A New Approach in Risk Stratification by Coronary CT Angiography.

For a decade, coronary computed tomographic angiography (CCTA) has been used as a promising noninvasive modality for the assessment of coronary artery disease (CAD) as well as cardiovascular risks. CCTA can provide more information incorporating the presence, extent, and severity of CAD; coronary plaque burden; and characteristics that highly correlate with those on invasive coronary angiography. Moreover, recent techniques of CCTA allow assessing hemodynamic significance of CAD. CCTA may be potentially used as a substitute for other invasive or noninvasive modalities. This review summarizes risk stratification by anatomical and hemodynamic information of CAD, coronary plaque characteristics, and burden observed on CCTA

Multiple tests of association with biological annotation metadata

We propose a general and formal statistical framework for multiple tests of association between known fixed features of a genome and unknown parameters of the distribution of variable features of this genome in a population of interest. The known gene-annotation profiles, corresponding to the fixed features of the genome, may concern Gene Ontology (GO) annotation, pathway membership, regulation by particular transcription factors, nucleotide sequences, or protein sequences. The unknown gene-parameter profiles, corresponding to the variable features of the genome, may be, for example, regression coefficients relating possibly censored biological and clinical outcomes to genome-wide transcript levels, DNA copy numbers, and other covariates. A generic question of great interest in current genomic research regards the detection of associations between biological annotation metadata and genome-wide expression measures. This biological question may be translated as the test of multiple hypotheses concerning association measures between gene-annotation profiles and gene-parameter profiles. A general and rigorous formulation of the statistical inference question allows us to apply the multiple hypothesis testing methodology developed in [Multiple Testing Procedures with Applications to Genomics (2008) Springer, New York] and related articles, to control a broad class of Type I error rates, defined as generalized tail probabilities and expected values for arbitrary functions of the numbers of Type I errors and rejected hypotheses. The resampling-based single-step and stepwise multiple testing procedures of [Multiple Testing Procedures with Applications to Genomics (2008) Springer, New York] take into account the joint distribution of the test statistics and provide Type I error control in testing problems involving general data generating distributions (with arbitrary dependence structures among variables), null hypotheses, and test statistics.Comment: Published in at http://dx.doi.org/10.1214/193940307000000446 the IMS Collections (http://www.imstat.org/publications/imscollections.htm) by the Institute of Mathematical Statistics (http://www.imstat.org

Faculty Spotlight

Professor Nicholas Rine talks about his teaching and work

Faculty Spotlight

Professor Nicholas Rine talks about his teaching and work

Accumulation of rare coding variants in genes implicated in risk of human cleft lip with or without cleft palate.

Cleft lip with/without cleft palate (CLP) is a common craniofacial malformation with complex etiologies, reflecting both genetic and environmental factors. Most of the suspected genetic risk for CLP has yet to be identified. To further classify risk loci and estimate the contribution of rare variants, we sequenced the exons in 49 candidate genes in 323 CLP cases and 211 nonmalformed controls. Our findings indicated that rare, protein-altering variants displayed markedly higher burdens in CLP cases at relevant loci. First, putative loss-of-function mutations (nonsense, frameshift) were significantly enriched among cases: 13 of 323 cases (~4%) harbored such alleles within these 49 genes, versus one such change in controls (p = 0.01). Second, in gene-level analyses, the burden of rare alleles showed greater case-association for several genes previously implicated in cleft risk. For example, BHMT displayed a 10-fold increase in protein-altering variants in CLP cases (p = .03), including multiple case occurrences of a rare frameshift mutation (K400 fs). Other loci with greater rare, coding allele burdens in cases were in signaling pathways relevant to craniofacial development (WNT9B, BMP4, BMPR1B) as well as the methionine cycle (MTRR). We conclude that rare coding variants may confer risk for isolated CLP

