JM Guérit
- JM Seelig
- JN Guilburd
- JP Coles
- JR Jinkins
- JR Kuo
- JS Moyer
- JT Flaada
- JT Katzen
- JT Liu
- JV Rosenfeld
- JY Jiang
- K Haselsberger
- K Mori
- K Thillainayagam
- K Turetschek
- K Wester
- KH Chan
- KL Holloway
- KL Roos
- KS Lee
- L Llamas
- L Stuke
- LA Levin
- LF Marshall
- LF Marshall
- LF Marshall
- LN Sykes Jr
- LR Gentry
- LT Holly
- M Abe
- M Asghar
- M Balki
- M Blaha
- M Borzone
- M Caroli
- M Clavel
- M Domenicucci
- M Gaab
- M Gelabert-González
- M Gladwell
- M Holzschuh
- M Natarajan
- M Oertel
- M Samii
- M Smits
- M Smits
- M Souza De
- M Stanisic
- M Takeshi
- M Tisdall
- M Tokmak
- M Trevou du
- M Zumkeller
- MA Howard 3rd
- MA Kaufmann
- MA Poca
- MA Zanini
- MB Bender
- MB Gutman
- MB Harris
- MD Trevou du
- MG Hamilton
- MJ Haydel
- MK Chedid
- ML Fackler
- MR Bullock
- MR Bullock
- MR Bullock
- MR Bullock
- MR Bullock
- MR Klauber
- N Badjatia
- N Juul
- N King
- N Nathoo
- N Stocchetti
- N Stocchetti
- N Stocchetti
- NA Mushkudiani
- NA Tenn-Lyn
- NK Malik
- No authors listed
- No authors listed
- No authors listed
- NR Temkin
- O Dupuis
- O Lesieur
- O Necajauskaite
- OL Alves
- OL Cremer
- P Gastone
- P McCrory
- P Missori
- P Platzer
- P Riesgo
- P Scolozzi
- PA Gómez
- PA Hofman
- PA Jones
- PA Nee
- PC Davis
- PC Whitfield
- PD LeRoux
- PE Vos
- PJ Hutchinson
- PJ Offner
- PL Reilly
- PM Parizel
- PO Grande
- PR Cooper
- PR Miller
- PW Schaefer
- R Braakman
- R Braakman
- R Bullock
- R Bullock
- R Duhem
- R Hierner
- R Weigel
- RD Lobato
- RD Lobato
- RD Muchow
- RD Zafonte
- RI Ernestus
- RJ Mannion
- RJ Moulton
- RM Chesnut
- RM Chesnut
- RM Chesnut
- RM Chesnut
- RM Ruff
- RN Kjellberg
- RS Martins
- RS Polin
- RW Evans
- RW Rimel
- S Gatscher
- S Lin
- S Manolidis
- S Palmer
- S Shafi
- S Tuli
- S Yilmazlar
- SA Al-Haddad
- SA Bolliger
- SA Bowers
- SC Choi
- SC Stein
- SH Park
- SJ Evans
- SJ Goodman
- SJ Griffiths
- SJ Masters
- SJ Masters
- SK Gudeman
- SL Bratton
- SL Dawson
- SL Galbraith
- SM Fakhry
- SN Gusmão
- SP Baker
- SP Baker
- SP Thiruppathy
- SR Meerhoff
- T Bouras
- T Gale
- T Hayashi
- T Ingebrigtsen
- T Iwabuchi
- T Kerner
- T Murano
- T Mussack
- T Skandsen
- T Stegemann
- T Sundstrøm
- T Ucar
- T Watanabe
- TA Gennarelli
- TA Gennarelli
- TA Gennarelli
- TA Gennarelli
- TA Gennarelli
- TA Gennarelli
- TA Gennarelli
- TA Huisman
- TF Sun
- TJ Cummings
- TJ Martin
- TM Markwalder
- TP Sullivan
- TS Ellis
- TT Lee
- TT Lee
- TW Kim
- TW Vitaz
- U Meier
- V Darrouzet
- V Smrkolj
- VC Prabhu
- VG Ramesh
- VM Synek
- VP Culotta
- W Liang
- W Rosenblum
- WK Guerra
- Y Ishiwata
- Y Kurokawa
- Y Taguchi
- Z Kotwica
- Z Kotwica
- ZC Sifri
- ZN Litvack
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study