The direct numerical simulations of the turbulent wakes of axisymmetric bodies

Results of direct numerical simulations of turbulence are compared with both laboratory data and self-similarity theory for the case of the turbulent wakes of towed, axisymmetric bodies. In general, the agreement of the simulation results with both the laboratory data and the self-similarity theory is good, although the comparisons are hampered by inadequate procedures for initializing the numerical simulations

Flow losses in flexible hose, volume 1 Final report

Empirical method for predicting flow loss of gas or liquid in flexible hose

An approximate method for calculating three-dimensional inviscid hypersonic flow fields

An approximate solution technique was developed for 3-D inviscid, hypersonic flows. The method employs Maslen's explicit pressure equation in addition to the assumption of approximate stream surfaces in the shock layer. This approximation represents a simplification to Maslen's asymmetric method. The present method presents a tractable procedure for computing the inviscid flow over 3-D surfaces at angle of attack. The solution procedure involves iteratively changing the shock shape in the subsonic-transonic region until the correct body shape is obtained. Beyond this region, the shock surface is determined using a marching procedure. Results are presented for a spherically blunted cone, paraboloid, and elliptic cone at angle of attack. The calculated surface pressures are compared with experimental data and finite difference solutions of the Euler equations. Shock shapes and profiles of pressure are also examined. Comparisons indicate the method adequately predicts shock layer properties on blunt bodies in hypersonic flow. The speed of the calculations makes the procedure attractive for engineering design applications

Functional and Structural Adaptations of Skeletal Muscle to Microgravity

Our purpose is to summarize the major effects of space travel on skeletal muscle with particular emphasis on factors that alter function. The primary deleterious changes are muscle atrophy and the associated decline in peak force and power. Studies on both rats and humans demonstrate a rapid loss of cell mass with microgravity. In rats, a reduction in muscle mass of up to 37% was observed within 1 week. For both species, the antigravity soleus muscle showed greater atrophy than the fast-twitch gastrocnemius. However, in the rat, the slow type I fibers atrophied more than the fast type II fibers, while in humans, the fast type II fibers were at least as susceptible to space-induced atrophy as the slow fiber type. Space flight also resulted in a significant decline in peak force. For example, the maximal voluntary contraction of the human plantar flexor muscles declined by 20–48% following 6 months in space, while a 21 % decline in the peak force of the soleus type I fibers was observed after a 17-day shuttle flight. The reduced force can be attributed both to muscle atrophy and to a selective loss of contractile protein. The former was the primary cause because, when force was expressed per cross-sectional area (kNm-2), the human fast type II and slow type I fibers of the soleus showed no change and a 4% decrease in force, respectively. Microgravity has been shown to increase the shortening velocity of the plantar flexors. This increase can be attributed both to an elevated maximal shortening velocity (V0) of the individual slow and fast fibers and to an increased expression of fibers containing fast myosin. Although the cause of the former is unknown, it might result from the selective loss of the thin filament actin and an associated decline in the internal drag during cross-bridge cycling. Despite the increase in fiber V0, peak power of the slow type I fiber was reduced following space flight. The decreased power was a direct result of the reduced force caused by the fiber atrophy. In addition to fiber atrophy and the loss of force and power, weightlessness reduces the ability of the slow soleus to oxidize fats and increases the utilization of muscle glycogen, at least in rats. This substrate change leads to an increased rate of fatigue. Finally, with return to the 1 g environment of earth, rat studies have shown an increased occurrence of eccentric contraction-induced fiber damage. The damage occurs with re-loading and not in-flight, but the etiology has not been established

Districts Taking Charge of the Principal Pipeline

Six urban school districts received support from The Wallace Foundation to address the critical challenge of supplying schools with effective principals. The experiences of these districts may point the way to steps other districts might take toward this same goal. Since 2011, the districts have participated in the Principal Pipeline Initiative, which set forth a comprehensive strategy for strengthening school leadership in four interrelated domains of district policy and practice:Leader standards to which sites align job descriptions, preparation, selection, evaluation, and support.Preservice preparation that includes selective admissions to high-quality programs.Selective hiring, and placement based on a match between the candidate and the school.On-the-job evaluation and support addressing the capacity to improve teaching and learning, with support focused on needs identified by evaluation.The initiative also brought the expectation that district policies and practices related to school leaders would build the district's capacity to advance its educational priorities. The evaluation of the Principal Pipeline Initiative has a dual purpose: to analyze the processes of implementing the required components in the participating districts from 2011 through 2015; and then to assess the results achieved in schools led by principals whose experiences in standards-based preparation, hiring, evaluation, and support have been consistent with the initiative's requirements. This report addresses implementation of all components of the initiative as of 2014, viewing implementation in the context of districts' aims, constraints, and capacity

Cultivating Talent through a Principal Pipeline

This report, the second in a series, describes early results of Wallace's Principal Pipeline Initiative, a multi-year effort to improve school leadership in six urban school districts. The report describes changes in the six districts' practices to recruit, train and support new principals. It also offers early lessons for other districts considering changes to their own principal pipelines

