New eco-friendly procedure for the synthesis of 4-arylmethylene-isoxazol-5(4<i>H</i>)-ones catalyzed by pyridinium <i>p</i>-toluenesulfonate (PPTS) in aqueous medium

<p>In this work we describe a new, highly efficient method for the synthesis of 3-methyl-4-arylmethylidene-isoxazol-5(4H)-one derivatives by a three-component reaction between aromatic aldehydes, ethyl acetoacetate, and hydroxylamine hydrochloride under the influence by PPTS as a low-toxicity, inexpensive, commercially available and easy to handle catalyst. The advantages of this procedure are good yields, short reaction times, simplicity of implementation, and respect of the environment.</p

AlCl3-promoted reaction of cycloalkanones with hydrazones: A convenient direct synthesis of 4,5,6,7-tetrahydro-1H-indazoles and their analogues (vol 60, 150988, 2019)

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