2,283 research outputs found
Activstion of insulin-receptor-kinase in intact HIRc and hepatoma G2-cells: Effect of dexamethasone
The relationship between insulin binding, insulin activation of insulin-receptor tyrosine kinase, and insulin stimulation of glucose uptake in isolated rat adipocytes
We have studied the relationship between insulin activation of insulin-receptor kinase and insulin stimulation of glucose uptake in isolated rat adipocytes. Glucose uptake was half-maximally or maximally stimulated, respectively, when only 4% or 14% of the maximal kinase activity had been reached. To investigate this relationship also under conditions where the insulin effect on activation of receptor kinase was decreased, the adipocytes were exposed to 10 microM-isoprenaline alone or with 5 micrograms of adenosine deaminase/ml. An approx. 30% (isoprenaline) or approx. 50% (isoprenaline + adenosine deaminase) decrease in the insulin effect on receptor kinase activity was found at insulin concentrations between 0.4 and 20 ng/ml, and this could not be explained by decreased insulin binding. The decreased insulin-effect on kinase activity was closely correlated with a loss of insulin-sensitivity of glucose uptake. Moreover, our data indicate that the relation between receptor kinase activity and glucose uptake (expressed as percentage of maximal uptake) remained unchanged. The following conclusions were drawn. (1) If activation of receptor kinase stimulates glucose uptake, only 14% of the maximal kinase activity is sufficient for maximal stimulation. (2) Isoprenaline decreases the coupling efficiency between insulin binding and receptor-kinase activation, this being accompanied by a corresponding decrease in sensitivity of glucose uptake. (3) Our data indicate that the signalling for glucose uptake is closely related to receptor-kinase activity, even when the coupling efficiency between insulin binding and kinase activation is altered. They thus support the hypothesis that receptor-kinase activity reflects the signal which originates from the receptor and which is transduced to the glucose-transport system
Quantum scissors: teleportation of single-mode optical states by means of a nonlocal single photon
We employ the quantum state of a single photon entangled with the vacuum
(|1,0>-|0,1>), generated by a photon incident upon a symmetric beam splitter,
to teleport single-mode quantum states of light by means of the Bennett
protocol. Teleportation of coherent states results in truncation of their Fock
expansion to the first two terms. We analyze the teleported ensembles by means
of homodyne tomography and obtain fidelities of up to 99 per cent for low
source state amplitudes. This work is an experimental realization of the
quantum scissors device proposed by Pegg, Phillips and Barnett (Phys. Rev.
Lett. 81, 1604 (1998)
Effekt von Dexamethason auf die Insulinbindung und die insulinabhängige Aktivierung der Insulinrezeptorkinase in intakten Zellen
The Wendelstein Calar Alto Pixellensing Project (WeCAPP): the M31 Nova catalogue
We present light curves from the novae detected in the long-term, M31
monitoring WeCAPP project. The goal of WeCAPP is to constrain the compact dark
matter fraction of the M31 halo with microlensing observations. As a by product
we have detected 91 novae benefiting from the high cadence and highly sensitive
difference imaging technique required for pixellensing. We thus can now present
the largest CCD and optical filters based nova light curve sample up-to-date
towards M31. We also obtained thorough coverage of the light curve before and
after the eruption thanks to the long-term monitoring. We apply the nova
taxonomy proposed by Strope et al. (2010) to our nova candidates and found 29
S-class novae, 10 C-class novae, 2 O-class novae and 1 J-class nova. We have
investigated the universal decline law advocated by Hachichu and Kato (2006) on
the S-class novae. In addition, we correlated our catalogue with the literature
and found 4 potential recurrent novae. Part of our catalogue has been used to
search for optical counter-parts of the super soft X-ray sources detected in
M31 (Pietsch et al. 2005). Optical surveys like WeCAPP, and coordinated with
multi-wavelength observation, will continue to shed light on the underlying
physical mechanism of novae in the future.Comment: 15 pages, 15 figures, 7 tables, A&A accepted for publication. The
appendix is stored in the Data Conservanc
Progressor: Social navigation support through open social student modeling
