129 research outputs found
The PCA Lens-Finder: application to CFHTLS
We present the results of a new search for galaxy-scale strong lensing
systems in CFHTLS Wide. Our lens-finding technique involves a preselection of
potential lens galaxies, applying simple cuts in size and magnitude. We then
perform a Principal Component Analysis of the galaxy images, ensuring a clean
removal of the light profile. Lensed features are searched for in the residual
images using the clustering topometric algorithm DBSCAN. We find 1098 lens
candidates that we inspect visually, leading to a cleaned sample of 109 new
lens candidates. Using realistic image simulations we estimate the completeness
of our sample and show that it is independent of source surface brightness,
Einstein ring size (image separation) or lens redshift. We compare the
properties of our sample to previous lens searches in CFHTLS. Including the
present search, the total number of lenses found in CFHTLS amounts to 678,
which corresponds to ~4 lenses per square degree down to i=24.8. This is
equivalent to ~ 60.000 lenses in total in a survey as wide as Euclid, but at
the CFHTLS resolution and depth.Comment: 21 pages, 12 figures, accepted for publication on A&
Recommended from our members
Meta-analysis of stomatitis in clinical studies of everolimus: incidence and relationship with efficacy.
BackgroundEverolimus, an oral mammalian target of rapamycin (mTOR) inhibitor, is used to treat solid tumors and tuberous sclerosis complex (TSC). Stomatitis, an inflammation of the mucous membranes of the mouth, is a common adverse event associated with mTOR inhibitors, including everolimus. We conducted a meta-analysis of data from seven randomized, double-blind phase 3 clinical trials of everolimus to determine the clinical impact of stomatitis on efficacy and safety.Patients and methodsData were pooled from the safety sets of solid tumor [breast cancer (BOLERO-2 and BOLERO-3), renal cell carcinoma (RECORD-1), carcinoid tumors (RADIANT-2), and pancreatic neuroendocrine tumors (RADIANT-3)] and TSC studies (EXIST-1 and EXIST-2). Data from solid tumor trials and TSC trials were analyzed separately.ResultsThe rate of stomatitis was 67% in the solid tumor trials (973/1455 patients) and 70% in the TSC trials (110/157 patients). Most stomatitis events were grade 1/2, with grade 3/4 events reported in only 9% (solid tumor trials) and 8% (TSC trials) of patients. Low TSC patient numbers prevented an in-depth evaluation of stomatitis and response. In the solid tumor trials, most first stomatitis episodes (89%; n = 870) were observed within 8 weeks of starting everolimus. Patients with stomatitis occurring within 8 weeks of everolimus initiation had longer progression-free survival (PFS) than everolimus-treated patients without stomatitis in BOLERO-2 {8.5 versus 6.9 months, respectively; hazard ratio (HR), 0.78 [95% confidence interval (CI), 0.62-1.00]} and RADIANT-3 [13.9 versus 8.3 months, respectively; HR, 0.70 (95% CI, 0.48-1.04)]. A similar trend was observed in RECORD-1 [HR, 0.90 (95% CI, 0.66-1.22)] and RADIANT-2 [HR, 0.87 (95% CI, 0.61-1.22)] but not in BOLERO-3 [HR, 1.01 (95% CI, 0.75-1.36)].ConclusionsStomatitis did not adversely affect PFS, supporting the administration of everolimus in accordance with standard management guidelines
A Framework for Measurement Feedback to Improve Decision-Making in Mental Health
The authors present a multi-level framework for conceptualizing and designing measurement systems to improve decision-making in the treatment and prevention of child and adolescent mental health problems as well as the promotion of well-being. Also included is a description of the recommended drivers of the development and refinement of these measurement systems and the importance of the architecture upon which these measurement systems are built. The authors conclude with a set of recommendations for the next steps for the field
On the Maximum Crossing Number
Research about crossings is typically about minimization. In this paper, we
consider \emph{maximizing} the number of crossings over all possible ways to
draw a given graph in the plane. Alpert et al. [Electron. J. Combin., 2009]
conjectured that any graph has a \emph{convex} straight-line drawing, e.g., a
drawing with vertices in convex position, that maximizes the number of edge
crossings. We disprove this conjecture by constructing a planar graph on twelve
vertices that allows a non-convex drawing with more crossings than any convex
one. Bald et al. [Proc. COCOON, 2016] showed that it is NP-hard to compute the
maximum number of crossings of a geometric graph and that the weighted
geometric case is NP-hard to approximate. We strengthen these results by
showing hardness of approximation even for the unweighted geometric case and
prove that the unweighted topological case is NP-hard.Comment: 16 pages, 5 figure
Dispositional optimism as a correlate of decision-making styles in adolescence
Despite the numerous psychological areas in which optimism has been
studied, including career planning, only a small amount of research has been done to
investigate the relationship between optimism and decision-making styles. Consequently,
we have investigated the role of dispositional optimism as a correlate of different
decision-making styles, in particular, positive for effective styles and negative for
ineffective ones (doubtfulness, procrastination, and delegation). Data were gathered
through questionnaires administered to 803 Italian adolescents in their last 2 years of
high schools with different fields of study, each at the beginning stages of planning
for their professional future. A paper questionnaire was completed containing measures
of dispositional optimism and career-related decision styles, during a vocational
guidance intervention conducted at school. Data were analyzed using stepwise multiple
regression. Results supported the proposed model by showing optimism to be a strong
correlate of decision-making styles, thereby offering important intervention guidelines
aimed at modifying unrealistically negative expectations regarding their future and
helping students learn adaptive decision-making skills
Efficacy and safety of everolimus in combination with trastuzumab and paclitaxel in Asian patients with HER2+ advanced breast cancer in BOLERO-1
The needs of foster children and how to satisfy them:A systematic review of the literature
Family foster care deeply influences the needs of children and how these are satisfied. To increase our knowledge of foster childrenâs needs and how these are conceptualized, this paper presents a systematic literature review. Sixty- four empirical articles from six databases were reviewed and categorized (inter-rater agreement K = .78) into four categories: medical, belongingness, psychological and self-actualization needs. The results give a complete overview of needs that are specific to foster children, and what can be implemented to satisfy these needs. This study shows psychological needs are studied more often compared to the other categories, which specially relates to much attention for mental health problems. Furthermore, most articles focus on how to satisfy the needs of foster children and provide no definition or concrete conceptualization of needs. Strikingly, many articles focus on childrenâs problems instead of their needs, and some even use these terms interchangeably. This review illustrates that future research should employ a proper conceptualization of needs, which could also initiate a shift in thinking about needs instead of problems
Biofabrication: an overview of the approaches used for printing of living cells
The development of cell printing is vital for establishing biofabrication approaches as clinically relevant tools. Achieving this requires bio-inks which must not only be easily printable, but also allow controllable and reproducible printing of cells. This review outlines the general principles and current progress and compares the advantages and challenges for the most widely used biofabrication techniques for printing cells: extrusion, laser, microvalve, inkjet and tissue fragment printing. It is expected that significant advances in cell printing will result from synergistic combinations of these techniques and lead to optimised resolution, throughput and the overall complexity of printed constructs
Everolimus plus exemestane as first-line therapy in HR+, HER2â advanced breast cancer in BOLERO-2
- âŠ