SISTEM IJON PADA USAHATANI CENGKEH DI DESA RAANAN BARU KECAMATAN MOTOLING BARAT KABUPATEN MINAHASA SELATAN

This study aims to describe the prevailing sijon system in clove farming in Raanan Baru Village, West Motoling Subdistrict. This research was conducted for 3 (three) months starting from the preparation phase until the preparation of the report that is since December 2017 s / d February 2018. The data used in this study is primary data which is research data obtained directly from the farmers as respondents and data secondary data which is a research data obtained indirectly through agency information or documents relating to this research and village data. Sampling method in this study using purposive sampling method, meaning that researchers determine their own samples taken because there are certain considerations. Data Analysis Method in this research is processed by using descriptive analysis and then Analysis This data is processed / presented in written form and table. The process of bond transfers in Raanan Baru Village has been going on for generations and has even taken root in the village community itself. From the results of case studies encountered in the field stated that the transaction system of ijon that occurred in Raanan Baru Village, West Motoling Subdistrict of South Minahasa Regency is done on the basis of both parties have agreed and have good intention to do the transaction of debt by only having mutual trust with each other

ANALISIS KERENTANAN KAWASAN PERMUKIMAN PADA KAWASAN RAWAN BANJIR DI BAGIAN HILIR SUNGAI SARIO

The objectives of this research are: (1) Analyzing any susceptibility factors that can influence people downstream of Sario River to settle or not stay in settlements located in flood prone areas, (2) Reviewing the policy of flood-prone settlement management what is most effective in overcoming the existing flood problems at the site. This research was conducted in September until November 2017. Sampling method used was purposive sampling method. Analytical technique used in this research using quantitative method that is using logistic regression. The results of this study indicate that (1) the most influencing factor of the person staying in the flood prone area downstream of the Sario River is the social susceptibility factor precisely the social ties, ie the close kinship between the members of the community in the location. (2) Furthermore, the most appropriate government program for dealing with settlements of the lower flood prone areas of the Sario River is through the creation of a retaining river basin or river dredging

Visual-Vestibular Habituation and Balance Training for Motion Sickness

Background and Purpose. This case report describes physical therapy for motion sickness in a 34-year-old woman. The purpose of the report is twofold: (1) to provide an overview of the literature regarding motion sickness syndrome, causal factors, and rationale for treatment and (2) to describe the evaluation and treatment of a patient with motion sickness. Case Description and Outcomes. The patient initially had moderate to severe visually induced motion sickness, which affected her functional abilities and prevented her from working. Following 10 weeks of a primarily home-based program of visualvestibular habituation and balance training, her symptoms were alleviated and she could resume all work-related activities. Discussion. Although motion sickness affects nearly one third of all people who travel by land, sea, or air, little documentation exists regarding prevention or management

Pola Alokasi Waktu dan Kontribusi Pendapatan Perempuan Pedagang Sayuran di Pasar Pinasungkulan Karombasan Manado

This study aims to determine the pattern of time allocation of women vegetable traders and their contribution to the household income. This research was conducted in Pinasungkulan Market, Karombasan, Manado for two month from June to July 2016. The primary data was collected from interviews with 15 women vegetable sellers who have a family. Secondary data were obtained from Sub-office Pinasungkulan Market. Data analysis was used descriptive analysis techniques. The results showed that, in general, women vegetables traders in the Pinasungkulan Market have started selling vegetables after they were married. Because as wives, they realized that they have to support their husbands to earn money for a living because of their husband\u27s income is not sufficient. Time allocation patterns of the woman vegetable seller shave used an average of 15 hours per day for all their activities. They are selling vegetables, domestic activities and others social activities. Their time allocation daily respectivley consists of sold vegetables activities spend on average 8.9 hours (59.40%), for households 2, 6 hours/day (17.30%) and for other activities such as watching television and attending worship and other social activities, an average of 3.5 hours (23.3%). The conclusion from this study that the pattern of time allocation by women vegetable vendors in the Market of Pinasungkulan, Karombasan, women spend more time on economic activities than from domestic activities. Women vegetable sellers have earned average income of IDR 4.400 million per month with a 59.27% ​​contribution to the family income. While their husband shave contributed to the family income is lower than the wife of 19.09% with an average income of IDR 1.417 million per month. The contribution of other members of the household is income, especially children, are IDR 1.607 million per month (21.64%). Therefore, it can be concluded that women vegetables traders in Pinasungkulan Market are primary source of support for family