The increased volumes of online learning content have produced two problems: how to help students to find the most appropriate resources and how to engage them in using these resources. Personalized and social learning have been suggested as potential ways to address these problems. Our work presented in this paper combines the ideas of personalized and social learning in the context of educational hypermedia. We introduce Progressor, an innovative Web-based tool based on the concepts of social navigation and open student modeling that helps students to find the most relevant resources in a large collection of parameterized self-assessment questions on Java programming. We have evaluated Progressor in a semester-long classroom study, the results of which are presented in this paper. The study confirmed the impact of personalized social navigation support provided by the system in the target context. The interface encouraged students to explore more topics attempting more questions and achieving higher success rates in answering them. A deeper analysis of the social navigation support mechanism revealed that the top students successfully led the way to discovering most relevant resources by creating clear pathways for weaker students. © 2013 Taylor and Francis Group, LLC
Folding Langmuir Monolayers
The maximum pressure a two-dimensional surfactant monolayer is able to
withstand is limited by the collapse instability towards formation of
three-dimensional material. We propose a new description for reversible
collapse based on a mathematical analogy between the formation of folds in
surfactant monolayers and the formation of Griffith Cracks in solid plates
under stress. The description, which is tested in a combined microscopy and
rheology study of the collapse of a single-phase Langmuir monolayer of
2-hydroxy-tetracosanoic acid (2-OH TCA), provides a connection between the
in-plane rheology of LM's and reversible folding
How Do Software Startups Pivot? Empirical Results from a Multiple Case Study
In order to handle intense time pressure and survive in dynamic market,
software startups have to make crucial decisions constantly on whether to
change directions or stay on chosen courses, or in the terms of Lean Startup,
to pivot or to persevere. The existing research and knowledge on software
startup pivots are very limited. In this study, we focused on understanding the
pivoting processes of software startups, and identified the triggering factors
and pivot types. To achieve this, we employed a multiple case study approach,
and analyzed the data obtained from four software startups. The initial
findings show that different software startups make different types of pivots
related to business and technology during their product development life cycle.
The pivots are triggered by various factors including negative customer
feedback.Comment: Conference publication, International Conference on Software Business
(ICSOB'16), Sloveni
Evolution of the polarization of the optical afterglow of the gamma-ray burst GRB 030329
We report 31 polarimetric observations of the afterglow of GRB 030329 with
high signal-to-noise and high sampling frequency. We establish the polarization
light curve, detect sustained polarization at the percent level, and find
significant variability of polarization degree and angle. The data imply that
the afterglow magnetic field has small coherence length and is mostly random,
probably generated by turbulence.Comment: Nature 426 (13. Nov. 2003), 2 figure
Shielding efficiency and E(J) characteristics measured on large melt cast Bi-2212 hollow cylinders in axial magnetic fields
We show that tubes of melt cast Bi-2212 used as current leads for LTS magnets
can also act as efficient magnetic shields. The magnetic screening properties
under an axial DC magnetic field are characterized at several temperatures
below the liquid nitrogen temperature (77 K). Two main shielding properties are
studied and compared with those of Bi-2223, a material that has been considered
in the past for bulk magnetic shields. The first property is related to the
maximum magnetic flux density that can be screened, Blim; it is defined as the
applied magnetic flux density below which the field attenuation measured at the
centre of the shield exceeds 1000. For a cylinder of Bi-2212 with a wall
thickness of 5 mm and a large ratio of length over radius, Blim is evaluated to
1 T at T = 10 K. This value largely exceeds the Blim value measured at the same
temperature on similar tubes of Bi-2223. The second shielding property that is
characterized is the dependence of Blim with respect to variations of the sweep
rate of the applied field, dBapp/dt. This dependence is interpreted in terms of
the power law E = Ec(J/Jc)^n and allows us to determine the exponent n of this
E(J) characteristics for Bi-2212. The characterization of the magnetic field
relaxation involves very small values of the electric field. This gives us the
opportunity to experimentally determine the E(J) law in an unexplored region of
small electric fields. Combining these results with transport and AC shielding
measurements, we construct a piecewise E(J) law that spans over 8 orders of
magnitude of the electric field.Comment: 16 pages, 7 figure
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