1,572 research outputs found
Everyday ecocide, toxic dwelling, and the inability to mourn: a speculative response to geographies of extinction
In responding to the spatiotemporally specific geographies of extinction charted in the articles in this special section, this article reflects on the sociocultural factors that inform the ways in which extinction is framed and impede recognition of the enormity of the anthropogenic extinction event in which we are all bound. This article argues that we are living in an era of ecocide, where the degradation of biodiversity and eradication of species go hand-in-hand with the degradation and eradication of nonmodern culture and identity, and it explores some possible reasons why modern society is failing to respond to impending crisis. Fine-grained stories of spatiotemporally specific geographies of extinction can help to counter the logic of colonization and bring everyday ecocide into view. For the particular multispecies communities they concern, they can also feed into the creation of ritual practices of penitential mourning in ways that enable a collective grieving process poised to activate an ecosocial transformation. The authors consider the implications of grief and mourning—and of not mourning—in what can be seen as not only a terrible time but also the end of (lived) time. They conclude with some reflections of local acts of resistance, witnessing, and narrative
Covariation of Pluripotency Markers and Biomechanical Properties in Mouse Embryonic Stem Cells
Variable Selection and Model Averaging in Semiparametric Overdispersed Generalized Linear Models
We express the mean and variance terms in a double exponential regression
model as additive functions of the predictors and use Bayesian variable
selection to determine which predictors enter the model, and whether they enter
linearly or flexibly. When the variance term is null we obtain a generalized
additive model, which becomes a generalized linear model if the predictors
enter the mean linearly. The model is estimated using Markov chain Monte Carlo
simulation and the methodology is illustrated using real and simulated data
sets.Comment: 8 graphs 35 page
Pharmacokinetics of propofol in severely obese surgical patients
BACKGROUND: Existing PK models of propofol include sparse data from very obese patients. The aim of this study was to develop a PK model based on standardised surgical conditions and spanning from normal-weight up to, and including, a high number of very obese patients. METHODS: Adult patients scheduled for laparoscopic cholecystectomy or bariatric surgery were studied. Anaesthesia was induced with propofol 2 mg/kg adjusted body weight over 2 min followed by 6 mg/kg/h adjusted body weight over 30 min. For the remainder of the operation anaesthesia was maintained with sevoflurane. Remifentanil was dosed according to clinical need. Eight arterial samples were drawn in a randomised block sampling regimen over a span of 24 h. Time-concentration data were analysed by population PK modelling using non-linear mixed-effects modelling. RESULTS: Four hundred and seventy four serum propofol concentrations were collected from 69 patients aged 19-60 years with a BMI 21.6-67.3 kg/m2 . Twenty one patients had a BMI above 50 kg/m2 . A 3-compartment PK model was produced wherein three different body weight descriptors and sex were included as covariates in the final model. Total body weight was found to be a covariate for clearance and Q3; lean body weight for V1, V2 and Q2; predicted normal weight for V3 and sex for V1. The fixed allometric exponent of 0.75 applied to all clearance parameters improved the performance of the model. Accuracy and precision were 1.4% and 21.7% respectively in post-hoc performance evaluation. CONCLUSION: We have developed a new PK model of propofol that is suitable for all adult weight classes. Specifically, it is based on data from an unprecedented number of individuals with very high BMI
Can fractals mitigate blast loading?
Fractals are self-similar objects; a shape or pattern made up of an infinitely repeating series of smaller copies of the original. Self-similarity is common in nature – trees, coastlines, shells – and infinitely-repeating fractals possess the interesting characteristic of having finite
volume but infinite surface area (hence the 'Coastline Paradox'). Whilst it is not possible to achieve infinite fractal iterations in real-life, pre-fractals (a self-similar structure with a finite number of iterations) have a sufficiently large area:volume ratio to be useful in a number of
engineering applications, such as antennae and heat exchangers. The properties of a blast wave are substantially altered after it comes into contact with an obstacle: reflection of the wavefront diverts the blast away from its primary path, and diffraction around the obstacle edge induces vortices and further diverts momentum. This raises an interesting question: can fractals mitigate blast loading? Specifically, does the large area:volume property of pre-fractal obstacles increase
the propensity for a blast wave to divert energy away from its original path, thereby mitigating the blast load downstream of the obstacle? This paper details a rigorous experimental study on the blast mitigation of the first three iterations of a Sierpinski carpet subjected to the blast load from PE4 explosives, with downstream, upstream, and on-obstacle pressures directly measured by flush-mounted pressure gauges. The results show that mitigation is enhanced with increasing iteration number, and that the mitigation behaviour of a pre-fractal obstacle is fundamentally different to that of a simple, singular obstacle. This proof-of-concept study opens up the possibility of using natural self-similar structures, such as trees and hedges, for sustainable and less
intrusive blast protection in urban environments
Experimental investigation of blast mitigation of pre-fractal obstacles
Obstacles arranged into a pre-fractal shape (Sierpinski carpet) were tested for their blast attenuation abilities using 250 g PE4 at three different scaled distances (Z = 1.87, 2.24, 2.99 m/kg1/3). Three pre-fractal iterations were tested, as well as free-field tests for comparative purposes. Reductions in peak overpressure up to 26% and peak specific impulse up to 19% were observed, attributed to a mechanism known as ‘trapping’. This mechanism is characterised by a reduction in the ability of a blast wave to advect downstream, with corresponding increases in pressure observed within the bounds of the pre-fractal obstacle. Attenuation magnitudes and areas of reduced pressure and impulse were found to be drastically different with each pre-fractal iteration, with a transition from shadowing to wave trapping as the obstacles more closely resembled true fractals. A linear dependence on a newly-defined obstruction factor (OF) was found for arrival time, overpressure and impulse at the sensor locations, suggesting that the attenuation of a pre-fractal obstacle is inherently determinable. The results indicate that the mechanism of blast mitigation of pre-fractal obstacles is fundamentally different from singular or arrays of regular obstacles, and could be exploited further to develop novel protective structures with enhanced blast attenuation
Stellar Hydrodynamics in Radiative Regions
We present an analysis of the response of a radiative region to waves
generated by a convective region of the star; this wave treatment of the
classical problem of ``overshooting'' gives extra mixing relative to the
treatment traditionally used in stellar evolutionary codes. The interface
between convectively stable and unstable regions is dynamic and nonspherical,
so that the nonturbulent material is driven into motion, even in the absence of
``penetrative overshoot.'' These motions may be described by the theory of
nonspherical stellar pulsations, and are related to motion measured by
helioseismology. Multi-dimensional numerical simulations of convective flow
show puzzling features which we explain by this simplified physical model.
