Diffuse somatostatin-immunoreactive D-cell hyperplasia in the stomach and duodenum

This paper presents the first case of extensive, diffuse, somatostatin- immunoreactive D-cell hyperplasia in the human stomach and duodenum. It occurred in a 37-yr-old woman, who showed clinical signs of dwarfism, obesity, dryness of the mouth, and goiter. The density of the distribution of D cells was increased 39-fold in the stomach fundus, 23- fold in the proximal antrum, 25-fold in the distal antrum, and 31-fold in the upper duodenum in comparison with normal values. At the same time, the gastrin-immunoreactive cells were increased 2.3-fold in the antrum. Although the range in size of the D cells was within normal limits in all regions examined, the G cells showed pronounced hypertrophy of up to 127%. A possible relationship between the immuno- histochemical findings and the clinical picture is discussed

Physical Condition, Sex, and Age-Class of Eastern Red-Backed Salamanders ( Plethodon cinereus

Nonforested habitats such as open fields and pastures have been considered unsuitable for desiccation-prone woodland salamanders such as the Eastern Red-backed Salamander (Plethodon cinereus). Recent research has suggested that Plethodon cinereus may not only disperse across but also reside within open habitats including fields, meadows, and pastures. However, presence and high densities of P. cinereus within agriculturally disturbed habitats may be misleading if these populations exhibit atypical demographic characteristics or decreased physical condition relative to forest populations. We surveyed artificial cover boards from 2004-2005 to compare physical condition, sex ratios, and age-class structure of P. cinereus among woodland, woodland-meadow edge, silvopasture, and meadow sites in the central Appalachian Mountains of southern West Virginia. Physical condition of salamanders was not significantly different among the four habitats. Furthermore, adult sex ratios of P. cinereus typically were not significantly different from 1 : 1 and were similar between forested and non-forested sites, although populations within silvopastures were biased towards females. However, adult salamanders were significantly more abundant than juveniles in all habitat types, with differences most pronounced within meadow habitats. Our study indicates that relatively small, non-forested habitats such as silvopastures and meadows may not adversely affect the overall physical condition or sex ratios of Plethodon cinereus. However, the paucity of juveniles within disturbed meadows indicates that these agriculturally modified habitats may negatively impact reproduction or that immature salamanders are at a physiological or competitive disadvantage in comparison to adults, particularly when surface cover is limited

Transition-Metal-Doping of CaO as Catalyst for the OCM Reaction, a Reality Check

In this study, first-row transition metal-doped calcium oxide materials (Mn, Ni, Cr, Co., and Zn) were synthesized, characterized, and tested for the OCM reaction. Doped carbonate precursors were prepared by a co-precipitation method. The synthesis parameters were optimized to yield materials with a pure calcite phase, which was verified by XRD. EPR measurements on the doped CaO materials indicate a successful substitution of Ca2+ with transition metal ions in the CaO lattice. The materials were tested for their performance in the OCM reaction, where a beneficial effect towards selectivity and activity effect could be observed for Mn, Ni, and Zn-doped samples, where the selectivity of Co- and Cr-doped CaO was strongly reduced. The optimum doping concentration could be identified in the range of 0.04-0.10 atom%, showing the strongest decrease in the apparent activation energy, as well as the maximum increase in selectivity

Water resistant surfaces using zinc oxide structured nanorod arrays with switchable wetting property

This study presents an experimental approach for fabricating super hydrophobic coatings based on a dual roughness structure composed of zinc oxide nanorod arrays coated with a sputtered zinc oxide nano layer. The ZnO nanorod arrays were grown by means of a low temperature electrochemical deposition technique 75 C on FTO substrates. The ZnO nanorods show a 002 orientation along the c axis, and have a hexagonal structure, with an average length of 710 nm, and average width of 156 nm. On the other hand, the crystallite size of the top coating sputtered ZnO layer is of 30 nm. The as deposited ZnO nanorod arrays exhibited a hydrophobic behavior, with a surface water contact angle of 108 , whereas the dual scale roughness ZnO nanorods coated with sputtered ZnO exhibited a super hydrophobic behavior, with a surface water contact angle of 157 and a high water droplet adhesion. The photo catalytic activity of the samples was investigated against the degradation of methylene blue under UV A irradiation 365 nm . The ZnO nanorod arrays showed good photocatalytic activity whereas the superhydrophobic ZnO nanorod arrays top coated with sputtered ZnO showed minimal activity regarding the degradation of methylene blue. The superhydrophobic films exhibited high sensitivity to UV light, with a UV induced switching behavior from super hydrophobic to super hydrophilic after only 30 min of UV exposur

