Rebuilding communities through public space interventions: Co-learning from Beirut’s reconstruction after the 2020 port blast

The participatory analysis of public space projects in Beirut is a research project implemented between October 2022 and May 2023 to map the different public space interventions that took place in Beirut following the port blast in 2020 and co-learn from the different actors involved to enhance future public space interventions in Lebanon. The research is documented in this guide, which synthesises the main learnings. This research project builds on previous related research and in particular the DeCID handbook on co-designing built projects with children affected by displacement (Rigon, Conti, Dabaj, 2021). The DeCID handbook is the key output of the GCRF-funded research implemented as a partnership by the Bartlett DPU and CatalyticAction, involving UNICEF and UN-Habitat; it collected evidence on the different dimensions of the impact of co-designed built projects. Additionally, as part of another GCRF funded project, “Assessing Vulnerabilities for urban recovery solutions in Beirut Post-Explosion” (Pietrostefani, et al., 2021), CatalyticAction with PROCOL Lebanon (previously RELIEF centre) investigated the role that public spaces play in addressing vulnerabilities in the neighbourhood of Karantina in Beirut post explosion. CatalyticAction also worked with UNDP Lebanon to research streets as public spaces in Karantina. The latter two research projects were implemented following a participatory approach that recruited and trained citizen scientists from the neighbourhood. These research projects highlighted a need to better understand the impact of the public space built projects completed as a response to the Beirut blast. Furthermore, CatalyticAction led the implementation of 11 public space projects in Beirut post explosion, and during various coordination meetings, local authorities and key stakeholders highlighted the need for a coordinated response that takes into account contextual specificities and residents’ needs

Communication with the patient in General Practice

Patient communication plays an essential role in everyday clinical practice in General Practice (GP). It is possible to observe the communication skillstechniques in European countries, during the exchange programmes for GP trainees, which are organised by the Vasco da Gama Movement. The patientagenda often does not match the physician’s and sometimes is also neglected or misinterpreted. This may lead to low patient satisfaction and suboptimalclinical practice. Knowing how to approach the patient’s problems and fears, besides managing his/hers expectations, is of high importance in order toenhance satisfaction and quality of care. Furthermore, GP’s unique position should be considered, as he/she can discuss difficult and sensible topicswith his/her patients. The ICE (Ideas, Concerns and Expectations) model is an example of holistic and patient-centred approach, which is appropriatefor GPs, and explores the patient’s point of view concerning diagnosis and treatment. The importance of medical communication is also emphasised ineducation. For instance, a correct and consistent assessment of the communication skills in GP is possible with the use of the MAAS-Global scale

“Good Vibrations”: A workshop on oscillations and normal modes

We describe some theatrical strategies adopted in a two hour workshop in order to show some meaningful experiments and the underlying useful ideas to describe a secondary school path on oscillations, that develops from harmonic motion to normal modes of oscillations, and makes extensive use of video analysis, data logging, slow motions and applet simulations. Theatre is an extremely useful tool to stimulate motivation starting from positive emotions. That is the reason why the theatrical approach to the presentation of physical themes has been explored by the group “Lo spettacolo della Fisica” (http://spettacolo.fisica.unimi.it) of the Physics Department of University of Milano for the last ten years (Carpineti et al., JCOM, 10 (2011) 1; Nuovo Cimento B, 121 (2006) 901) and has been inserted also in the European FP7 Project TEMI (Teaching Enquiry with Mysteries Incorporated, see http://teachingmysteries.eu/en) which involves 13 different partners coming from 11 European countries, among which the Italian (Milan) group. According to the TEMI guidelines, this workshop has a written script based on emotionally engaging activities of presenting mysteries to be solved while participants have been involved in nice experiments following the developed path

Dynamic amyloid and metabolic signatures of delayed recall performance within the clinical spectrum of Alzheimer’s disease

