70 research outputs found
Scalable Group Level Probabilistic Sparse Factor Analysis
Many data-driven approaches exist to extract neural representations of
functional magnetic resonance imaging (fMRI) data, but most of them lack a
proper probabilistic formulation. We propose a group level scalable
probabilistic sparse factor analysis (psFA) allowing spatially sparse maps,
component pruning using automatic relevance determination (ARD) and subject
specific heteroscedastic spatial noise modeling. For task-based and resting
state fMRI, we show that the sparsity constraint gives rise to components
similar to those obtained by group independent component analysis. The noise
modeling shows that noise is reduced in areas typically associated with
activation by the experimental design. The psFA model identifies sparse
components and the probabilistic setting provides a natural way to handle
parameter uncertainties. The variational Bayesian framework easily extends to
more complex noise models than the presently considered.Comment: 10 pages plus 5 pages appendix, Submitted to ICASSP 1
Low-loss criterion and effective area considerations for photonic crystal fibers
We study the class of endlessly single-mode all-silica photonic crystal
fibers with a triangular air-hole cladding. We consider the sensibility to
longitudinal nonuniformities and the consequences and limitations for realizing
low-loss large-mode area photonic crystal fibers. We also discuss the
dominating scattering mechanism and experimentally we confirm that both macro
and micro-bending can be the limiting factor.Comment: Accepted for Journal of Optics A - Pure and Applied Optic
Manacled to Identity: Cosmopolitanism, Class, and ‘The Culture Concept’ in Stephen Crane
This article begins with a close reading of Stephen Crane’s short story ‘Manacled’ from 1900, which situates this rarely considered short work within the context of contemporary debates about realism. I then proceed to argue that many of the debates raised by the tale have an afterlife in our own era of American literary studies, which has frequently focused on questions of ‘identity’ and ‘culture’ in its reading of realism and naturalism to the exclusion of the importance of cosmopolitan discourses of diffusion and exchange across national borders. I then offer a brief reading of Crane’s novel George’s Mother, which follows Walter Benn Michaels in suggesting that the recent critical attention paid to particularities of cultural difference in American studies have come to conflate ideas of class and social position with ideas of culture in ways that have ultimately obscured the presence of genuine historical inequalities in US society. In order to challenge this critical commonplace, I situate Crane’s work within a history of transatlantic cosmopolitanism associated with the ideas of Franz Boas and Matthew Arnold to demonstrate the ways in which Crane’s narratives sought out an experience of the universal within their treatments of the particular
Heritability and Familial Aggregation of Diverticular Disease: A Population-Based Study of Twins and Siblings
BACKGROUND & AIMS: Little is known about the role of heritable factors in diverticular disease. We evaluated the contribution of heritable factors to the development of diverticular disease diagnosed at a hospitalization or outpatient visit.
METHODS: Using nationwide patient registries, we identified 142,123 incident cases of diverticular disease diagnosed at a hospitalization (1977-2011) or an outpatient hospital visit (1995-2011) in Denmark, including cases in 10,420 index siblings and 923 twins. We calculated standardized incidence ratios for siblings versus the general population and concordance rates for monozygotic versus dizygotic twin pairs as measures of relative risk (RR).
RESULTS: The RR for diverticular disease in siblings of index cases was 2.92 (95% confidence interval [CI], 2.50-3.39) compared with the general population. The RRs were similar irrespective of the sex of the sibling or index case and were particularly strong in siblings of hospitalized cases and cases that underwent surgery. The proband-wise concordance rate for monozygotic twins was double that of dizygotic twins (0.16 [95% CI, 0.11-0.22] vs 0.07 [95% CI, 0.05-0.11], respectively). The RR of diverticular disease in one twin when the other had diverticular disease was 14.5 (95% CI, 8.9-23) for monozygotic twins compared with 5.5 (95% CI, 3.3-8.6) for dizygotic twins. Associations were stronger in female monozygotic twins compared with male twins (tetrachoric correlation, 0.60 [95% CI, 0.49-0.70] vs 0.33 [95% CI, 0.13-0.51]; P = .03 in an analysis stratified by sex and zygosity). We estimate that 53% (95% CI, 45%-61%) of susceptibility to diverticular disease results from genetic factors.
CONCLUSIONS: Based on a population-based study in Denmark, genetic factors appear to contribute to development of diverticular disease
Unbiased Functional Proteomics Strategy for Protein Kinase Inhibitor Validation and Identification of bona fide Protein Kinase Substrates: Application to Identification of EEF1D as a Substrate for CK2
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How the other half lives : studies among the tenements of New York
Layoutgetreues Digitalisat der Ausg.: New York : Scribner's, 1890.
Standort: Universität Marburg, Zentralbibliothek (000)
Signatur: X 87/330
Digitalisiert 201
How the other half lives : studies among the tenements of New York
Layoutgetreues Digitalisat der Ausg.: New York : Scribner's, 1890. Standort: Universität Marburg, Zentralbibliothek (000) Signatur: X 87/330 Digitalisiert 201
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