Evaluation of the SPAR thermal analyzer on the CYBER-203 computer

The use of the CYBER 203 vector computer for thermal analysis is investigated. Strengths of the CYBER 203 include the ability to perform, in vector mode using a 64 bit word, 50 million floating point operations per second (MFLOPS) for addition and subtraction, 25 MFLOPS for multiplication and 12.5 MFLOPS for division. The speed of scalar operation is comparable to that of a CDC 7600 and is some 2 to 3 times faster than Langley's CYBER 175s. The CYBER 203 has 1,048,576 64-bit words of real memory with an 80 nanosecond (nsec) access time. Memory is bit addressable and provides single error correction, double error detection (SECDED) capability. The virtual memory capability handles data in either 512 or 65,536 word pages. The machine has 256 registers with a 40 nsec access time. The weaknesses of the CYBER 203 include the amount of vector operation overhead and some data storage limitations. In vector operations there is a considerable amount of time before a single result is produced so that vector calculation speed is slower than scalar operation for short vectors

Investigation of the roles of the actin cytoskeleton remodelling proteins coronin and CAP1 in platelet function

Platelets undergo profound rapid F-actin cytoskeleton remodeling and experience morphological and functional changes in response to receptor-mediated signaling from damaged blood vessel walls. The evolutionarily conserved proteins coronin 1 and adenylyl cyclase-associated protein 1 (CAP1) regulate the F-actin cytoskeleton and participate in signaling events. They are abundant in platelets but until recently their roles were poorly understood. Subcellular fractionation found coronin 1 is mainly cytosolic, but a significant amount associates with membranes in an actin- independent manner and does not translocate to or from the membrane upon platelet stimulation or inhibition. Coronin 1, 2 and 3 associate with the Triton insoluble cytoskeleton upon platelet stimulation. Immunostainings of spread platelets revealed that coronin 1, 2 and 3 demonstrate strong accumulation at F- actin nodules and display diffuse cytoplasmic localisation with discontinuous accumulation at the cell cortex. This is consistent with the role of coronins as integrators of extracellular signals with actin remodeling. Ablation of coronin 1 in platelets is associated with impaired translocation of integrin β2 to the cell surface upon stimulation with thrombin. However, morphological and functional defects are absent including Arp2/3 complex translocation, VASP phosphorylation, spreading ability, secretion, basal receptor levels, αIIbβ3 activation and haemostasis. While integrin β2 translocation appears specifically or predominantly dependent on coronin 1, the lack of other phenotypes suggests a high extent of functional overlap and redundancy among coronins 1, 2 and 3 in platelets. Subcellular fractionation found that ~20% of CAP1 is membrane-associated in an F-actin independent manner. Immunostainings demonstrated that in basal platelets CAP1 is mostly cortical whereas stimulation results in translocation to the cytosol in a significant proportion of platelets which can be inhibited by prostacyclin or nitric oxide. This places CAP1 at a crossroad of signalling pathways that controls platelet activation by contributing to actin remodelling at the cell cortex and actin nodules during platelet spreading

Six Districts Begin the Principal Pipeline Initiative

This first report of an ongoing evaluation of The Wallace Foundation's Principal Pipeline Initiative describes the six participating school districts' plans and activities during the first year of their grants. The evaluation, conducted by Policy Studies Associates and the RAND Corporation, isintended to inform policy makers and practitioners about the process of carrying out new policies and practices for school leadership and about the results of investments in the Principal Pipeline Initiative. This report is based on collection and analysis of qualitative data, including the districts' proposals, work plans, and progress reports and semi-structured interviews in spring 2012 with 91 administrators employed by districts and their partner institutions. Leaders in all districts report wanting to enlarge their pools of strong applicants for principal positions and to identify and cultivate leadership talent as early as possible in educators' careers.Districts are actively working on allrequired pipeline components: (1) with stakeholder participation, they have developed standards and identified competencies for principals, which they plan to use to guide principal training, hiring, evaluation, and support; (2) they are initiating or strengthening partnerships with university training programs; (3) for hiring, they have standard performance tasks and are developing systems to capture data on candidates' experience; (4) they have diagnostic evaluation tools and are working to build the capacity of principals' supervisors and mentors to support principals' skill development. In addition, all are also bolstering district-run training programs for graduates of university training programs who aspire to become principals

Sensitivity of mixing layers to three-dimensional forcing

It is well known that turbulent mixing layers are dominated by large scale, fairly coherent structures, and that these structures are related to the stability characteristics of the flow. These facts have led researchers to attempt controlling such flows by selectively forcing certain unstable modes, which can in addition have the effect of suppressing other modes. Much of the work on controlling the mixing layer has relied on forcing 2-D instabilities. The results of forcing 3-D instabilities are addressed. The objectives of the work are twofold: to understand how a mixing layer responds to 3-D perturbations, and to test the validity of an amplitude expansion in predicting the mixing layer development. The amplitude expansion could be very useful in understanding and predicting the 3-D response of the flow to a variety of initial conditions