Associations between pathophysiological events and cognitive measures provide insights regarding brain networks affected during the clinical progression of Alzheimer’s disease (AD). In this study, we assessed patients’ scores in two delayed episodic memory tests, and investigated their associations with regional amyloid deposition and brain metabolism across the clinical spectrum of AD. We assessed the clinical, neuropsychological, structural, and positron emission tomography (PET) baseline measures of participants from the Alzheimer’s Disease Neuroimaging Initiative. Subjects were classified as cognitively normal (CN), or with early (EMCI) or late (LMCI) mild cognitive impairment, or AD dementia. The memory outcome measures of interest were logical memory 30 min delayed recall (LM30) and Rey Auditory Verbal Learning Test 30 min delayed recall (RAVLT30). Voxel-based [18F]florbetapir and [18F]FDG uptake-ratio maps were constructed and correlations between PET images and cognitive scores were calculated. We found that EMCI individuals had LM30 scores negatively correlated with [18F]florbetapir uptake on the right parieto-occipital region. LMCI individuals had LM30 scores positively associated with left lateral temporal lobe [18F]FDG uptake, and RAVLT30 scores positively associated with [18F]FDG uptake in the left parietal lobe and in the right enthorhinal cortex. Additionally, LMCI individuals had LM30 scores negatively correlated with [18F]florbetapir uptake in the right frontal lobe. For the AD group, [18F]FDG uptake was positively correlated with LM30 in the left temporal lobe and with RAVLT30 in the right frontal lobe, and [18F]florbetapir uptake was negatively correlated with LM30 scores in the right parietal and left frontal lobes. The results show that the association between regional brain metabolism and the severity of episodic memory deficits is dependent on the clinical disease stage, suggesting a dynamic relationship between verbal episodic memory deficits, AD pathophysiology, and clinical disease stages

Proposal of early CT morphological criteria for response of liver metastases to systemic treatments in gastroenteropancreatic neuroendocrine tumors:Alternatives to RECIST

RECIST 1.1 criteria are commonly used with computed tomography (CT) to evaluate the efficacy of systemic treatments in patients with neuroendocrine tumors (NETs) and liver metastases (LMs), but their relevance is questioned in this setting. We aimed to explore alternative criteria using different numbers of measured LMs and thresholds of size and density variation. We retrospectively studied patients with advanced pancreatic or small intestine NETs with LMs, treated with systemic treatment in the first-and/or second-line, without early progression, in 14 European expert centers. We compared time to treatment failure (TTF) between responders and non-responders according to various criteria defined by 0%, 10%, 20% or 30% decrease in the sum of LM size, and/or by 10%, 15% or 20% decrease in LM density, measured on two, three or five LMs, on baseline (≤1 month before treatment initiation) and first revaluation (≤6 months) contrast-enhanced CT scans. Multivariable Cox proportional hazard models were performed to adjust the association between response criteria and TTF on prognostic factors. We included 129 systemic treatments (long-acting somatostatin analogs 41.9%, chemotherapy 26.4%, targeted therapies 31.8%), administered as first-line (53.5%) or second-line therapies (46.5%) in 91 patients. A decrease ≥10% in the size of three LMs was the response criterion that best predicted prolonged TTF, with significance at multivariable analysis (HR 1.90; 95% CI: 1.06–3.40; p =.03). Conversely, response defined by RECIST 1.1 did not predict prolonged TTF (p =.91), and neither did criteria based on changes in LM density. A ≥10% decrease in size of three LMs could be a more clinically relevant criterion than the current 30% threshold utilized by RECIST 1.1 for the evaluation of treatment efficacy in patients with advanced NETs. Its implementation in clinical trials is mandatory for prospective validation. Criteria based on changes in LM density were not predictive of treatment efficacy. Clinical Trial Registration: Registered at CNIL-CERB, Assistance publique hopitaux de Paris as “E-NETNET-L-E-CT” July 2018. No number was assigned. Approved by the Medical Ethics Review Board of University Medical Center Groningen.</p

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals &lt;1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Is my daughter still a virgin? Can you, please, check it, doctor?

Gender-based violence is a pervasive public health problem, let alone a violation of human rights. The World Health Organization (WHO) has estimated that, overall, 35% of women worldwide have experienced physical and/or sexual intimate partner violence or nonpartner sexual violence. In 2016, the author had the privilege to work with an outstanding group of people that helps sexual and gender-based violence (SGBV) survivors in Port-au-Prince, Haiti. The clinic, run by an international nongovernmental organizations, open walk-in to anyone in need, is functioning to the present day. In its 1st year along, the clinic helped almost 1000 survivors, mainly underaged girls. At the clinic, a highly qualified staff of local doctors and nurses, psychologists, and social workers is available, free of charge, 24 h a day, 7 days a week, and accessible to SGBV survivors in absolute confidentiality. Survivors are offered all the support they might need as per the WHO guidelines, from medical assistance (treating of physical injuries, testing and preventing sexually transmitted diseases such as HIV or hepatitis B, and also gynecological and obstetric care) to psychological counseling, as well as specific referrals to shelters, legal aid, or secondary care as needed. Virginity still is highly valued in Haiti, and the father, mother, the beau-mare, or aunt of the survivor will often approach the doctor and anxiously whisper the question: “Is my daughter (goddaughter, niece) still a virgin?”, “Can you, please, check it, Doctor?” This article presents the perspective of SGBV survivors clinic in Port-au-Prince, Haiti