A thermodynamically self-consistent theory for the Blume-Capel model

We use a self-consistent Ornstein-Zernike approximation to study the Blume-Capel ferromagnet on three-dimensional lattices. The correlation functions and the thermodynamics are obtained from the solution of two coupled partial differential equations. The theory provides a comprehensive and accurate description of the phase diagram in all regions, including the wing boundaries in non-zero magnetic field. In particular, the coordinates of the tricritical point are in very good agreement with the best estimates from simulation or series expansion. Numerical and analytical analysis strongly suggest that the theory predicts a universal Ising-like critical behavior along the $\lambda$-line and the wing critical lines, and a tricritical behavior governed by mean-field exponents.Comment: 11 figures. to appear in Physical Review

Nonanalytic corrections to the specific heat of a three-dimensional Fermi liquid

We revisit the issue of the leading nonanalytic corrections to the temperature dependence of the specific heat coefficient, $\gamma (T)=C(T)/T,$ for a system of interacting fermions in three dimensions. We show that the leading temperature dependence of the specific heat coefficient $\gamma (T)-\gamma (0) \propto T^3 \ln T$ comes from two physically distinct processes. The first process involves a thermal excitation of a single particle-hole pair, whose components interact via a nonanalytic dynamic vertex. The second process involves an excitation of three particle-hole pairs which interact via the analytic static fixed-point vertex. We show that the single-pair contribution is expressed via the backscattering amplitude of quasiparticles at the Fermi surface. The three-pair contribution does not have a simple expression in terms of scattering in particular directions. We clarify the relation between these results and previous literature on both 3D and 2D systems, and discuss the relation between the nonanalyticities in $\gamma$ and those in spin susceptibilities

Quasiparticle Interface States in Junctions Involving d-Wave Superconductors

Influence of surface pair breaking, barrier transmission and phase difference on quasiparticle bound states in junctions with d-wave superconductors is examined. Based on the quasiclassical theory of superconductivity, an approach is developed to handle interface bound states. It is shown in SIS' junctions that low energy bound states get their energies reduced by surface pair breaking, which can be taken into account by introducing an effective order parameter for each superconductor at the junction barrier. More interestingly, for the interface bound states near the continuous spectrum the effect of surface pair breaking may result in a splitting of the bound states. In the tunneling limit this can lead to a square root dependence of a nonequilibrium Josephson current on the barrier transmision, which means an enhancement as compared to the conventional critical current linear in the transmission. Reduced broadening of bound states in NIS junctions due to surface pair breaking is found.Comment: 27 pages, Latex fil

Functional and Pharmacological Analysis of Cardiomyocytes Differentiated from Human Peripheral Blood Mononuclear-Derived Pluripotent Stem Cells

SummaryAdvances in induced pluripotent stem cell (iPSC) technology have set the stage for routine derivation of patient- and disease-specific human iPSC-cardiomyocyte (CM) models for preclinical drug screening and personalized medicine approaches. Peripheral blood mononuclear cells (PBMCs) are an advantageous source of somatic cells because they are easily obtained and readily amenable to transduction. Here, we report that the electrophysiological properties and pharmacological responses of PBMC-derived iPSC CM are generally similar to those of iPSC CM derived from other somatic cells, using patch-clamp, calcium transient, and multielectrode array (MEA) analyses. Distinct iPSC lines derived from a single patient display similar electrophysiological features and pharmacological responses. Finally, we demonstrate that human iPSC CMs undergo acute changes in calcium-handling properties and gene expression in response to rapid electrical stimulation, laying the foundation for an in-vitro-tachypacing model system for the study of human tachyarrhythmias

Redundant Information from Thermal Illumination: Quantum Darwinism in Scattered Photons

We study quantum Darwinism, the redundant recording of information about the preferred states of a decohering system by its environment, for an object illuminated by a blackbody. We calculate the quantum mutual information between the object and its photon environment for blackbodies that cover an arbitrary section of the sky. In particular, we demonstrate that more extended sources have a reduced ability to create redundant information about the system, in agreement with previous evidence that initial mixedness of an environment slows---but does not stop---the production of records. We also show that the qualitative results are robust for more general initial states of the system.Comment: 23 pages, 7 figure