Gravity waves generated at the interface are dissipated, resulting in slow
circulation and mixing seen outside the formal convection zone. The approach
may be extended to deal with rotation and composition gradients. Tests of this
description in the stellar evolution code TYCHO produce carbon stars on the
asymptotic giant branch (AGB), an isochrone age for the Hyades and three young
clusters with lithium depletion ages from brown dwarfs, and lithium and
beryllium depletion consistent with observations of the Hyades and Pleiades,
all without tuning parameters. The insight into the different contributions of
rotational and hydrodynamic mixing processes could have important implications
for realistic simulation of supernovae and other questions in stellar
evolution.Comment: 27 pages, 5 figures, accepted to the Astrophysical Journa
Observations from Preliminary Experiments on Spatial and Temporal Pressure Measurements from Near-Field Free Air Explosions
It is self-evident that a crucial step in analysing the performance of protective structures is to be able to accurately quantify the blast load arising from a high explosive detonation. For structures located near to the source of a high explosive detonation, the resulting pressure is extremely high in magnitude and highly non-uniform over the face of the target. There exists very little direct measurement of blast parameters in the nearfield, mainly attributed to the lack of instrumentation sufficiently robust to survive extreme loading events yet sensitive enough to capture salient features of the blast. Instead literature guidance is informed largely by early numerical analyses and parametric studies. Furthermore, the lack of an accurate, reliable data set has prevented subsequent numerical analyses from being validated against experimental trials. This paper presents an experimental methodology that has been developed in part to enable such experimental data to be gathered. The experimental apparatus comprises an array of Hopkinson pressure bars, fitted through holes in a target, with the loaded faces of the bars flush with the target face. Thus, the bars are exposed to the normally or obliquely reflected shocks from the impingement of the blast wave with the target. Pressure-time recordings are presented along with associated Arbitary-Langrangian-Eulerian modelling using the LS-DYNA explicit numerical code. Experimental results are corrected for the effects of dispersion of the propagating waves in the pressure bars, enabling accurate characterisation of the peak pressures and impulses from these loadings. The combined results are used to make comments on the mechanism of the pressure load for very near-field blast events
LBT and Spitzer Spectroscopy of Star-Forming Galaxies at 1 < z < 3: Extinction and Star Formation Rate Indicators
We present spectroscopic observations in the rest-frame optical and near- to
mid-infrared wavelengths of four gravitationally lensed infrared (IR) luminous
star-forming galaxies at redshift 1 < z < 3 from the LUCIFER instrument on the
Large Binocular Telescope and the Infrared Spectrograph on Spitzer. The sample
was selected to represent pure, actively star-forming systems, absent of active
galactic nuclei. The large lensing magnifications result in high
signal-to-noise spectra that can probe faint IR recombination lines, including
Pa-alpha and Br-alpha at high redshifts. The sample was augmented by three
lensed galaxies with similar suites of unpublished data and observations from
the literature, resulting in the final sample of seven galaxies. We use the IR
recombination lines in conjunction with H-alpha observations to probe the
extinction, Av, of these systems, as well as testing star formation rate (SFR)
indicators against the SFR measured by fitting spectral energy distributions to
far-IR photometry. Our galaxies occupy a range of Av from ~0 to 5.9 mag, larger
than previously known for a similar range of IR luminosities at these
redshifts. Thus, estimates of SFR even at z ~ 2 must take careful count of
extinction in the most IR luminous galaxies. We also measure extinction by
comparing SFR estimates from optical emission lines with those from far-IR
measurements. The comparison of results from these two independent methods
indicates a large variety of dust distribution scenarios at 1 < z < 3. Without
correcting for dust extinction, the H-alpha SFR indicator underestimates the
SFR; the size of the necessary correction depends on the IR luminosity and dust
distribution scenario. Individual SFR estimates based on the 6.2 micron PAH
emission line luminosity do not show a systematic discrepancy with extinction,
although a considerable, ~0.2 dex scatter is observed.Comment: Accepted for publication in The Astrophysical Journal; 14 pages, 8
figure
- …